Feasibility study to assess the delivery of a lifestyle intervention (TreatWELL) for patients with colorectal cancer undergoing potentially curative treatment by Annie S Anderson, Ronan E O’Carroll, Martine Stead, Robert J C Steele, Mary Wells, Maureen Macleod, Anna Campbell, Jacqui A Sugden, Jackie Rodger, Jennifer McKell

“…The majority of participants (77%) had a body mass index>25 kg/m2 and none was underweight. Physical activity data showed a positive trend towards increased activity overall, but no other changes in secondary outcomes were detected.Conclusions To make this intervention feasible for testing as a full trial, further research is required on (a) recruitment optimisation, (b) appropriate assessment tools, (c) protocols for phase 2 and 3, which can build in flexibility and (d) ways for NHS staff to facilitate the programme.Trial registration number ISRCTN52345929; Post-results.…”
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Paul'Ün Kutsadığı Tanrısal Bağ Olarak Gnostik Kutsal Evlilik - The Gnostic Holy Marriage as The Divine Tie was Blessed by Paul by Kürşat Akalın

“…Suyla yıkanma tek kelimeyle bedenselleri tanrısal evliliğe hazırlayarak bütünlüğü ve mükemmelliği sağlayacaktır. Bu yolla, seçilmişler suyla yaptıkları banyoyla, demiurgik ruhluların bedenleriyle de ilgilenmektedirler. …”
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Unleashing the potential of a low CpG Passer transposon for superior CAR-T cell therapy by Jianyao Zeng, Yan Sun, Yan Sun, Yuan Fang, Xiaodie Wang, Qian Huang, Pingjing Zhang, Meiqi Shao, Pei Wang, Jingbo Cheng, Meng Di, Tao Liu, Qijun Qian, Qijun Qian, Qijun Qian

“…Flow cytometry and luciferase reporter assays were employed for mutation screening. BALB/c mice and M-NSG mice were used to evaluate the inflammatory response and efficacy of LCG CAR-T in vivo, with TIL grouping detected via immunohistochemistry.ResultsIn this study, we modified the newly discovered Passer (JL) transposon to construct a low-CpG content transposon for CAR-T cell (LCG CAR-T cell) preparation. …”
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Construction of a radiogenomic signature based on endoplasmic reticulum stress for predicting prognosis and systemic combination therapy response in hepatocellular carcinoma by Huai-Yu Wu, Shu-Ya Cao, Zheng-Gang Xu, Tian- Wang, Gu-Wei Ji, Ke Wang

“…Drug sensitivity analysis found that most sensitive drugs target the phosphatidylinositol 3-kinase/ mechanistic target of rapamycin (PI3K/mTOR) signaling pathway. Further research revealed the expression of STC2 in the endothelial cells (ECs), particularly plasmalemma vesicle associated protein (PLVAP) + ECs, and may regulate the reprogramming and function of macrophages. …”
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Citronellol-functionalized natural silica: a biogenic approach for antifungal and antibacterial material applications by Guillermo P. Lopez, Guillermo P. Lopez, Leyanet Barberia Roque, Katerine Igal, Katerine Igal, Erasmo Gámez Espinosa, Erasmo Gámez Espinosa, Natalia Bellotti, Natalia Bellotti

“…For bacterial strains, Dt*QC achieved a minimum inhibitory concentration (MIC) of 0.15 mg/mL against Staphylococcus aureus and demonstrated over 99.9% bacterial reduction, even at lower concentrations. …”
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Rare and syndromic tumours in South African children: A novel report from Sub-Saharan Africa by Alessia Pisapia, Guy Shemesh, Derek Harrison

“…Tumours were classified according to criteria described by international literature. (Ethics: M190920) Results: One hundred and eighty-six tumours were identified, with an average incidence of 10 %. …”
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In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats by Will J. Costain, Arsalan S. Haqqani, Greg Hussack, Henk van Faassen, Etienne Lessard, Binbing Ling, Eric Brunette, Dao Ly, Hung Fang, Jennyfer Bultinck, Steven Geysens, Gwenda Pynaert, Kathleen Piens, Stefan Ryckaert, Franck Fudalej, Wouter Vervecken, Danica Stanimirovic

“…IDS and IGF1R3H5-IDS exhibited very short (< 10 min) serum half-life (t1/2α), while constructs containing either HSA or anti-serum albumin sdAbs (R28 or M79) showed 8–11 fold increases in the area under the curve (AUC) in serum. …”
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Insights into a Renowned Fishery: Distinct Spatial Patterns, Environmental Predictors and Species Associations of Trophy-Class Spotted Seatrout (<i>Cynoscion nebulosus</i> [Cuvier... by Catherine Eckert, Elliot Briell, Ethan Getz

“…Depth, turbidity, and season were good predictors of the abundance of adult-class trout, which were most abundant at increased depths (>2 m), low-to-moderate turbidity (~125 NTU), and in the spring season (April–June). …”
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CDC20‐Mediated Selective Autophagy Degradation of PBRM1 Affects Immunotherapy for Renal Cell Carcinoma by Yizeng Fan, Weichao Dan, Taotao Que, Yi Wei, Bo Liu, Zixi Wang, Yulin Zhang, Yuzhao Wang, Tianjie Liu, Yanxin Zhuang, Mengxing Li, Chendong Guo, Jin Zeng, Bohan Ma, Lei Li

“…Here, it is demonstrated that PBRM1 knockdown induced M1 macrophage polarization and infiltration, which enhanced the efficacy of anti‐PD‐1 immunotherapy in RCC. …”
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Impact of Postshock Transcutaneous Pacing on Chest Compression Quality during Resuscitation: A Simulation-Based Pilot Study by Wojciech Telec, Tomasz Kłosiewicz, Radosław Zalewski, Julia Żukowska-Karolak, Artur Baszko, Mateusz Puślecki

“…In the second, simultaneous with compressions, one of the rescuers started transcutaneous pacing (TCP) with a current output of 200 mA and a pacer rate of 80 ppm. TCP was finished after 30 seconds (experimental group). …”
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Cuproptosis-Related Signature Predicts the Prognosis, Tumor Microenvironment, and Drug Sensitivity of Hepatocellular Carcinoma by Xiangjun Qi, Jiayun Guo, Guoming Chen, Caishan Fang, Leihao Hu, Jing Li, Chi Zhang

“…However, the role of CRGs in Hepatocellular Carcinoma (HCC) remains unknown. Method. The mRNA transcriptome profiling data, somatic mutation data, and copy number gene level data of The Cancer Genome Atlas-Liver Hepatocellular Carcinoma project (TCGA-LIHC) were downloaded for subsequent analysis. …”
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Jiawei Suanzaoren decoction for the treatment of perimenopausal insomnia: clinical observation and experimental study by Li-Qiong Chen, Yong-Can Zhou, Fang Ning, Ming-Jin Zhu

“…The mechanism behind this improvement may be related to the regulation of Estradiol (E2), Follicle-Stimulating Hormone (FSH), and luteinizing hormone (LH) levels, as well as the mRNA expression levels of 5-HT1a, 5-HT2a, GABAARα1, and GABAARγ2 receptors in the hypothalamus.…”
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Acute Exposure to Microcystin-Producing Cyanobacterium Microcystis aeruginosa Alters Adult Zebrafish (Danio rerio) Swimming Performance Parameters by Luiza Wilges Kist, Angelo Luis Piato, João Gabriel Santos da Rosa, Gessi Koakoski, Leonardo José Gil Barcellos, João Sarkis Yunes, Carla Denise Bonan, Maurício Reis Bogo

“…In this study, we assessed behavioral patterns and whole-body cortisol levels of adult zebrafish (Danio rerio) exposed to cell culture of the microcystin-producing cyanobacterium M. aeruginosa (MC-LR, strain RST9501). MC-LR exposure (100 μg/L) decreased by 63% the distance traveled and increased threefold the immobility time when compared to the control group. …”
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Seroprevalence of Foot and Mouth Disease Virus Infection in Some Wildlife and Cattle in Bauchi State, Nigeria by Y. J. Atuman, C. A. Kudi, P. A. Abdu, O. O. Okubanjo, A. Abubakar, Y. Wungak, H. G. Ularamu

“…Wild animals were immobilized using a combination of etorphine hydrochloride (M99® Krüger-Med South Africa) at 0.5–2 mg/kg and azaperone (Stresnil®, Janssen Pharmaceuticals (Pty.) …”
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Association between Air Pollution and Risk of Hospital Admission for Pediatric Pneumonia in a Tropical City, Kaohsiung, Taiwan by Peng-Huei Liu, Kuo-Chen Huang, Yu-Lun Tseng, I-Min Chiu, Hsiu-Yung Pan, Fu-Jen Cheng

“…Furthermore, higher PM2.5 concentration (> 45 µg m–3) was associated with prolonged hospital LOS (OR: 0.217, 95% CI: 0.03–0.404, P = 0.023), especially for younger children (≤ 5 years). …”
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Additively manufactured ultrafine grained Aermet100 with superior mechanical property by Yanwen Liang, Jie Liu, Xiaotian Zhang, Yonghao Weng, Sheng Zhong, Tiannan Li, Peng Zhang, Chunpan Yang, Ying Xing, Jiazhe Fu, Kehong Wang

“…The results indicate that the specimens were well-formed, achieving a relative density of 99.99% through an optimal combination of process parameters: a laser power of 220 W, scanning speed of 1000 mm/s, scanning rotation of 67°, and hatch spacing of 0.07 mm.The additively manufactured Aermet100 specimens exhibited ultrafine grains with an average size of 0.4 μm. Tempering of the as-built specimens at 482 °C for 2 h resulted in the highest strength and hardness. …”
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The association between serum ferritin levels and the risk of gestational diabetes mellitus: a prospective cohort study by Shaofei Su, Shen Gao, Enjie Zhang, Jianhui Liu, Shuanghua Xie, Yue Zhang, Ruixia Liu, Wentao Yue, Chenghong Yin

“…Results The median serum ferritin level in the first trimester was 57.7 ng/mL, and 13.5% of participants developed GDM. After multivariate adjustment, the RRs and 95% CIs for incident GDM across baseline serum-ferritin quintiles were 1.099 (0.940–1.285), 1.228 (1.055–1.430), 1.186 (1.018–1.383) and 1.179 (1.017–1.367), respectively. …”
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Association between Comorbidities and Progression of Transvalvular Pressure Gradients in Patients with Moderate and Severe Aortic Valve Stenosis by Tim Salinger, Kai Hu, Dan Liu, Scharoch Taleh, Sebastian Herrmann, Daniel Oder, Daniel Gensler, Jonas Müntze, Georg Ertl, Kristina Lorenz, Stefan Frantz, Frank Weidemann, Peter Nordbeck

“…Laboratory parameters, medication, and prevalence of eight known cardiac comorbidities and risk factors (hypertension, diabetes, coronary heart disease, peripheral artery occlusive disease, cerebrovascular disease, renal dysfunction, body mass index ≥30 Kg/m2, and history of smoking) were analyzed. Patients were divided into slow (Pmean < 5 mmHg/year) or fast (Pmean ≥ 5 mmHg/year) progression groups. …”
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Association of serum and local GRP78 and CHOP expressions with disease progression in patients with non-traumatic osteonecrosis of femoral head by Peng Zhang, Qing-He Ye, Wen-Xiu Zhu, Yong-Heng Zhao, Hong-Xun Zhu, Biao-Fang Wei

“…A total of 42 ONFH patients at FICAT stage 3, 40 patients at FICAT stage 4, and 49 FNF patients received total hip replacement (THR). The mRNA and protein levels of CHOP and GRP78 were elevated in necrotic area compared to the non-necrotic area of ONFH patients and the FH tissues of FNF patients with statistical significance. …”
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Lifestyle risk factors for overweight and obesity among rural Indian adults: a community-based prospective cohort study by Rajesh Kumar Rai, Sabri Bromage, Jan-Walter De Neve, Anamitra Barik

“…India’s nutrition transition has led to an increased burden of overweight/obesity (body mass index of ≥23 kg/m2), driven by lifestyle factors like poor diet, inactivity, and substance use, prompting public health interventions. …”
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