Uncovering the significance of CBX3 as an up-and-coming biomarker in cardio-vascular health by Muhammad Aamir Wahab, Nunzio Del Gaudio, Biagio Gargiulo, Vincenzo Quagliariello, Nicola Maurea, Michele Grieco, Rosaria Benedetti, Angela Nebbioso, Lucia Altucci, Mariarosaria Conte

“…In patients with CVD affected by lung cancer risk, CBX3 exerts a sophisticated mechanism of action, suppressing the proliferation, migration, and formation of neointima in vascular smooth muscle cells (VSMCs) by affecting the Notch3 pathway, indicating a potential protective function against vascular remodeling and atherosclerosis. …”
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The Role of Pharmaceutical Innovation in Clinical Practice Guidelines for Chronic Diseases by Meaghan Roach, Natalie Land, Jennifer Hernandez, Reina Rau, Jacquelyn W. Chou, Stacey S. Hickson, Danielle F. Rollmann, J. Ross Maclean

“…Clinical practice guidelines published from 2000 to 2021 were identified for five chronic diseases: ischemic heart disease (IHD), non-small cell lung cancer (NSCLC), chronic obstructive pulmonary disease (COPD), Alzheimer’s disease (AD), and type 2 diabetes (T2D). …”
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Diversity of TCR repertoire predicts recurrence after CRT followed by durvalumab in patients with NSCLC by Masayuki Shirasawa, Tatsuya Yoshida, Takaji Matsutani, Yuki Takeyasu, Naoko Goto, Shigehiro Yagishita, Shigehisa Kitano, Hiroaki Kuroda, Toyoaki Hida, Takayasu Kurata, Yuichiro Ohe

“…Abstract Chemoradiotherapy (CRT) followed by durvalumab is standard for unresectable locally advanced non-small-cell lung cancer (LA-NSCLC). This study assesses how CRT alters the T-cell receptor (TCR) repertoire in CD8 + PD-1 + T-cells and its impact on clinical outcomes. …”
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Tacrolimus and mycophenolate mofetil in corticosteroid-resistant hepatitis secondary to tislelizumab: a case report by Chang Jiang, Shanxian Guo

“…In patients with extensive-stage small-cell lung cancer (ES-SCLC), the first-line use of tislelizumab combined with chemotherapy has shown significant efficacy. …”
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Genistein Implications in Radiotherapy: Kill Two Birds with One Stone by Xiongxiong Liu, Tong Zheng, Yanyu Bao, Ping Li, Ting Zhao, Yan Liu, Hui Wang, Chao Sun

“…Preclinical studies demonstrated genistein efficacy in various cancer models, such as breast, prostate, and lung cancer. Despite limited clinical studies, the existing evidence supports the potential of genistein in improving the therapeutic effect of radiotherapy. …”
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Severe anti-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor encephalitis with prolonged hyperammonemia: a case report by Chunxia Yan, Lingling Bai, Jingwei Du, Zonglei Chong, Guangjun Xu, Xiaoqian Yang

“…However, 10 months after discharge, he was readmitted to the hospital due to seizures and subsequently diagnosed with lung cancer. The patient eventually passed away at home. …”
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Herbaspirillum Infection in Humans: A Case Report and Review of Literature by Rashmi Dhital, Anish Paudel, Nidrit Bohra, Ann K. Shin

“…We present a 58-year-old female with non-small-cell lung cancer (NSCLC) who presented with pneumonia and was found to have Herbaspirillum seropedicae bacteremia. …”
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Application progress of artificial intelligence in tumor diagnosis and treatment by Fan Sun, Fan Sun, Fan Sun, Fan Sun, Li Zhang, Li Zhang, Li Zhang, Li Zhang, Zhongsheng Tong, Zhongsheng Tong, Zhongsheng Tong, Zhongsheng Tong

“…This review examines recent advancements in AI applications across tumor imaging diagnostics, pathological analysis, and treatment optimization, with a particular focus on breast cancer, lung cancer, and liver cancer. By synthesizing findings from peer-reviewed studies published over the past decade, this paper analyzes the role of AI in enhancing diagnostic accuracy, streamlining therapeutic decision-making, and personalizing treatment strategies. …”
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Chasing cancer: does the social-to-medical spending ratio relate to cancer incidence and mortality in Canadian provinces? A retrospective cohort study by Tony Reiman, Robin Urquhart, Lindsay McLaren, Cameron MacLellan, Paul Kershaw, Ronald D Kneebone, Daniel J Dutton

“…The relationship is statistically insignificant and negligible for lung cancer incidence and cancer mortality.Conclusion The ratio was significantly associated with a decrease in three out of four cancer incidence categories, but not mortality. …”
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Best practices in the management of thyroid dysfunction induced by immune checkpoint inhibitors by Ichiro Yamauchi, Daisuke Yabe

“…There is evidence that overt thyroid irAEs are associated with good prognosis, at least in non-small cell lung cancer. Although the clinical features have been well clarified, the management strategies require further refinement. …”
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A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. by Courtney A Granville, Regan M Memmott, Andria Balogh, Jacopo Mariotti, Shigeru Kawabata, Wei Han, Jaclyn Lopiccolo, Jason Foley, David J Liewehr, Seth M Steinberg, Daniel H Fowler, M Christine Hollander, Phillip A Dennis

“…These studies support clinical testing of rapamycin or other agents that target Treg in K-Ras driven human lung cancer.…”
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Biological Evaluation of Platinum(II) Sulfonamido Complexes: Synthesis, Characterization, Cytotoxicity, and Biological Imaging by Charini Maladeniya, Taniya Darshani, Sameera R. Samarakoon, Frank R. Fronczek, W. M. C. Sameera, Inoka C. Perera, Theshini Perera

“…Mammalian cell toxicity of ligands and complexes was assessed with NCI–H292 nonsmall-cell lung cancer cells. Further, C1 and C2 showed significantly low IC50 values compared with N(SO2azobenz)dpa and PtCl2(N(SO2quin)dpa). …”
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Predicting noncoding RNA and disease associations using multigraph contrastive learning by Si-Lin Sun, Yue-Yi Jiang, Jun-Ping Yang, Yu-Han Xiu, Anas Bilal, Hai-Xia Long

“…Additionally, this study has conducted case analyses using K-MGCMLD, which has validated the associations of all the top 30 miRNAs predicted to be associated with lung cancer and Alzheimer’s diseases.…”
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CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies by Lena Gockeln, Florian Wirsdörfer, Verena Jendrossek

“…Consolidation with PD-1/PD-L1-based immune checkpoint blockade after concurrent platinum-based chemo-radiotherapy has become the new standard of care for advanced stage III unresectable non-small cell lung cancer (NSCLC) patients. In order to further improve therapy outcomes, innovative combinatorial treatment strategies aim to target additional immunosuppressive barriers in the tumor microenvironment such as the CD73/adenosine pathway. …”
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Comparative analysis of alectinib and brigatinib in real-world treatment of advanced NSCLC with ALK rearrangements by Kyuhwan Kim, Kyu Yean Kim, Hye Seon Kang, Ah Young Shin, Sung Kyoung Kim, Chan Kwon Park, Sang Haak Lee, Seung Joon Kim, Jeong Uk Lim, Chang Dong Yeo

“…Background and objectives: This study aimed to compare the efficacy of the second-generation anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs) alectinib and brigatinib in the treatment of advanced non-small-cell lung cancer (NSCLC) with ALK rearrangements based on real-world data. …”
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PPARG Could Work as a Valid Therapeutic Strategy for the Treatment of Lung Squamous Cell Carcinoma by Shunbin Shi, Guiping Yu, Bin Huang, Yedong Mi, Yan Kang, Julia Pia Simon

“…Previous studies showed that PPAR-gamma (PPARG) ligands might serve as potential therapeutic agents for nonsmall cell lung cancer (NSCLC). However, a few studies reported the specific relationship between PPARG and lung squamous cell carcinoma (LSCC). …”
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Solitary metastasis in the internal auditory canal from non-small cell lung carcinoma: A case report by Julie De Boos, Marie Bruyneel, Ionela Bold

“…Discussion: IAC metastases are rare, representing only 0.3%–0.7 % of all lesions in this anatomical space. Lung cancer is a common primary source. Clinically, IAC metastases manifest with acute onset and rapid symptom progression, often mimicking benign conditions. …”
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Synthesis, Spectral Characterization, and Thermal and Cytotoxicity Studies of Cr(III), Ru(III), Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) Complexes of Schiff Base Derived from 5-H... by Amani S. Alturiqi, Abdel-Nasser M. A. Alaghaz, Reda A. Ammar, Mohamed E. Zayed

“…The cytotoxic activities of all inspected compounds were evaluated towards human breast (MCF-7) and lung cancer (A549) cell lines.…”
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An UPLC-MS/MS Method for Determination of Osimertinib in Rat Plasma: Application to Investigating the Effect of Ginsenoside Rg3 on the Pharmacokinetics of Osimertinib by Zhenzhen Ying, Jingyao Wei, Ruijuan Liu, Fang Zhao, Yifang Yu, Xin Tian

“…Osimertinib is a novel oral, potent, and irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for treatment of advanced T790M mutation-positive advanced non-small cell lung cancer, which is commonly combined with ginsenoside Rg3 in clinic to enhance the efficacy and minimize adverse reactions. …”
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Respiratory patient experience of measures to reduce risk of COVID-19: findings from a descriptive cross-sectional UK wide survey by Andrew Cumella, Nicholas S Hopkinson, Michael Laffan, Joe Farrington-Douglas, Keir EJ Philip

“…Long-term respiratory conditions reported included asthma (83%), chronic obstructive pulmonary disease (10%), bronchiectasis (4%), interstitial lung disease (2%) and ‘other’ (<1%) (eg, lung cancer and pulmonary endometriosis).Outcome measures Study responses related to impacts on key elements of healthcare, as well as practical, psychological and social consequences related to the COVID-19 pandemic and social distancing measures.Results 45% reported disruptions to care, including cancellations of appointments, investigations, pulmonary rehabilitation, treatment and monitoring. …”
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