Is Whole‐Brain Radiotherapy for Brain Metastases an Overestimated Therapy? A Retrospective Study of Real‐World Data Using Landmark Analyses by Florian Hoelzl, Oliver Koelbl, Isabella Gruber

“…Results The median patient age was 62 years. Non‐small cell lung cancer (n = 95), breast cancer (n = 53), and small cell lung cancer (n = 48) were the most frequent cancer types. …”
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NT5E Mediates Cisplatin Resistance in NSCLC Through the PI3K-AKT Signaling Pathway by Liangfeng Zheng, Jian Liu, Feiyue Ji, Chunxiang Li, Ye Qian, Lili Shao, Xiaomin Lu

“…This finding provides important insights for a deeper understanding of the mechanism of drug resistance in lung cancer and serves as a theoretical basis for the development of new therapeutic strategies and drugs.…”
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Paraneoplastic Mononeuritis Multiplex as a Presenting Feature of Adenocarcinoma of the Lung by Esra Ekiz, Abdullah Ozkok, Nazan Kader Ertugrul

“…Neurologic syndromes in lung cancer include Lambert-Eaton myasthenic syndrome, polyneuropathy, cerebellar degeneration, and rarely mononeuritis multiplex. …”
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Colorectal cancer: state-of-the-art by Ya. S. Tsimmerman

“…CRC is the 2nd most common cause of morbidity after the lung cancer. It includes hereditary non-polyposis CRC (Lynch syndrome), hereditary CRC at familial adenomatosis and sporadic (non-hereditary) CRC. …”
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Chemoradiation-Induced Superior Vena Cava Syndrome: A Case Report by Mathieu Castonguay, George Rodrigues, Mark Vincent, Richard A Malthaner, Lin-Ruo Guo

“…A case of a 54-year-old man who developed superior vena cava syndrome secondary to vascular fibrosis, 30 months after radical chemoradiation for stage III non-small cell lung cancer, is presented. The literature regarding the etiology, diagnosis and treatment of this rare entity is discussed.…”
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Indications, contributing factors, and short-term outcomes of pneumonectomy: an 8-year retrospective study in a resource-limited setting by Mekonnen Feyissa Senbu, Dereje Gulilat, Hiwot Tadesse Habtamu

“…Today, pneumonectomy is primarily indicated for non-small cell lung cancer (NSCLC) worldwide. However, it carries a higher risk of morbidity and mortality compared to less extensive lung resections. …”
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Brief Report: Precision Language and Deletion of the “S” Word by Ciara Lockstadt, MD, Mary M. Pasquinelli, DNP, Jill Feldman, MD, Jamie L. Studts, PhD, Jamie S. Ostroff, PhD, Li Liu, PhD, Ella A. Kazerooni, MD, Robert A. Smith, PhD, Lisa Carter-Bawa, PhD, Lawrence E. Feldman, MD

“…Introduction: In 2021, the International Association for the Study of Lung Cancer (IASLC) published the IASLC Language Guide as guidance on preferred language and phrasing in oral and written communications, including presentations at conferences. …”
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Dried Apricot Polyphenols Suppress the Growth of A549 Human Lung Adenocarcinoma Cells by Inducing Apoptosis via a Mitochondrial-Dependent Pathway by Caiyun Zhao, Jingteng Wang, Jintian Guo, Wenjing Gao, Bin Li, Xin Shang, Li Zheng, Bin Wu, Yinghua Fu

“…Meanwhile, tumor growth was also inhibited by DAPs in an A549 tumor-bearing mouse model, Bax and caspase-3 were upregulated, and Bcl-2 was downregulated, inducing apoptosis of lung cancer cells. In conclusion, DAPs could inhibit lung cancer cell growth by inducing apoptosis due to cell cycle arrest and mitochondria-dependent pathways.…”
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Alerting the illusion of smoking improves quality of life in Chinese male cancer survivors by Juan Xia, Peng Wu, Jiwei Wang, Jinming Yu

“…As for smoking cessation, the proportion of lung cancer survivors who quit smoking was higher than that of other types of cancer survivors. …”
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CAR-T therapy for endocrine neoplasms: novel targets and combination of therapies by Fang Wang, Ruiqi Zhang, Zhaokai Zhou, Run Shi, Fu Peng, Yudi Xu, Shuai Yang, Zhan Wang, Pengpeng Zhang, Rui Tu, Chun Zhang, Xingchen Liu, Jun Cai

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KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC by Jinghan Li, Daiwang Shi, Siyi Li, Xiang Shi, Yu Liu, Yi Zhang, Gebang Wang, Chenlei Zhang, Tian Xia, Hai-long Piao, Hong-Xu Liu

“…Abstract Immunotherapy has become a prominent first-line cancer treatment strategy. In non-small cell lung cancer (NSCLC), the expression of PD-L1 induces an immuno-suppressive effect to protect cancer cells from immune elimination, which designates PD-L1 as an important target for immunotherapy. …”
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Dose-response risks of all-cause, cancer, and cardiovascular disease mortality according to sex-specific cigarette smoking pack-year quantiles by Jieun Hwang, Suyoung Jo, Heewon Kang, Eunsil Cheon, Sung-il Cho

“…Among men, HR for death from lung cancer was 3.13 (95% CI: 2.06– 4.75) in former smokers and tended to increase with each pack-year quantile (range HR: 5.72–17.11). …”
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Assessing Lung and Skin Cancer Risks for Steel and Iron Manufacturing Industry Workers Exposed to Polycyclic Aromatic Hydrocarbons by Ying-Fang Wang, Yu-Chieh Kuo, Ming-Yeng Lin, Perng-Jy Tsai

“…The estimated lifetime excessive lung cancer risks for the latter (2.09 × 10−3) were lower than that of the former (3.43 × 10-3–8.84 × 10−3), they were all higher than the significant risk (10−3) defined by the US Supreme Court. …”
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EGFR-Mutated Lung Adenocarcinoma With Li–Fraumeni Syndrome: The Imperative for Germline Testing in Patients With a Family History, a Case Report by Hiroyuki Fujii, MD, Yusuke Okuma, MD, PhD, Makoto Hirata, MD, PhD, Yuki Shinno, MD, PhD, Tatsuya Yoshida, MD, PhD, Yasushi Goto, MD, PhD, Hidehito Horinouchi, MD, PhD, Noboru Yamamoto, MD, PhD, Yuichiro Ohe, MD, PhD

“…Further research is warranted to delineate the impact of germline variants on treatment outcomes and secondary cancer prevention in lung cancer.…”
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Long-Term Oncological Outcomes Related to Lymphadenectomy in Clinical Stage I NSCLC: A Multicenter Retrospective Experience by Beatrice Manfredini, Carmelina Cristina Zirafa, Alessandro Stefani, Gaetano Romano, Greta Alì, Riccardo Morganti, Ilaria Ceccarelli, Federico Davini, Pier Luigi Filosso, Franca Melfi

“…Background: Lymphadenectomy is considered a key part of the radical treatment of resectable lung cancer, although its appropriate extension in early stages is a debated topic due to the great heterogeneity of studies in the literature. …”
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Research on Lung Nodule Detection Based on Improved Target Detection Network by Ye Li, Qian Wu, Hongwei Sun, Xuewei Wang

“…Lung nodules are an early symptom of lung cancer. The earlier they are found, the more beneficial it is for treatment. …”
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A Role of Three-Dimensional (3D)-Reconstruction in the Classification of Lung Adenocarcinoma by Maristela L. Onozato, Veronica E. Klepeis, Yukako Yagi, Mari Mino-Kenudson

“…However, the high-resolution images of large object areas and different fields of view obtained by 3D-reconstruction make one wonder whether it can add a new insight into lung adenocarcinoma, the most frequent histology type of lung cancer characterized by its morphological heterogeneity.…”
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Nivolumab-Induced Encephalitis in Hereditary Leiomyomatosis and Renal Cell Cancer Syndrome by Benjamin Chaucer, Abriella Stone, Augustus Demanes, Shawn M. Seibert

“…Nivolumab is one of the chemotherapeutic agents commonly used for treatment of renal cell carcinoma, metastatic melanoma, and metastatic non-small cell lung cancer. While common side effects are known and well documented, encephalitis is documented as an extremely rare side effect. …”
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The Antiapoptotic RBM5/LUCA-15/H37 Gene and Its Role in Apoptosis and Human Cancer: Research Update by Mirna M Maarabouni, Gwyn T Williams

“…The candidate tumour-suppressor gene, LUCA-15/RBM5/H37, maps to the lung cancer tumour-suppressor locus 3p21.3. The LUCA-15 gene locus encodes at least four alternatively spliced transcripts that have been shown to function as regulators of apoptosis, a fact which may have major significance in tumour regulation. …”
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Colonic Metastasis with Anemia Leading to a Diagnosis of Primary Lung Adenocarcinoma by Vasa Jevremovic, Amer Abboud, Stuart Krauss

“…It is extremely rare for lung cancer to present with symptoms of a gastrointestinal metastasis and even more so pertaining to the colon. …”
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