PAX6 enhances Nanog expression by inhibiting NOTCH signaling to promote malignant properties in small cell lung cancer cells by Xiao-Fang Guo, Ling-Ling Wang, Fei-Meng Zheng, He-Ping Li

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Small Interfering RNA Targeted to ASPP2 Promotes Progression of Experimental Proliferative Vitreoretinopathy by Xiao-Li Chen, Yu-Jing Bai, Qin-Rui Hu, Shan-Shan Li, Lv-Zhen Huang, Xiao-Xin Li

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Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…The flavonoid polyphenol luteolin (LU) has anti-inflammatory and antidiabetes activities, but its effects regarding retinal protection remain unknown. …”
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Визначення віку людини за фото на основі нейронних мереж by Євгеній Вербенко, Ольга Мацуга

“…AlexNet впровадив використання ReLU-активації, dropout та max-pooling, тоді як VGG-19 підкреслив глибші архітектури з малими фільтрами. …”
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Single-cell sequencing uncovers the mechanistic role of DAPK1 in glioma and its diagnostic and prognostic implications by Tian-Hang Yu, Yan-Yu Ding, Yan-Yu Ding, Si-Guo Zhao, Jie-Hui Zhao, Yu Gu, Dong-Hui Chen, Fang Zhang, Wen-Ming Hong, Wen-Ming Hong

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Geographical origin traceability of kiwifruit products using stable isotope and multi-element analysis with multivariate modeling: Feature extraction, selection of model and variab... by Wang Shuanhui, Chen Chang, Tian Jing, Liu Zhi, Mei Xianxian, Zhou Jialu, Wang Dongguang, Zhu Shaohua

“…Supervised methods, partial least squares-discriminant analysis (PLS-DA) and its derivative algorithm (OPLS-DA), linear discriminant analysis (LDA), enhanced identification performance and finally elevated the accuracies to 100 % for all kiwifruit origins. Lu, Tb, Eu, Ho, Pm, Y, δ34S, δ2H, δ15N, Mg, Se were main contributive variables for LDA modeling (AUC value >0.5). …”
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Exploring the antimicrobial and antioxidative potential of Leucas aspera (Willd.) link: Phytochemical screening, molecular docking, and HR-LC/MS profiling against SARS-CoV-2 protei... by Thavasiaanatham Seenivasan Shalini, Ragothaman Prathiviraj, Poomalai Senthilraja

“…Molecular docking of the 19 compounds against the SARS-CoV-2 main protease (3CLPro) protein (PDB ID: 6LU7) and spike protein receptor binding domain (SGp-RBD) protein (PDB ID: 2GHV) revealed Famprofazone and Loxtidine compounds having the highest binding affinity with LibDock scores of 105.53 and 116.70 respectively. …”
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An Efficient 3D Convolutional Neural Network for Dose Prediction in Cancer Radiotherapy from CT Images by Lam Thanh Hien, Pham Trung Hieu, Do Nang Toan

“…To ensure that the predicted doses do not have negative values, which are not valid for radiation doses, a rectified linear unit (ReLU) function is applied to the output to convert negative values to zero. …”
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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn’s Disease by Yang X, Pan Y, Gao CP, Li H, Zhang YH, Huang CL, Cao L, Xiao SY, Zhou Z

“…Xue Yang,* Yan Pan,* Cai-Ping Gao, Hang Li, Ying-Hui Zhang, Chun-Li Huang, Lu Cao, Shi-Yu Xiao, Zhou Zhou Department of Gastroenterology, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhou Zhou; Shi-Yu Xiao, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People’s Republic of China, Email doublezhouu2006@163.com; xiaoshiyu57@163.comPurpose: Intestinal fibrous stenosis due to Crohn’s disease (CD) is highly prevalent. …”
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Single-cell sequencing elucidates the mechanism of NUSAP1 in glioma and its diagnostic and prognostic significance by Meng-Yu Zhao, Zhao-Lei Shen, Hongzhen Dai, Wan-Yan Xu, Li-Na Wang, Yu- Gu, Jie-Hui Zhao, Tian-Hang Yu, Cun-Zhi Wang, Jia-feng Xu, Guan-Jun Chen, Dong-Hui Chen, Wen-Ming Hong, Wen-Ming Hong, Fang Zhang

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Renaissance Man, Man of his Times: Norman Mailer’s "The White Negro" and Literary Manhood in 1950s America by Matthew Kriz

“…Il propose que l’essai soit lu comme une condamnation de la définition de la masculinité dans les années 50, la solution donnée par Mailer à ce problème étant la libération sexuelle, ce qui équivaut à un repositionnement de la masculinité américaine, qui n’est pas vue uniquement comme définie par une classe moyenne blanche hétérosexuelle.…”
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Genetic Structure of Endangered Species <i>Anagallis foemina</i> Mill. and Abundant Weed <i>Anagalis arvensis</i> L. Occurring in Segetal Habitats in South-Eastern Poland by Ewa Kwiecińska-Poppe, Sylwia Sowa, Joanna Lech, Małgorzata Haliniarz, Edyta Paczos-Grzęda

“…Within the <i>A. foemina</i> group, two subgroups were distinguished: the first subgroup included genotypes from the Lublin Upland (LU) and Volhynian Polesie (VP), while the second subgroup consisted of genotypes from Western Volhynian Upland (VU). …”
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Nanoliposomal L-Asparaginase and Its Antitumor Activities in Lewis Lung Carcinoma Tumor-Induced BALB/c Mice by Thi Thao Do, Thi Phuong Do, Thi Nga Nguyen, Thi Cuc Nguyen, Thi Thu Phuong Vu, Thi Giang An Nguyen

“…The in vitro cytotoxic activity of liposomal L-ASP was less effective against LLC, MCF-7 (human breast carcinoma), HepG2 (human hepatocellular carcinoma), SK-LU-1 (human lung carcinoma), and NTERA-2 (pluripotent human embryonic carcinoma) cells than that of free L-ASP. …”
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Esketamine at a Clinical Dose Attenuates Cerebral Ischemia/Reperfusion Injury by Inhibiting AKT Signaling Pathway to Facilitate Microglia M2 Polarization and Autophagy by Gao Y, Li L, Zhao F, Cheng Y, Jin M, Xue FS

“…Ying Gao,1 Lu Li,1 Fang Zhao,1 Yi Cheng,1 Mu Jin,2 Fu-Shan Xue1,3 1Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Anesthesiology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital, Fujian Provincial Hospital, Fuzhou, People’s Republic of ChinaCorrespondence: Mu Jin, Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, No. 2 An-Zhen Road, Chao-Yang District, Beijing, 100029, People’s Republic of China, Tel +86-13366600987, Email jinmu0119@hotmail.com Fu-Shan Xue, Department of Anesthesiology, Beijing Friendship Hospital, Capital Medical University, No. 95 Yong-An Road, Xi-Cheng District, Beijing, 100050, People’s Republic of China, Tel +86-13911177655, Fax +86-591-88217841, Email xuefushan@aliyun.com; xuefushan@mail.ccmu.edu.cnPurpose: This study aimed to assess the protective effect of a clinical dose esketamine on cerebral ischemia/reperfusion (I/R) injury and to reveal the potential mechanisms associated with microglial polarization and autophagy.Methods: Experimental cerebral ischemia was induced by middle cerebral artery occlusion (MCAO) in adult rats and simulated by oxygen-glucose deprivation (OGD) in BV-2 microglial cells. …”
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Àgbéyẹ̀wò Ipa àti Ipò Àwọn Ọmọdé Nínú Ìpohùn Òrìṣà Ẹgbẹ́ Ọ̀gbà ní Agbègbè Yewa-Awórì, Ẹ̀gbá, àti Ìjẹ̀bú by Sauban Alade Isola

“…Iṣé ̣ yìí tún ṣe àfi ̣ - hàn àwọn ìdí pàtàkì tí wón fi ń ṣe ọdún ìbílè ̣ fún Òrìṣà Ẹgbé ̣ gẹ́ gẹ́ bí èyí tí wó ̣ n ̣ 294 Ishọla gbé àwọn ìpohùn inú rè kalè ̣ fún è ̣ kọ́ ẹ̀ sìn, ìwà ọmọlúàbí, àṣà àti ìṣe pè ̣ lú oríṣìí ̣ àwọn ìlànà ìbara-ẹni-gbépò fún àwọn ọmọ wọn. …”
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Rhein Mitigates Lung Injury in Severe Acute Pancreatitis Through the Inhibition of MARK4-Mediated Microtubule Destabilization by Sun Z, Liu J, Ge P, Cao Y, Liu J, Wen H, Luo X, Pei B, Jin Z, Li H, Xun L, Luo Y, Yang Q, Chen H

“…Zhenxuan Sun,1– 3,&ast; Jie Liu,1– 3,&ast; Peng Ge,1– 3,&ast; Yinan Cao,4 Jin Liu,1– 3 Haiyun Wen,1– 3 Xinyu Luo,1– 3 Boliang Pei,1– 3 Zuocang Jin,1,3 Huijuan Li,3 Lu Xun,1– 3 Yalan Luo,5 Qi Yang,6 Hailong Chen1– 3 1Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 2Institute (College) of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 3Laboratory of Integrative Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 4Day Surgery Center, Dalian Municipal Central Hospital, Dalian, Liaoning, 116033, People’s Republic of China; 5Department of Gastroenterology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116011, People’s Republic of China; 6Department of Traditional Chinese Medicine, The Second Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, 116023, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hailong Chen, Department of General Surgery, The First Affiliated Hospital of Dalian Medical University, Zhongshan Road 222, Dalian, Liaoning, 116011, People’s Republic of China, Tel +86 411 83635963, Fax +86 411 83622844, Email chenhailong@dmu.edu.cnPurpose: Explore the therapeutic effect and molecular mechanism of rhein on severe acute pancreatitis associated acute lung injury (SAP-ALI).Methods: The SAP-ALI rat model was constructed by retrograde injection of 5% sodium taurocholate into the pancreaticobiliary duct, and pulmonary microvascular endothelial cell (PMVEC) injury model was induced by LPS. …”
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Àkànlò-èdè Tuntun Nínú Àwọn Orin Ọ ̀ dọ ́ Ìwòyí by Dayo Akanmu

“…Nínú ìtúpalè wa ni ó ti hàn pé àwọn o ̣ ̣ ̀ kọrin tàka-súfèé òde-òní fe ̣ ́ ràn láti máa ṣe àmúlò àkànlò èdè Yorùbá tuntun bí i ‘oúnjẹ ọmọ’ (fún obìnrin tí ó ní ọyàn ńlá èyí tí ó bù kún ẹwà a rè ), ‘je ̣ ̣ ̀ wà’ (s ̣ ̀ ewo ̣ ̀ n), ‘ojúẹle ̣ ́ gba’ (oluko, ará oko èèyàn tàbí ẹni tí ojú re ̣ ̀ dúdú), ‘gbé bo ̣ ́ dì ẹ’ (lo ọpọlọ tàbí ọgbo ̣ ́ n orí ẹ) àti ‘yàúyàhúù’ (àwọn tí ó ń fi e ̣ ̀ rọ ayélujára lu jìbìtì) ge ̣ ́ ge ̣ ́ bí o ̣ ̀ nà ìbániso ̣ ̀ ro ̣ ̀ àti ìdánilárayá. …”
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Takdim by Halil Burak Sakal, Merve Yildiz

“…Modern Çin edebiyatının önemli yazarlarından olan Lu Xun'un eserleri üzerinden Çin medeniyetindeki birey ve toplum anlayışının ele alındığı çalışmada gelenekten modernizme geçişte yaşanan zorluklara yer verilmiştir. …”
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Effects of pesticide dichlorvos on liver injury in rats and related toxicity mechanisms by Pengcheng Zhang, Zixian Zhou, Jiaqi Yao, Yuhong Jiang, Hang Lei, Zhijun Xie, Juan Li, Xianlin Zhao, Lv Zhu, Meihua Wan, Ling Liu, Wenfu Tang

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Association Between Liver Fibrosis and Risk of Incident Stroke and Mortality: A Large Prospective Cohort Study by Zijie Wang, Zhitao Gong, Jianshang Wen, Shanyu Zhang, Xiao Hu, Wenliang Guo, Yanghua Tian, Qi Li

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