Efficient Acquisition of Fully Human Antibody Genes against Self-Proteins by Sorting Single B Cells Stimulated with Vaccines Based on Nitrated T Helper Cell Epitopes by Liangliang Jiang, Tao Jiang, Jianhua Luo, Yanliang Kang, Yue Tong, Xiaoda Song, Xiangdong Gao, Wenbing Yao, Hong Tian

“…This NitraTh can also break immune tolerance to autoantigens, such as human epidermal growth factor receptor 2 (HER2) and cannabinoid receptor 1, and induce strong specific IgM+ B cell responses in vitro. HER2-NitraTh vaccine can also stimulate the generation of HER2-specific IgG+ B cells in human immune system mice, which was established by cotransplanting lymphocytes and autologous dendritic cells in immunodeficient mice. …”
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Production, Characterization, and In Vitro Antifungal Evaluation of Itraconazole-Loaded Fibrous Sheets Prepared by Electrospinning with a Factorial Design by Emőke-Margit Rédai, Orsolya Péterfi, Attila Levente Gergely, Enikő Barabás, Andrada Pintea, Paula Antonoaea, Robert-Alexandru Vlad, Nicoleta Todoran, Cornelia-Titiana Cotoi, Adriana Ciurba, Emese Sipos

“…Fibrous mats were prepared under the following experimental conditions: 10, 12.5, and 15 cm needle–collector distance, 20 kV tension, and 1, 1.5, and 2 mL/hour flow rate. The fibers were characterized by SEM, DSC, FTIR, assays, disintegration tests, dissolution tests, and in vitro antifungal activity. …”
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Droplets Cas13a‐RPA measurement delineates potential role for plasma circWDR37 in colorectal cancer by Jingsong Xu, Li Cao, Shuang Yang, Ying Jian, Yu Liu, Zhen Shen, Qian Liu, Xiang Chen, Min Li, Shun Li, Xiaolei Zuo, Min Li, Hua Wang

“…The detection limit of circWDR37 by µDCR was found to be 10 copies/mL, which is higher than that of qPCR. The clinical sample findings demonstrated that circWDR37 detection can be utilized to effectively screen for CRC at an early stage and enable accurate assessment of prognosis. …”
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Molecular cloning and expression dynamics of Atrogin-1 in muscle tissue of Russian sturgeon (Acipenser gueldenstaedtii) under high salt stress by Yong-Juan Mo, Yi-Li Gao, Shi-Jjian Xu, Bin Wang, Jingping Wu, Peng Yu, Ming Li, Xiangtao Kang, Zhi-Qiang Han

“…A significant upregulation of atrogin-1 mRNA was observed at salinities of 16 ‰ and 24 ‰ compared to the control group. …”
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Oridonin: A natural terpenoid having the potential to modulate apoptosis and survival signaling in cancer by Abhishek Chauhan, Hemant Joshi, Divya Kandari, Diwakar Aggarwal, Ritu Chauhan, Hardeep Singh Tuli, Arpit Mehrotra, Abhilasha Sood, Ujjawal Sharma, Darin Mansor Mathkor, Shafiul Haque, Naveen Chandra Joshi, Laurent Dufossé

“…Its derivatives, such as 13p, exhibit enhanced potency by arresting the G2/M phase and targeting drug-resistant cells with minimal toxicity. …”
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Anti-Methanogenic Potential of Seaweeds and Impact on Feed Fermentation and Rumen Microbiome In Vitro by Pradeep Kumar Malik, Atul Purshottam Kolte, Shraddha Trivedi, Govindan Tamilmani, Archit Mohapatra, Shalini Vaswani, Johnson Belevendran, Artabandhu Sahoo, Achamveetil Gopalakrishnan, Raghavendra Bhatta

“…The ranking of seaweeds in terms of CH₄ production (mL/g OM) is as follows: <i>Sargassum wightii</i> < <i>Kappaphycus alvarezii</i> < <i>Acanthophora specifera</i> < <i>Padina gymnospora</i> < <i>Spyridia filamentosa</i>. …”
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Excess Sensitivity and Financial Development in the Iranian Households by Amineh Mahmoudzadeh, Kamyab Rajabizadeh, Majid Einian

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Water homeostasis gene expression in the kidney of broilers divergently selected for water conversion ratio by Kentu Lassiter, Loujain Aloui, Elizabeth S. Greene, Marciela Maqaeda, Travis Tabler, Sami Dridi, Robert F. Wideman, Jr., Sara Orlowski, Walter G. Bottje

“…Molecular analyses from Exp. 1 showed that the renal expression of arginine vasopressin (AVP), angiotensinogen (AGT), angiotensin II receptor type 1 and 2 (AT1/2), sodium-potassium ATPase subunit B1 (ATP1B1), and aquaporin 3 (AQP3) were upregulated in HWE compared to the LWE line. In contrast, mRNA expression of mesotocin receptor (MTR), AT1/2, AQP1/2, and occludin were significantly higher in females than in males. …”
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Diagnostic Accuracy of Serum Prostate Specific Antigen and Gleason Score in Determining the Presence of Skeletal Metastasis in Prostate Cancer Patients: a Pakistani Perspective by Taimoor Nasir, Syeda Neha Aamer, Saman Waqar, Wafa Omer

“…Prostate Specific Antigen (PSA) and Gleason Scores (GS) were determined using commercially available ELECSYS® assays in the Modular Analytics E170 (Roche Diagnostics) and histopathology respectively. Tc99m methylene diphosphonate (MDP) was used to perform the Bone scan. …”
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Associations of PM2.5 with Chronic Obstructive Pulmonary Disease in Shipyard Workers: A Cohort Study by Nguyen Thanh Tung, Ching-Huang Lai, Chih-Hong Pan, Wei-Liang Chen, Chung-Ching Wang, Che-Wei Liang, Chi-Yu Chien, Kai-Jen Chuang, Huynh Nguyen Xuan Thao, Hoang Ba Dung, Tran Phan Chung Thuy, Hsiao-Chi Chuang

“…We observed that a 1-µg m−3 increase in PM2.5 deposition in lung regions (total lung, and head and nasal, tracheobronchial, and alveolar regions) was associated with decreases (β coefficients) in FeNO, FVC, FEV1, PEF, FEF25%–75%, FEF25%, and FEF50% (all p < 0.05). …”
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How trait mindfulness protects late adolescents from stress-induced sleep problems: the unique role of mindfulness facets and gender differences by Huiting Cao, Jing Qian, Fenghua Tang, Yunyan Dong, Haining Ren, Xiaoran Xue, Ningning Mao, Xiaoyu Liu

“…Methods The study tracked 1,926 Chinese vocational high school students (M age = 18.49) over a year, assessing them for their sleep problems, perceived impact of stressful life events, and mindfulness facets through self-reported questionnaires. …”
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The association between perceived social support and self-management behaviors in adolescents and young adults with inflammatory bowel disease: the chain mediating role of basic ps... by Yangfan Zhu, Yangfan Zhu, Yueyue Chen, Yuman Tang, Xin Zhang, Qiao Shen, Fei Li, Hao Wang, Xianlan Zheng

“…Mediating effects were analyzed using the bootstrap method.ResultsA total of 183 adolescents and young adults with IBD (male: 71.58%), aged 13 to 24 years old (M = 20.33, SD = 3.03), were included in the analysis. …”
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Productivity and ecological functions of naturally regrown pine forests of the Ukrainian Polissia by Petro Lakyda, Volodymyr Blyshchyk

“…Based on the indicators of basic wood density (341 kg·(m3)-1), the studied stands have a slightly lower density compared to other pine forests of the Ukrainian Polissia zone, which are characterized by high moisture content in wood at a young age, soil conditions (structure, mechanical composition, fertility), which has a significant impact on the formation of late wood, and, consequently, on its density. …”
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GLP‐1 Receptor Agonists Alleviate Diabetic Kidney Injury via β‐Klotho‐Mediated Ferroptosis Inhibition by Shasha Tian, Saijun Zhou, Weixi Wu, Yao lin, Tongdan Wang, Haizhen Sun, A‐Shan‐Jiang A‐Ni‐Wan, Yaru Li, Chongyang Wang, Xiaogang Li, Pei Yu, Yanjun Zhao

“…Notably, Smg treatment significantly increases the mRNA expression of KLB through the activation of the cyclic adenosine monophosphate (cAMP) signaling pathway, specifically through the phosphorylation of protein kinase A (PKA) and cAMP‐response element‐binding protein (CREB). …”
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Monster Radio Jet (>66 kpc) Observed in Quasar at z ∼​​​​​ 5 by Anniek J. Gloudemans, Frits Sweijen, Leah K. Morabito, Emanuele Paolo Farina, Kenneth J. Duncan, Yuichi Harikane, Huub J. A. Röttgering, Aayush Saxena, Jan-Torge Schindler

“…Furthermore, we observe the rest-frame UV spectrum of J1601+3102 with Gemini/GNIRS to examine its black hole properties, which results in a mass of 4.5 × 10 ^8 M _⊙ with an Eddington luminosity ratio of 0.45. …”
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Real-Time Neuropsychological Testing for Hydrocephalus: Ultra-Fast Neuropsychological Testing During Infusion and Tap Test in Patients with Idiopathic Normal-Pressure Hydrocephalus by Ilaria Guarracino, Sara Fabbro, Daniele Piccolo, Serena D’Agostini, Miran Skrap, Enrico Belgrado, Marco Vindigni, Francesco Tuniz, Barbara Tomasino

“…Based on cerebrospinal fluid dynamics, 63.15% of the patients presented a resistance to outflow > 12 mmHg/mL/min, while 88% had a positive tap test response. …”
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Phytochemical Profile Screening and Selected Bioactivity of <i>Myrtus communis</i> Berries Extracts Obtained from Ultrasound-Assisted and Supercritical Fluid Extraction by Ilir Mërtiri, Gigi Coman, Mihaela Cotârlet, Mihaela Turturică, Nicoleta Balan, Gabriela Râpeanu, Nicoleta Stănciuc, Liliana Mihalcea

“…The UAE extract showed the lowest IC50 value among the two extracts, with an average of 8.37 ± 0.52 µg/mL DW. The antibacterial activity of the extracts was assessed <i>in vitro</i> against <i>Bacillus</i> spp., <i>Escherichia coli</i>, and <i>Staphylococcus aureus</i> using the disk diffusion method. …”
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Synthesizing Local Capacities, Multi-Source Remote Sensing and Meta-Learning to Optimize Forest Carbon Assessment in Data-Poor Regions by Kamaldeen Mohammed, Daniel Kpienbaareh, Jinfei Wang, David Goldblum, Isaac Luginaah, Esther Lupafya, Laifolo Dakishoni

“…. = 0.05) and the locally known species <i>M’buta</i> (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mover accent="true"><mrow><mi>x</mi></mrow><mo>~</mo></mover></mrow></semantics></math></inline-formula> = 6 kg/ha, P-holm-adj. = 5.45 × 10⁻⁹) exhibiting a significantly higher median AGC. …”
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Effect of molases addition on survival and growth of tiger shrimp Penaeus monodon Fab. larva treated with SKT-b Vibrio probiotic bacteria by , Widanarni, Wira H Saputra, Dinamella Wahjuningrum

“…Hasil uji in vitro menunjukkan bakteri Vibrio SKT-b dapat tumbuh pada media molase dengan populasi mencapai 0,41×108 CFU/mL. Hasil uji in vivo menunjukkan perlakuan MB3 menghasilkan kelangsungan hidup (93,3%) dan pertumbuhan bobot (35,94%) tertinggi, namun tidak berbeda nyata dengan kontrol yang menghasilkan kelangsungan hidup dan pertumbuhan bobot berturut-turut 83,3% dan 30,38%. …”
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Mortality and immunological indicators of men who have sex with men living with HIV on antiretroviral therapy: a 10-year retrospective cohort study in Southern China by Huaxiang Lu, Huanhuan Chen, Shujia Liang, Yuhua Ruan, He Jiang, Jinghua Huang, Guangjie Tan, Xiuling Wu, Jianjun Li, Chen Gong, Qiuying Zhu, Guanghua Lan

“…In Cox model, with 2,144 cases, immunological indicators of increased mortality risk included a baseline CD4+ count below 200 cells/µL (aHR: 4.58, 95% CI: 2.28–9.19), a median (aHR: 8.46, 95% CI: 3.05–23.46), and a final (aHR: 4.43, 95% CI: 1.06–18.45) ratio below 0.7 and a median (aHR: 9.47, 95% CI: 4.02–22.35) and final (aHR: 14.46, 95% CI: 4.50–46.50) viral load 100,000 copies/mL and above. Conclusions Mortality among MSM PLHIV on ART in Guangxi is relatively low, and both high viral loads and low CD4+/CD8+ T cell ratios during treatment and at recent follow-up are strongly predictive of a serious prognosis and should be closely monitored.…”
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