PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…Results RT-qPCR results showed that PTEN expression was significantly increased in RCC tumor tissues compared to normal tissues (p < 0.01). However, PTEN mRNA levels were significantly reduced in 786-O cells compared to HK-2 cells (p < 0.01). …”
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TSH Levels in Subclinical Hypothyroidism in the 97.5th Percentile of the Population by Laura Pérez-Campos Mayoral, María Teresa Hernández-Huerta, Gabriel Mayoral-Andrade, Eduardo Pérez-Campos Mayoral, Edgar Zenteno, Ruth Martínez-Cruz, Héctor Martínez Ruíz, Margarito Martínez Cruz, Alma Dolores Pérez Santiago, Eduardo Pérez-Campos

“…Generally, two different groups are identified for treatment by levels of 10 and 20 mIU/L. Nevertheless, the question remains, “what cutoff point should be chosen?” …”
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Plasma S100A8/A9 level predicts response to immune checkpoint inhibitors in patients with advanced non-small cell lung cancer by Tadahiro Kuribayashi, Rie Kinoshita, Kiichiro Ninomiya, Go Makimoto, Toshio Kubo, Kammei Rai, Eiki Ichihara, Katsuyuki Hotta, Masahiro Tabata, Yoshinobu Maeda, Katsuyuki Kiura, Shinichi Toyooka, Masakiyo Sakaguchi, Kadoaki Ohashi

“…The TTF and OS were worse in patients with high plasma S100A8/A9 levels (≥ 2.475 µg/mL) (median TTF: 4.3 vs. 8.5 months, p = 0.009; median OS: 15.4 vs. 38.0 months, p = 0.001). …”
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مدى وعى أعضاء هیئة التدریس بجامعة المنوفیة بالانتحال العلمى : دراسة استکشافیة by د. السید رجب الأسرج

“…Which candestroy the entire course of scientific research, and then had a clear impact onthe delay in the classification of Arab universities among the lists of the bestuniversities in the world.In view of the seriousness of this phenomenon, which clarified the extentof ignorance of some researchers about what they do, whether intentionally orunintentionally, the researcher tried in the folds of this study to define what isscientific plagiarism and the difference between it and scientific quotation, as wellas the definition of the program applied to detect scientific plagiarism at MenoufiaUniversity, and the methods and means used for advertising and advertising Theprogram for detecting scientific plagiarism, and how to avoid falling into scientificplagiarism, as well as the difficulties that researchers face when examining theirintellectual production to reveal and determine the percentage of scientificcitation, this researcher has prepared a questionnaire for researchers of all   disciplines M. In Menoufia University, as well as through personal interviews anddirect observation, and the questionnaire was distributed to the study sample andrepresentative of all scientific disciplines for all job categories (graduate student,teaching assistant, assistant teacher, teacher, assistant professor, professor),which numbered about (100) researchers, The study reached a set of results, themost important of which is that more than two-thirds of the study sample reportedtheir knowledge of the difference between quotation and plagiarism, and thestudy also demonstrated the presence of statistically significant differences in thescale of knowledge of the difference between plagiarism and quotation inavoiding plagiarism in scientific research with a different degree, as reported (76)Researcher) proportions Its percentage (76%) of the total sample size is that theyare fully aware of the permissible percentage in the process of scientificquotation. …”
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Synthesis of Nanocrystalline Mn-Doped Bi₂Te₃ Thin Films via Magnetron Sputtering by Joshua Bibby, Angadjit Singh, Emily Heppell, Jack Bollard, Barat Achinuq, Sarah J. Haigh, Gerrit van der Laan, Thorsten Hesjedal

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Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome by Lucas Streckwall, Nancy Martini, Claudia Sedlinsky, León Schurman, María Virginia Gangoiti, Antonio Desmond McCarthy

“…After 14 days, and for another 4 weeks, MET (100 mg/kg per day) was added to half of each group’s drinking source, thus C (water), F (fructose), M (MET) and FM (fructose + MET). Serum and adipose tissue were collected. …”
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The morphological, clinical, and prognostic factors in the management of giant anterior communicating artery aneurysms: A systematic review of cases by Roua Nasir, Midhat e Zahra Naqvi, Salaar Ahmed, Maarij ul Hassan, Rabeet Tariq, Saad Akhter Khan, Pia Koeskemeier, Rajiv K. Khajuria, Mohammad Hamza Bajwa, Sajjad Muhammad

“…The mean age was 52 years with an overall male preponderance (3:1). 73% presented with symptoms; mostly visual impairment/loss and subarachnoid hemorrhage. 82% had favorable outcomes (mRS 0–2). 56% had a mean maximum diameter between 25 and 30 mm. …”
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Developmental and molecular effects of pure-tone sine wave exposure on early zebrafish embryo development: Implications for reproductive health by Yan Zuo, Zhilan Bai, Kaixuan Yang, Ziyuan Lin, Xiaolin Hu, Huaqin Sun

“…To elucidate the molecular mechanisms underlying these effects, we employed transcriptomics, metabolomics, and epigenomics (m6A-MeRIP-seq). KEGG enrichment analysis revealed significant alterations in arachidonic acid metabolism, axon guidance, and ubiquitin-mediated proteolysis. …”
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Early therapeutic drug monitoring of methotrexate and its association with acute kidney injury: A retrospective cohort study by Nicolás Tentoni, Miriam Hwang, Gabriela Villanueva, Ryan Combs, Jennifer Lowe, Laura B. Ramsey, Zachary L. Taylor, Thais Murciano Carrillo, María Dolores Aumente, Teresa López‐Viñau López, Carmelo Rizzari, Scott C. Howard

“…After adjusting for age, sex, dose (mg/m2), infusion duration, HDMTX course, and baseline estimated glomerular filtration rate, it remained significant for AKI with an OR of 1.29 and 95% confidence interval of 1.03–1.65. …”
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Changes in Intestinal Microbiota Are Associated with Islet Function in a Mouse Model of Dietary Vitamin A Deficiency by Yunting Zhou, Junming Zhou, Yumin Zhang, Jun Tang, Bo Sun, Wei Xu, Xiaohang Wang, Yang Chen, Zilin Sun

“…VAD diet-driven changes in intestinal microbiota followed the inflammatory response with increased intestinal permeability and higher mRNA expression of intestinal inflammatory cytokines through nuclear factor-κB signaling pathway activation. …”
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Prevalence of anaemia and its associated factors among HIV-infected adults at the time of ART initiation at Debre Markos Comprehensive Specialized Hospital, Northwest Ethiopia: a r... by Agazhe Aemro, Belayneh Shetie Workneh, Enyew Getaneh Mekonen, Mulugeta Wassie, Basazinew Chekol

“…After multivariate analysis, an increased risk of anaemia was seen among males (adjusted OR (AOR)=2.45; 95% CI: 1.51 to 3.98); those not attending formal education (AOR=2.38; 95% CI: 1.12 to 5.05); those who had baseline CD4+ T cell count ≤200 cells/mm3 (AOR=4.67; 95% CI: 2.78 to 7.85); had body mass index (BMI) &lt;18.5 kg/m2 (AOR=2.43; 95% CI: 1.42 to 4.16) and had ambulatory/bedridden baseline functional status (AOR=2.69; 95% CI: 1.41 to 5.12).Conclusion The current study showed that a significant proportion of HIV-infected adults developed anaemia at the time of ART initiation. …”
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Development and demographic parameters of Fall Armyworm (Spodoptera frugiperda J.E. Smith) when feeding on rice (Oryza sativa) by Md Panna Ali, Sheikh Shamiul Haque, Md Mosaddeke Hossain, Md Nazmul Bari, Mir Md Moniruzzaman Kabir, Tapon Kumar Roy, Juel Datta, Mohammad Tofazzal Hossain Howlader, Syed Nurul Alam, Timothy J. Krupnik

“…When the Fall Armyworm consumed maize instead of rice, there was an increase in the reproduction rate (R 0), the intrinsic rate of natural increase (r m ), and the finite rate of increase (λ). For instance, when FAW fed on rice, the rm value was 0.121, whereas it rose to 0.173 when FAW fed on maize. …”
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Are facility service delivery models meeting the sexual and reproductive health needs of adolescents in Sub-Saharan Africa? A qualitative evidence synthesis by Yusupha Sanyang, Saikou Sanyang, Alice Norah Ladur, Mamady Cham, Nicola Desmond, Florence Mgawadere

“…These findings call for expanding out-of-facility services, adopting mHealth solutions, enhancing provider training, strengthening confidentiality, and reducing financial barriers to ensure equitable and effective access to services.…”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Results: The limits of detection of the multiplexed PCR were in the range of 5–100 CFU/mL for fungal spiked human blood samples. Against the clinical diagnosis of proven or probable IFDs, the findings show that the LFA system produced a high specificity of 99.4 % while the sensitivity was only moderate at 47.8 % due to the difficulty of extracting fungal DNA from blood samples. …”
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Circulating, Extracellular Vesicle-Associated Tissue Factor in Cancer Patients with and without Venous Thromboembolism by Valentina Lami, Dario Nieri, Marta Pagnini, Mario Gattini, Claudia Donati, Mariella De Santis, Alessandro Cipriano, Erica Bazzan, Andrea Sbrana, Alessandro Celi, Tommaso Neri

“…EV were isolated by differential centrifugation from 4 mL of peripheral blood; the final EV pellet (16,000× <i>g</i> for 45 min) was resuspended in 100 μL saline and tested for TF using a one-step clotting assay. …”
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Slurry Synthesis and Thin-Film Fabrication Toward Production of Li₂O-B₂O₃-Al₂O₃-Based Multilayer Oxide Solid-State Batteries for Internet of Things Applications by Jihyun Park, Jongmin Choi, Jihye Seo, Wolil Nam, Soobeom Lee, Seungchan Cho, Kyungchul Park, Geonhyoung An, Beomkyeong Park, Moonhee Choi

“…We successfully developed the conditions for producing thin films from 21 μm thick solid-electrolyte sheets of Li₂O-B₂O₃-Al₂O₃, one of the most promising candidates for multilayer solid-state batteries. …”
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Iron deficiency, supplementation, and sports performance in female athletes: A systematic review by Michael Pengelly, Kate Pumpa, David Bruce Pyne, Naroa Etxebarria

“…Studies were included that evaluated the effects of iron deficiency or FeSup on sports performance in high-level (maximal oxygen uptake (VO2max) > 45 mL/kg/min, or trained > 5 h/week) iron deficient (ID) (serum ferritin (sFer) < 40 µg/L) female athletes. …”
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Pulse wave parameters as a predictor of the development of post-transplant diabetes mellitus after kidney transplantation by Dominika Macakova, Josef Zadrazil, David Karasek, Veronika Kucerova, Katerina Langova, Lubica Cibickova

“…Pulse wave parameters for developing PTDM: Pre-transplant Aortic PP > 45 mmHg (AUC = 0.757) and PWV > 8.5 m/s (AUC = 0.730) were strong predictors of the development of PTDM after 3 months (p < 0.0001). …”
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Study of Ultrasound-Assisted Low-Pressure Closed Acid Digestion Method for Trace Element Determination in Rock Samples by Inductively Coupled Plasma Mass Spectrometry by Xijuan Tan, Yunxiu Ren, Ting Liang, Denghong Wang

“…In this paper, a method of ultrasound-assisted low-pressure closed acid digestion followed by inductively coupled plasma mass spectrometry (ICP-MS) analysis was proposed for trace element quantification in rock samples. By using 1.5 mL of a binary acid mixture of HNO₃–HF with a ratio of 2:1, rock powder samples of 50 mg were completely decomposed in 12 h at 140 °C after 4 h of ultrasonic treatment with or without pressure relief procedure. …”
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The anthropogenic activities in Makere north forest reserve in Tanzania and implications to conservation by Eberehard Daudi, Hussein Luswaga, Pensia Mapunda, Hamisi Nchimbi

“…Field data were collected from 120 field plots of 800 m2 (0.08 hectare) sizes in three (3) forest study sites bordering Makere, Nyamidaho, and Mvugwe villages. …”
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