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41801
Development of RNA interference-based therapy for rare genetic diseases
Published 2024-08-01“…RNAi employs small RNA molecules, such as small interfering RNA (siRNA) and microRNA (miRNA), to bind specific mRNA molecules and prevent their translation into proteins. …”
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41802
Experimental and Numerical Simulation Studies of RC Beams under the Actions of Equal Energy Impact Loads
Published 2020-01-01“…In addition, when the impact velocity is 2.25 m/s and the impact mass is 400 kg, the beam has the most serious damage; (2) compared with the mass, the impact velocity has more obvious effects on the peak value of cumulative impact force, mid span displacement, and rebar strain; (3) with the decrease of the impact velocity (the increase of the mass), the local damage of the beam is gradually weakened and the overall damage is gradually exacerbated. …”
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41803
Post-pedagogical Syndrome of the Digimodernism Age
Published 2019-09-01“…The author relies on the post-postmodern age interpretations presented in the works of S. Abramson, M. Epstein, R. Eschelman, A. Kirby, J. Mensch, P. …”
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41804
The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling
Published 2025-02-01“…LFA1 activation did not induce autophagy, whereas it increased mTOR and AMPK activity. LFA1-dependent AMPK activation enhances LFA1 and LC3 clustering and adhesion. …”
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41805
Círculos de leitura como experiência pedagógica para a formação de leitores
Published 2024-09-01“…Na metodologia, utilizou-se a técnica dos Círculos de Leitura de Cosson (2021a), e enfatizou-se a mediação pedagógica, realizada pela professora de Língua Portuguesa, na leitura da obra Matilda e o Clube de Leitura, de Roberta M. R. Trevisan (2022). Os resultados indicam que a proposta pedagógica se revelou eficaz, proporcionando a participação ativa dos estudantes na leitura e na escrita dos diários. …”
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41806
Particle size distributions and shape identification of pozzolanic materials via various dimensional representations
Published 2025-03-01“…Through the pozzolanic properties and Feret diameters of less than 35 μm for the specimens, we illustrate the capabilities of CBP, FA, and TSA in replacing OPC in cementitious composites. …”
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41807
Optimal On-Load Tap Changer Tap Control Method for Voltage Compliance Rate Improvement in Distribution Systems, Based on Field Measurement Data
Published 2025-01-01“…This paper proposes an optimal control method for the on-load tap changer (OLTC) of a substation’s main transformer (M.TR), to maximize the voltage compliance rate (VCR) in distribution system feeders. …”
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41808
Pharmaceutical approaches for COVID-19: An update on current therapeutic opportunities
Published 2023-06-01“…Various natural compounds such as sarsapogenin, lycorine, biscoclaurine, vitamin B12, glycyrrhizic acid, riboflavin, resveratrol and kaempferol, various vaccines and drugs such as AZD1222, mRNA-1273, BNT162b2, Sputnik V, and remdesivir, lopinavir, favipiravir, darunavir, oseltamivir, and umifenovir, resp., have been discussed comprehensively. …”
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41809
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41810
Estrategias para la comercialización de producciones cinematográficas colombianas
Published 2018-01-01“…Lo que permitió la construcción de un sistema categorial que asoció las diferentes estrategias para la comercialización de los filmes con las diferentes etapas del proceso de realización cinematográfico.CÓDIGOS JEL M31; L82.…”
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41811
The Role of pH in PEG-b-PAAc Modification of Gadolinium Oxide Nanostructures for Biomedical Applications
Published 2012-01-01“…Variation of the material synthesis conditions (additives and pH) allows controlling particle size (40 nm to μm range) and rod aspect ratio (5 to 18). It was shown that PEG-b-PAAc (poly(ethylene glycol) poly(acrylic acid) block polymer) is suitable to provide the required chemical durability, dispersion stability, and noncytotoxic behaviour for biomedical applications, where the coating of Gd2O3 with a protecting and biocompatible layer is essential in order to prevent the release of toxic Gd3+ ions. …”
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41812
Study of the Impact Energy Releasing Characteristics of Al/PTFE/W Energetic Jets
Published 2020-01-01“…At an impact energy threshold of 106.1 MJ/m2, the chemical reaction of the Al/PTFE/W (45%) energetic jets is saturated. …”
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41813
Evaluation of the In Vitro and In Vivo Antioxidant Potentials of Aframomum melegueta Methanolic Seed Extract
Published 2014-01-01“…The extract (25–400 μg/mL concentration) produced concentration dependent increase in antioxidant activity in 2, 2-diphenylpicrylhydrazine photometric assay. …”
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41814
Energy Dissipation and Particle Size Distribution of Granite under Different Incident Energies in SHPB Compression Tests
Published 2020-01-01“…This critical incident energy was found to be 0.29–0.33 MJ/m3. As the incident energy was smaller than the critical incident energy, the rock specimens remained unruptured after the impact. …”
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41815
Quasi-static and dynamic compression behavior of stacked pyramidal lattice structures with I-beam struts
Published 2025-01-01“…These novel lattice structures are 3D-printed considering three different stacking sequences, and their stiffness, strength, and energy absorption properties are experimentally assessed through low-velocity impact (1.54 m/s) and quasi-static compression tests. Additionally, dynamic finite element (FE) simulations are carried out to delve deeper into the collapse mechanisms and failure processes. …”
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41816
Phenotypic detection of carbapenem-resistant Enterobacterales in clinical isolates at a tertiary care hospital
Published 2024-01-01“…They were tested for carbapenem resistance by Kirby–Bauer disk diffusion method and then tested for carbapenemase production by ethylenediaminetetraacetic acid (EDTA)–disk synergy test and Modified Carbapenem Inactivation Method (mCIM). Results: This study was conducted from February 2021 to August 2022. …”
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41817
The value of a metabolic and immune-related gene signature and adjuvant therapeutic response in pancreatic cancer
Published 2025-01-01“…Predictive accuracy was assessed using Kaplan-Meier (K-M) curves, calibration plots, and ROC curves. Additional analyses, including GSAE and immune cell infiltration studies, were conducted to explore relevant biological mechanisms and predict therapeutic efficacy.ResultsAn 8-gene prognostic model (AK2, CXCL11, TYK2, ANGPT4, IL20RA, MET, ENPP6, and CA12) was established. …”
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41818
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41819
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41820
Izbor lokacija za smeštaj rezervi tehničkih materijalnih sredstava primjenom metoda operacionih istraživanja
Published 1990-05-01“…U matematički model donosilac odluke može, ovisno o konkretnoj situaciji, unijeti i dodatno ograničenje na broj lokacija: m Ʃ yi≤n, gdje je n maksimalno dozvoljeni broj lokacija. …”
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