Capivasertib enhances chimeric antigen receptor T cell activity in preclinical models of B cell lymphoma by Hui-Ju Hsieh, Ryan Urak, Mary C. Clark, Larry W. Kwak, Stephen J. Forman, Xiuli Wang

“…We found that ex vivo 0.25 μM capivasertib treatment during the period of T cell stimulation during manufacture enhanced the antitumor activity of CAR T cells in B cell lymphoma mouse models. …”
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Assessment of the Efficiency of Thermal Waste Regeneration in the Blown Impassable Channels of Heating Mains by V. A. Sednin, T. V. Bubyr

“…The following conditions in this case were accepted: the air flow rate is not higher than 8 m/s, the length of the heat pipeline section ensures the air temperature at the outlet of the channel at which there is no increase in heat losses from mains water pipelines to the ground under normal operating conditions of heating networks. …”
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Cell-Specific Regulation of Inflammatory Cytokines and Acute-Phase Proteins by the Glucocorticoid Receptor by Rebecca Winkler, Hong Lu

“…Primary human hepatocytes (PHH) were treated with combinations of tumor necrosis factor alpha (TNFα), lipopolysaccharide (LPS), and dexamethasone (DEX) for 24 h, following which chemokine mRNA and protein expression were analyzed using qPCR and enzyme-linked immunosorbent assay assays. …”
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Effects of Algal-Derived β-Glucan on the Growth Performance, Intestinal Health, and Aeromonas veronii Resistance of Ricefield Eel (Monopterus albus) by Yu Guo, Zijing Yuan, Yueyun Han, Daiqin Yang, Hanwen Yuan, Fuxian Zhang

“…In this study, we conducted an 8-week feeding trial to investigate the effects of β-glucan on the growth performance, intestinal health, and Aeromonas veronii resistance of Monopterus albus (M. albus). Three hundred healthy fish (initial body weight: 12.38 ± 0.50 g) were randomly divided into five groups: A1 (basal diet) was considered the control group, whereas A2, A3, A4, and A5 were the experimental groups. …”
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Polydatin-Induced Shift of Redox Balance and Its Anti-Cancer Impact on Human Osteosarcoma Cells by Alessio Cimmino, Magda Gioia, Maria Elisabetta Clementi, Isabella Faraoni, Stefano Marini, Chiara Ciaccio

“…Using cell-based biochemical assays, we found that cytotoxic doses of PD (100–200 µM) promote ROS production, deplete glutathione (GSH), and elevate levels of both total iron and intracellular malondialdehyde (MDA), which are key markers of ferroptosis. …”
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Hypoxia inducible factor-dependent upregulation of Agrp in glomus type I cells of the carotid body by Luis Leon-Mercado, Ivan Menendez-Montes, Jonathan Tao, Bandy Chen, David P. Olson, C. Mackaaij, C.G.J. Cleypool, Laurent Gautron

“…In this study, utilizing histological and molecular biology techniques, we have identified a significant expression of Agrp mRNA and AgRP peptide production in glomus type I cells within the mouse carotid body (CB). …”
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Gamma-Tocotrienol Stimulates the Proliferation, Differentiation, and Mineralization in Osteoblastic MC3T3-E1 Cells by Weili Xu, Pan He, Shenghua He, Pengju Cui, Yaqing Mi, Yang Yang, Yang Li, Shaobo Zhou

“…Our results showed that γ-tocotrienol (2–8 μmol/L) significantly improved the cell proliferation (p<0.05), but it did not affect cell cycle progression. γ-Tocotrienol significantly increased alkaline phosphatase (ALP) activity (p<0.05), secretion levels of osteocalcin (OC) and osteonectin (ON), and mRNA levels of collagen type I (Col I) of MC3T3-E1 cells. …”
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Accelerated Storage Testing of Vacuum-Dried <i>Lactobacillus acidophilus TISTR 1338</i> for Feed by Apichet Muenaram, Bhundit Innawong, Imrana Niaz Sultan, Muhammad Waseem Khan, Hamza Ghilzai, Afrasiab Khan Tareen, Pramuk Parakulsuksatid

“…With wasted cells at 0.5%, molasses concentration at 11% at 2.14 109 CFU/mL at 22 h, precise growth rate at 0.39 h⁻¹, and yield cell mass at 1.67 1011 CFU/g sugar, yeast produced the maximum cell mass. …”
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Prevalence and predictors of NTM in presumed/confirmed drug-resistant TB by E.T. Abbew, R. Laryea, F. Sorvor, Y.A. Poku, N. Lorent, D. Obiri-Yeboah, L. Lynen, L. Rigouts

“…Of these, 53 (23.6%) were identified at the species level, with a predominance of M. intracellulare (66.0%). MPT64 testing missed 18 (3%) MTBc isolates. …”
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Combination of inflammatory proteins in serum can be used to diagnose papillary thyroid carcinoma with lymph node metastasis by Yongqin Pan, Guanghao Wang, Delin Chen, Zhihui Wu, Yimwing Kei, Mingxi Xu

“…Further analysis revealed that IL12B and IL1A mRNAs were significantly overexpressed in patients with PTC-LNM. …”
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TNRC6C Functions as a Tumor Suppressor and Is Frequently Downregulated in Papillary Thyroid Cancer by Zhenqin Cai, Tianyu Zhai, Dilidaer Muhanhali, Yan Ling

“…In this study, we aimed to confirm the effect of TNRC6C on PTC and investigate the underlying molecular mechanism. The difference of mRNA level of TNRC6C between PTC tissue and noncancerous thyroid tissue and the association of expression level of TNRC6C with clinicopathological features of PTC were analyzed using TCGA data. …”
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Finding Ways to Lift Barriers to Care for Chronic Pain Patients: Outcomes of Using Internet-Based Self-Management Activities to Reduce Pain and Improve Quality of Life by Kevin Rod

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Development of a Sensitive Chemiluminescence Immunoassay for the Quantification of Folic Acid in Human Serum by Xiang Chen, Qiyang Zhou, Ting Zhang, ChunXin Wang, Zheng Yu, Hadji Ahamada, Zhonghu Bai, Xuan Huang

“…The limitation of detection (LOD) is 0.44 ng/mL. The intra-assay coefficient of variation (CV) is 3.6%–7.1%, the interassay CV is 4.2%–7.5%, and the recovery rate is 92.1%–103.5%. …”
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Algae extract-based nanoemulsions for photoprotection against UVB radiation: an electrical impedance spectroscopy study by Aura Rocío Hernández, Lady Sepulveda, Yoshie Hata, Leonardo Castellanos, Sebastian Björklund, Tautgirdas Ruzgas, Marcela Aragón

“…The nanoemulsions had an average droplet size of 128.5 ± 8.6 nm, a PDI of 0.25 ± 0.06, and a zeta potential of 45.14 ± 0.02 mV. Compared to the control group, the photoprotective capacity of the oil-in-water nanoemulsions was statistically significant. …”
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Multi-omics analysis in inclusion body myositis identifies mir-16 responsible for HLA overexpression by Daphne Wijnbergen, Mridul Johari, Ozan Ozisik, Peter A.C. ‘t Hoen, Friederike Ehrhart, Anaïs Baudot, Chris T. Evelo, Bjarne Udd, Marco Roos, Eleni Mina

“…These subnetworks are related to antigen processing and presentation, chemokine-mediated signaling, immune response-signal transduction, rRNA processing, and mRNA splicing. An interesting finding is that the antigen processing and presentation subnetwork links the underexpressed miR-16-5p to overexpressed HLA genes by negative expression correlation. …”
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Integration of planetary health in undergraduate and postgraduate medical education: protocol for a scoping review by Lindsey Sikora, Daniel I McIsaac, Husein Moloo, Rajajee Selvam, Nieve Seguin, Lisa Zhang, Ariane Lacaille-Ranger

“…We plan to disseminate our results via publication in a peer-reviewed journal or conference presentation.Trial registration number This protocol has been registered in Open Science Framework (10.17605/OSF.IO/7M6GZ).…”
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Six-year performance of risk-based selection for lung cancer screening in the Manchester Lung Health Check cohort by Matthew Sperrin, Haval Balata, Richard Booton, Hilary A Robbins, Philip A J Crosbie, Patrick Goodley

“…Here we report the performance of the PLCOm2012 risk model, which calculates 6 year lung cancer risk, in a cohort invited for lung cancer screening in a socioeconomically deprived area.Methods and analysis Calibration (expected/observed (E/O) lung cancer diagnoses over 6 years) and discrimination (area under the receiver operating characteristic curve) of PLCOm2012 and other models was performed in Manchester Lung Health Check (M-LHC) participants, where PLCOm2012 ≥1.51% was used prospectively to determine screening eligibility. …”
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Electrochemical properties of hydroxyapatite immobilization material for potential cytosensor fabrication by Dennis Adusei, Bernard O. Asimeng, Francis D. Krampa, Elvis K. Tiburu

“…Also, the EIS showed impedance values of 0.70 for HEK 293T, 0.62 for PC 12, and 0.52 mΩ for RBC. The findings indicate that SHAp/PEDOT: PSS enables the differentiation of cell proliferation signals through voltammetric and impedimetric measurements. …”
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Long noncoding RNA GDIL acts as a scaffold for CHAC1 and XRN2 to promote platinum resistance of colorectal cancer through inhibition of glutathione degradation by Xuan Deng, Lu Chang, Lingyu Tang, Haoqin Jiang, Xiao Xu, Xinju Zhang, Jian Chen, Liu Dong, Qianqian Xu, Ruoshui Cao, Jianbin Xiang, Ming Guan

“…Mechanistically, GDIL binds and re-localizes the nuclear protein XRN2 to the cytoplasm, where GDIL further serve as a scaffold for XRN2 to identify and degrade CHAC1 mRNA. Suppression of GDIL with selective antisense oligonucleotide, restored drug sensitivity in platinum resistant cell lines and delayed drug resistance in cell line- and patient-derived xenografts. …”
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Cardiac Migration of Endogenous Mesenchymal Stromal Cells in Patients with Inflammatory Cardiomyopathy by Caroline Schmidt-Lucke, Felicitas Escher, Sophie Van Linthout, Uwe Kühl, Kapka Miteva, Jochen Ringe, Thomas Zobel, Heinz-Peter Schultheiss, Carsten Tschöpe

“…The presence of MSC in EMB, cardiac inflammation, and SDF-1α mRNA expression were detected via immunohistochemistry and real-time PCR. …”
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