Black carp RNF115 restricts IRF3/7-mediated antiviral signaling in innate immunity by Yixuan He, Qun Wang, Lili Xiao, Hui Wu, Jun Xiao, Jun Zou, Hao Feng

“…Overexpression of RNF115 impaired interferon (IFN) and the related interferon-stimulated gene (ISG) mRNA expression, while upregulating SVCV replication. …”
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A bibliometric analysis of the top 100 most cited articles on corticospinal tract regeneration from 2004 to 2024 by Saijilafu, Saijilafu, Ling-Chen Ye, Huanyi Li, Haokun Li, Xinyi Lin, Kehui Hu, Zekai Huang, Chimedragchaa Chimedtseren, Linjun Fang, Saijilahu, Ren-Jie Xu

“…These seminal papers amassed an aggregate of 18,321 citations, with individual citation counts ranging from 83 to 871 and a median of 136 citations per paper. Schwab M. E., stood out as the most prominent contributor, with significant authorship in 9 of the 100 papers. …”
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Utilizing TP53 hotspot mutations as effective predictors of gemcitabine treatment outcome in non-small-cell lung cancer by Yen-Han Tseng, Trieu Thi My Tran, Jinghua Tsai Chang, Yu-Tang Huang, Anh Thuc Nguyen, Ian Yi‑Feng Chang, Yi-Tung Chen, Hao-Wen Hsieh, Yue-Li Juang, Peter Mu-Hsin Chang, Tzu-Yi Huang, Ying-Chih Chang, Yuh-Min Chen, Hsuan Liu, Chi-Ying F. Huang

“…This potential effectiveness might arise from its ability to disrupt DNA damage repair processes, leading to G2/M phase cell cycle arrest or an augmentation of mitotic abnormalities, eventually cause cell death. …”
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Salvianolic Acid D Alleviates Cerebral Ischemia-Reperfusion Injury by Suppressing the Cytoplasmic Translocation and Release of HMGB1-Triggered NF-κB Activation to Inhibit Inflammat... by Wen Zhang, Junke Song, Wan Li, Dewen Kong, Yu Liang, Xiaoyue Zhao, Guanhua Du

“…Cytokines and cytokine mRNA, including TNF-α, IL-1β, and IL-6, were studied via ELISA and PCR methods. …”
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Inhibition of Mitochondrial Fission Reverses Simulated Microgravity-Induced Osteoblast Dysfunction by Enhancing Mechanotransduction and Epigenetic Modification by Qiusheng Shi, Yaxin Song, Jingqi Cao, Jing Na, Zhijie Yang, Xinyuan Chen, Ziyi Wang, Yubo Fan, Lisha Zheng

“…These mitochondrial alterations are linked to elevated reactive oxygen species levels, a decrease in ΔΨm, and a metabolic shift from oxidative phosphorylation to glycolysis, resulting in decreased adenosine triphosphate production, which are all indicative of mitochondrial dysfunction. …”
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The roles of cannabis potency and gender in cannabis dependence and anxiety in recent cannabis users with trauma exposure histories by T. Snooks, S.H. Stewart, P. Romero-Sanchiz, S. DeGrace, S.P. Barrett, H.C.R. Bernusky, P.G. Tibbo

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Nefrolitotomía percutánea en prono y supino, ¿cuál técnica es mejor?: estudio comparativo by Ricardo Contreras-García, Jeffer D. Álvarez-Villarraga, Mariana Saavedra-Castrillón, Jorge E. Palacios-Riascos, Daniel Díaz-Cardona, Héctor A. Ramírez-Vásquez

“…Objetivo: Comparar el desempeño de la nefrolitotomía percutánea (NLP) en dos posiciones (prono y supino) en un centro de referencia. Método: Es un estudio de corte transversal, analítico, de pacientes sometidos a NLP entre enero de 2017 a octubre de 2021, en Cali (Colombia). …”
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Dual-release hydrocortisone treatment improves serum and peripheral blood mononuclear cell inflammatory and immune profiles in patients with autoimmune primary adrenal insufficienc... by Laura Tomasello, Antonina Coppola, Giuseppe Pizzolanti, Giuseppe Pizzolanti, Carla Giordano, Giorgio Arnaldi, Valentina Guarnotta

“…After 12 months of DR-HC treatment, we found significantly lower IL-6 (p = 0.019), IL-17A (p = 0.046), COX-2 (p < 0.001), HSP-70 (p = 0.006), and TXN-1 (p = 0.008) and higher PD-L1 (p < 0.001) and IDO (p < 0.001) mRNA values compared to baseline. After 12 months of DR-HC treatment, a significant increase in CD4+ T cells (p = 0.012), PD-L1 (p = 0.003), and IDO (p < 0.001) and a decrease in CD8+ T cells (p < 0.001), IL-6 (p = 0.003), IL-17A (p = 0.0014), COX-2 (p < 0.001), HSP-70 (p = 0.005), and TXN-1 (p = 0.0008), as well as a significantly higher conversion in the CD4+/CD8+ ratio (p = 0.033), were observed compared to conventional GCs.ConclusionsThe switch from conventional GCs to DR-HC treatment altered the T lymphocyte phenotype and CD4+/CD8+ ratio in a Treg-independent manner, inducing significant improvements in the immune and inflammatory profile in PAI.…”
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Comprehensive genomic and transcriptomic profiling of pulmonary nodules in synchronous multiple primary lung cancer by Xingsheng Liu, Kun Qian, Lei Su, Xiaoru Tian, Xin Zhao, Tengteng Wang, Li Han, Zhenzhen Li, Peilong Zhang, Ruotian Wang, Baodong Liu, Yuanbo Li, Xiaogang Tan, Yi Zhang

“…Additionally, among the significantly up-regulated cell cycle-related genes in the major nodules when compared with minor nodules, CCNE1 mRNA expression demonstrated significant correlation with poor prognosis in the lung cancer. …”
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Characterization of the colostrum proteome of primiparous Holstein cows and its association with colostrum immunoglobulin G concentrations by Ezequias Castillo-Lopez, Patrick Biber, Arife Sener-Aydemir, Karin Hummel, Ebrahim Razzazi-Fazeli, Nicole Reisinger, Qendrim Zebeli, Susanne Kreuzer-Redmer, Thomas Hartinger

“…Most abundant proteins were complement C3 (Q2UVX4), alpha-S1-casein (P02662), Ig-like domain-containing protein (A0A3Q1M032), albumin (A0A140T897), polymeric immunoglobulin receptor (P81265), lactotransferrrin (P24627), and IGHG1*01 (X16701_4). …”
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Differentiating Liver Metastases from Primary Liver Cancer: A Retrospective Study of Imaging and Pathological Features in Patients with Histopathological Confirmation by Laura Andreea Ghenciu, Mirela Loredana Grigoras, Luminioara Maria Rosu, Sorin Lucian Bolintineanu, Laurentiu Sima, Octavian Cretu

“…Vascular invasion was more common in primary liver cancer (45.5% vs. 11.1%, <i>p</i> = 0.01). AFP levels > 400 ng/mL were significantly associated with primary liver cancer (63.6% vs. 4.8%, <i>p</i> < 0.001). …”
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Improving serum redox balance, inflammatory status, physical function, and cognitive ability through dual-task resistance training and detraining in nursing home residents by Erivaldo Machado Araújo, Hélio José Coelho-Júnior, Caio Victor Sousa, Thiago dos Santos Rosa, Ivo Vieira Sousa Neto, Emanuele Marzetti, Octávio Luiz Franco, Samuel da Silva Aguiar

“…Results: Dual-task RT significantly enhanced balance (p = 0.027) and 4 m walking speed (p = 0.027) post-training compared to the baseline. …”
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Accumulation of advanced oxidation protein products aggravates bone-fat imbalance during skeletal aging by Yu-Sheng Huang, Jia-Wen Gao, Rui-Feng Ao, Xin-Yu Liu, Di-Zheng Wu, Jun-Long Huang, Chen Tu, Jing-Shen Zhuang, Si-Yuan Zhu, Zhao-Ming Zhong

“…The antioxidant NAC, after scavenging ROS, ameliorated the AOPPs-induced lineage switch and senescence in MSCs by inhibiting the PI3K/AKT/mTOR pathway. Conclusion: Our findings revealed the involvement of AOPPs in age‐related switch between osteogenic and adipogenic differentiation, and illuminated a novel potential mechanism underlying bone-fat imbalance during skeletal aging. …”
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Dexmedetomidine versus Dexamethasone as an Adjuvant to Ropivacaine in Transversus Abdominis Plane Block in Infraumbilical Surgeries for Postoperative Analgesia: A Randomised Clinic... by Anupama Kumari, Aarjvi Patel, Payal Berawala, Sara Mary Thomas

“…The total volume was made up to 50 mL with normal saline. Postoperative pain was assessed using VAS scores. …”
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Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses by Hongyu Yu, Shaoyuan Cui, Yan Mei, Qinggang Li, Lingling Wu, Shuwei Duan, Guangyan Cai, Hanyu Zhu, Bo Fu, Li Zhang, Zhe Feng, Xiangmei Chen

“…Polarization of naïve CD4+ T cells (Th0 cells) towards the Th1 phenotype was induced by coculture with activated mesangial cells, and the resulting Th1 cells showed increased mRNA and protein expression of inflammation-associated genes. …”
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Production and metabolic responses of Montbéliarde and Holstein cows during the periparturient period and a sequential feed-restriction challenge by J.A.A. Pires, A. De La Torre, L. Barreto-Mendes, I. Cassar-Malek, I. Ortigues-Marty, F. Blanc

“…During early lactation, energy balance was lower (5 vs. 16 MJ/d) and plasma NEFA (270 vs. 163 µM) were greater for HOLS than MONT, respectively. …”
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Evaluación del potencial genético de germoplasma exótico de soja para incrementar el contenido de aceite en el grano by S. B. Bologna, D. O. Soldini, J. J. Carreras

“…Se utilizó un diseño experimental de bloques completos al azar con 3 repeticiones y parcelas de 12 plantas a 0,50 x 0,50 m. Se evaluó: número de días a floración (NDF) y a madurez (NDM), período reproductivo (PR), productividad de granos (PG), peso de 100 semillas (PS) y porcentaje de aceite (OL). …”
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Evaluation of CellerateRX Surgical Powder utility in reducing groin complications after femoral exposure by Vy C. Dang, BS, Eric K. Peden, MD, Trisha Roy, MD, PhD, Alan B. Lumsden, MD, Linda Le, MD, Charudatta S. Bavare, MD, Sohaib K. Mhaidi, MD, Maham Rahimi, MD, PhD

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A Digital Tool (Technology-Assisted Problem Management Plus) for Lay Health Workers to Address Common Mental Health Disorders: Co-production and Usability Study in Pakistan by Maham Saleem, Shamsa Zafar, Thomas Klein, Markus Koesters, Adnan Bashir, Daniela C Fuhr, Siham Sikander, Hajo Zeeb

“…In round 1 conducted in laboratory settings, 6 LHWs participated in role plays and completed the 15-item mHealth Usability App Questionnaire (MUAQ) (score range 0-7). …”
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A novel arterial coupler with non-return snap-fit connection approach optimized arterial end-to-end anastomotic technique: An experimental study by Hong-Bo Guo, Mo-Fei Wang, Ren-Qi Yin, Kang-Kang Zhi

“…The results of electromagnetic flowmeter, vascular Doppler ultrasound, and pathological examination showed that QAC-assisted anastomotic arteries were superior to hand-sewn arteries in terms of postoperative blood flow (16.86 ± 3.93 vs. 10.36 ± 0.92 mL/min) and vascular patency in 6 weeks after surgery. …”
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