AdipoR1 enhances the radiation resistance via ESR1/CCNB1IP1/cyclin B1 pathway in hepatocellular carcinoma cells by Yuhan Gan, Linhui Zhu, Yimo Li, Ruoting Ge, Jiahe Tian, Yuxin Chen, Xiang He, Shumei Ma, Xiaodong Liu

“…KEGG enrichment analysis indicated that the cell cycle and ubiquitination degradation pathways may be involved in the regulation of radiation resistance by AdipoR1.The knockdown of AdipoR1 can attenuate the radiation-induced G2/M phase arrest through cyclin B1.By the ubiquitination IP assay and a rescue experiment, we confirmed that CCNB1IP1 regulated the ubiquitination and degradation of cyclin B1. …”
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Association of environmental, demographic and clinical parameters with physical activity in children with asthma by Jane Berrill, Peter James, Antonis Michanikou, Emmanouil Galanakis, Eleni Michaelidou, Paraskevi Kinni, Nikos Kalivitis, Giorgos Kouvarakis, Emily Vasiliadou, Chrysanthos Savvides, Filippos Tymvios, Petros Koutrakis, Panayiotis K. Yiallouros, Panayiotis Kouis

“…For a follow-up period of 4 months, 186 children with asthma demonstrated a decrease of 796 steps (95% CI: -1080, -512) on days with precipitation compared to non-precipitation days and a decrease of 96 steps (95% CI: -182, -9) for every 10 µg/m3 increase in PM10. The relationship between temperature and daily steps was characterized by an inverted U-shape. …”
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PMA Induces Vaccine Adjuvant Activity by the Modulation of TLR Signaling Pathway by Dool-Ri Oh, Hu Won Kang, Jong-Ro Kim, Sunoh Kim, In-Kyu Park, Joon Haeng Rhee, Won Keun Oh, Young Ran Kim

“…Phorbol 12-myristate 13-acetate (PMA) was isolated as an active component of Croton tiglium by activity-guided fractionation, column chromatography, HPLC, NMR, and MS. PMA at a range of nM induced PKC-dependent NF-κB activation and IL-8 production in both TLR5− and TLR5+ assay systems. …”
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Effect of ultrasonic modification on the protective activity of Flammulina velutipes polysaccharide to prevent ethanol-induced injury on GES-1 cells by Jinrong Xiao, Xin Chen, Jingsi Zhang, Yifan Wang, Lei Zhong, Qiping Zhan, Qiuhui Hu, Liyan Zhao

“…With increasing ultrasound intensity, the protective effect of FVPs on GES-1 cells was significantly enhanced by more effective prevention of intracellular reactive oxygen species (ROS) production and more promotion of expression of triglyceride factor 2 (TFF2), prostaglandin E2 (PGE2), epidermal growth factor (EGF), and transforming growth factor β1 (TGF-β1) mRNA. The ultrasonic modification might be an effective way to develop novel F. velutipes polysaccharides that could effectively resist the gastric injury caused by excessive alcohol consumption.…”
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Benzo[1,2-b:6,5-b’]dithiophene-4,5-diamine: A New Fluorescent Probe for the High-Sensitivity and Real-Time Visual Monitoring of Phosgene by Yingzhen Zhang, Jun Xiao, Ruiying Peng, Xueliang Feng, Haimei Mao, Kunming Liu, Zhenzhong Liu, Chunxin Ma

“…Among existing detecting methods, this fluorescent system stands out as it can respond to phosgene within a mere 30 s and has a detection limit as low as 0.16 μM in solution. Furthermore, the sensing mechanism was rigorously validated through high-resolution mass spectrometry (HRMS) and density functional theory (DFT) calculations. …”
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Antibiotic Resistance Profile of Indigenous Streptococcus thermophilus and Lactobacillus bulgaricus Strains Isolated from Traditional Yogurt by Bahareh Moghimi, Maryam Ghobadi Dana, Reza Shapouri, Maryam Jalili

“…Lactobacillus bulgaricus isolates did not harbor tetM, cat1, rpoB, vanA, linA, and strA-strB antibiotic resistance genes. …”
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IGF-1R Inhibition Suppresses Cell Proliferation and Increases Radiosensitivity in Nasopharyngeal Carcinoma Cells by Zhe Wang, Guangyan Liu, Jiwei Mao, Min Xie, Ming Zhao, Xuefen Guo, Shanshan Liang, Heming Li, Xuefeng Li, Ruoyu Wang

“…Moreover, linsitinib further boosted IR-induced DNA damage, G2-M cell cycle delay, and apoptosis in NPC cells. …”
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NT-proBNP and Major Adverse Cardiovascular Events in Patients with ST-Segment Elevation Myocardial Infarction Who Received Primary Percutaneous Coronary Intervention: A Prospective... by Zuoan Qin, Yaoyao Du, Quan Zhou, Xuelin Lu, Li Luo, Zhixiang Zhang, Ning Guo, Liangqing Ge

“…In patients with STEMI who underwent PCI, Log2 NT-proBNP was positively correlated with MACE within 1 month when the Log2 NT-proBNP was >11.66 (NT-proBNP >3.236 pg/mL).…”
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Protein hydrolysate as an efficient and environmental-friendly swelling inhibitor in clay formations by Yahya Dashti-Rahmatabadi, Hamid Saeidian, Javad Mokhtari, Zohreh Mirjafary

“…The adsorption of the HPC onto bentonite (Bent) particles leads to a significant change in the zeta potential, shifting from − 32.5 to + 58.0 mV. Thermogravimetric analysis indicated that when temperatures surpass 200 °C, the Bent powder obtained from the aqueous solution of the HPC undergoes a notable increase in mass loss, quantified at 20.40%. …”
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Prevalence and risk factors of hyperuricaemia in non-obese Chinese: a single-centre cross-sectional study by Chengfu Xu, Jinghua Wang, Xinyu Wang, Yishu Chen, Shenghui Chen, Haoliang Zhai

“…Exclusion criteria: (1) those with body mass index ≥24 kg/m2; (2) those with incomplete anthropometric and biochemical data; (3) those with a history of malignancy and (4) those under urate-lowering treatment.Primary and secondary outcome measures The prevalence and factors associated with hyperuricaemia in non-obese Chinese adults.Results Of the 5731 non-obese subjects enrolled, 538 (9.4%) were identified as having hyperuricaemia, specifically 16.3% in men and 4.6% in women. …”
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Nutritional Value and Consumer Acceptance of New Cereal Bars Offered to Children by Białek Małgorzata, Rutkowska Jarosława, Radomska Justyna

“…Storage of bars did not influence their content of oxidation and hydrolysis products, resulting from a substantial content of total phenolics (TPC) (53.64 mg GAE/100 mL of extract) and DPPH scavenging activity at the level of 24%. …”
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Imbalance of the Gut Microbiota May Be Associated with Missed Abortions: A Perspective Study from a General Hospital of Hunan Province by Bingsi Gao, Xingping Zhao, Xinyi Liu, Xuan Yang, Aiqian Zhang, Huan Huang, Yu-ligh Liou, Dabao Xu

“…Prevotella, Lactobacillus, and Paracoccus were significantly more abundant in the control group than in the case group at the genus level (P<0.05). (2) KEGG pathway enrichment analysis found significant differences in 27 signaling pathways and metabolic pathways between the two groups of differentially expressed genes (all adjusted P<0.05). (3) The positive rate of M. hominins (MH) detection in the control group was significantly higher in the MA group (χ2=7.853, P=0.004). …”
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Joint Use of Skull Base Surgery in a Case of Pediatric Parotid Gland Carcinoma by Yuri Ueda, Kiyoaki Tsukahara, Kazuhiro Nakamura, Ray Motohashi, Minoru Endo, Hiroki Sato, Yasuaki Katsube, Mamoru Suzuki

“…In addition to the skin and temporomandibular joint, infiltration into the anterior wall of the external auditory meatus and masseter muscle was also seen, and T4N0M0 stage IV parotid carcinoma was diagnosed. Skin was resected together with the pinna, and temporal craniotomy and skull base surgery were performed to resect the temporomandibular joint capsule and external auditory meatus en bloc, and mandible dissection was conducted. …”
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Effect of Weed Management Practices on Citrus Growth and Cost of Production at Young Mandarin Orchard in Palpa, Nepal by Deepa Parajuli, Hom Nath Giri, Mamta Adhikari, Bidya Ojha, Astha Pokharel, Anusuya Aaradhana Panthee

“…Results of the study showed that plastic mulch was an efficient method providing lower average weed diversity (1.7); weed density in all days after treatment (DAT) (0.5, 0.6, 1.9, 6.6, and 1.1 m−2); and weed dry weight at 15, 30, and 45 DAT (0.1, 0.3, and 0.4 gm−2). …”
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Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 by Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze

“…The resultant protein was reconstituted using SMA copolymers with a specific yield of 300 µg/mL of lysate. Functionally, the protein demonstrated significant kinase domain phosphorylation (t < 0.0001). …”
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Development of Chitosan-Polyacrylic Acid Complex Systems for Enhanced Oral Delivery of Lactobacillus Gasseri and Bifidobacterium Bifidum Probiotics by AL-Fawares O, Alshweiat A, Abuawad A

“…Additionally the loaded probiotic exhibited an anti-biofilm effect at 0.5 mg/mL concentration level.Conclusion: The CS-PAA complexes demonstrate a promising mechanism for the effective delivery of incorporated probiotics. …”
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Inhibitory Effect of Flavonoid Extract of Lotus Leaf on Alcohol-Induced Gastric Injury by Antioxidant Capacity in Mice by Yi Chen, Qin Li, Zhiping Kuang, Xin Zhao, Ruokun Yi, Xiaowei He, Guangjing Feng

“…The quantitative polymerase chain reaction (qPCR) and Western blot results proved that FELL upregulated the mRNA and protein expressions of SOD1, SOD2, CAT, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR), neuronal nitric oxide synthase (nNOS), and endothelial nitric oxide synthase (eNOS) and downregulated the expression of inducible nitric oxide synthase (iNOS) in the gastric tissue of mice with gastric injury. …”
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Optimizing Phaeodactylum tricornutum cultivation: integrated strategies for enhancing biomass, lipid, and fucoxanthin production by Mostafa E. Elshobary, Walaa A. Abo-Shanab, Stephan S. W. Ende, Mohammed Alquraishi, Rania A. El-Shenody

“…Results Optimized medium (− 50%N%, + 50% P, Zero-Si, 2 g glycerol) under low-intensity blue light (100 μmol m⁻2 s⁻1) improved biomass to 1.6 g L⁻1, with lipid productivity reaching 539.25 mg g⁻1, while fucoxanthin increased to 20.44 mg g−1. …”
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Ictiofauna de la Ensenada de la Siguanea (Cuba) by Tsai García-Galano, Zenaida María Navarro Martínez, Leandro Rodríguez-Viera, Jorge Angulo-Valdés

“…Las especies incluidas fueron capturadas entre los años 2015−2017 en la Ensenada de la Siguanea (Cuba), en áreas con menos de 1,75 m de profundidad, con fondos arenosos, fangosos y pastizales marinos, cercanos a manglares. …”
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Efficacy and Safety of Drug-Eluting Bead TACE in the Treatment of Primary or Secondary Liver Cancer by Jiabing Wang, Haoqian Xu, Ying Wang, Long Feng, Fengming Yi

“…Objective response rate (ORR) and disease control rate (DCR) were evaluated by mRECIST. The pain was assessed using a numerical rating scale (NRS) where 0 represented no pain, and a score of ten was unbearable. …”
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