Overcoming hypoxia-induced breast cancer drug resistance: a novel strategy using hollow gold-platinum bimetallic nanoshells by Lian-Ying Zhang, Xiao-Tong Chen, Rong-Tian Li, Wei Meng, Guo-Qin Huang, Yong-Jian Chen, Feng-Jun Ge, Qun Zhang, Yu-Jun Quan, Cai-Tao Zhang, Yi-Fei Liu, Ming Chen, Jin-Xiang Chen

“…Significantly, the increased availability of oxygen further re-polarizes immunosuppressive M2 macrophages into antitumor M1 macrophages. This study presents a novel strategy to tackle tumor proliferation and enhance tumor response to chemotherapy, offering hope for reversing in drug resistance in cancerous lesions. …”
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The microenvironment cell index is a novel indicator for the prognosis and therapeutic regimen selection of cancers by Xian-Yan Yang, Nian Chen, Qian Wen, Yu Zhou, Tao Zhang, Ji Zhou, Cheng-Hui Liang, Li-Ping Han, Xiao-Ya Wang, Qing-Mei Kang, Xiao-Xia Zheng, Xue-Jia Zhai, Hong-Ying Jiang, Tian-Hua Shen, Jin-Wei Xiao, Yu-Xin Zou, Yun Deng, Shuang Lin, Jiang-Jie Duan, Jun Wang, Shi-Cang Yu

“…Results MCI consists of the six types of MCs, which can precisely predict the prognosis of the TNBC patients. scRNA-seq, SRT, and mIF analyses verified the existence and proportions of these cells. …”
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Multi-trace elements-enriched functional drink accelerates gastric ulcer repair via the HGF/c-Met/STAT3 pathway by Yongnan Piao, Nuoya Wang, Mingji Jin, Jianyu Piao, Mingfeng Han, Zifei Wang, Chunhua Quan, Jishan Yin, Zhonggao Gao, Wenxiang Cui, Shuangqing Wang, Xiuquan Quan

“…Rats were administered anhydrous ethanol (5 mL/kg) orally to induce gastric ulcers and were then randomly assigned to a model, an omeprazole (OME, 20 mg/kg), FD with low-dose (FD-L), medium-dose (FD-M), high-dose (FD-H), FD without added TEs (FD without TEs), and an omeprazole+low-dose group (OME + L). …”
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Clinical features and predictors of atrial fibrillation in patients with light‐chain or transthyretin cardiac amyloidosis by Maria Papathanasiou, Aiste‐Monika Jakstaite, Sara Oubari, Johannes Siebermair, Reza Wakili, Julia Hoffmann, Alexander Carpinteiro, Tim Hagenacker, Andreas Thimm, Christoph Rischpler, Lukas Kessler, Tienush Rassaf, Peter Luedike

“…AF patients had lower left ventricular ejection fraction (47 vs. 53%, P < 0.005), higher left atrial volume index (54 vs. 46 mL/m2, P = 0.007), higher pulmonary artery pressure (42 vs. 31 mmHg, P = 0.008), and worse tricuspid annular plane systolic excursion values (17 vs. 20 mm, P = 0.01). …”
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Application of probiotic microcapsules Bacillus cereus BR2 with different doses for the prevention of Aeromonas hydrophila NFC1 infection in catfish Clarias sp. by Nurul Faoziyatunnisa, Munti Yuhana, Dinamella Wahjuningrum, Sri Nuryati, Usamah Afiff

“…Pemeliharaan ikan dilanjutkan setelah uji tantang dengan A. hydrophila NFC1 (106 CFU/mL) yang dilakukan hingga 10 hari pasca injeksi. …”
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Synaptotagmin-1 attenuates myocardial programmed necrosis and ischemia/reperfusion injury through the mitochondrial pathway by Teng Sun, Jialei Li, Shuang Wang, Yu Han, Xiangyu Tao, Min Yuan, Zhijie Jing, Ting Liu, Yuehong Qi, Siqi Liu, Yanlin Feng, Jiasong Chang, Lan Zhou, Lijuan Gao, Jianyun Shi, Ruihong Ning, Jimin Cao

“…In exploring the underlying mechanisms, we found that Syt1 interacted with Parkin and promoted Parkin-catalyzed CypD ubiquitination, thus inhibited mitochondrial membrane permeability transition pore (mPTP) opening and ultimately suppressed cardiomyocyte necrosis. …”
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Pre-existing IgG antibodies to HCoVs NL63 and OC43 Spike increased during the pandemic and after COVID-19 vaccination by Zahra Hasan, Kiran Iqbal Masood, Marc Veldhoen, Shama Qaiser, Marta Alenquer, Mishgan Akhtar, Sadaf Balouch, Junaid Iqbal, Yaqub Wassan, Shahneel Hussain, Khalid Feroz, Sajid Muhammad, Atif Habib, Akbar Kanji, Erum Khan, Afsar Ali Mian, Rabia Hussain, Maria Joao Amorim, Zulfiqar A. Bhutta

“…Further, we investigated the effect of inactivated and mRNA COVID-19 vaccinations on antibody responses to the pandemic and endemic coronaviruses.We measured IgG antibodies to Spike of SARS-CoV-2, HCoV-NL63 and HCoV-OC43 by ELISA. …”
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Al–Si alloyed uncoated hot stamping steels for enhanced oxidation resistance by Zhaoqi Song, Kaixun Wang, Haitao Zhao, Long Ma, Junheng Gao, Honghui Wu, Yuhe Huang, Chaolei Zhang, Jun Lu, Shuize Wang, Xinping Mao

“…Notably, the scale thickness decreases with increasing Al content, reaching just 3.5 μm at 0.48% Al, which is substantially lower than the 46 μm observed in 22MnB5 steel. …”
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Étude archéozoologique du quartier portuaire romain de Saint-Lupien à Rezé/Ratiatum (Loire-Atlantique) : les vestiges fauniques en pied de berge by Aurélia Borvon

“…They originate from different sectors of an area called “area 4”, which refers to the different occupations of the riverbank harbour and its immediate environment over a distance of nearly 200 m. In the different parts of “area 4”, various taxa have been identified, both large-sized ones such as cattle, and very small-sized ones such as fish or shrimp. …”
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ارزیابی پتانسیل ترسیب کربن توسط گیاه جو در خاک‌های شور (مطالعه موردی: شهرستان گمیشان، استان گلستان)... by نور محمد مکرری کر, حسین کاظمی, بهنام کامکار, سمانه بخشنده

“…در اراضی شهرستان گمیشان در دو بخش اراضی با هدایت الکتریکی زیاد (بیشتر از dS/m12) و اراضی با هدایت الکتریکی کم (کمتر از dS/m12) و مقایسه آن‌ها بود. …”
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Hexane extract from Lindera communis roots: wound healing properties and membrane-disruptive activities against methicillin-resistant Staphylococcus aureus by Miaomiao Wang, Miaomiao Wang, Miaomiao Wang, Xian Hu, Xian Hu, Xian Hu, Liya Liu, Liya Liu, Liya Liu, Liya Liu, Yi Zhong, Yi Zhong, Yi Zhong, Wanlin Li, Wanlin Li, Wanlin Li, Qing Zhang, Qing Zhang, Qing Zhang, Congli Xu, Chunlin Long, Chunlin Long, Chunlin Long, Chunlin Long, Chunlin Long

“…The results are that LCH affected the growth of methicillin-resistant Staphylococcus aureus (MIC: 0.1 mg/mL) through morphological alterations and disrupting cell surface structures, causing membrane hyperpolarization and altering membrane integrity. …”
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4-1BB agonist targeted to fibroblast activation protein α synergizes with radiotherapy to treat murine breast tumor models by Ignacio Melero, Alvaro Teijeira, Christian Klein, Maria E Rodriguez-Ruiz, Christina Claus, Pablo Umana, Tamara Tanos, Carlos E De Andrea, Carlos Luri-Rey, Paloma Sanchez-Mateos, Leticia Fernández-Rubio, María Collantes, Irantzu Serrano-Mendioroz, Celia Barrio-Alonso, Antonio Rullan, Jon Ander Simon, Eneko Garate-Soraluze, Claudia del Pilar Herrero

“…Selective monoclonal antibody (mAb)-mediated depletions of immune cell populations, neutralizing interferon alpha/beta receptor 1 (IFNAR-I) IFNAR and interferon (IFN)-γ mAbs and gene-modified mice (4-1BB−/−) were used to delineate the immune cell subsets and mechanisms required for efficacy. 67Ga labeled muFAP-4-1BBL tracked by SPECT-CT was used to study biodistribution. …”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Background Immune checkpoint inhibitors (ICIs) show a tremendous activity in microsatellite instability-high (MSI-H) metastatic colorectal cancer (mCRC), but a consistent fraction of patients does not respond. …”
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Transcriptomic and proteomic analysis of the jejunum revealed the effects and mechanism of protocatechuic acid on alleviating Salmonella typhimurium infection in chickens by Sheng Zhang, Qin Wang, Xiangtian Yao, Jingjing Dong, Guanhuo Li, Yingan Zang, Shouqun Jiang, Yibing Wang

“…Dietary protocatechuic acid (600 mg/kg) was effective to alleviate Salmonella infection, as it suppressed the levels of cytokines and complement protein by inhibiting MAPK, I-κB kinase/NF-κB and enhancing the mTOR signaling pathway, thus offset the decline in weight loss and intestinal injury caused by infection.…”
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A multicenter, randomized, double-blind, placebo-controlled phase 3 study of Socazolimab or placebo combined with carboplatin and etoposide in the first-line treatment of extensive... by Zhiwei Chen, Jianhua Chen, Dingzhi Huang, Wei Zhang, Lin Wu, Tienan Yi, Qiming Wang, Liang Han, Liping Tan, Yinyin Li, Zhihong Zhang, Na Li, Jie li, Tongmei Zhang, Ying Hu, Hongmei Sun, Youhua Wu, Zhiyong He, Runxiang Yang, Peng Cheng, Xingya Li, Jianhua Shi, Guohua Yu, Daiyuan Ma, Benjamin Xiaoyi Li, Xiangrong Dai, Michael Wong, Yujie Li, Xiaohui Yu, Shun Lu, for the Socazolimab Study Group

“…Eligible Patients were randomly assigned (1:1) to receive four cycles (21 days as one cycle) of intravenous carboplatin (area under the curve of 5 mg/mL per min, day 1 of each cycle) and etoposide (100 mg/m² of body-surface area, on days 1–3 of each cycle) with either socazolimab (5 mg/kg, day 1 of each cycle) or matching placebo, following maintenance therapy with socazolimab or placebo. …”
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Exploring the Impact of Drought Stress on the Yield and Yield Components of Cumin (Cuminum cyminum L.) Ecotypes by Vahid Bazr Afshan, Farzad Paknejad, Hamid Reza Fanay, davood Habibi, Morteza Siavoshi

“…The lowest seed yield of 65.8 g m-2 was recorded for the ecotype Khorasan Razavi 12. …”
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Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma by Zhong Zheng, Jian-Biao Wang, Rui Sun, Nan Wang, Xiang-Qin Weng, Tian-Yuan Xu, Di Fu, Yan Feng, Peng-Peng Xu, Shu Cheng, Li Wang, Yan Zhao, Bin Qu, Chuan-Xin Huang, Wei-Li Zhao

“…One-hundred and fifteen patients were enrolled and treated with rituximab 375 mg/m2 intravenously on day 0 and lenalidomide 25 mg orally on day 1–10 for 6 cycles of induction treatment, as well as lenalidomide for 6 cycles and rituximab for 8 cycles of maintenance treatment. …”
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Utilizing of black cumin (Nigella sativa) flour to increase the immunity system of tilapia (Oreochromis niloticus) against Aeromonas hydrophila bacteria attack by Norma Rizki Silviana, Rosidah, Wahyuniar Pamungkas, Roffi Grandiosa

“…A. hydrophila bacteria used to infect fish had a density of 108 CFU/mL. The Parameters used were total leukocyte, hematocrit, total leukocyte differential, clinical symptoms, survival rate and water quality. …”
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Clinical study on the treatment of chronic heart failure with a novel D‐shant atrium shunt device by Xiaoke Shang, Mei Liu, Yucheng Zhong, Xueli Wang, Song Chen, Xiaojuan Fu, Ming Sun, Mingxing Xie, Yuhe Ke, Ying Guan, Changdong Zhang, Nianguo Dong

“…Magnetic resonance imaging showed a reduction in the volume of the left ventricle (182.00 ± 27.02 mL vs. 125.75 ± 16.11 mL, P < 0.05). Cardiac catheter examination showed the mean left atrium pressure or pulmonary capillary wedge pressure decreased postoperatively (31.83 ± 11.55 vs. 18.00 ± 5.51 mmHg, P < 0.05). …”
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A chromosome-level genome assembly of Meteorus pulchricornis Wesmael (Hymenoptera: Braconidae) by Shiji Tian, Ruizhong Yuan, Xingzhou Ma, XiaoHan Shu, Yu Fang, Zhaohe Lu, Qiuyu Qu, Yu Jin, Jiabao Gong, Yanlin Peng, Ziqi Wang, Xiqian Ye, Xuexin Chen, Pu Tang

“…In this study, we present a high-quality, chromosome-level genome assembly of M. pulchricornis, characterized by high accuracy and contiguity. …”
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