Impaired RelA signaling and lipid metabolism dysregulation in hepatocytes: driving forces in the progression of metabolic dysfunction-associated steatotic liver disease by Yihuai He, Jinlian Jiang, Lili Ou, Yunfen Chen, Aikedaimu Abudukeremu, Guimei Chen, Weiwei Zhong, Zhigang Jiang, Nuerbiye Nuermaimaiti, Yaqun Guan

“…In conclusion, impaired RelA signaling and disrupted lipid metabolism form a detrimental feedback loop in hepatocytes that promotes MASLD progression. …”
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Hot and cold exposure triggers distinct transcriptional and behavioral responses in laboratory-inbred pond snails by Veronica Rivi, Anuradha Batabyal, Cristina Benatti, Fabio Tascedda, Johanna Maria Catharina Blom, Ken Lukowiak

“…These data suggest, albeit at the transcriptional level, the existence of a negative feedback loop necessary for sustaining cellular functions when metabolic demands might shift towards conserving energy during prolonged cold exposure. …”
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Enhanced AC/DC optimal power flow via nested distributed optimization for AC/VSC-MTDC hybrid power systems by Haixiao Li, Pedro P. Vergara, Robert Dimitrovski, Hongjin Du, Aleksandra Lekić

“…Subsequently, a nested distributed optimization method with double iteration loops is developed to offer optimal system-wide decision-making through a more “thorough” distributed communication architecture. …”
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Are Suggested Hiking Times Accurate? A Validation of Hiking Time Estimations for Preventive Measures in Mountains by Marco Vecchiato, Nicola Borasio, Emiliano Scettri, Vanessa Franzoi, Federica Duregon, Sandro Savino, Andrea Ermolao, Daniel Neunhaeuserer

“…<i>Materials and Methods</i>: A cross-sectional analysis was conducted using data from 25 Italian loop trails selected via the Wikiloc platform, considering user-uploaded GPS data from at least 20 users per trail. …”
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Inhibition of inflammatory cell infiltration by antagonistic peptides that specifically bind to CCR5 via regulation of the NF-kB signaling pathway in rats with colitis by Yang-Da Song, Yi-Hang Song, Si-Xue Liu, Hua-Rong Huang, Ying-Qiang Zhong

“…Previously, we synthesized two peptides (GH and HY peptides) that specifically bind to the first and the second extracellular loops (ECL1 and ECL2, respectively) of CCR5 and preliminarily found an inhibitory effect of these peptides on colitis. …”
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Retinoblastoma-binding Protein 9 Suppresses Intestinal Inflammation and Inflammation-induced Tumorigenesis in MiceSummary by Kensuke Hamada, Yuki Nakanishi, Yu Muta, Mayuki Omatsu, Kosuke Iwane, Munehiro Ikeda, Jiayu Chen, Yoko Masui, Naoki Aoyama, Nobukazu Agatsuma, Go Yamakawa, Takahiro Utsumi, Hiroki Kitamoto, Makoto Okabe, Yoshiro Itatani, Takumi Adachi, Koubun Yasuda, Shuji Yamamoto, Akihisa Fukuda, Etsushi Kuroda, Masaki Ohmuraya, Kazutaka Obama, Seiichi Hirota, Hiroki Ikeuchi, Kenji Nakanishi, Hiroshi Seno

“…An in vitro kinase assay revealed that RBBP9 directly regulated JAK/STAT1 signaling by suppressing STAT1 phosphorylation. A positive feedback loop involving epithelial cell apoptosis, commensal microbiome invasion, and activation of submucosal immune activity was identified in Rbbp9-/- mouse intestines through enhanced JAK/STAT1 signaling in RBBP9-deficient epithelial cells and macrophages. …”
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Changes in sediment connectivity and its impact on sediment transport in a typical watershed of Southern Jiangxi Province, China by Fei Sheng, Tingxin Yi, Yanyan Wang, Haijin Zheng, Shiyu Liu, Xiaofei Nie, Longsong Hu, Haifeng Li

“…Under single rainstorm conditions, the proportion of each runoff-sediment loop curve varied greatly across different periods. …”
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Spatial and single-cell transcriptomics reveal cellular heterogeneity and a novel cancer-promoting Treg cell subset in human clear-cell renal cell carcinoma by Lijuan Wang, Qian He, Weijun Qin, Xiyu Song, Yumeng Zhu, Wenwen Geng, Jianhua Jiao, Hongjiao Liu, Ruo Chen, Xiuxuan Sun, Jiejie Geng, Zhinan Chen

“…They were colocalized with MRC1+FOLR2+ tumor-associated macrophages (TAMs) at the tumor-normal interface to form a positive feedback loop, maintaining a synergistic procarcinogenic effect. …”
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A participatory needs assessment to map the system dynamics of overweight related behaviours of 10-14-year-old adolescents living in an underserved neighbourhood in Amsterdam, the... by Helga Emke, Rabab Chrifou, Coosje Dijkstra, Wilma Waterlander, Karien Stronks, Stef Kremers, Mai Chinapaw, Teatske Altenburg

“…These adolescents acted as co-researchers and created Causal Loop Diagrams (CLDs) for each EBRB and explored important underlying mechanisms for unhealthy EBRBs. …”
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LoCS-Net: Localizing convolutional spiking neural network for fast visual place recognition by Ugur Akcal, Ugur Akcal, Ugur Akcal, Ivan Georgiev Raikov, Ekaterina Dmitrievna Gribkova, Ekaterina Dmitrievna Gribkova, Anwesa Choudhuri, Anwesa Choudhuri, Seung Hyun Kim, Mattia Gazzola, Rhanor Gillette, Rhanor Gillette, Ivan Soltesz, Girish Chowdhary, Girish Chowdhary, Girish Chowdhary

“…Our approach offers a simpler training pipeline while yielding significant improvements in both training and inference times compared to SOTA SNNs for VPR. Hardware-in-the-loop tests using Intel's neuromorphic USB form factor, Kapoho Bay, show that our on-chip spiking models for VPR trained via the ANN-to-SNN conversion strategy continue to outperform their SNN counterparts, despite a slight but noticeable decrease in performance when transitioning from off-chip to on-chip, while offering significant energy efficiency. …”
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Characteristics, Mortality, and Clinical Outcomes of Hospitalized Patients with COVID-19 and Diabetes: A Reference Single-Center Cohort Study from Poland by Michał Kania, Konrad Mazur, Michał Terlecki, Bartłomiej Matejko, Jerzy Hohendorff, Zlata Chaykivska, Mateusz Fiema, Marianna Kopka, Małgorzata Kostrzycka, Magdalena Wilk, Tomasz Klupa, Przemysław Witek, Barbara Katra, Marek Klocek, Marek Rajzer, Maciej T. Malecki

“…In a multivariate logistic regression, factors associated with a higher risk of death were age >65 years, glycaemia >10 mmol/L, CRP and D-dimer level, prehospital insulin and loop diuretic use, presence of heart failure, and chronic kidney disease. …”
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Dielectric Temperature Stability and Enhanced Energy-Storage Performance of Sr_0.4Ba_0.6(Zr_0.2Ti_0.2Sn_0.2Ta_0.2Nb<sub>... by Yingying Zhao, Ziao Li, Shiqiang Yang, Pu Mao, Ruirui Kang

“…Additionally, the SBN40-H ceramics exhibit slim P–E loops with negligible hysteresis, which is considered to be related to the existence of weakly coupled relaxors. …”
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Targeting CXCL8 signaling sensitizes HNSCC to anlotinib by reducing tumor-associated macrophage-derived CLU by Xin Hu, Yikang Ji, Mi Zhang, Zhihui Li, Xinhua Pan, Zhen Zhang, Xu Wang

“…Conclusion Our results provide novel evidence of a feedback loop between cancer cells and TAMs in glucose-deficient regions. …”
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Nailfold Capillaroscopy in Early Stages of Mixed Connective Tissue Disease in a Sample of Egyptian Patients by Yasser A Elmotaleb Gazar, Hesham Salah Hamoud, Sherif Mohamed Ismail

“…Nailfold examination for the study subjects was performed describing architectural derangement, capillary density changes, mega capillary and enlarged loops, microhemorrhages, and angiogenesis. Results: Of the sixty patients studied, 49 (81.7%) patients were females and 11 were males with a mean age of 31 years with a median of 29.5 and range 16–52 years. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…Atonal homolog 1 (Atoh1) is a transcription factor of the basic helix-loop-helix (bHLH) family essential for neurogenesis in the cerebellum, auditory hair cell differentiation, and intestinal stem cell specification. …”
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Pooled prevalence and associated factors of traditional uvulectom among children in Africa: A systematic review and meta-analysis. by Solomon Demis Kebede, Kindu Agmas, Demewoz Kefale, Amare Kassaw, Tigabu Munye Aytenew

“…The reuse of unsafe tools such as blades, needles, or thread loops exacerbates the spread of infectious diseases like HIV and hepatitis B. …”
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Structural equation modeling of the impact of disease activity on inflammatory bowel disease control: the mediating roles of self-efficacy and self-management behaviors by Yongli Zhu, Ke Liu, Jinfeng Jiang, Xin Cheng, Hao Wang, Feiyang Long, Kang Li, Changping Mu, Lijun Cui

“…High disease activity may reduce chronic disease management self-efficacy, impairing IBD control. Positive feedback loops involving self-management behaviors and enhanced self-efficacy are crucial for better disease control, as patients who perceive positive outcomes are more motivated to maintain these behaviors.…”
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Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis by Shasha Huang, Shumin He, Fei Xiao, Yang Zhou, Su Lyu

“…Circular RNAs (circRNAs) are highly stable in peripheral blood due to their special closed-loop structure, and reports have described their involvement in regulating inflammatory responses and cell injury in cardiomyocytes. …”
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Patient-Generated Collections for Organizing Electronic Health Record Data to Elevate Personal Meaning, Improve Actionability, and Support Patient–Health Care Provider Communicatio... by Drashko Nakikj, David Kreda, Karan Luthria, Nils Gehlenborg

“…Finally, collections might produce a misconstrued health picture, but bringing the physician in the loop for verification could increase their clinical validity. …”
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A Nanoparticle Comprising the Receptor-Binding Domains of Norovirus and <i>Plasmodium</i> as a Combination Vaccine Candidate by Ming Xia, Pengwei Huang, Frank S. Vago, Wen Jiang, Xi Jiang, Ming Tan

“…Methods: We generated a unique P₂₄-αTSR NP by inserting the αTSR domain into a surface loop of the P domain. The P-αTSR fusion proteins were produced in the <i>Escherichia coli</i> expression system and the fusion protein self-assembled into the P₂₄-αTSR NP. …”
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