Moxibustion Regulates the BRG1/Nrf2/HO-1 Pathway by Inhibiting MicroRNA-222-3p to Prevent Oxidative Stress in Intestinal Epithelial Cells in Ulcerative Colitis and Colitis-Associat... by Xuejun Wang, Haiyang Ji, Yanting Yang, Dan Zhang, Xiehe Kong, Xiaoying Li, Hongna Li, Yunqiong Lu, Guang Yang, Jie Liu, Huangan Wu, Jue Hong, Xiaopeng Ma

“…Meanwhile, we found that HPM suppressed miR-222-3p expression and upregulated the mRNA and protein expression of Brahma-related gene 1 (BRG1), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), while inhibiting Kelch-like ECH-associated protein 1 (Keap1) expression in IECs of UC and CAC mice. …”
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Single nucleotide polymorphism rs110861313 in the intergenic region of chromosome 23 is associated with the development of leukosis in the Russian Black Pied cattle by R. B. Aitnazarov, E. V. Ignatieva, T. A. Agarkova, N. G. Dvoeglazov, N. A. Osipova, V. V. Khramtsov, N. S. Yudin

“…FOXM1 is expressed in immune cells and can potentially affect the expression of the neighboring genes (LY6G5B, GPANK1, ABHD16A, LY6G6F, LY6G6E, CSNK2B, ApoM). Thus, we found that SNP rs110861313 in the intergenic region of bovine chromosome 23 is associated with the development of leukemia following BLV infection in the Russian Black Pied cattle.…”
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Exome sequencing reveals IFT172 variants in patients with non-syndromic cholestatic liver disease. by Magdaléna Neřoldová, Elżbieta Ciara, Janka Slatinská, Soňa Fraňková, Petra Lišková, Radana Kotalová, Janka Globinovská, Markéta Šafaříková, Lucie Pfeiferová, Hana Zůnová, Lenka Mrázová, Viktor Stránecký, Alena Vrbacká, Ondřej Fabián, Eva Sticová, Daniela Skanderová, Jan Šperl, Marta Kalousová, Tomáš Zima, Milan Macek, Joanna Pawlowska, A S Knisely, Stanislav Kmoch, Milan Jirsa

“…WES was used for reassessment of 34 patients (23 children) without diagnostic genotypes in ABCB11, ATP8B1, ABCB4 or JAG1 demonstrable by previous Sanger sequencing, and for primary assessment of additional 17 patients (10 children). Nasopharyngeal swab mRNA was analysed to address variant pathogenicity in two families.…”
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The Effect of Laminin-1-Doped Nanoroughened Implant Surfaces: Gene Expression and Morphological Evaluation by Humberto Osvaldo Schwartz-Filho, Kostas Bougas, Paulo G. Coelho, Ying Xue, Mariko Hayashi, Rafael Silveira Faeda, Rosemary Adriana Chiérici Marcantonio, Daisuke Ono, Fumio Kobayashi, Kamal Mustafa, Ann Wennerberg, Ryo Jimbo

“…Nanostructured implants were coated with laminin-1 (test; dilution, 100 μg/mL) and inserted into the rabbit tibiae. Noncoated implants were used as controls. …”
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International Laws Regulating Human Rights in Business Operations in Uganda: Issues and Challenges by Paul Atagamen Aidonojie, Tom Mulegi, Jufri Muwaffiq, Andrew Ikhayere Imiefoh, Antai Godswill Owoche

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CRISPR-based epigenetic editing of Gad1 improves synaptic inhibition and cognitive behavior in a Tauopathy mouse model by Lei Wan, Ping Zhong, Pei Li, Yong Ren, Wei Wang, Mingjun Yu, Henry Y. Feng, Zhen Yan

“…Cells transfected with a fusion protein consisting of the nuclease-null dCas9 protein and the catalytic core of p300 (dCas9p300), as well as a guide RNA targeting Gad1 promoter (gRNAGad1), had significantly increased Gad1 mRNA expression and histone acetylation at Gad1 promoter. …”
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Reestablishment of Redox Homeostasis in the Nociceptive Primary Afferent as a Mechanism of Antinociception Promoted by Mesenchymal Stem/Stromal Cells in Oxaliplatin-Induced Chronic... by Anna Lethicia L. Oliveira, Gisele G. L. Santos, Renan F. Espirito-Santo, Gessica Sabrina A. Silva, Afrânio F. Evangelista, Daniela N. Silva, Milena B. P. Soares, Cristiane Flora Villarreal

“…Moreover, MSC-treated neuropathic mice showed upregulation of Sod and Nrf2 mRNA in the sciatic nerve and DRG. In line with this result, MSC reduced markers of nitrosative stress and lipid peroxidation in the sciatic nerve and DRG from OIPN mice. …”
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Effect of Dry Aging on Beef Muscle Proteins by Galina V. Gurinovich, Irina S. Patrakova, Vladislav A. Khrenov, Marina V. Patshina, Antonina I. Shevchenko

“…The samples were isolated from the inner part of bone spinal-lumbar cuts after 21, 35, and 42 days of dry aging under the following conditions: 0–1°C, 74–75% relative humidity, 0.5 m/s air velocity. The samples were subjected to dry aging after 24 h at 4°C. …”
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Impact of functional re-education and environmental adaptation in cancer patients with respiratory pathology: Study protocol. by Eduardo Jose Fernandez-Rodriguez, Maria Isabel Rihuete-Galve, Alberto Garcia-Martin, Celia Sanchez-Gomez, Fausto Jose Barbero-Iglesias, Roberto Mendez-Sanchez, Ana Silvia Puente-Gonzalez, Susana Saez-Gutierrez, Emilio Fonseca-Sanchez, Juan Jesus Cruz-Hernandez

“…During these assessments, sociodemographic data will be collected, and the following scales will be administered: Barthel Index, Medical Research Council Dyspnoea Scale (mMRC), EuroQol 5-D questionnaire (EQ-5D), Visual Analogue Scale (VAS), Short Physical Performance Battery (SPPB), Tampa Scale for Kinesiophobia (TSK), and the Zarit Reduced Caregiver Burden Scale.…”
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El forraje verde hidropónico como una alternativa productiva en Patagonia Sur: Productividad y calidad nutricional de dos variedades de cebada (Hordeum vulgare) by J. A. BIRGI, V. GARGAGLIONE, V. UTRILLA

“…No se encontraron diferencias significativas en productividad entre las variedades, obteniéndose entre 18 y 21 kg/m2 de FVH en fresco. Asimismo, tampoco se encontraron diferencias significativas en cantidad de biomasa producida según el nivel de luz recibido, obteniendo similares rendimientos las bandejas ubicadas en una mejor posición lumínica que las ubicadas en el piso inferior. …”
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Evaluation of sex-based differences in below-the-knee plaque histology in patients who underwent amputation for chronic limb-threatening ischemia by Fouzul Kansul, Deborah Vela, MD, Judit Csore, MD, Bright Benfor, MD, Sasha Suarez, MD, Anahita Dua, MD, MBA, MSC, Trisha L. Roy, MD, PhD

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Exploring individual differences in online and face-to-face help-seeking intentions in case of impending mental health problems: The role of adult attachment, perceived social supp... by Jennifer Apolinário-Hagen, Annina Trachsel Dugo, Lisa Anhorn, Britta Holsten, Verena Werner, Simone Krebs

“…Methods: Data was collected from 301 adults from the German-speaking general population (age: M = 34.42, SD = 11.23; range: 18 - 65 years; 72.1% female) through an anonymous online survey. …”
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The Small Mobile Ozone Lidar (SMOL): instrument description and first results by F. Chouza, T. Leblanc, P. Wang, S. S. Brown, K. Zuraski, K. Zuraski, W. Chace, W. Chace, W. Chace, C. C. Womack, C. C. Womack, J. Peischl, J. Peischl, J. Hair, T. Shingler, J. Sullivan

“…An additional comparison with nearby surface ozone measuring instruments indicates unbiased measurements by the SMOL lidars down to 200 m a.g.l. Further comparison with the Goddard Earth Observing System Composition Forecast (GEOS-CF) model suggests that such lidars are a critical tool to perform model validation and can potentially be used for assimilation to air quality forecasts.…”
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Effects of diesel exhaust inhalation on cognitive performance in human volunteers: A randomized controlled crossover study by Jason Curran, A.J. Hirsch Allen, Christopher F. Rider, Robin Shutt, Chris Carlsten

“…Volunteers were exposed to two conditions for 120 min each, on separate order-randomized occasions: filtered air (FA) and DE (300 µg/m3 PM2.5) at the Air Pollution Exposure Laboratory (APEL) at Vancouver General Hospital (VGH). …”
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Development of High-performance Proton Transfer Reaction Time-of-Flight Mass Spectrometer by Chun-guang XIE, Ji-yang ZHANG, Tong YANG, Yu-liang HUANG, Shu-guang XIE, Hui ZHU, Jing-xuan SUN, Ping CHENG

“…Experimental tests showed that the system’s resolution (full width half maximum, FWHM) is better than 2 069 (for toluene), with the detection limit of 0.36 μg/m3, a linear range of 4 orders of magnitude, and a linear correlation coefficient (R2) of 0.991. …”
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EVALUATION OF THE ADAPTIVE PROPERTIES OF SPRING BARLEY VARIETIES ACCORDING TO THEIR YIELD CAPACITY IN THE ENVIRONMENTS OF THE NEAR-IRTYSH AREA IN OMSK PROVINCE by P. N. Nikolaev, P. V. Popolzukhin, N. I. Anisimov, O. A. Yusova, I. V. Safonova

“…The experimental part of the work was  carried out during 2011-2017, on the experimental fields of the  Siberian Research Institute of Agriculture, RAAS, located in the  southern forest-steppe in the vicinity of Omsk. The plot area was 10  m2, with 4 repetitions. The sowing rate was 4 million live grains per  1 hectare. …”
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Dose-dependent effects of hydroquinone on liver injury and lipid dysregulation based on SCD1/AMPK signaling pathway in C57BL/6 mice by Lijun Zou, Fen Lin, Jinying Wen, Jinyu Huang, Yue Tan, Hui Huang, Gonghua Hu

“…In contrast, the highest dose (50.0 mg/kg) resulted in elevated liver enzyme levels, indicative of liver damage, while lipid levels decreased. Notably, the mRNA or protein levels of SCD1 were upregulated in response to the lower doses of HQ (12.5 and 25.0 mg/kg), whereas AMPK activation and enhanced autophagy were observed in the 50.0 mg/kg HQ-treated group, reflecting an energy stress response. …”
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Dynamic analysis and optimal control of a hybrid fractional monkeypox disease model in terms of external factors by Saima Rashid, Abdul Bariq, Ilyas Ali, Sobia Sultana, Ayesha Siddiqa, Sayed K. Elagan

“…By taking into account the modified Atangana–Baleanu–Caputo (mABC) fractional difference operator, we develop an analytical framework for an outbreak caused by MPXV and broaden it to accommodate the fractional scenario. …”
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A systematic literature review to evaluate the cardiac and cerebrovascular outcomes of patients with Fabry disease treated with agalsidase Beta by Gavin Y. Oudit, Gavin Y. Oudit, Pronabesh DasMahapatra, Nicole Lyn, Florence R. Wilson, Adekemi Adeyemi, Chae Sung Lee, Ana Crespo, Mehdi Namdar

“…Significant reductions in cardiac mass were demonstrated after 1 year of treatment in a single-arm study using cardiac MRI [left ventricular mass (LVM) 193–178 g; LVM index 102–94 g/m2; both p < 0.05]. Rates of composite cardiac events (3.8%–24.0%; four studies, follow-up 2–10 years) and cerebrovascular events (0.0%–18.9%; 12 studies, follow-up 1–10 years) were numerically lower than rates for placebo (follow-up 3 years).ConclusionLiterature over the last 20 years indicates that agalsidase beta treatment may lead to stabilization or regression of cardiac structural thickness and mass, and reduction in cardiac and cerebrovascular events relative to placebo.…”
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Chemical Composition Characteristics and Source Apportionment of PM2.5 in Ceramic Industrial Base during Winter by Xiang Tu, Xiaozhen Fang, Hansun Fang, Changlin Ye, Zugen Liu, Xuehui Jia, Dan He, Jinliang Wang, Hong Huang, Changwei Zou, Chenglong Yu

“…The results showed that the average PM2.5 concentration during sampling period was 134 ± 74.7 µg m−3, which exceeding World Health Organization (WHO) Air Quality Guidelines levels. …”
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