Tuberculosis vaccines and therapeutic drug: challenges and future directions by Yajing An, Ruizi Ni, Li Zhuang, Ling Yang, Zhaoyang Ye, Linsheng Li, Seppo Parkkila, Ashok Aspatwar, Wenping Gong

“…We spotlight innovative approaches, such as multi-antigen vaccines and mRNA technology platforms. Furthermore, the review delves into current TB therapeutics, particularly for multidrug-resistant tuberculosis (MDR-TB), exploring promising agents like bedaquiline (BDQ) and delamanid (DLM), as well as the potential of host-directed therapies. …”
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Activation of Human Neutrophils by the Anti-Inflammatory Mediator Esenbeckia leiocarpa Leads to Atypical Apoptosis by Rafael de Liz, Heros Horst, Moacir Geraldo Pizzolatti, Tânia Silvia Fröde, Denis Girard

“…At a noncytotoxic concentration of 500 μg/mL, CHE increased actin polymerization and cell signaling events, especially p38 MAPK. …”
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α-Amylase and α-Glucosidase Inhibitory Activities of Phenolic Extracts from Eucalyptus grandis × E. urophylla Bark by Ping Jiang, Jia Xiong, Fei Wang, Mary H. Grace, Mary Ann Lila, Rui Xu

“…Seven fractions were derived from EB-E; among them EB-E-7 showed the highest significant inhibition of both enzymes, with IC50 of 1.40±0.18 and 1.72±0.12 μg/mL, respectively. EB-E and its active fraction EB-E-7 showed highest contents of total phenolics: 178.79±4.68 and 920.4±5.46 mg GAEag−1, respectively. …”
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Factors Associated With Multi-Drug Resistant Organisms Among Bronchiectasis Patients: A Retrospective Study of Bronchiectasis Patients in Jordan by Al Oweidat K, Toubasi AA, Khraisat FA, Al-Sayegh TN, Al-Harasis LM, Albtoosh AS

“…Khaled Al Oweidat,1 Ahmad A Toubasi,2 Farah A Khraisat,2 Thuraya N Al-Sayegh,2 Layla M Al-Harasis,3 Asma S Albtoosh1 1Department of Respiratory and Sleep Medicine, Department of Internal Medicine, School of Medicine, The University of Jordan, Amman, Jordan; 2Faculty of Medicine, The University of Jordan, Amman, Jordan; 3Faculty of Medicine, the Jordan University of Science and Technology, Irbid, JordanCorrespondence: Ahmad A Toubasi, Faculty of Medicine, the University of Jordan, Amman, 11942, Jordan, Tel +962798035061, Email tubasi_ahmad@yahoo.comBackground: Bronchiectasis, a respiratory ailment, significantly impacts the life expectancy of individuals. …”
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Atypical Radiographic Presentation of Cryptococcus Pneumonia in a Newly Diagnosed HIV Patient by Arthur Cacacho, Umair Ashraf, Arsalan Rehmani, Masooma Niazi, Misbahuddin Khaja

“…Interferon-gamma release assay, Mycobacterium tuberculosis PCR, and acid-fast bacilli staining of the bronchoalveolar lavage were negative for the M. tuberculosis complex. Conclusion. The similarities in clinical and imaging findings among patients with acute immunodeficiency syndrome with coinfections make diagnoses difficult; thus image-guided biopsies are essential to confirm diagnoses.…”
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Eurotium Cristatum Postfermentation of Fireweed and Apple Tree Leaf Herbal Teas by Tatiana A. Efimenko, Elena F. Shanenko, Tatiana G. Mukhamedzhanova, Olga V. Efremenkova, Yuriy A. Nikolayev, Elena N. Bilanenko, Marina V. Gernet, Artem G. Grishin, Ivan N. Serykh, Sergey V. Shevelev, Byazilya F. Vasilyeva, Svetlana N. Filippova, Galina I. El-Registan

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Rapid adsorption of selenium removal using iron manganese-based micro adsorbent by Sundus Saeed Qureshi, Sheeraz Ahmed Memon, Rafi-ul-Zaman, Nanik Ram, Sumbul Saeed, Nabisab Mujawar Mubarak, Rama Rao Karri

“…Micro-particles were characterized by using energy-dispersive X-ray spectroscopy for elemental analysis after adsorption, which confirms the adsorption of selenium on the surface of the micro-composite adsorbent, scanning electron microscopy, which shows particles are circular in shape and irregular in size, Brunauer–Emmett–Teller which results from the total surface area of particles were 59.345m2/g, Zeta particle size, which results from average particles size were 39.8 nm. …”
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Tocilizumab, an Exploratory Treatment for Severe COVID-19 Patients by Yong Wang, Yongfeng Chen, Xiangdong Zhou

“…The median level of IL-6 before TCZ administration was 27.91 (7.42–210.90) pg/mL. Serum IL-6 level tended to further spike firstly and then gradually decreased after TCZ therapy in 10 patients. …”
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Surfacing and diving behavior associated with thermal physiology in oceanic habitats of skipjack tuna (Katsuwonus pelamis) in the western north Pacific Ocean by Yoshinori Aoki, Takashi Kitagawa, Hidetada Kiyofuji

“…We quantified surfacing and diving behavior as an index of vertical behavior and estimated the whole-body heat transfer coefficient (λ) during the cooling and warming phases associated with diving using body and water temperature records as indicators of thermal physiology.ResultsIn the southern mixed layer areas, SKJ were widely distributed at a depth layer <200 m, whereas they were restricted to the surface in the strong thermocline areas in the north. …”
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Human Placenta-Derived Mesenchymal Stem Cells Reduce Mortality and Hematoma Size in a Rat Intracerebral Hemorrhage Model in an Acute Phase by Bo Young Choi, Ok Joon Kim, Sae-Hong Min, Jeong Hyun Jeong, Sang Won Suh, Tae Nyoung Chung

“…Expression of tight junction proteins (ZO-1, occludin) and coagulation factor VII mRNA was also compared. Mortality rate (50% versus 8.3%), hematoma size, ventricular size, hemispheric enlargement, and degenerating neuron count were significantly lower in the MSC-treated group (p=0.034, 0.038, 0.001, 0.022, and <0.001, resp.), while the expression of ZO-1 and occludin was higher (p=0.007 and 0.012). …”
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The Effect of Serine Protease Inhibitors on Airway Inflammation in a Chronic Allergen-Induced Asthma Mouse Model by Chih-Che Lin, Li-Jen Lin, Shulhn-Der Wang, Chung-Jen Chiang, Yun-Peng Chao, Joseph Lin, Shung-Te Kao

“…BALB/c mice (6 mice/group) were intratracheally inoculated with five doses of Dermatophagoides pteronyssinus (Der p; 50 μL, 1 mg/mL) at one-week intervals. Therapeutic doses of FUT (0.0625 mg/kg), FOY (20 mg/kg), or UTI (10,000 U/kg) were, respectively, injected intraperitoneally into these mice. …”
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Propuesta metodológica para la apropiación y construcción social del conocimiento a través de la cartografía comunitaria y la Investigación Acción Participativa. Un acercamiento a... by Catherine Osorio Londoño, Daniela Carvajal Mazo, Leiidy Yulied Sepúlveda Goez

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Exploring northeast India’s culturable soil Actinomycetia for potent antibacterial agents against gram-positive bacterial pathogens of clinical importance by Aditya Narayan Konwar, Surajit Basak, Shalini Gurumayum, Jagat Chandra Borah, Debajit Thakur

“…Toxicity studies against animal liver cell lines indicated that the ethyl acetate extract was non-toxic at concentrations below 125 µg/mL, compared to Vancomycin, which was found to be hepatotoxic at similar concentrations. …”
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5-Fluorouracil-β-Cyclodextrin conjugates:Linker strategies to enhance the anticancer efficacy and reduce the side effects by Liangliang Hu, Ting Meng, Davies Marabada, Zhichao Jin, Qing Huang, Shijie Wei, Zhizhong Wang

“…The cytotoxicity assays on human colon cancer cell lines HT-29 and normal colon epithelial cells NCM-460 demonstrated that the IC50 value of the 5-FUBA-β-CD conjugate for the HT-29 cells was 38.72 ± 0.13 μM, indicating superior antitumor activity compared to both 5-FUBA-β-CD and 5-FU. …”
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Photocatalytic activity of spectro-pure titanium dioxide: Effects of crystalline structure, specific surface area and sorption properties by Evgeny I. Kapinus, Tatyana A. Khalyavka, Valentina V. Shimanovskaya, Tatyana I. Viktorova, Vladimir V. Strelko

“…Particles of all the TiO2 samples had a globular shape of diameter between 10 and 30 μm. When compared to the corresponding technical-grade samples, the optically pure anatase and rutile demonstrated higher photocatalytic activity in the destruction of tetradecylpyridinium chloride, Methylene Blue and tetrachlorofluorescein as well as in reduction of Cr2O7, MnO4, [Fe(CN)6]3− and [Fe(CN)6]4−. …”
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Black Carbon Concentration and Potential Source Regions: A Case Study of the Yellow River Basin in Shandong Province, China by Yuxia Wang, Yanni Rong, Kai Qu, Qing Zhao, Yingming Jiang, Xiaolei Bao, Yang Wang

“…The monthly average BC concentrations in Jinan ranged from 0.69 to 3.92 µg m–3. BC concentration exhibited a pronounced diurnal variation, which decreased from the morning peak to afternoon. …”
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Urban Green Spaces in Brazil: Challenges and Opportunities in the Context of the COVID-19 Pandemic by Romero Gomes Pereira da Silva, Cláudia Lins Lima, Sterling D. Quinn, Aneta Afelt, Anne-Elisabeth Laques, Carlos Hiroo Saito

“…Urban green spaces of over 625 m2 were mapped in 117 municipalities, the total area of 4170 km2 representing 37.4% of the urban spaces analyzed in the five  metropolitan regions. …”
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An Ultra-Wide Range D-Shaped Fiber SPR Sensor with a Nanostructure of Gold–MoS₂ and Sodium for the Simultaneous Measurement of Refractive Index and Temperature by Xinglian Lu, Xiantong Yu, Jun Zhou, Min Chang, Dunke Lu

“…Specifically, it reaches 195,149 dB/m when RI = 1.34 at 30 °C. This is much higher than that of most previous studies, and the requirements for inspection equipment can be lowered in this case. …”
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Facile Synthesis of Graphene Oxide/Titanate Nanotube Composites and Their Application for Cobalt(II) Removal by Min-Da Xu, Zhen Jin, Wen-Jie Xie, De-Cai Wang, Guang-Song Xu, Ai-Jing Wang, Ran Zhang, Jian Huang

“…This hierarchical morphology endows the GTNT composites with not only the high specific surface area of 236.9 m2/g but also abundant porous structure, both of which are benefit for Co(II) adsorption. …”
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Identifying skin surface chemicals as potential tuberculosis diagnostic biomarkers using ultra performance liquid chromatography-high resolution mass spectrometry by Madelien Wooding, Kornelis van Pletzen, Yvette Naudé

“…Early and accurate diagnosis of active TB is essential for enhancing patient care, improving outcomes, and interrupting the transmission cycles of Mycobacterium tuberculosis (M.tb). Metabolomics proves to be an emerging area of study for the development of a non-invasive approach to TB diagnostics.. …”
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