Hepatitis associated with immune checkpoint inhibitors-based combinations of other therapies: A real-world pharmacovigilance analysis based on the FDA adverse event reporting syste... by Zhaohui Li, Zixiang Zhou, Nan Zhang, Binhe Tian, Xiangqi Chen, Haitao Zhao, Hanping Wang

“…Abstract Background The combination regimen with immune checkpoint inhibitors (ICIs) and other therapies has been widely applied for patients with non-small-cell lung cancer (NSCLC). To date, no literature has systematically addressed the risk of hepatitis associated with the combination therapy. …”
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Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer by Hang Lin, Lingzhi Qu, Hudie Wei, Ming Guo, Xiaojuan Chen, Qianmeng Lin, Huajun Zhang, Shuyan Dai, Yongheng Chen

“…Recently, bozitinib, a highly selective c-Met kinase inhibitor, has shown remarkable potency in selectively inhibiting MET-altered non-small cell lung cancer and secondary glioblastoma. In this study, we investigate the antitumor activity of bozitinib against MET-amplified gastric cancer and elucidate its molecular mechanism. …”
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Vision Improvement after Osimertinib Treatment in Paraneoplastic Optic Neuropathy Associated with Lung Adenocarcinoma by Masaomi Kubota, Nobumasa Tamura, Takaaki Hayashi, Euido Nishijima, Haruhiko Yanagisawa, Akira Kojima, Tadashi Nakano

“…Because the tumor tissue was found to be positive for the EGFR T790M resistance mutation by bronchoscopy, the EGFR-TKI treatment was changed to osimertinib, decreasing the size of the lung cancer lesions. Her BCVA improved to hand motion in BE. …”
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Cancer Burden Disease Attributable to PM2.5 and Health Risk by PM2.5-bound Toxic Species in Two Urban Chilean Municipalities by Ye Li, Franz Muñoz-lbañéz, Ana Maldonado-Alcaíno, Darby Jack, Beizhan Yan, Li Xu, Marco Acuña, Manuel Leiva-Guzman, Ana Valdés, Dante D. Cáceres

“…The attributable fraction (AF) of deaths due to lung cancer from long-term exposure to PM2.5 reached 54% (95% CI: 25–72) in Coyhaique vs. 43% (95% CI: 19–46) in Independencia. …”
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PET-Assessed Metabolic Tumor Volume Across the Spectrum of Solid-Organ Malignancies: A Review of the Literature by Anusha Agarwal, Chase J. Wehrle, Sangeeta Satish, Paresh Mahajan, Suneel Kamath, Shlomo Koyfman, Wen Wee Ma, Maureen Linganna, Jamak Modaresi Esfeh, Charles Miller, David C. H. Kwon, Andrea Schlegel, Federico Aucejo

“…Across various solid tumor malignancies, including lung cancer, head and neck cancer, breast cancer, esophageal cancer, and colorectal cancer, the current literature has demonstrated an association between MTV and various clinical outcomes. …”
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Efficacy and safety of NeoAdjuvant chemotherapy with or without tIslelizumab followed by debulking surgery for oVarian cancEr (NAIVE study) in China: study protocol of an open-labe... by Ying Zhu, Jianwei Zhou, Zhigang Zhang, Jiaojiao Zhang, Jing Fei, Xiaoqing Zhu

“…The combination of neoadjuvant immunotherapy with chemotherapy has recently demonstrated remarkable efficacy, particularly in melanoma and lung cancer, with notable pathological responses and therapeutic benefits in tumour tissue. …”
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Immune checkpoint inhibitor-induced diabetes mellitus: clinical characteristics and risk factors by Mei Zhan, Mei Zhan, Qinran Long, Qinran Long, Jinhan He, Jinhan He, Jinhan He, Litao Huang, Bin Wu, Bin Wu, Haixia Xu, Li Mo, Ting Xu

“…In all patients, hypertension, hyperlipidemia, using glucocorticoids or immunosuppressants, lung cancer, and using more than one pathway of ICI were associated with a higher risk of ICI-DM. …”
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An Integrated Approach for Conducting long-term PM2.5 Exposure and Health Impact Assessments for Residents of a City-scale by Ming-Shing Ho, Ming-Yeng Lin, Chih-Da Wu, Jung-Der Wang, Li-Hao Young, Hui-Tsung Hsu, Bing-Fang Hwang, Perng-Jy Tsai

“…By reference to the results obtained from MMS9yr, using AQMS9yr and h_LUR9yr would respectively lead to the underestimation of the attributed fraction (AFs) ~21%–36% and 18%–26% for the 5 disease burdens, including ischemic heart disease, stroke, chronic obstructive pulmonary disease, lung cancer, and lower respiratory tract infection. …”
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Dietary intake of tomato and lycopene, blood levels of lycopene, and risk of total and specific cancers in adults: a systematic review and dose–response meta-analysis of prospectiv... by Arghavan Balali, Kimia Fathzadeh, Gholamreza Askari, Omid Sadeghi, Omid Sadeghi

“…Also, an inverse association was observed between blood lycopene levels and lung cancer mortality (Pooled RR: 0.65, 95% CI: 0.45–0.94, I2 = 0, p = 0.022).ConclusionOur findings show that dietary intake and blood levels of lycopene are associated with a lower risk of cancer and death due to cancer.Clinical trial registrationCRD42023432400.…”
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Log odds of positive lymph nodes compared to positive lymph node ratio and number of positive lymph nodes in prognostic modeling for patients with NSCLC undergoing lobectomy or tot... by Qiming Huang, Shai Chen, Zhenjie Li, Longren Wu, Dongliang Yu, Linmin Xiong

“…BackgroundMethods such as the number of positive lymph nodes (nPLN), lymph node ratio (LNR), and log odds of positive lymph nodes (LODDS) are used to predict prognosis in patients with non-small cell lung cancer (NSCLC). We hypothesized that LODDS could be a superior independent predictor of prognosis and aimed to compare its effectiveness with nPLN and LNR in predicting survival outcomes in stage I-IIIA NSCLC patients.MethodsWe utilized data from the Surveillance, Epidemiology, and End Results (SEER) 17 registry (2010–2019) to study NSCLC patients, focusing on those who underwent surgery with confirmed lymph node involvement (N1 or N2 disease). …”
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Insights into the mechanisms of serplulimab: a distinctive anti-PD-1 monoclonal antibody, in combination with a TIGIT or LAG3 inhibitor in preclinical tumor immunotherapy studies by Yizhou Zhang, Ruicheng Wei, Ge Song, Xinyi Yang, Mengli Zhang, Wei Liu, Aiying Xiong, Xuehan Zhang, Qianhao Li, Wan-Jen Yang, Chencheng Han, Rui Liu, Chen Hu, Qingyu Wang, Jun Zhu, Yongqiang Shan

“…For instance, in the field of small cell lung cancer (SCLC) where the majority of anti-PD-1 antibodies have yielded limited success, serplulimab produced impressive survival improvements and was approved for this indication by China’s National Medical Products Administration. …”
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Development of delayed pulmonary toxicities and transcriptional changes in pre-existing interstitial lung disease mice after partial thoracic irradiation by Jiamei Fu, Xinglong Liu, Yuchuan Zhou, Shengnan Zhao, Liang Zeng, Yan Pan, Jianghong Zhang, Kevin M. Prise, Chunlin Shao, Yaping Xu

“…Abstract Background Lung cancer patients with comorbid interstitial lung disease (LC-ILD) have an increased risk of developing severe or even fatal radiation pneumonitis after thoracic radiotherapy. …”
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High tumor mutational burden predicts favorable response to anti-PD-(L)1 therapy in patients with solid tumor: a real-world pan-tumor analysis by Sehhoon Park, Jaeyun Jung, You Jeong Heo

“…Among TMB-H patients, the most common cancer type was colorectal cancer (n=108, 42.0%), followed by gastric cancer (GC; n=49, 19.1%), bladder cancer (n=21, 8.2%), cholangiocarcinoma (n=21, 8.2%), non-small cell lung cancer (n=17, 6.6%), melanoma (n=8, 3.1%), gallbladder cancer (GBC; n=7, 2.7%), and others (n=26, 10.1%). …”
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Personalized screening strategies for TP53 R337H carriers: a retrospective cohort study of tumor spectrum in Li-Fraumeni syndrome adult carriersResearch in context by Pedro A.F. Galante, Gabriela D.A. Guardia, Janina Pisani, Renata L. Sandoval, Mateus C. Barros-Filho, Ana Carolina Leite Vieira Costa Gifoni, Diogo F.C. Patrão, Patricia Ashton-Prolla, Vitor Fiorin de Vasconcellos, Claire Freycon, Arnold Levine, Pierre Hainaut, Maria Isabel Achatz

“…Common second malignancies were breast cancer in females and lung cancer in males. Interpretation: This study shows that R337H is associated with a lifetime risk of multiple LFS-spectrum cancers but with incomplete penetrance, particularly in males. …”
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Gambaran Pengetahuan dan Sikap Mahasiswa Fakultas Kedokteran Universitas Andalas tentang Rokok by Yosantaraputra ., Yanwirasti ., Abdiana .

“…Cigarette contains more than 4000 chemical compounds, in which 60of the mare carcinogenic. More than 85% of lung cancer patients are smokers. There are also some other cancers that has relationships withcigarettes. …”
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Cancer mortality and sectors of employment: a cohort study in Italy by Stefania Massari, Lisa Bauleo, Claudio Gariazzo, Paola Michelozzi, Luca Dei Bardi, Nicolas Zengarini, Sara Maio, Massimo Stafoggia, Marina Davoli, Giovanni Viegi, Giulia Cesaroni, Alessandro Marinaccio, on behalf of the BIGEPI Collaborative Group

“…In men we observed an increased mortality risk for stomach cancer in the printing and paper industry (HR = 1.69, 95% CI:1.11–2.57) as well as for stomach and lung cancer in cleaning activities (HR = 1.98, 95% CI:1.13–3.49 and HR = 1.55, 95% CI:1.22–1.98, respectively). …”
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Phosphorylation of SIRT7 by ATM causes DNA mismatch repair downregulation and adaptive mutability during chemotherapy by Lianhui Sun, Guangjian Fan, Zhuqing Zhang, Dong Chang, Xiaoyu Zhang, Tongqing Zhang, Jichuan Geng, Xiaoxia Zhang, Menghan Lin, Chen Hu, Jiaqi Zhou, Mengxue Wang, Liu Cao, Mary Zhang, Baokun He, Shengping Zhang, Chuangui Wang

“…Our study reveals a negative correlation between SIRT7 protein levels and MMR core protein MSH2 levels in cervical and lung cancer tissues. SIRT7 destabilizes MSH2, promoting MSI and mutagenesis. …”
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The infiltration risk prediction models by logistic regression for ground-glass pulmonary nodules: a systematic review and meta-analysis by Mengqian Li, Mengqian Li, Xiaomei Zhang, Yuxin Lai, Yunlong Sun, Tianshu Yang, Xinlei Tan

“…The independent risk factors included in the model can help medical workers to identify the high-risk groups of invasive lung cancer in ground-glass nodules in time and improve the prognosis.…”
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In vitro anticancer effects of frankincense and its nanoemulsions for enhanced cancer cell targeting by Rayya A. Al-Balushi, Aiswarya Chaudhuri, Raghuram Kandimalla, Ashanul Haque, Khalaf M. Alenezi, Mohd. Saeed, Mohammad Changez, Thuraya Al Harthy, Mohammed Al Hinaai, Samra Siddiqui, Ashish Kumar Agrawal, Farrukh Aqil, Farrukh Aqil

“…Cytotoxicity, wound healing, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) assays were performed against breast cancer (MDA-MB-231, MDA-MB-231-TR) and lung cancer (A549, A549-TR, H1299) cell lines.ResultsThe optimized FO-NEs exhibited an average particle size of 65.1 ± 4.21 nm, a PDI of 0.258 ± 0.04, and a zeta potential of −22.3 ± 1.2 mV. …”
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Deep learning-based synthetic CT for dosimetric monitoring of combined conventional radiotherapy and lattice boost in large lung tumors by Hongwei Zeng, Xiangyu E, Minghe Lv, Su Zeng, Yue Feng, Wenhao Shen, Wenhui Guan, Yang Zhang, Ruping Zhao, Jingping Yu

“…Methods This study employed cone-beam computed tomography from 115 lung cancer patients to develop a U-Net +  + deep learning model for generating synthetic CT (sCT). …”
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