Mitochondrial Dysfunction: A Basic Mechanism in Inflammation-Related Non-Communicable Diseases and Therapeutic Opportunities by Anna Hernández-Aguilera, Anna Rull, Esther Rodríguez-Gallego, Marta Riera-Borrull, Fedra Luciano-Mateo, Jordi Camps, Javier A. Menéndez, Jorge Joven

“…Regulating mitochondrial function may require a multifaceted approach that includes drugs and plant-derived phenolic compounds with antioxidant and anti-inflammatory activities that improve mitochondrial biogenesis and act to modulate the AMPK/mTOR pathway.…”
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Annual Variation of PM2.5 Chemical Composition in Ho Chi Minh City, Vietnam Including the COVID-19 Outbreak Period by Ngoc Tran, Yusuke Fujii, Vinh Xuan Le, Nguyen Doan Thien Chi, Hiroshi Okochi, To Thi Hien, Norimichi Takenaka

“…The PM2.5 mass concentration during the sampling period was 28.44 ± 11.55 µg m−3 (average ± standard deviation). OC, EC, and total WSIs accounted for 30.7 ± 6.6%, 9.7 ± 2.9%, and 24.9 ± 6.6% of the PM2.5 mass, respectively. …”
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MMP9-Associated Tumor Stem Cells, CCL1-Silenced Dendritic Cells, and Cytokine-Induced Killer Cells Have a Remarkable Therapeutic Efficacy for Acute Myeloid Leukemia by Activating T... by Min Dong, Guozhen Zhang, Jie Meng, Biou Liu, Duanfeng Jiang, Feng Liu

“…Large differentially expressed mRNAs were verified by RT-qPCR assay, and MMP9 and CCL1 were selected for subsequent studies in vivo and in vitro experiments. …”
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Comparing Clinical Outcomes of Five-Strand Hamstring Tendon Autograft and Quadrupled Hamstring Tendon Autograft for Single Bundle Anterior Cruciate Ligament Reconstruction in Filip... by Albert Ian Villegas, Emmanuel Roy Mata, Jose Antonio San Juan, John Rey Go, Vick Roland Ladica

“…Result: The study included 18 patients, showing no significant differences in demographic characteristics such as age (24.78 vs. 27.67 years, p = 0.202), height (1.71 vs. 1.64 meters, p = 0.146), weight (84.43 vs. 74.98 kg, p = 0.252) or body mass index (28.95 vs. 27.98 kg/m², p = 0.714); average return to sports (10.63 vs. 11.83 months, p = 0.642). …”
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Pioglitazone Attenuates Drug-Eluting Stent-Induced Proinflammatory State in Patients by Blocking Ubiquitination of PPAR by Zhongxia Wang, Tao Zhang, Lizhe Sun, Ruifeng Li, Yuanyuan Wei, Xiaojuan Fan, Zuyi Yuan, Junhui Liu, Tao Chen

“…After 12 weeks of treatment, plasma concentrations of high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and matrix metalloproteinase-9 (MMP-9) were significantly decreased in PIO group compared to the Con group (P=0.035, 0.011, 0.008, and 0.012, resp.). DES-induced mRNA expressions of IL-6, TNF-α, and MMP-9 in circulating MNC were significantly blocked by PIO (P=0.031, 0.012, and 0.007, resp.). …”
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Recovery of Phenolic Compounds with Antioxidant Capacity Through Solid-State Fermentation of Pistachio Green Hull by Andrés Javier Ordoñez-Cano, Ulises Ramírez-Esparza, Fernando Méndez-González, Mónica Alvarado-González, Ramiro Baeza-Jiménez, Leonardo Sepúlveda-Torre, Lilia Arely Prado-Barragán, José Juan Buenrostro-Figueroa

“…The highest values for both TPC and AC were achieved in treatment 8 (60% moisture, 5 × 10⁶ spores/mL, and 1 L/Kgwm min), resulting in a 129% and 1039% increase, respectively. …”
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Land cover change mitigated 20 % of the total increased evapotranspiration in tropical Lancang-Mekong River Basin during 2001–2019 by Houbing Chen, Yaoliang Chen, Lamin R. Mansaray, Longwei Li, Shusen Wang

“…LCCs caused a net reduction of 7.44 billion m³ in ET water consumption. This decrease in ET, may intensify the surface runoff and raise the risk of extreme floods in the rain season. …”
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Muramyl Dipeptide Enhances Lipopolysaccharide-Induced Osteoclast Formation and Bone Resorption through Increased RANKL Expression in Stromal Cells by Masahiko Ishida, Hideki Kitaura, Keisuke Kimura, Haruki Sugisawa, Tomo Aonuma, Haruhiko Takada, Teruko Takano-Yamamoto

“…The number of osteoclasts, the level of mRNA for cathepsin K and tartrate-resistant acid phosphatase (TRAP), the ratio of the bone destruction area, the level of tartrate-resistant acid phosphatase form 5b (TRACP 5b), and C-terminal telopeptides fragments of type I collagen as a marker of bone resorption in mice administrated both LPS and MDP were higher than those in mice administrated LPS or MDP alone. …”
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Association of Glioblastoma Multiforme Stem Cell Characteristics, Differentiation, and Microglia Marker Genes with Patient Survival by Sandra Bien-Möller, Ellen Balz, Susann Herzog, Laura Plantera, Silke Vogelgesang, Kerstin Weitmann, Carolin Seifert, Matthias A. Fink, Sascha Marx, Angela Bialke, Chitra Venugopal, Sheila K. Singh, Wolfgang Hoffmann, Bernhard H. Rauch, Henry W. S. Schroeder

“…Furthermore, the role of these proteins for patient survival and their expression in LN18 stem-like neurospheres was analyzed. At mRNA level, ABCG2 and CD95 were reduced, GFAP was unchanged; all other investigated markers were increased in GBM. …”
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REPEATED THERAPEUTIC LEUKAPHERESIS - A SOLE TREATMENT DURING PREGNANCY AS A BRIDGE BEFORE TYROSINE KINASE INHIBITORS FOR A PREGNANT WOMAN WITH CHRONIC MYELOGENOUS LEUKEMIA – A CASE... by Ivan Tonev, Chavdar Botev, Georgui Balatzenko, Milcho Mincheff

“…Results:The patient's WBC count was kept between 170 and 270 x 109/L until childbirth, and immediately after delivery, imatinib mesylate therapy was initiated.A healthy male child with a weight of 2250 kg and height of 46 сm was born. The mother achieved hematologic, cytogenetic and molecular remission within the next 6-9 months after initiation of tyrosine kinase inhibitor therapy. …”
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Cloning, expression, and purification of fusion antigens MPT83 and ESAT6 from the local strain of Mycobacterium tuberculosis in Escherichia coli as a seed vaccine candidate against... by Rusdina Bte Ladju, Ahyar Ahmad, Abdul Karim, Rugaiyah Arfah, Rosana Agus, Najdah Hidayah, Muhammad Nasrum Massi, Astutiati Nurhasanah, Harningsih Karim, Irda Handayani

“…Eradicating tuberculosis (TB) globally is increasingly challenging with the growing number of drug-resistant Mycobacterium tuberculosis (M. tuberculosis) strains. The development of more potent TB vaccines is critical to complement overall TB control strategies and overcome the growing challenge of drug resistance. …”
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aPD-L1-facilitated theranostic and tumor microenvironment remodeling of pancreatic cancer via docetaxel-loaded phase-transformation nanoparticles triggered by low-intensity pulsed... by Yi Tang, Qingling Shen, Peng Lin, Zhixin Chen, Denghui Fan, Minling Zhuo, Yajiao Gan, Yixi Su, Qingfu Qian, Liwu Lin, Ensheng Xue, Zhikui Chen

“…This treatment strategy also led to the infiltration of CD8+ T cells, the downregulation of Treg cells, the promotion of M1 macrophage polarization, the inhibition of fibrosis to reduce tumor stromal pressure, and the facilitation of perfluoropentane (PFP) gasification to release O2 and improve tumor hypoxia. …”
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The Effects of Vitamin D on Gentamicin-Induced Acute Kidney Injury in Experimental Rat Model by Ender Hur, Alev Garip, Asuman Camyar, Sibel Ilgun, Melih Ozisik, Sena Tuna, Murat Olukman, Zehra Narli Ozdemir, Eser Yildirim Sozmen, Sait Sen, Fehmi Akcicek, Soner Duman

“…Thirty nonuremic Wistar albino rats were divided into 3 groups: Control group, 1 mL saline intramuscular (im) daily; Genta group, gentamicin 100 mg/kg/day (im); Genta + vitamin D, gentamicin 100 mg/kg/day (im) in addition to 1α, 25 (OH)2D3 0.4 mcg/kg/day subcutaneously for 8 days. …”
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Vitamin D Deficiency in Patients with Type 2 Diabetes Mellitus with and without Pulmonary Tuberculosis by Wahiduddin Wahiduddin, Agung Pranoto, Sudjarwo Sudjarwo

“…Vitamin D deficiency was not associated with the incidence of pulmonary TB in T2DM, whereas female sex, age> 50 years, BMI ? 25.0 kg /m2, and duration of T2DM> 5 years were associated with vitamin D deficiency (p <0.05). …”
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To Investigate the Associations of Dyslipidemia and BMI, as Risk Factors Leading to Insulin Resistance and Development of Type2 Diabetes Mellitus in Baqubah City by Safa Nadhum Mohammed, Walaa Esmael Jassim, Najah Ali Mohammed

“…While means of age and BMI (kg/m²) of cases were (54.27±13.35, 32.20±2.23) versus the mean for the control group (47.12±10.77, 26.04±1.65) respectively. …”
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Creation and study of emmer (<i>Triticum dicoccum</i>) × triticale hybrids by O. G. Silkova, Y. N. Ivanova, P. I. Stepochkin

“…The hybrid DT6 and the breeding form DT 6/186 obtained from it had high grain productivity (785 ± 41 and 822 ± 74 g/m2, respectively), but, like the paternal form of triticale UK 30/33, had a reduced nature of the grain. …”
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Concurrent Renorrhaphy During Renal Mass Excision in Laparoscopic Nephron-Sparing Surgery: A Novel Surgical Technique by Nurullah Hamidi, Tuncel Uzel

“…The bleeding amount was 150 mL. The pathologic report confirmed a 2.5 × 2 × 2 cm clear cell renal cell carcinoma. …”
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Monitoring of prostate-specific antigen in men with benign prostate enlargement receiving 5-alpha reductase inhibitors: a non-interventional, cross-sectional study of real-world pr... by Juan Manuel Palacios, Pratiksha Kapse, Vanessa Cortes, Marcio Augusto Averbeck, Alberto Budia Alba, Suryakant Somvanshi, Danilo Souza Lima da Costa Cruz, Fiona Pereira

“…The most selected trigger for prostate biopsy was “if doubled (adjusted) prostate-specific antigen level after 6 months of treatment is > 4 ng/mL” (Spain 39%, Brazil 37%). Many urologists were moderately/very concerned about the effect on prostate-specific antigen when switching 5-alpha reductase inhibitor formulation. …”
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The Use of Machine Learning to Create a Risk Score to Predict Survival in Patients with Hepatocellular Carcinoma: A TCGA Cohort Analysis by Samer Tohme, Hamza O Yazdani, Amaan Rahman, Sanah Handu, Sidrah Khan, Tanner Wilson, David A Geller, Richard L Simmons, Michele Molinari, Christof Kaltenmeier

“…Long-term outcomes of patients with HCC can be predicted using a simplified scoring system based on tumor mRNA gene expression levels. This tool could assist clinicians and researchers in identifying patients at increased risks for recurrence to tailor specific treatment and follow-up strategies for individual patients.…”
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Double-blind, randomized, placebo-controlled pilot clinical trial with gamma-band transcranial alternating current stimulation for the treatment of schizophrenia refractory auditor... by Xiaojuan Wang, Xiaochen Zhang, Yuan Chang, Jingmeng Liao, Shuang Liu, Dong Ming

“…In this work, we applied a frontal-temporal-parietal 40 Hz-tACS stimulation strategy for treating auditory hallucinations and further explored the effect of tACS on functional connectivity of brain networks. 32 schizophrenia patients with refractory auditory hallucinations received 20daily 20-min, 40 Hz, 1 mA sessions of active or sham tACS on weekdays for 4 consecutive weeks, followed by a 2-week follow-up period without stimulation. …”
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