The Accuracy of the NSQIP Universal Surgical Risk Calculator Compared to Operation-Specific Calculators by Mark E. Cohen, PhD, Yaoming Liu, PhD, Bruce L. Hall, MD, PhD, MBA, FACS, Clifford Y. Ko, MD, MS, MSHS, FACS

“…Operation-specific risk calculators (OS-RC) and OS-RCs with operation-specific predictors (OSP-RC) were independently developed for each of 6 operative groups (colectomy, whipple pancreatectomy, thyroidectomy, abdominal aortic aneurysm (open), hysterectomy/myomectomy, and total knee arthroplasty) and 14 outcomes using the same 80%/20% rule applied to the appropriate subsets of the 5M records. Predictive accuracy was evaluated using the area under the receiver operating characteristic curve (AUROC), the area under the precision-recall curve (AUPRC), and Hosmer-Lemeshow (H-L) P values, for 13 binary outcomes, and mean squared error for the length of stay outcome. …”
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Functional Characterization of the SHIP1-Domains Regarding Their Contribution to Inositol 5-Phosphatase Activity by Spike Murphy Müller, Nina Nelson, Manfred Jücker

“…To determine the contribution of the individual domains to catalytic activity, the full-length protein was compared with truncated constructs lacking one or more domain(s), regarding the substrate turnover (k_cat) and catalytic efficiency (k_cat/K_m) towards ci8-PtdIns(3,4,5)P₃. …”
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Stabilization of metal-doped magnesium oxide nanoparticles with PAMAM dendrimers to improve alpha-amylase enzyme inhibition by Jaison Jeevanandam, Mara Gonçalves, Rita Castro, Juan Gallo, Manuel Bañobre-López, João Rodrigues

“…The smaller size (∼11–72 nm), surface charge (ca. 17–24 mV), crystallite size ranging from 9.07 nm (Zn-doped MgO) to 17.44 nm (Ag-doped MgO), and distinct shapes have led to enhanced stabilization via G5 dendrimer. …”
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Reference Intervals of Central Aortic Blood Pressure and Augmentation Index Assessed with an Oscillometric Device in Healthy Children, Adolescents, and Young Adults from Argentina by Alejandro Diaz, Yanina Zócalo, Daniel Bia, Edmundo Cabrera Fischer

“…First, we evaluated if RIs for males and females were necessary using correlation and covariate analysis. Second, mean (M) and standard deviation (SD) age-related equations were obtained for cSBP and cAIx, using parametric regression methods based on fractional polynomials. …”
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From ecological menace to roadside attraction: 28 years of evidence support successful biocontrol of purple loosestrife by Bernd Blossey, Victoria Nuzzo, Stacy B. Endriss

“…We used a standardized monitoring protocol to record insect abundance and L. salicaria stem densities and heights in 1‐m2 permanent quadrats at 33 different wetlands and followed sites for up to 28 years. …”
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Perceived coercion amongst healthcare workers during the COVID-19 pandemic by Andrea S. Stoltenberg, Veronica Ranieri, Hege Kristine N. Dahlen, Eleni Nastouli, SAFER Investigators, Roger Almvik, Sarah J. L. Edwards, Sunjeev K. Kamboj

“…On average, across the three PPCS-HCW scale factors, HCWs showed low levels of perceived coercion (M = 0.22 (95% CI [0.11, 0.33] on a − 3 to + 3 scale). …”
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Discovery of the bacterial HslV protease activators as lead molecules with novel mode of action by Aurangzeb Sana, Aurongzeb Muhammad, Shamim Shahbaz, Rashid Yasmeen, Khan Khalid Mohammed, Aziz Tariq, Alharbi Metab, Alasmari Abdullah F.

“…These compounds have demonstrated effective dose 50 values within the sub-micromolar range, i.e., 0.4–0.58 µM. Normal mode analysis investigations provided additional confirmation regarding the stability of the conformational interactions between the HslV protease and the active compounds. …”
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Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…Effects of vernolactone on the expression of autophagy-related genes (LC3, Beclin 1, PI3K, Akt, and mTOR) were evaluated using real-time PCR. 2,2-Diphenyl-1-2,2-diphenyl-picrylhydrazyl (DPPH) radical scavenging assay, 2,2′-azinobis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging, and ferric reducing antioxidant power (FRAP) assays were also carried out to evaluate the antioxidant activity of vernolactone. …”
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A patient choice‐driven lifestyle intervention lowers HbA1c in type 2 diabetes: A feasibility study by Nathan R. Weeldreyer, Mindy L. McEntee, Matthew P. Martin, Chong D. Lee, Farshad Fani Marvasti, Glenn A. Gaesser, Rodger Kessler, Siddhartha S. Angadi

“…Modest reductions were observed for waist circumference (115.5 ± 12.6 vs. 112.5 ± 15.2 cm; p = 0.014, 95% CI: −5.66 to −0.26), body weight (97.7 ± 21.9 vs. 95.6 ± 23.9 kg; p = 0.016. 95% CI: −3.84 to −0.31), and BMI (33.7 ± 7.2 vs. 32.8 ± 7.5 kg/m2; p = 0.028, 95% CI: −1.29 to −0.12). This 90‐day, patient choice‐intervention was successful at lowering HbA1c in patients with T2D. …”
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Optimization of the Solid-state Fermentation Process for Morchella esculenta Fermented Wheat and Analysis of Its Nutritional Components, Physicochemical Properties and Antioxidant... by Dandan GU, Xue DONG, Jinxiu ZHANG, Xiaoru WANG, Zongshuo ZHAO, Li'an WANG

“…The results showed that the optimal fermentation conditions were a material to liquid ratio of 1:0.9 (g:mL), an initial substrate pH of 7.0, an inoculum amount of 5 inoculum blocks (each with a diameter of 0.8 cm), and a fermentation duration of 10 days. …”
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End-to-end dataflow engineering framework of honey manufacturing from intermediates to process by TAS1R2@AuNPs/SPCE biosensor coupled with quality transfer principle by Xiaoyan Hu, Jingqi Zeng, Lijuan Ma, Xiaomeng Wang, Jing Du, Lu Yao, Zhisheng Wu

“…Furthermore, a hypersensitized TAS1R2@AuNPs/SPCE biosensor was developed to identify biological quality attributes of honey, the powerful affinities between honey intermediates and the TAS1R2 receptor were discovered (KD < 1 × 10−8 M), and the abnormal batches of B2, B23 and C23 were diagnosed by TAS1R2@AuNPs/SPCE biosensor and multivariable algorithm. …”
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Feasibility of home-based transcranial direct current stimulation combined with personalized word retrieval for improving naming in primary progressive aphasia by Allan George, Eric McConathey, Amy Vogel-Eyny, Elizabeth Galletta, Giuseppina Pilloni, Leigh Charvet

“…During the first 30-min, participants received tDCS over the left inferior frontal gyrus (anode F7, cathode O1) at 2.0 mA. Language measures were remotely administered at baseline and intervention end.ResultsWe enrolled 10 patients (age: 70 ± 7 years; 60% male) with confirmed logopenic variant (n = 2), semantic variant (n = 2), or unspecified (n = 6) PPA. …”
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Using a region-specific ice-nucleating particle parameterization improves the representation of Arctic clouds in a global climate model by A. B. Gjelsvik, R. O. David, T. Carlsen, F. Hellmuth, S. Hofer, Z. McGraw, Z. McGraw, H. Sodemann, H. Sodemann, T. Storelvmo, T. Storelvmo

“…The change in CLWP in boreal autumn and winter is found to likely be the dominant contributor to the annual average increase in net surface CRE of 2 W m<span class="inline-formula">⁻²</span>. …”
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NCAPD3‐mediated AKT activation regulates prostate cancer progression by Yi Zhang, Wanlin Xie, Xicui Zong, Yuanyuan Fang, Jia Ren, Zuolei Jing, Yong Wei, Shan Lu, Qingyi Zhu, Ping Liu

“…This led to an increase in phosphorylation of AKT at Thr 308 and Ser 473 through JAK2/PI3K and EZH2/NSD2/mTORC2 pathways, respectively. Moreover, there was a positive mutual activation between STAT3 and JAK2, further enhanced by NCAPD3 to promote PCa progression. …”
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Clinical Factors Influencing Phenotype of HCMV-Specific CD8+ T Cells and HCMV-Induced Interferon-Gamma Production after Allogeneic Stem Cells Transplantation by Inmaculada Gayoso, Sara Cantisán, Carolina Cerrato, Joaquín Sánchez-García, Carmen Martin, Rafael Solana, Antonio Torres-Gomez, Julian Torre-Cisneros

“…In addition, a detectable IFN-γ production in response to HCMV peptides (cutoff 0.2 IU/mL IFN-γ; “reactive” QuantiFERON-HCMV test) was statistically associated with HCMV replication after transplantation (OR=11; P=0.026), recipients ≥40 versus <40 years old (OR=11; P=0.026), and the use of peripheral blood versus bone marrow as stem cell source (OR=17.5; P=0.024). …”
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Características de pacientes con tumor germinal testicular tipo seminoma y masa retroperitoneal posquimioterapia by María A. Ocampo-Gómez, María C. Moreno-Matson, David Ruiz, Marino Cabrera, Rodolfo Varela

“…Objetivo: Describir las caracter&iacute;sticas cl&iacute;nicas y patol&oacute;gicas de los pacientes con tumor germinal testicular tipo seminoma con masa residual posquimioterapia (post-QT) con marcadores tumorales negativos llevados a linfadenectom&iacute;a retroperitoneal (LRP). M&eacute;todo: Se incluyeron pacientes con TGTS y masa residual post-QT entre el a&ntilde;o 2007-2021 en nuestra instituci&oacute;n. …”
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Advances in Hemodynamic Analysis in Cardiovascular Diseases Investigation of Energetic Characteristics of Adult and Pediatric Sputnik Left Ventricular Assist Devices during Mock Ci... by Alexander A. Pugovkin, Aleksandr G. Markov, Sergey V. Selishchev, Leonie Korn, Marian Walter, Steffen Leonhardt, Leo A. Bockeria, Olga L. Bockeria, Dmitry V. Telyshev

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Improving prognostic evaluations in patients with stage IIIb light chain cardiac amyloidosis: role of haemodynamic parameters by Jingyi Li, Yang Lu, Xiqi Xu, Zhuang Tian, Jian Li, Shuyang Zhang

“…Patients with a PAWP/CI ratio above 11 mmHg/L/min/m2 had markedly poorer survival. Kaplan‒Meier analysis highlighted the prognostic significance of the ratio, revealing distinct survival differences. …”
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Construction and Characterization of Adenovirus Vectors Encoding Aspartate-β-Hydroxylase to Preliminary Application in Immunotherapy of Hepatocellular Carcinoma by Yujiao Zhou, Feifei Liu, Chengmin Li, Guo Shi, Xiaolei Xu, Xue Luo, Yuanling Zhang, Jingjie Fu, Aizhong Zeng, Limin Chen

“…Firstly, the total AAH mRNA was extracted from human HCC tissues; the cDNA was amplified by RT-PCR, verified, and sequenced after TA cloning. …”
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Comparison of enrichment methods for efficient nitrogen fixation on a biocathode by Rous, Axel, Santa-Catalina, Gaëlle, Desmond-Le Quémener, Elie, Trably, Eric, Bernet, Nicolas

“…Current densities up to -15 A/m² were observed in the polarized cathode enrichments and a significant increase of the microbial biomass on the cathode was shown between 132 and 214 days of enrichment.These results confirmed an enrichment in autotrophic and diazotrophic bacteria on the polarized cathode. …”
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