Targeting PCSK9, through an innovative cVLP-based vaccine, enhanced the therapeutic activity of a cVLP-HER2 vaccine in a preclinical model of HER2-positive mammary carcinoma by Laura Scalambra, Francesca Ruzzi, Olga Maria Pittino, Maria Sofia Semprini, Chiara Cappello, Stefania Angelicola, Arianna Palladini, Patrizia Nanni, Louise Goksøyr, Cyrielle Fougeroux, Manuel L. Penichet, Adam Frederik Sander, Pier-Luigi Lollini

“…Proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is a novel therapeutic strategy for the management of dyslipidemia by enhancing the clearance of low-density lipoprotein cholesterol receptors, however recent evidence also shows links between PCSK9 and cancer cells. We present an innovative immunization approach combining capsid virus-like particle (cVLP)-based vaccines against HER2 and PCSK9. …”
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A novel methodology for assessing the hygroscopicity of aerosol filter samples by N. Raparthi, A. S. Wexler, A. S. Wexler, A. S. Wexler, A. S. Wexler, A. M. Dillner

“…This method uses the same filter sample for both hygroscopicity measurements and chemical characterization, thereby providing an opportunity to link the measured hygroscopicity with ambient particle composition. …”
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Genomic insights into genetic diversity and seed coat color change in common bean composite populations by Eva Plestenjak, Eva Plestenjak, Mohamed Neji, Lovro Sinkovič, Vladimir Meglič, Barbara Pipan

“…Key GO terms included phosphatidylinositol-biphosphate binding, exocytosis, and vesicle-mediated transport, suggesting a link between cellular transport and pigment deposition in the seed coat.DiscussionThe study demonstrates significant genetic diversity within and among common bean composite populations, with KIS_Amand and SRGB_00366 exhibiting the highest phenotypic and genetic variability. …”
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Speciation of Potentially Carcinogenic Trace Nickel(II) Ion Levels in Human Saliva: A Sequential Metabolomics-Facilitated High-Field ¹H NMR Investigation by Kayleigh Hunwin, Georgina Page, Mark Edgar, Mohammed Bhogadia, Martin Grootveld

“…<b>Conclusions:</b> The results acquired demonstrated the value of linking advanced experimental design and multivariate metabolomics/statistical analysis techniques to ¹H NMR analysis for such speciation studies. …”
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Integrated analysis of the prevalence and influencing factors of poststroke dysphagia by Xiaopeng Wen, Baochao Fan, Jie Zhan, Hao Wen, Huihui Ban, Yujiao Yang, Chenyang Tao, Cui Li, Kunbin Li, Liming Lu

“…More high-quality epidemiological research is needed to explore the links between PSD, demographic characteristics, and stroke-related factors. …”
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Nine draft genome sequences of Claviceps purpurea s.lat., including C. arundinis, C. humidiphila, and C. cf. spartinae, pseudomolecules for the pitch canker pathogen Fusarium circi... by Brenda D. Wingfield, Miao Liu, Hai D. T. Nguyen, Frances A. Lane, Seamus W. Morgan, Lieschen De Vos, P. Markus Wilken, Tuan A. Duong, Janneke Aylward, Martin P. A. Coetzee, Kasia Dadej, Z. Wilhelm De Beer, Wendy Findlay, Minette Havenga, Miroslav Kolařík, Jim G. Menzies, Kershney Naidoo, Olivia Pochopski, Parivash Shoukouhi, Quentin C. Santana, Keith A. Seifert, Nicole Soal, Emma T. Steenkamp, Catherine T. Tatham, Margriet A. van der Nest, Michael J. Wingfield

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Characterization of cellular immune system at different ages in water buffalo (Bubalus bubalis) by Maria C. Scata’, Giovanna De Matteis, Francesco Grandoni, Gabriele Di Vuolo, Giovanna Cappelli, Domenico Vecchio

“… The immune system is part of a regulatory network linking physiology, pathophysiology and behavior and it can be regarded as a source of biomarkers for monitoring health and animal welfare. …”
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Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…The difference of MoCA total score (p=0.006), language (p=0.0026) and executive function (p=0.0004) scores between the groups was statistically significant. 40% of PD patients and 10% of controls were diagnosed with mild cognitive impairment (p=0.015). 30% of PD patients and 10% of control subjects scored 7 points or above in HAD anxiety subscale (p=0.021). The possible link between disturbances of visual perception and UPDRS Mentation, Behavior and Mood subscore (p=0.05), Activities of Daily Living subscore (p=0.064), and RGCL thickness of the left eye (p=0.056) was determined. …”
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Convolutional neural networks for sea surface data assimilation in operational ocean models: test case in the Gulf of Mexico by O. Zavala-Romero, O. Zavala-Romero, A. Bozec, E. P. Chassignet, J. R. Miranda, J. R. Miranda

“…We also establish a clear link between the CNNs' architecture and complexity and their overall performance.…”
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A comprehensive, population level evaluation of previously reported drug triggers of pemphigus highlights immunomodulatory capacity as a common characteristic by Justin Baroukhian, Kristina Seiffert-Sinha, Animesh A. Sinha

“…Despite anecdotal reports linking multiple drugs to PV, corroborating evidence from large datasets is missing.ObjectiveTo examine the extent to which previously reported associations between a comprehensive list of 36 drugs implicated in PV pathogenesis could be replicated using population-level pharmacovigilance data.DesignSeries of observational, retrospective, case-control, pharmacovigilance analyses (one analysis/drug, 36 total).SettingPopulation based.ParticipantsIndividuals who submitted a report of a drug-related adverse event to the FDA from Q4 of 2003 to Q2 of 2023.ExposureCases were identified by the presence of adverse events described by the MedDRA preferred term “pemphigus” (10034280) and then sorted based on exposure to each of the drugs of interest.Main outcomes and measuresReporting Odds Ratios (RORs) quantifying the association between a given drug exposure and reports of pemphigus adverse events.ResultsThe analyses revealed statistically significant associations between reports of pemphigus and exposure to 11/36 previously reported drugs, two of which had particularly high RORs (&gt;200) [gold sodium thiomalate (ROR, 266.0; 95% CI, 202.6-349.3) and hydroxychloroquine (ROR, 282.6; 95% CI, 261.0-306.1)], three had very strong RORs (14-45) [penicillamine (ROR, 30.5; 95% CI, 11.4-81.7), piroxicam (ROR, 14.8; 95% CI, 8.2-26.7), and imiquimod (ROR, 42.3; 95% CI, 26.2-68.3)], and six had modestly strong RORs (2-5) [rifampin (ROR, 2.8; 95% CI, 1.4-5.6), hydrochlorothiazide (ROR, 1.6; 95% CI, 1.2-2.1), irbesartan (ROR, 2.7; 95% CI, 1.6-4.4), lisinopril (ROR, 5.3; 95% CI, 4.5-6.2), nivolumab (ROR, 2.7; 95% CI, 1.8-4.1), and nifedipine (ROR, 3.0; 95% CI, 1.9-5.0)]. …”
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Bioenergetic Modeling of the Relationship Between Voltage and Electroactive Microbial Biomass Yield for Bioelectrochemical Carbon Dioxide Reduction to Methane by Vafa Ahmadi, Nabin Aryal

“…While most studies assume constant growth yields or rely on empirical estimates, this study presents a novel thermodynamic model, linking anodic oxidation and cathodic carbon dioxide (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>C</mi><mi>O</mi></mrow><mrow><mn>2</mn></mrow></msub></mrow></semantics></math></inline-formula>) reduction to methane (<inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mrow><mi>C</mi><mi>H</mi></mrow><mrow><mn>4</mn></mrow></msub></mrow></semantics></math></inline-formula>) by growing microbial biofilm. …”
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Sources of right to freedom of peaceful assembly by М. А. Sambor

“…This aspect of the sources of law cannot be neglected, since in this case the sources of law, including the sources of the right to freedom of peaceful assembly, are significantly depleted, and a number of links in the chain of law are lost. Therefore, the nature of the origin of the right to freedom of peaceful assembly, which is identified with human nature, is important for the study of the sources of the right to peaceful assembly, and therefore the right to freedom of peaceful assembly is a natural human right that determines its social activity and role in society. …”
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L’africanisation de l’Église évangélique au Maroc : revitalisation d’une institution religieuse et dynamiques d’individualisation by Bernard Coyault

“…After considering the influence of the virtual religious field (internet) on the church as well as the links between the EEAM and the informal network of house churches existing on its margins, this article will explore the articulation between a changing religious institution on one hand, and, on the other hand, the individual religious trajectories it generates with their own dynamics, oscillating between adhesion, contestation or subversion.…”
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The History of Miss Jane Pittman by Christopher Mulvey

“…Brown, A Fugitive Slave Written by Himself, published in 1847, will show how close these links are. But William Wells Brown’s Narrative is only one of at least sixty pre-Civil War slave narratives, and, though it is an exceptionally good one, there is another reason for singling out its author. …”
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PD-L1/TLR7 dual-targeting nanobody-drug conjugate mediates potent tumor regression via elevating tumor immunogenicity in a host-expressed PD-L1 bias-dependent way by Wei Huang, Ji Zhou, Jia Li, Yakun Wan, Chao Hu, Meng Liu, Pan Xu, Feng Tang, Jianhua Sun, Xiaolu Yu, Yiru Long, Binfan Chen, Yongliang Tong, Mengwen Shan, Xiaomin Jia, Henglei Lu, Runqiu Chen, Jin Ren, Guangyi Jin, Likun Gong

“…Toll-like receptors (TLRs) establish the link between innate and adaptive immunity, which can assist T-cell activation and serve as promising targets for combination to enhance ICB therapy. …”
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DEVELOPMENT AND EVALUATION OF AN ANTERIORLY MOUNTED MICROPROCESSOR-CONTROLLED POWERED HIP JOINT PROSTHESIS by Kelly Brannen, Natalie Baddour, Lucas Cho, David Langlois, Patrick Dumond, Edward Lemaire

“…Furthermore, a control system to improve movement and function is needed and is currently under development. Article PDF Link: https://jps.library.utoronto.ca/index.php/cpoj/article/view/44494/33657 How To Cite: Brannen K, Baddour N, Cho L, Langlois D, Dumond P, Lemaire E.D. …”
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Spare Parts Inventory Optimization for Military Vehicles Using a Mixed Probability Distribution by Mojtaba Salehi, Mojtaba Omidvar, Shohreh Shariati

“…In this context, spare parts are one of the most important links in performing optimal maintenance and repairs and quickly returning equipment to the production line. …”
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Adhesive micro-liquid for efficient removal of bacterial biofilm infection by Ying Wang, Zhibang Li, Lingli Ji, Jiao Sun, Fei Gao, Ruiqing Yu, Kai Li, Wenjun Wang, Weiwei Zhao, Qi-Zhi Zhong, Shaohua Ge, Jianhua Li

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MicroRNAs Expression Profile in MN1-Altered Astroblastoma by Francesca Gianno, Evelina Miele, Claudia Sabato, Elisabetta Ferretti, Simone Minasi, Francesca Romana Buttarelli, Debora Salerno, Natalia Pediconi, Giuseppe Rubens Pascucci, Francesca Guerrieri, Andrea Ciolfi, Simone Pizzi, Maura Massimino, Veronica Biassoni, Elisabetta Schiavello, Marco Gessi, Sofia Asioli, Angela Mastronuzzi, Antonio d’Amati, Giuseppina Catanzaro, Elisabetta Viscardi, David Capper, Felice Giangaspero, Manila Antonelli

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Diversity in the medical research ecosystem: a descriptive scientometric analysis of over 49 000 studies and 150 000 authors published in high-impact medical journals between 2007... by Leo Anthony Celi, Jonathan Shaffer, Marie-Laure Charpignon, Liam G McCoy, Luis Filipe Nakayama, Jack Gallifant, Urvish Jain, Joao Matos, Pia Gabrielle I Alfonso, Marisa Cobanaj, Amelia Morel Fiske, Alexander J Gates, Frances Dominique V Ho, Mohammad Kashkooli, Naira Link

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