Gender differences in efficiency of the telemedicine care of heart failure patients. The results from the TeleEduCare-HF study by Agata Bielecka-Dąbrowa, Dariusz Trzmielak, Agata Sakowicz, Kamil Janikowski, Maciej Banach

“…The men, despite lower LVEF, felt short of breath/tired when climbing the stairs up than women (3 [2–4] vs. 2 floors [1–3]; p = 0.001), had higher distance in meters when walking on flat ground (400 [200–400] vs. 300 m [100–400]; p = 0.0001), and less frequently had to get up to go to the toilet at night (p = 0.03). …”
Get full text

Vectorized Treg-depleting αCTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject ‘cold’ tumors by Laetitia Fend, Eric Quemeneur, Monika Semmrich, Jean-Baptiste Marchand, Matilda Rehn, Nathalie Silvestre, Linda Mårtensson, Johann Foloppe, Ingrid Teige, Björn Frendeus, Petra Holmkvist, Carolin Svensson, Christelle Remy, Patricia Kleinpeter, Jules Deforges, Fred Junghus, Kirstie L Cleary, Mimoza Bodén

“…Here we assess and identify spatially restricted exposure to a novel strongly Treg-depleting, checkpoint-blocking, vectorized αCTLA-4, as a highly efficacious and potentially safe strategy to target CTLA-4.Methods A novel human IgG1 CTLA-4 antibody (4-E03) was identified using function-first screening for monoclonal antibodies (mAbs) and targets associated with superior Treg-depleting activity. …”
Get full text

NALCN expression is down-regulated and associated with immune infiltration in gastric cancer by Xuewei Li, Xuewei Li, Na Wu, Chen Wang, Beibei Pei, Xiaoyan Ma, Jun Xie, Jun Xie, Wenhui Yang

“…Consistent with these findings, the expression trend of NALCN mRNA in the GEO database mirrored the experimental results. …”
Get full text

Ibuprofen reduces inflammation, necroptosis and protects photoreceptors from light-induced retinal degeneration by Ping-Wu Zhang, Zi-He Wan, Weifeng Li, Abhishek Vats, Kunal Mehta, Laura Fan, Lingli Zhou, Sean Li, Gloria Li, Casey J. Keuthan, Cynthia Berlinicke, Cheng Qian, Noriko Esumi, Elia J Duh, Donald J. Zack

“…Twenty-four hour after LD, retinal mRNA expression for the inflammatory-factors tumor necrosis factor (Tnf), interleukin-1 beta (Il1B), and C-C motif chemokine ligand 2 (Ccl2) increased by 10-, 17-, and 533-fold, respectively; in IBU-treated animals, the expression levels of these inflammatory factors were not significantly different from no-LD controls. …”
Get full text

Liraglutide Decreases Liver Fat Content and Serum Fibroblast Growth Factor 21 Levels in Newly Diagnosed Overweight Patients with Type 2 Diabetes and Nonalcoholic Fatty Liver Diseas... by Xinyue Li, Xiaojuan Wu, Yumei Jia, Jing Fu, Lin Zhang, Tao Jiang, Jia Liu, Guang Wang

“…Those newly diagnosed overweight patients with T2DM and NAFLD had a BMI of 27.6±0.5 kg/m2. They had higher levels of FGF21 (159.6±35.7 vs. 124.1±42.9 pg/ml, P<0.001) and increased liver fat content (19.3±9.4 vs. 4.5±0.6%, P<0.001) compared to the controls. …”
Get full text

AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane by Yinglian Pan, Qiushi Yin, Zhaoliang Wang, Gang Wu, Kun Liu, Xiaowei Li, Jinchen Liu, Jiangzheng Zeng, Bo Lin, Wei Li, Mingyue Zhu, Mengsen Li

“…Mechanistically, the results demonstrated that AFP enhanced CD47 membrane translocation by interacting with Hu-Antigen R(HuR), an RNA-binding protein that regulates mRNA stability and translation. AFP alters the subcellular distribution of HuR, increasing its cytoplasmic accumulation and binding to CD47 transcript. …”
Get full text

Prevalence of vitamin D deficiency and its association with adverse obstetric outcomes among pregnant women in Uganda: a cross-sectional study by Cristina Reverzani, Daniel Zaake, Faridah Nansubuga, Herman Ssempewo, Leonard Manirakiza, Anthony Kayiira, Gilbert Tumwine

“…The data were analysed by logistic regression analysis at the univariate, bivariate and multivariate levels.Results The prevalence of vitamin D deficiency, defined as a serum 25(OH)D concentration less than 20 ng/mL, was 40.2%. This was seen more among the Muslims (OR 2.4, 95% CI 1.33 to 4.43, p value 0.004), members of the Banyankore tribe (OR 2.1, 95% CI 1.02 to 4.36, p value 0.043) and primigravidae (OR 0.6 for women with parity of 1–4 compared with primigravidity, 95% CI 0.36 to 0.94, p value 0.028). …”
Get full text

MicroRNA-132, Delivered by Mesenchymal Stem Cell-Derived Exosomes, Promote Angiogenesis in Myocardial Infarction by Teng Ma, Yueqiu Chen, Yihuan Chen, Qingyou Meng, Jiacheng Sun, Lianbo Shao, Yunsheng Yu, Haoyue Huang, Yanqiu Hu, Ziying Yang, Junjie Yang, Zhenya Shen

“…Expression levels of miR-132 in exosomes and HUVECs were quantified by real-time PCR. The mRNA levels of miR-132 target gene RASA1 in HUVECs were quantified by real-time PCR. …”
Get full text

Th1/Th2 Cells and Associated Cytokines in Acute Hepatitis E and Related Acute Liver Failure by Jian Wu, Yurong Guo, Xuan Lu, Fen Huang, Feifei Lv, Daqiao Wei, Anquan Shang, Jinfeng Yang, Qiaoling Pan, Bin Jiang, Jiong Yu, Hongcui Cao, Lanjuan Li

“…Seventeen healthy controls (HCs) were also included who were negative for anti-HEV IgM and IgG. Results. There was no significant difference in viral load and HEV RNA in the AHE and HEV-ALF groups (both P>0.05). …”
Get full text

Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…Additionally, forty ESBL genes, particularly critical genes such as blaCTX-M and blaNDM-1, were also identified in Salmonella isolates. …”
Get full text

Immune Modulation Effect of Administration of Rice Bran Extract with Increased Solubility Fermented by <i>Lentinus edodes</i> UBC-V88 in Cyclophosphamide-Treated Mice Model by Gi-Jung Kim, Yelim Jang, Ji-Yoon Hong, Kyoung-Tae Kwon, Dae-Weon Kim, Dae-Jung Kang, Sung-Joo Hwang, Jung-Yun Lee, Emmanouil Apostolidis, Young-In Kwon

“…The levels of the immunoglobulin (Ig) G in the group treated with FRB (21.98 ± 2.17, <i>p</i> < 0.01) were significantly increased when compared to the RB group (18.48 ± 1.52 μg/mL, <i>p</i> < 0.01). The expression of serum cytokines, including IL-1α (<i>p</i> < 0.05), IL-2 (<i>p</i> < 0.05), IL-6 (<i>p</i> < 0.001), IL-12 p70 (<i>p</i> < 0.01), IFN-γ (<i>p</i> < 0.01), and TNF-α (<i>p</i> < 0.01) were also significantly increased by the administration of FRB (0.5 g/kg-b.w.). …”
Get full text

Epidemiology and impact of device-specific infections on patients receiving left ventricular assist devices by Amit Iyengar, MD MSE, Jason Feinman, MD, Joyce Jiang, BS, Cindy Song, BA, Spencer Kim, BA, Alvin Mathew, MD, Sophia Golec, MD, Aarti Rao, MD, Ankitha Radakrishnan, MD, Michaela Asher, MPhil, David Rekhtman, BS, John DePaolo, MD PhD, Noah Moss, MD, Shinobu Itagaki, MD, Anelechi Anyanwu, MD, Joyce Wald, DO, Marisa Cevasco, MD MPH, Aditya Parikh, MD

“…Predictors of infection included Black race (LSI vs No LSI: 46.2% vs 29.2%, p=0.021) and body mass index (median 29.7 vs 26.2 kg/m2, p=0.007). Median time to infection was 231 days (112−423), with 19 (26.8%) patients requiring surgical debridement. …”
Get full text

Litiasis urinaria en el donante cadavérico: respuestas a la penumbra urológica desde un análisis bibliométrico by Federico Solórzano-Torrejano, Gabriela Castañeda-Millán, Juan C. Álvarez-Restrepo, Kateir Contreras-Villamizar, William Fajardo-Cediel, David A. Castañeda-Millán

“…Objetivo: Exponer la producci&oacute;n bibliogr&aacute;fica y las implicaciones cl&iacute;nicas de la urolitiasis en el proceso de donaci&oacute;n y TxR incluyendo la perspectiva con injertos de donante cadav&eacute;rico. M&eacute;todos: An&aacute;lisis bibliom&eacute;trico ejecutado mediante una b&uacute;squeda sistem&aacute;tica de la literatura en Medline, Embase, SciELO, Cochrane Central, Google Acad&eacute;mico y Web of Science utilizando combinaciones de los t&eacute;rminos MesH &ldquo;urolithiasis&rdquo;, &ldquo;kidney calculi&rdquo;, &ldquo;ureteral calculi&rdquo;, &ldquo;tissue and organ procurement&rdquo;, &ldquo;brain death&rdquo;, &ldquo;living donors&rdquo; y &ldquo;kidney transplantation&rdquo;. …”
Get full text

بررسی دیاژنز، ژئوشیمی و کیفیت مخزنی سازند فهلیان در یکی از میادین نفتی جنوب غرب ایران by امیر کاظمی, محمدعلی صالحی, جواد سبحانی, جواد هنرمند, نواب خدائی

“…تخلخل و تراوایی مغزه در بخش مخزنی سازند فهلیان در توالی مورد مطالعه به ترتیب دارای تغییراتی در محدوده 01/0 تا 5/27% و کمتر از 01/0 تا بیشتر از mD 630 می‌باشد. این تغییرات در تخلخل و تراوایی شدیداً وابسته به فرآیندهای دیاژنزی با پیروی از الگوی تغییرات رخساره‌ای است. …”
Get full text

Differences in the Cardiovascular Risk Assessment in Cardiology Outpatients in Mali: Comparison between Framingham Body Mass Index-Based Tool and Low-Information World Health Organ... by Bâ Hamidou Oumar, Sangaré Ibrahima, Camara Youssouf, Sidibé Noumou, Coulibaly Souleymane, Cissoko Yacouba, Sidibé Samba, Konaté Massama, Maiga Asmaou Kéita, Doumbia Coumba Thiam, Touré Mamadou, Diakité Mamadou, Menta Ichaka, Diall Ilo Bella

“…Means for age, body mass index (BMI), and systolic blood pressure (SBP) were, respectively, 53.81 ± 16.729 years, 25.29 ± 06.151 kg/m2, and 139.49 ± 27.110 mm Hg. Using the li-WHO prediction chart gives a much higher proportion of low-risk patients compared to bmi-Frm (83.6 vs. 37.7). …”
Get full text

Cardiovascular function shows early impairment in asymptomatic adolescents diagnosed with type 1 diabetes mellitus: an ultrasound-derived myocardial work study by Martina Ghirardo, Martina Ghirardo, Irene Cattapan, Irene Cattapan, Jolanda Sabatino, Jolanda Sabatino, Alice Pozza, Alice Pozza, Jennifer Fumanelli, Jennifer Fumanelli, Martina Avesani, Joaquin Gutierrez De Rubalcava Doblas, Carlo Moretti, Biagio Castaldi, Giovanni Di Salvo

“…Patients with stage 1 hypertension or a pre-hypertensive state exhibited pathological pulse wave velocities with values exceeding 8 m/s (&gt;99th percentile).ConclusionsTo the best of our knowledge, this was the first study to investigate MW in T1D adolescents. …”
Get full text

Association between Loa loa microfilaremia and anatomical hyposplenia in a rural area of the Republic of Congo: a population-based cross-sectional study by Charlotte Boullé, Elodie Lebredonchel, Jérémy T. Campillo, Valentin Dupasquier, Marlhand C. Hemilembolo, Sébastien D. S. Pion, Jean Claude Djontu, Ludovic Rancé, Philippe Souteyrand, François Missamou, Michel Boussinesq, Francine Ntoumi, Cédric B. Chesnais

“…Blood samples were analyzed for L. loa MFD, Plasmodium-PCR, Anti-Plasmodium falciparum-IgG, total IgM, sickle-cell disease status, and hematological abnormalities. …”
Get full text

Reactive agility training to prevent frailty in older adults – a randomized controlled trial. by Eric Lichtenstein, Martin Keller, Ralf Roth, Sebastian Ludyga, Oliver Faude

“…Methods Forty-six healthy older adults (28 females, mean age 69.5 ± 6.8 years, BMI 25.9 ± 3.4 kg/m²) were randomly assigned to either a control (CON) or agility training (AT) group. …”
Get full text

Spatiotemporal Variation of Water Use Efficiency and Its Responses to Climate Change in the Yellow River Basin from 1982 to 2018 by Jie Li, Fen Qin, Yingping Wang, Xiuyan Zhao, Mengxiao Yu, Songjia Chen, Jun Jiang, Linhua Wang, Junhua Yan

“…This research was conducted based on Gross Primary Productivity (GPP), Evapotranspiration (ET), meteorological station data, and land use/cover data, and the methods of Ensemble Empirical Mode Decomposition (EEMD), trend variation analysis, the Mann–Kendall Significant Test (M-K test), and Partial Correlation Analysis (PCA) methods. …”
Get full text

Therapeutic potential of the neutralizing monoclonal antibody 45G3 against encephalomyocarditis virus by Yanfang Zhang, Zhiying Wang, Yaohui Fang, Qiong Zhu, Jie Fu, Sijing Hu, Jiayin Jin, Min Zhou, Xijia Liu, Danna Zhang, Shouwei Huang, Yali Deng, Lingling Xie, Shu Shen, Jing Ye, Fei Deng, Shengbo Cao

“…This antibody exhibited high specificity for EMCV conformational epitopes, excluding linear epitopes, and demonstrated potent in vitro neutralizing activity, with an IC50 of 0.01873 μg/mL. Immunoelectron microscopy (IEM) revealed a strong direct interaction between the 45G3 antibody and EMCV particles. …”
Get full text