Machine learning based predictive model and genetic mutation landscape for high-grade colorectal neuroendocrine carcinoma: a SEER database analysis with external validation by Ruixin Wu, Ruixin Wu, Sihao Chen, Sihao Chen, Yi He, Yi He, Ya Li, Song Mu, Aishun Jin, Aishun Jin

“…The median OS for the cohort was 10 months, whereas CSS was 11 months. Six variables (M stage, LODDS, Nodes positive, Surgery, Radiotherapy, and Chemotherapy) were screened as key prognostic indicators. …”
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Origanum majorana Essential Oil Lacks Mutagenic Activity in the Salmonella/Microsome and Micronucleus Assays by Andrea dos Santos Dantas, Luiz Carlos Klein-Júnior, Miriana S. Machado, Temenouga N. Guecheva, Luciana D. dos Santos, Régis A. Zanette, Fernanda B. de Mello, João Antonio Pêgas Henriques, João Roberto Braga de Mello

“…Cytotoxicity was only observed at concentrations higher than or equal to 0.05 μg/mL. Moreover, when tested in noncytotoxic concentrations, O. majorana essential oil was not able to induce chromosome mutation. …”
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Investigating the Effect and Potential Mechanism of Rhamnetin 3-<i>O</i>-α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro by Dandan Deng, Borong Zhao, Hong Yang, Songsong Wang, Ziying Geng, Jiangtao Zhou, Guane Yang, Liwen Han

“…The hepatoprotective activity of ARR was evaluated by assessing liver morphology, liver function indices, oxidative stress, and the mRNA expression levels of inflammation-related genes in the zebrafish model. …”
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Food addiction and associated factors in newly diagnosed patients with schizophrenia: a cross-sectional comparison with siblings and healthy controls by Feten Fekih-Romdhane, Youssef Boukadida, Abir Hakiri, Wided Homri, Majda Cheour, Souheil Hallit

“…FA was assessed using the modified version of the Yale Food Addiction Scale (mYFAS 2.0). The Metacognitions Questionnaire (MCQ-30) and the Emotion Regulation Questionnaire were administered to the patients’ group. …”
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Comparative transcriptomics and metabolomics provide insight into degeneration‐related physiological mechanisms of Morchella importuna after long‐term preservation by Ying Chen, Xuelian Cao, Liyuan Xie, Jie Tang, Lixu Liu, Di Wang, Xiang Wu, Tianhai Liu, Yang Yu, Yong Wang, Francis Martin, Weihong Peng, Hao Tan

“…Agricultural production of the prized ascomycete mushroom Morchella importuna (black morel) typically suffers from reduced yield and malformed ascocarps owing to culture degeneration. This study compared M. importuna cultures subjected to five different long‐term preservation treatments, using transcriptomics and metabolomics. …”
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Adaptive Modification in Agonist Common Drive After Combined Blood Flow Restriction and Neuromuscular Electrical Stimulation by Yi-Ching Chen, Chia-Chan Wu, Yeng-Ting Lin, Yueh Chen, Ing-Shiou Hwang

“…Post-test force fluctuations increased (p =0.031), along with a decrease in the mean inter-spike interval (M_ISI) in the ECRL (p =0.022). Factor analysis revealed an increase in the proportion of motor units (MUs) jointly regulated by the neural mode for both ECRB and ECRL, coupled with a decline in independently regulated MUs. …”
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Factors affecting patient satisfaction during endoscopic procedures by Maryam Ghazala, E-Hinna Rashk, Sardar Saman, Khan Jahangir, Isram Javaria, Hassan Fayyaz

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Elevation of High-Mobility Group Protein Box-1 in Serum Correlates with Severity of Acute Intracerebral Hemorrhage by Yu Zhou, Kun-Lin Xiong, Sen Lin, Qi Zhong, Feng-Lin Lu, Hong Liang, Jing-Cheng Li, Jing-Zhou Wang, Qing-Wu Yang

“…Compared with normal controls, patients with ICH had markedly elevated levels of HMGB1, which was significantly correlated with the levels of IL-6 and TNF-α, NIHSS score at the 10th day, and mRS score at 3 months. In comparison with the control group, the levels of HMGB1 in the perihematomal tissue in mice with ICH increased dramatically, peaked at 72 hours, and decreased at 5 days. …”
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Quantitative Proteomics Analysis Reveals XDH Related with Ovarian Oxidative Stress Involved in Broodiness of Geese by Ning Zhou, Yaoyao Zhang, Youluan Jiang, Wang Gu, Shuai Zhao, Wanwipa Vongsangnak, Yang Zhang, Qi Xu, Yu Zhang

“…Antioxidant activity (GSH, CAT, SOD, T-AOC, and the content of H₂O₂) and the mRNA expression levels of antioxidant genes (GPX, SOD-1, SOD-2, CAT, COX-2, and Hsp70) were significantly higher in pre-broody geese compared to laying geese, while the expression of apoptosis-related genes (p53, Caspase-3, and Caspase-9) increased and the anti-apoptotic gene Bcl-2 decreased. …”
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Intravenous Infusion of Dexmedetomidine Combined Isoflurane Inhalation Reduces Oxidative Stress and Potentiates Hypoxia Pulmonary Vasoconstriction during One-Lung Ventilation in Pa... by Rui Xia, Jinjin Xu, Hong Yin, Huozhi Wu, Zhengyuan Xia, Daiwei Zhou, Zhong-yuan Xia, Liangqing Zhang, Haobo Li, Xiaoshan Xiao

“…Anesthesia was maintained with intravenous remifentanil and inhalational isoflurane (1.0–2.0%), with concomitant infusion of dexmedetomidine 0.7 μgkg−1h−1 in DISO and saline 0.25 mL kg−1h−1 in NISO group. Hemodynamic variables or depth of anesthesia did not significantly differ between groups. …”
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A Retrospective Analysis of Thromboembolic Phenomena in Mechanically Ventilated Patients with COVID-19 by Fahad Faqihi, Abdulrahman Alharthy, Abdullah Balhamar, Nasir Nasim, Khaled Alanezi, Feisal Alaklobi, Ziad A. Memish, Mike Blaivas, Saleh A. Alqahtani, Dimitrios Karakitsos

“…The sensitivity, specificity, and positive and negative predictive values of a cutoff D-dimer level of 3.0 μg/mL for predicting PE were 74.5%, 95.1%, 86.8%, and 91.9%, respectively. …”
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Study on hot deformation behavior and microstructure evolution of ultrafine W-0.5 wt%La2O3 alloy wire during processing by Yuan Yao, Jianwei Guo, Shizhong Wei, Jinghong Yang, Zhou Li, Hongan Geng, Liujie Xu

“…Combined with the hot processing map, the optimum process parameters of tungsten alloy were determined to be 1400 °C–1600 °C, 0.01–0.05s−1. The φ35.5 μm ultra-fine tungsten wire was prepared according to this parameter. …”
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Effects of Lemon Beverage Containing Citric Acid with Calcium Supplementation on Bone Metabolism and Mineral Density in Postmenopausal Women: Double-Blind 11-Month Intervention Stu... by Hiromi Ikeda, Tadayuki Iida, Masanori Hiramitsu, Takashi Inoue, Satomi Aoi, Miho Kanazashi, Fumiko Ishizaki, Toshihide Harada

“…Using a double-blind protocol, subjects in the LECA and LE groups consumed one bottle containing 290 mL of the test beverage each day. The ratio of change in BMD after 11 months was significantly higher in the LECA group as compared to the control and LE groups. …”
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Knockdown of RFC4 inhibits cell proliferation of oral squamous cell carcinoma in vitro and in vivo by Pengyue You, Di Wang, Zheng Liu, Shuzhen Guan, Ning Xiao, Haotian Chen, Xin Zhang, Lichuan Wu, Guizhen Wang, Haitao Dong

“…Knockdown of RFC4 led to G2/M phase cell cycle arrest and inhibited the proliferation of OSCC cells both in vitro and in vivo. …”
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Winter tick sharing between ungulates in the Greater Yellowstone Ecosystem and implications for apparent competition by Troy Koser, Alynn Martin, Alyson Courtemanch, Laura Thompson, Benjamin Wise, Gary Fralick, Sarah Dewey, Amy Girard, Brandon Scurlock, Jared Rogerson, Kennan Oyen, Paul Cross

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Immunogenicity and Protective Efficacy of a Novel Recombinant BCG Strain Overexpressing Antigens Ag85A and Ag85B by Chun Wang, Ruiling Fu, Zhenhua Chen, Kun Tan, Lingxia Chen, Xindong Teng, Jia Lu, Chunwei Shi, Xionglin Fan

“…In this study, three rBCG strains overexpressing immunodominant antigens Ag85B (rBCG::85B), Ag85A (rBCG::85A), or both (rBCG::AB) of Mycobacterium tuberculosis were constructed, respectively. rBCG strains showed higher level of overexpression of Ag85A and/or Ag85B proteins than BCG containing empty vector pMV261(rBCG::261), which had low levels of endogenous expression of both proteins as expected. rBCG::AB strain could provide the strongest short-term and long-term protection in the lung against intravenous infection with virulent M. tuberculosis than rBCG::261 control and other two rBCG strains overexpressing single antigen. …”
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Estimation of daily groundwater evapotranspiration from diurnal variations of lysimeter experiments data in an arid zone by Peng Yao, Fengzhi Shi, Yuehui Wang, Ningze Dai, Chengyi Zhao

“…Using an automatic water level-compensating lysimeter, ETg was monitored hourly for P euphratica, T ramosissima, and bare land at groundwater depths of 0.7, 1.1, and 1.5 m in August 2023. Variations at hourly and daily scales were analyzed, and a modified White method was applied to estimate ETg. …”
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Pain Reduction in Patellofemoral Knee Patients During 3-Month Intervention with Biomechanical and Sensorimotor Foot Orthoses: A Randomized Controlled Clinical Study by Steven Simon, Andreas Heine, Jonas Dully, Carlo Dindorf, Oliver Ludwig, Michael Fröhlich, Stephan Becker

“…<b>Results:</b> Statistical analysis revealed no statistically significant interaction between ToMs and treatment groups but a significant main effect on Kujala anterior knee pain scores (M_Diff = 10.189; <i>p</i> = 0.014) and 12-week VAS (<i>p</i> = 0.001). …”
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<i>In Silico</i> Investigation of γ-Sitosterol Isolated from the Ethanol Extract of <i>Artocarpus camansi</i> Leaves as a Sunscreen Agent by Rosnani Nasution, Rafna Azura, Muhammad Bahi, Nur Balqis Maulydia, Reza Akbar Bastian, Michelia Mutiara Hilda, Marianne Marianne

“…The pure compound is thought to be γ-sitosterol by analysis of its molecular weight similarity and positive ion fragment m/z with a melting point of 147 °C. From the molecular docking, it is known that γ-sitosterol has the highest binding affinity value of −7.4 and −8.2 kcal/mol to human neutrophile collagenase (PDB ID: 1BZS) and fibroblast collagenase-1 (PDB ID: 966C), respectively. …”
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Optimising subsurface integrity and surface quality in mild steel turning: A multi-objective approach to tool wear and machining parameters by Muhammad Imran, Suo Shuangfu, Bai Yuzhu, Wang Yuming, Naveed Raheel

“…The optimal machining parameters, determined as Vc = 125.6 m/min, f = 0.35 mm/rev, and ap = 0.7 mm, demonstrate the efficacy of the optimization techniques in achieving enhanced surface quality and making a significant contribution to the field of machining and manufacturing.…”
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