Identification of natural phytochemicals as AKT2 inhibitors using molecular docking and dynamics simulations as potential cancer therapeutics by Jibon Kumar Paul, Mahir Azmal, Md Naimul Haque Shohan, Mohua Mrinmoy, ANM Shah Newaz Been Haque, Omar Faruk Talukder, Ajit Ghosh

“…The PI3K/AKT/mTOR pathway is central in regulating key cellular processes such as proliferation, survival, metabolism, and angiogenesis. …”
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The impact of exercise intensity and duration for swim training‐induced adaptations in cardiac structure and function in women with mild hypertension by Tórur Sjúrðarson, Nikolai B. Nordsborg, Jacobina Kristiansen, Lars Juel Andersen, Peter Krustrup, Kasper Kyhl, Magni Mohr

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Halofuginone prevents inflammation and proliferation of high-altitude pulmonary hypertension by inhibiting the TGF-β1/Smad signaling pathway by Jiangtao Wang, Lina Guan, Jian Yu, Bohua Ma, Huihua Shen, Guozhu Xing, Yawei Xu, Qiufang Li, Juan Liu, Qin Xu, Wenhui Shi, Jia He, Yixuan Huang, Dongfeng Yin, Wu Li, Rui Wang

“…In the present study, we evaluated the efficacy of HF on HAPH by establishing a 6000 m HAPH rat model. Male Sprague–Dawley rats were divided into normoxia, normoxia + halofuginone (1 mg/kg), hypoxia, and hypoxia + halofuginone (1 mg/kg) groups. …”
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Enhancing water solubility of phytosterols through Co-amorphization with food-grade coformers by Yuxin Li, Yingting Luo, Xuening Song, Yuzhuo Wang, Simiao Liu, Fazheng Ren, Lingyan Kong, Hao Zhang

“…A 20:1 (w/w) PS-Nic co-amorphous (CM) mixture, prepared via freeze-drying, achieved a solubility of 1536.4 μg/mL, significantly higher than pure PS. X-ray diffraction and differential scanning calorimetry confirmed the amorphous state of the mixture. …”
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Cerebral Reorganization in Subacute Stroke Survivors after Virtual Reality-Based Training: A Preliminary Study by Xiang Xiao, Qiang Lin, Wai-Leung Lo, Yu-Rong Mao, Xin-chong Shi, Ryan S. Cates, Shu-Feng Zhou, Dong-Feng Huang, Le Li

“…The change in voxel counts in the primary sensorimotor cortex of the lesioned hemisphere is significantly correlated with improvement of 10 m walk time after VRET (r=−0.719). Conclusions. …”
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Identifying households with children who have complex needs: a segmentation model for integrated care systems by Roberta Piroddi, Andrea Astbury, Wesam Baker, Kostantinos Daras, Joe Rafferty, Iain Buchan, Benjamin Barr

“…Method Working with stakeholders—in an English region of 2.7m population- we agreed a definition of families having complex needs which would benefit from service integration – including households with high intensity use, who had both physical and mental health problems amongst both adults and children and wider social risks. …”
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Effect of cardanol on the physical and chemical properties of sodium caseinate-coated papers for packaging applications by Jihyeon Hwang, Yeon-Ji Jo, Dowan Kim

“…Consequently, with increasing CL content, the hydrophobicity of the CasNa/CL-coated papers is enhanced with a reduction in the water-vapor transmittance rate from 461.3 ± 2.0 to 389.8 ± 3.9 g/m2·day and an increase in the water contact angle from 56.6 ± 2.4° to 72.9 ± 1.1°. …”
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A comparative study of analgesic effect between ultrasound-guided posterior vis-a-vis lateral transversus abdominis plane block in patients undergoing total abdominal hysterectomy... by Rajib Sikder, Sankar Roy, Arunava Biswas, Dipasri Bhattacharya

“…Ultrasound-guided lateral TAP block and posterior TAP block were administered bilaterally with 20 mL 0.25% bupivacaine in the L group and P group, respectively, on each side of the abdomen after skin closure at the end of the operation. …”
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Uncovering mercury accumulation and the potential for bacterial bioremediation in response to contamination in the Singalila National Park by Sukanya Acharyya, Soumya Majumder, Sudeshna Nandi, Arindam Ghosh, Sumedha Saha, Malay Bhattacharya

“…Particular focus was on Sandakphu (3636 m), the highest peak in West Bengal, India. It harboured 6.77 ± 0.01 mg/kg of total mercury in its topsoil. …”
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Efficacy and Safety of Sofosbuvir-Based Direct-Acting Antiviral Agents Treatment for Patients with Genotype 3/6 Hepatitis C Virus Infection by Yong-yu Mei, You-ming Chen, Yuan-kai Wu, Xiao-hong Zhang, Wen-xiong Xu

“…Baseline HCV RNA was 6.29 ± 0.89log10 IU/mL. The numbers of GT 3a, 3b, and 6a patients were 10, 12, and 32, respectively. …”
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Antibacterial and Mosquito Repellent Potential of Eight Citrus Cultivars and Their Chemical Composition by Mehwish Nawaz, Bait Ullah, Muhammad Ghazanfar Abbas, Muhammad Binyameen, Violeta Apšegaitė, Raimondas Mozūraitis, Muhammad Azeem

“…<i>C. limon</i> peel EO exhibited the highest antibacterial activity among all citrus peel EOs with the minimum inhibitory concentration of 312 μg/mL against <i>Staphylococcus aureus</i>. The <i>C. aurantium</i> and <i>C. sinensis</i> var. …”
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Adaptation variation of easiness on environmental, social, and governance components in the selected sustainability developments by F.R. Sutikno, N.A. Sasongko, I.N. Djarot, H.S. Dillon

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Effects of Elemental Mercury Vapor Inhalation on Arterial Blood Gases, Lung Histology, and Interleukin-1 Expression in Pulmonary Tissues of Rats by Liqaa A. Raffee, Khaled Z. Alawneh, Ruba A. Alassaf, Abdallah Alzoubi, Musa A. Alshehabat, Nadeem Alabdallah, Abdel-Hameed Al-Mistarehi

“…A short-term group (STG) and a long-term group (LTG) were exposed to 500 μg/m3 of mercury vapor 2 hrs/day for 21 days and 65 days, respectively. …”
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A Synoptic- and Remote Sensing-based Analysis of a Severe Dust Storm Event over Central Asia by Parya Broomandi, Kaveh Mohammadpour, Dimitris G. Kaskaoutis, Aram Fathian, Sabur F. Abdullaev, Vladimir A. Maslov, Amirhossein Nikfal, Ali Jahanbakhshi, Bakhyt Aubakirova, Jong Ryeol Kim, Alfrendo Satyanaga, Alireza Rashki, Nick Middleton

“…The extremely high PM concentrations (PM10 > 10,000 µg m−3 in Tashkent) could endanger both human health and the environment, especially in a region suffering from high susceptibility to wind erosion and significant land degradation and desertification. …”
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The effects of Bifidobacterium animalis QC08 on reducing uric acid level and providing renal protection in mice with hyperuricemia by Huijia Mao, Yang Fan, Fang Tan, Xingyao Long

“…Additionally, Bifidobacterium animalis QC08 was found to regulate the mRNA transcription of renal uric acid transporters, leading to significantly upregulation of the expression levels of UAT, ABCG2, and OAT1 genes (p &lt; 0.05).ConclusionBifidobacterium animalis QC08 demonstrates certain uric acid-lowering, anti-inflammatory, and renal protective effects, which are associated with the inhibition of XOD activity and the modulation of the expression levels of uric acid transporter genes (UAT, ABCG2, and OAT1).…”
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TCAD Simulation Study of Cylindrical Vertical Double-Surrounding-Gate a-InGaZnO FETs and Geometric Parameter Optimization by Yue Zhao, Lihua Xu, Chuanke Chen, Xufan Li, Kexin Shang, Di Geng, Lingfei Wang, Ling Li

“…These results will boost a design technology co-optimization flow of the future DSG-a-IGZO-FET-based extremely large-scale and high-density M3D memory.…”
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Application of the hypoplastic model for validating direct shear tests to investigate the impact of fines on the behavior of chlef sand by Benali Nougar, Abdelkader Brahimi, Djamel Edddine Bouri, Abdallah Krim, Omar Safer, Kamel Menad, Ahmed Arab

“…The soils used for the preparation of the samples were the Chlef sand, Chlef silt and M’zilla clay and a mixture composed of 50% of silt and 50% of clay. …”
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Structure and immunomodulatory activity of Lentinus edodes polysaccharides modified by probiotic fermentation by Jingjing Liang, Meina Zhang, Xiaohan Li, Yuan Yue, Xiaowei Wang, Mengzhen Han, Tianli Yue, Zhouli Wang, Zhenpeng Gao

“…NF-LEP and F-LEP improved immune organ indices, immunoglobulin (IgG and IgM) and cytokines concentrations; restored the antioxidation capacity of liver; and maintained the balance of gut microbiota. …”
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Environmental sustainability profiles assessment of HPLC stability indicating method for quantitation of piracetam and vincamine in pharmaceutical medications by Samya Sh. Alenezi, Ayman A. Gouda, Ragaa El Sheikh, Niaf A. Badahdah, Muneer E Alzuhiri, Ali H. Magrabi, Asim L. Jilani, Ahmed S. Darwish

“…The mobile phase consists of 0.05 M potassium dihydrogen phosphate buffer pH 3.5:ethanol absolute (60:40, by volume), at a flow rate of 1.0 ml/min. …”
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Pre-sowing treatment of vetch hairy seeds, viсia villosa using ultraviolet irradiation by A. Semenov, T. Sakhno, O. Hordieieva, Y. Sakhno

“…The most effective dose of ultraviolet irradiation applied to vetch hairy seeds; vicia villosa was 1000 J/m2. At this dose the seed vigour increases by 23.6%, germination by 15.1%, the mass of germinated seeds by 17.3%, the content of a- and b-chlorophyll by 12.4%, and 17.5%, respectively, the carotenoid content increased by 13.9%. …”
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