Branched-Chain Amino Acids (BCAAs): Revisiting Their Role in Sport and Health by Aleksandra Kajtel, Anna Skowronek, Martyna Piekarska, Katarzyna Dąbek, Michał Ochwat, Maria Sudoł, Gabriela Mierzwa

“…BCAA metabolism primarily occurs in skeletal muscle and liver, with leucine activating key signaling pathways like mTORC1, promoting muscle growth and reducing protein breakdown. …”
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不同刺激方案对卵巢低反应患者体外受精结局影响的比较 by 刘晓娉, 李婷婷

“…【结果】COS组患者扳机日 子宫内膜厚度（mm）和扳机日血清雌二醇（E2）水平（pg/mL）显著高于微刺激组，分别为11.4±2.5vs.9.6±2.5、 1200±710vs.560±470，差异均有统计学意义（P＜0.05）；两组扳机日血清黄体生成素（LH）、孕激素（P）水平差 异无统计学意义（P＞0.05）；COS组患者获卵数（4.1±2.8vs.2.8±1.9）和可利用胚胎数（2.0±1.6vs.1.5±1.4）均 多于微刺激组，差异有统计学意义（P＜0.05）；两组的胚胎种植率，每移植周期、每取卵周期以及每启动周期的临 床妊娠率，流产率，活产率差异均无统计学意义（P＞0.05）。…”
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Profil Literasi Matematika Siswa SMP dalam Menyelesaikan Soal Cerita Berdasarkan Prestasi Belajar Matematika by Muzayyanatul Jannah, Dwi Shinta Rahayu, Eka Resti Wulan

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高容量血液滤过在肝移植术后多器官功能障碍 综合征病人中的应用

“…【目的】 探讨高容量血液滤过(HVHF)在肝移植术后因严重感染引起多器官功能障碍综合征(MODS)患者中的应用65377; 【方法】 分析2003年12月至2008年12月肝移植术后因感染引起MODS进行连续性血液净化治疗74例患者的临床资料,根据超滤率是否大于35 mL/kg/h分为HVHF组(49例)和连续性静脉-静脉血液滤过(CVVH)组(25例)65377;记录治疗前和治疗后24 h65380;48 h65380;72 h APACHⅡ评分65380;电解质65380;血流动力学和呼吸功能各项指标,以及临床转归65377;分别对组内治疗后各时间点与治疗前以及两组间各时间点之间的观察指标进行比较65377; 【结果】 HVHF组患者,APACHⅡ评分65380;乳酸65380;肌酐65380;心率65380;多巴胺用量65380;气道平均压和气道峰压65380;氧合指数等指标在治疗后24 h65380;48 h65380;72 h较治疗前明显下降(P < 0.05)65377;CVVH组患者,APACHⅡ评分65380;乳酸65380;气道平均压和气道峰压值治疗前后无明显变化(P > 0.05),心率65380;多巴胺用量和氧合指数虽较前有所改善,但程度均不如HVHF组(P < 0.05)65377;HVHF组死亡率为59.2%(29/49),CVVH组为84.0%(21/25),两者具有统计学差异(χ2 = 4.652,P = 0.031)65377;【结论】 HVHF通过维持机体内环境的稳定,为其他治疗创造有利条件,有助于提高肝移植术后危重患者的生存率65377;…”
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经脐单孔腹腔镜乳头式输尿管膀胱再植术初步体会

“…【目的】 探讨采用自制多通道套管和常规器械经脐行腹腔镜下乳头式输尿管膀胱再植术的可行性和疗效65377;【方法】 2009年4月至2009年12月对9例输尿管末端狭窄或异位开口的患者行腹腔镜输尿管膀胱再植术65377;气管内全麻下经脐部切口置入自制多通道套管(用手套和两个弹性橡胶环制作而成)65377;从髂血管分叉处找到并游离异常输尿管至膀胱壁段处切断,末端1 cm纵行切开外翻缝合形成乳头,输尿管内置双J管,从膀胱后顶部切口插入膀胱约1 ~ 1.5 cm,4-0可吸收线间断吻合6针,检查无渗漏后放置盆腔引流65377;【结果】 全部手术均在单孔腹腔镜下成功完成,无需术中增加套管或开放手术65377;平均手术时间为87 min,平均估计失血量小于30 mL,无术中并发症发生,术后1 d可起床活动,引流管65380;尿管65380;双J管分别在2 d65380;7 d65380;30 d拔除,内镜下可见输尿管乳头,术后2 ~ 3月静脉尿路造影(IVU)及膀胱尿道造影未见吻合口狭窄和反流,脐部切口美观65377;【结论】 经脐单孔腹腔镜下输尿管膀胱再植术具有创伤小65380;美观经济65380;恢复快的优点65377;输尿管乳头式膀胱再植法狭窄率低65380;抗反流效果好,镜下操作简便,值得推广应用65377;…”
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Seroprevalence of SARS-CoV-2 virus antibodies and sociodemographic features of pregnant women in Mogadishu, Somalia: a cross-sectional survey study by Maryan Abdullahi Sh. Nur, Hassan Abdullahi Dahie, Nima Abdi Hassan, Bashiru Garba, Jamal Hassan Mohamoud, Najib Isse Dirie, Mohamed Hussein Adam

“…Also, out of the 141 pregnant women who had two children or less, 19.4% were positive for IgG/IgM antibodies. Participants who had close contact with patients with COVID-19 were significantly associated for testing positive with a p value 0.0001. …”
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Therapists perspectives on the Early Intervention after Rape study: a qualitative process evaluation of a randomized controlled trial by Tina Haugen, Joar Øveraas Halvorsen, Oddgeir Friborg, Berit Schei, Cecilie Therese Hagemann, Marianne Kjelsvik

“…The Early Intervention after Rape (EIR) study is a multisite randomized controlled trial designed to assess the efficacy and effectiveness of training SAC nurses and social workers to deliver a modified version of prolonged exposure therapy shortly after rape.Objective: This article aims to present a qualitative process evaluation of the implementation of the EIR study across three SACs in Norway, from the perspective of nurses and social workers.Method: We conducted semi-structured interviews with fifteen nurses and social workers, ten of whom received training in prolonged exposure therapy (mPE). We used Thematic Analysis to identify themes and subthemes.Results: Thematic analysis yielded four significant themes for process evaluation: (1) The quality of the new intervention modified prolonged exposure was considered satisfactory through training and supervision and delivered with good adherence to the manual, although some therapists perceived the manual as too rigid; (2) Adoption dynamics within the SACs are complex and include both enthusiasm for clinical research as well as resistance to change; (3) Narrow inclusion criteria and burden with participation for patients may limit reach and representativeness of the RCT; (4) Unintended consequences were identified, such as delayed start, conflicting advices and cross-contamination, underscoring the ongoing necessity for process evaluation alongside RCTs.Conclusion: This qualitative process evaluation offers insight into real-world clinical challenges with implementing a new intervention and conducting a multisite RCT within SACs in Norway. …”
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Assessment of the Chemical Diversity and Functional Properties of Secondary Metabolites from the Marine Fungus <i>Asteromyces cruciatus</i> by María Paz González-Troncoso, Catalina Landeta-Salgado, Javiera Munizaga, Ruth Hornedo-Ortega, María del Carmen García-Parrilla, María Elena Lienqueo

“…The analysis revealed the presence of anthraquinone compounds, including emodin (0.36 ± 0.08 mg/g DW biomass) and citrereosein in glucose medium and citrereosein and endocrocin in <i>M. pyrifera</i> medium. No such compounds were detected in <i>Durvillaea</i> spp. medium. …”
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Enhancement of Cognitive Benefits and Anti-Anxiety Effects of <i>Phytolacca americana</i> Fruits in a Zebrafish (<i>Danio rerio</i>) Model of Scopolamine-Induced Memory Impairment by Lucia-Florina Popovici, Ion Brinza, Florentina Gatea, Georgiana Ileana Badea, Emanuel Vamanu, Simona Oancea, Lucian Hritcu

“…This study aims to investigate the phenolic profile of hydroethanolic extracts from both fresh (PEC) and dried (PEU) fruits of <i>P. americana</i> using high-performance liquid chromatography (HPLC) and to evaluate their impact on anxiety-like behavior, memory, oxidative stress, and cholinergic status in zebrafish (<i>Danio rerio</i>, Tübingen strain) treated with scopolamine (SCO, 100 μM). Acute administration of PEC and PEU (0.1, 0.5, and 1 mg/L) was conducted for one hour per day. …”
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Novel lncRNA LncMSTRG.11341.25 Promotes Osteogenic Differentiation of Human Bone Marrow Stem Cells via the miR-939-5p/PAX8 Axis by Feifei Ni, Jianjun Li, Qin Yin, Yangyang Chen, Zengwu Shao, Hong Wang

“…These findings deepen our understanding of the regulatory role of lncRNA–miRNA–mRNA networks in the immune microenvironment of bone marrow, and highlight the important role played by the spleen as an immune organ in fracture healing.…”
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Renal Ischemia-Reperfusion Injury in a Diabetic Monkey Model and Therapeutic Testing of Human Bone Marrow-Derived Mesenchymal Stem Cells by Kyo Won Lee, Tae Min Kim, Kyeong Sik Kim, Seunghwan Lee, Junhun Cho, Jae Berm Park, Ghee Young Kwon, Sung Joo Kim

“…Moreover, histological findings and qRT-PCR analysis of Ngal mRNA in renal biopsy tissue showed that hBM-MSC promoted the recovery of tubular damage caused by AKI. …”
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Role of Dolutegravir/Lamivudine in the Management of Pregnant People Living with HIV-1: A Narrative Review by William R. Short, Parul Patel, Gustavo Verdier, Ana Puga, Vani Vannappagari, Annemiek de Ruiter, Bryn Jones

“…Two studies evaluated DTG/3TC during pregnancy and both reported high virologic suppression rates [HIV-1 ribonucleic acid (RNA) < 50 copies/mL at delivery: 97% (30/31) overall], no events of vertical transmission, and no new safety signals, consistent with the use of DTG-based 3-drug regimens in pregnancy. …”
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Proceso del cuidado aplicado en adulto mayor con hipertensión arterial by Geraldine Ruby Báez Rentera, Levi Rebeca Morales Miranda, Tamara Angela Ortega Albornoz, Chanell Sthefany Rafaile Bada, Milagros Lizbeth Uturunco Vera, Petronila Elizabeth Alvarado Chavez

“…Caso clínico: Proceso de cuidado enfermero aplicado durante 3 días a adulto mayor de iniciales A. M. B. de 73 años, de sexo femenino, con antecedentes de 2 años post COVID. …”
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Hypertensive disorders of pregnancy affected thyroid hormone synthesis via endoplasmic reticulum stress in preterm infant rats by Maomao Sun, Congrong Wu, Jie Jiang, Yue He, Sha Zhu, Yonghui Yu

“…While electron microscopy revealed that the endoplasmic reticulum of thyroid follicular epithelial cells was marked swollen within L-NAME group. Additionally, the mRNA expression of Ttf1, Pax8 and Tshr was down-regulated in thyroid tissues of L-NAME group. …”
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Wetland elevation change following beneficial use of dredged material nourishment by Brian D. Harris, Aleksandra Ostojic, Lenore P. Tedesco, Keith VanDerSys, Susan Bailey, Justin L. Shawler, Navid H. Jafari, Monica Chasten

“…Approximately two years post BUDM, the nourished area experienced a 0.19 ± 0.11-m increase in elevation. The comparison of elevation immediately after nourishment and two years post- nourishment found that approximately one-third of elevation loss was the result of consolidation of deposited dredged material and the underlying wetland foundation.DiscussionIt was found that a reliance on solely laboratory data can induce a large degree of uncertainty within projected surface elevations. …”
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The impact of glucagon-like peptide-1 (GLP-1) agonists in the treatment of eating disorders: a systematic review and meta-analysis by Hanieh Radkhah, Shiva Rahimipour Anaraki, Peyvand Parhizkar Roudsari, Razman Arabzadeh Bahri, Diar Zooravar, Sara Asgarian, Reza Hosseini Dolama, Ali Alirezaei, Razieh Khalooeifard

“…GLP-1 agonists significantly reduced BMI (− 1.48 kg/m2) and waist circumference (− 3.14 cm). Binge Eating Scale (BES) scores improved significantly (− 8.14 points; 95% CI − 13.13 to − 3.15; p < 0.01), though heterogeneity was noted. …”
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Inhibitory effects of oxyresveratrol on ERK and Smad1/2 phosphorylation and HSC activation in preventing carbon tetrachloride-induced rat liver fibrosis by Guliang Yang, Jianfeng Zhan, Yiwen Yang, Li Yuan, Peilei Wang, Chi-Tang Ho, Shiming Li

“…We demonstrated that rat liver oxidative damage induced by CCl4 was significantly alleviated after ORes feeding. Furthermore, the mRNA transcription levels of α-smooth muscle actinn (α-SMA), desmin, and two MMPs (MMP2 and MMP9) were reduced and the expression levels of transforming growth factor β1 (TGF-β1), p- small mother against decapen-taplegic protein (Smad)1/2 and p-extracellular signal-regulated kinases (ERK)1/2 in the liver tissue down-regulated dramatically. …”
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抑制NLRP3 炎症小体中Caspase-1 活化对大鼠颈动脉球囊损伤后内膜增生的保护作用 by 刘颖, 刘艳秋, 李翠玲, 姚凤娟, 刘东红

“…采用球囊损伤大鼠颈动脉的方法建立血管内膜增生动物模型，14 天后留取球囊损伤段血管，15 个血管片段制作冰冻切片，苏木精-伊红（HE）染色法测量内膜与中膜（I/M）面积比值；18根血管片段采用Western blot 检测NOD样受体蛋白3（NLRP3）炎症小体、 cleaved-Caspase-1、白介素（IL）-1β和IL-18 的表达。…”
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Low regulatory T-cells frequency is associated with graft rejection after small bowel transplantation: Clinical and experimental evidence. by Rodrigo Papa-Gobbi, Pablo Stringa, Maria Virginia Gentilini, Ivana Ivanoff, Mariana Machuca, Nidia Monserrat Arreola, Javier Serradilla, Karla Estefanía-Fernández, Paloma Talayero, María Velayos, Elena Sánchez-Zapardiel, Gabriel Gondolesi, Ane Andrés-Moreno, Martin Rumbo, Francisco Hernández-Oliveros

“…Notably, ACR correlated with a high CD8/CD4 ratio, loss of T-cell chimerism, mRNA upregulation of pro-inflammatory genes and diminished graft Treg frequency. …”
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Optimization of Black Garlic Protein Extraction Process and Exploration of Its Properties and Functions with Enzymatic Hydrolysis Products by Jian Liu, Yuanyuan Wang, Bo Wang, Wei Zhang, Xiaoyu Ren, Youchuang Zhang, Lijun Jiang, Chunming Dong, Guihong Zhao

“…Among the hydrolysates, the pepsin hydrolysate (BGPH-P) had the smallest particle size (188.57 ± 1.93 nm) and the highest Zeta potential (−29.93 ± 0.42 mV). Scanning electron microscopy showed that BGPH-P had the smallest and most dispersed particles. …”
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