Exploring the antiviral potential of shikimic acid against Chikungunya virus through network pharmacology, molecular docking, and in vitro experiments by Jialiang Xin, Xingxing Song, Haohong Zheng, Wenjing Li, Yuyang Qin, Wei Wang, Wei Wang, He Zhang, Guangneng Peng

“…In vitro experiments confirmed that SA significantly enhanced the viability of 293T and BHK-21 cells infected with CHIKV by ~25% and reduced viral load by over 20% at concentrations ranging from 1,000 to 31.25 μM. Additionally, SA was found to markedly downregulate the expression of CHIKV-related attachment factors ACTG1, TSPAN9, and TIM-1 in 293T cells infected with CHIKV. …”
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Sustainable CO₂ Capture: N,S-Codoped Porous Carbons Derived from Petroleum Coke with High Selectivity and Stability by Jiawei Shao, Yingyi Wang, Mingyang Che, Ya Liu, Yongfu Jiang, Qiang Xiao, Muslum Demir, Linlin Wang, Xin Hu

“…The optimized sample exhibited a high specific surface area of 1088 m²/g, a narrow micropore volume of 0.52 cm³/g, and considerable heteroatom doping (1.57 at.% nitrogen and 0.19 at.% sulfur). …”
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Un port rural antique de fond d’estuaire à Blainville-sur-Orne (Calvados) by Cécile Allinne

“…A reconstruction of this river environment is proposed, based on paleoenvironmental studies combined with the field investigations: the Dan river formed a shallow body of water, 20 to 30 m wide, 1 km upstream from the confluence with the Orne, which in Roman times opened up into a vast estuary. …”
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Study on the Electromigration Organization and Mechanical Properties of Sn2.5Ag0.7Cu0.1RE/Cu Solder Joints by Yuming Wang, Keke Zhang, Chao Zhang, Fupeng Huo, Yijie Gao

“…In addition, we observed the recrystallization of Cu₆Sn₅ grains in the anode region and an increase in the grain length and diameter to 6.8–31.9 μm, which further promoted electromigration polarity. …”
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Sulfated Cyclocarya paliurus polysaccharides exert immunomodulatory potential on macrophages via Toll-like receptor 4 mediated MAPK/NF-κB signaling pathways by Yue Yu, Haibin Zhu, Mingyue Shen, Qiang Yu, Yi Chen, Shiru Mo, Jianhua Xie

“…Results showed that SCP3 at 25−100 μg/mL increased viability and improved phagocytosis of RAW264.7 cells. …”
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Exploring the utility of different bulking agents for speeding up the composting process of household kitchen waste by Sania Mussa, Muhammad Farhan, Shoaib Ahmad, Khadija Zahra, Amina Kanwal, Qaiser Farid Khan, Muhammad Afzaal, Abdul Wahid, Pallab K. Sarker, Mohamed A. El-Sheikh, Shafaqat Ali

“…The pH range in all compost treatments was 7-8.5, Electrical conductivity range was 1.8–3.55 mS/cm, C/N ratio range was 15.4–18.1, water holding capacity range was 3.25–4.3 g water/g dry sample, total potassium range was 1.52–1.61%, total phosphorous range was 0.83–1.14%. …”
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Protective Effect of Sex Hormone-Binding Globulin against Metabolic Syndrome: In Vitro Evidence Showing Anti-Inflammatory and Lipolytic Effects on Adipocytes and Macrophages by Hiroki Yamazaki, Akifumi Kushiyama, Hideyuki Sakoda, Midori Fujishiro, Takeshi Yamamotoya, Yusuke Nakatsu, Takako Kikuchi, Sunao Kaneko, Hirotoshi Tanaka, Tomoichiro Asano

“…In this study, using adipocytes and macrophages, we focused on the in vitro effects of SHBG on inflammation as well as lipid metabolism. Incubation with 20 nM SHBG markedly suppressed lipopolysaccharide- (LPS-) induced inflammatory cytokines, such as MCP-1, TNFα, and IL-6 in adipocytes and macrophages, along with phosphorylations of JNK and ERK. …”
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Direct-acting oral anticoagulant removal by intraoperative hemoadsorption in CABG and/or single valve surgery: interim analysis of the International Safe and Timely Antithrombotic... by Michael Schmoeckel, Matthias Thielmann, Keti Vitanova, Thomas Eberle, Nandor Marczin, Kambiz Hassan, Andreas Liebold, Sandra Lindstedt, Georg Mächler, Marijana Matejic-Spasic, Daniel Wendt, Efthymios N. Deliargyris, Robert F. Storey

“…The mean 24-hour CTD was 771.3 ± 482.79mL. No device-related adverse events were reported. …”
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Neuropatía motora multifocal by Viridiana Robles-Sánche, Estefanía G. Torres-Marcín, Alicia Garmendia-Rebolledo, Plácido Coyac-Cuautle, Arturo García-Galicia, Deyaneira Palacios-Figuero, Nancy R. Bertado-Ramírez, Álvaro J. Montiel-Jarquín, Jorge Loria-Castellanos

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High and low dose radiotherapy combined with ICIs for MSS colorectal cancer patients with liver metastases: a phase I study (HaRyPOT) by Yuxuan Ding, Yong Feng, Yangfan Ye, Jiayi Shen, Chang Guo, Xia He, Liangjun Zhu, Lijun Wang

“…In exploratory endpoint analyses, tissue biopsies and paired hematologic samples from patients showed M2 macrophage reduction. Plasma cytokines IL-10, IL-17, and INF-α increased after treatment with both drugs.DiscussionIn summary, this is the first clinical trial demonstrating the safety and immunogenic activity of combined high and low dose radiotherapy with ICIs in MSS colorectal cancer liver metastases (CRLMs). …”
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Research progress on climate change adaptation strategies to control invasive crop pest in sub-Saharan Africa: a bibliometric and systematic review by Eméline Sêssi Pélagie Assèdé, Eméline Sêssi Pélagie Assèdé, Calvince Ouko Othoo, Calvince Ouko Othoo, Ahmadou Ly, Gobena Bayisa, Temesgen Gashaw Tarkegn, Temesgen Gashaw Tarkegn, Mègnissè Zohoun, Anje-Jokebed N’goran

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New insights into the salt-responsive regulation in eelgrass at transcriptional and post-transcriptional levels by Huan Zhao, Huan Zhao, Xu Dong, Xu Dong, Dazuo Yang, Dazuo Yang, Qingchao Ge, Qingchao Ge, Peng Lu, Peng Lu, Chang Liu, Chang Liu

“…Eelgrass (Zostera marina), a representative marine angiosperm, serves as an ideal model for investigating the mechanisms underlying salt tolerance.MethodsThis study integrated mRNA, sRNA, and degradome sequencing data to identify key genes associated with salt tolerance in eelgrass.ResultsThe results indicate that a series of genes involved in biological processes such as “in response to water deprivation” and “biosynthesis of secondary metabolites” respond to salt stress. …”
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A Realistic Approach to Calculating the Nitrogen Use Efficiency Index in Cereals with Winter Wheat (<i>Triticum aestivum</i> L.) as an Example by Witold Grzebisz, Jarosław Potarzycki

“…A N_in58 of 517 kg N ha⁻¹ resulted in a GD of 28.3 × 1000 grains m⁻², producing 9.47 t grain ha⁻¹. …”
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Spatial and temporal characteristics and driving mechanisms of recreational ecosystem services supply-demand mismatch in rapidly urbanizing areas: Evidence from the Yangtze River D... by Ruien Tang, Guolin Hou, Yueyi Chen, Xiao Liu, Shaoying Chu, Li Li

“…The matching types generally show a trend of decreasing L-L and M-L and a significantly increasing H-H. The changes in supply and demand risks at different levels are dominated by level-by-level migration, but the low-level units attract the higher level to leap downward across level transitions, thus indicating a significant spatial spillover effect. …”
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Wind–Wave Misalignment in Irish Waters and Its Impact on Floating Offshore Wind Turbines by Thomas Shanahan, Breiffni Fitzgerald

“…Using the ERA5 reanalysis dataset validated against Irish Marine Data Buoy Observation Network measurements, the results showed a satisfactory accuracy with an average wind speed error of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mo>−</mo><mn>0.54</mn></mrow></semantics></math></inline-formula> m/s and a strong correlation coefficient of <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><mn>0.92</mn></mrow></semantics></math></inline-formula>. …”
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GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection by Ying Wang, Lanjie Li, Danni Chen, Jiaheng Shan, Meijuan Yi, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi

“…Meanwhile, the AMPK/unc-51-like autophagy-activating kinase 1 (ULK1)/microtubule-associated protein 1 light chain 3 beta (LC3B) and AMPK/mammalian target of rapamycin (mTOR) signaling pathways involved in anti-AD effects of GENI. …”
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Fabrication and evaluation of a portable and reproducible quartz crystal microbalance immunochip for label-free detection of β-lactoglobulin allergen in milk products by Mingfei Pan, Liping Hong, Jingying Yang, Xiaoqian Xie, Kaixin Liu, Shuo Wang

“…Under optimal conditions, the proposed QCM immunochip exhibited good recognition of β-LG, with a calibration curve of ΔF = 12.877Cβ-LG0.4809 (R2 = 0.9982) and limit of detection of 0.04 μg/mL. Additionally, this portable QCM immunochip had good stability, high specificity, and no obvious cross-reaction to three other milk proteins (α-casein, α-lactalbumin, and lactoferrin). …”
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PENGARUH PEMBERIAN MADU ASLI HUTAN SIJUNJUNG TERHADAP TNF α DAN PENYEMBUHAN LUKA PADA TIKUS GALUR WISTAR JANTAN by Reni Puspita, Fadil Oenzil, Desmiwarti Desmiwarti

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Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity by Nouh AH, Elgendy FM, Gobran FA, Zhuravlova MS

“…Ahmed H Nouh,1 Fatma M Elgendy,2 Fatma A Gobran,3 Maryna S Zhuravlova4 1Al-Azhar University, Faculty of Medicine, Department of Dermatology, Venereology and Andrology, Cairo, Egypt; 2Ain Shams university, Faculty of medicine, Department of Pathology, Cairo, Egypt; 3Medical Laboratory at Sharkia Health Directorate, Ministry of Health, Belbeys, Egypt; 4Lugansk state medical University, Department of Pathology, Rivne, UkraineCorrespondence: Maryna S Zhuravlova, Email marynazhuravlovamd@gmail.comIntroduction: Marie-Unna hereditary hypotrichosis (MUHH) is an autosomal dominant disorder characterized by a specific pattern of hair loss. …”
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Detection Methods for Asparagine and Glutamine Contents in Fruits and Vegetables and Recommendations for Dietary Intake of Fruits and Vegetables in Patients with Urea Cycle Disorde... by YE Xinyu, LI Ziying, TANG Shujun, SUN Liping, ZHAO Yunxia, XIAO Weimin, GU Yaping, KUANG Huiying, CHEN Xin, YANG Guowu, HUANG Yali

“…The calibration curves for Asn and Gln showed a good linearity in the range of 10–1 000 ng/mL (R2 > 0.999), with limit of detection (LOD) and limit of quantification (LOQ) of 1.5 and 5.0 mg/100 g, respectively. …”
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