Unveiling the toxicity of JWH-018 and JWH-019: Insights from behavioral and molecular studies in vivo and vitro by Fenghua Zhou, Yan Shi, Sujun Tan, Xiaoli Wang, Weicheng Yuan, Shuqi Tao, Ping Xiang, Bin Cong, Chunling Ma, Di Wen

“…While both drugs had a similar binding pattern with shared linker binding pockets in CB1R, there were still differences in their spatial conformation. These findings shed light on the molecular pharmacology and activation mechanism of SCs for CB1R and should guide further research into the mechanisms underlying their deleterious effects in humans.…”
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Single-cell RNA sequencing highlights the role of distinct natural killer subsets in sporadic amyotrophic lateral sclerosis by Esther Álvarez-Sánchez, Álvaro Carbayo, Natalia Valle-Tamayo, Laia Muñoz, Joaquim Aumatell, Soraya Torres, Sara Rubio-Guerra, Jesús García-Castro, Judit Selma-González, Daniel Alcolea, Janina Turon-Sans, Alberto Lleó, Ignacio Illán-Gala, Juan Fortea, Ricard Rojas-García, Oriol Dols-Icardo

“…We analyzed differences in the proportions of PBMC, gene expression, and cell-cell communication patterns between ALS patients and HC, as well as their association with plasma neurofilament light (NfL) concentrations, a surrogate biomarker for neurodegeneration. …”
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Investigating the Effects of Debt Convergence of Companies on the Speed of Capital Structure Adjustment Considering the Time Horizon by Sayed Mojtaba Ahmadi, Mehdi Agha Beik Zadeh, Afsaneh Soroushyar

“…In conclusion, this study contributes to the existing literature by shedding light on the dynamic and nuanced nature of the capital structure adjustment process, underscoring the importance of considering debt convergence and adjustment timing when investigating these decisions.…”
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Genetic environmental interaction to achieve optimum physiological states of crossbred cattle in tropical climate by A. Aryogi, L. Affandhy, D. Pamungkas, S. Setiasih, Y.N. Anggraeny, P.W. Prihandini, P.R. Matitaputty, I.N. Suyasa, S. Rusdiana, D.T. Ramsiati, W.I Wulansari, M. Chanafi, D.K. Robba, M. Luthfi

“…This study is unique in its contribution of valuable insights into the potential interplay between tropical climate conditions and the genetic makeup of crossbred cattle. It sheds light on how this interaction influences the physiological and reproductive capabilities of the cattle, as well as the alterations in reproductive hormone secretion within this specific population. …”
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Three-dimensional direct lithography of stable quantum dots in hybrid glass by Dezhi Zhu, Shangben Jiang, Ying Wang, Dejun Liu, Weijia Bao, Liwei Liu, Junle Qu, Yiping Wang, Changrui Liao

“…Semiconductor quantum dots (QDs), as high-performance materials, play an essential role in contemporary industry, mainly due to their high photoluminescent quantum yield, wide absorption characteristics, and size-dependent light emission. It is essential to construct well-defined micro-/nano- structures using QDs as building blocks for micro-optic applications. …”
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Rapid molecular assays versus blood culture for bloodstream infections: a systematic review and meta-analysisResearch in context by Gabriella Anna Rapszky, Uyen Nguyen Do To, Veronika Eszter Kiss, Tamás Kói, Anna Walter, Dorottya Gergő, Fanni Adél Meznerics, Márton Rakovics, Szilárd Váncsa, Lajos Vince Kemény, Dezső Csupor, Péter Hegyi, Michael R. Filbin, Csaba Varga, Bánk G. Fenyves

“…Eleven RMAs were identified, with four included in the RMA-based subgroup analysis (LightCycler SeptiFast Test MGRADE®, IRIDICA BAC BSI assay, SepsiTest, MagicPlex Sepsis Test) and five additional ones in the pooled analysis (UMD-SelectNA, VYOO®, MicrobScan assay, MicrobScan-Kairos24/7, REBA Sepsis-ID test). …”
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RETRACTED: A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice by Shireen Mohammad, Sura Al Zoubi, Sura Al Zoubi, Debora Collotta, Nadine Krieg, Nadine Krieg, Bianka Wissuwa, Bianka Wissuwa, Gustavo Ferreira Alves, Gareth S. D. Purvis, Gareth S. D. Purvis, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Giuseppe Danilo Norata, Andrea Baragetti, Andrea Baragetti, Alberico Luigi Catapano, Alberico Luigi Catapano, Alberico Luigi Catapano, Egle Solito, Egle Solito, Elisabeth Zechendorf, Tobias Schürholz, Wilmar Correa-Vargas, Klaus Brandenburg, Sina M. Coldewey, Sina M. Coldewey, Massimo Collino, Muhammad M. Yaqoob, Lukas Martin, Lukas Martin, Christoph Thiemermann

“…The liver steatosis caused by feeding mice a HFD resulted in the activation of nuclear factor kappa light chain enhancer of activated B cells (NF-ĸB) (phosphorylation of inhibitor of kappa beta kinase (IKK)α/β, IκBα, translocation of p65 to the nucleus), expression of NF-ĸB-dependent protein inducible nitric oxide synthase (iNOS) and activation of the NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome, all of which were reduced by Peptide 19-2.5. …”
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Single-Photon Detectors for Quantum Integrated Photonics by Thu Ha Dao, Francesco Amanti, Greta Andrini, Fabrizio Armani, Fabrizio Barbato, Vittorio Bellani, Vincenzo Bonaiuto, Simone Cammarata, Matteo Campostrini, Samuele Cornia, Fabio De Matteis, Valeria Demontis, Giovanni Di Giuseppe, Sviatoslav Ditalia Tchernij, Simone Donati, Andrea Fontana, Jacopo Forneris, Roberto Francini, Luca Frontini, Gian Carlo Gazzadi, Roberto Gunnella, Ali Emre Kaplan, Cosimo Lacava, Valentino Liberali, Leonardo Martini, Francesco Marzioni, Claudia Menozzi, Elena Nieto Hernández, Elena Pedreschi, Paolo Piergentili, Paolo Prosposito, Valentino Rigato, Carlo Roncolato, Francesco Rossella, Matteo Salvato, Fausto Sargeni, Jafar Shojaii, Franco Spinella, Alberto Stabile, Alessandra Toncelli, Gabriella Trucco, Valerio Vitali

“…Applications such as quantum key distribution, quantum cryptography, and quantum computation demand the ability to detect individual quanta of light and distinguish between single-photon states and multi-photon states, particularly when operating within waveguide systems. …”
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ERBB4 selectively amplifies TGF-β pro-metastatic responses by Peihong Luo, Huanyu Hong, Baoling Zhang, Jie Li, Shuyi Zhang, Chaomin Yue, Jin Cao, Jia Wang, Yuhan Dai, Qingqing Liao, Pinglong Xu, Bing Yang, Xia Liu, Xia Lin, Yi Yu, Xin-Hua Feng

“…These selective effects facilitate lung cancer metastasis in mouse models. This discovery sheds light on the previously unrecognized role of SMAD4 as a substrate of ERBB4 and highlights the selective involvement of the ERBB4-SMAD4 regulatory axis in tumor metastasis.…”
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Protocol for engineering bone organoids from mesenchymal stem cells by Jian Wang, Dongyang Zhou, Ruiyang Li, Shihao Sheng, Guangfeng Li, Yue Sun, Peng Wang, Yulin Mo, Han Liu, Xiao Chen, Zhen Geng, Qin Zhang, Yingying Jing, Long Bai, Ke Xu, Jiacan Su

“…By mixing BMSCs with hydrogel to create a bone matrix-mimicking bioink and employing projection-based light-curing 3D printing technology, we constructed 3D-printed structures, which were then implanted subcutaneously into nude mice, away from the native bone microenvironment. …”
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Steady-state mixing state of black carbon aerosols from a particle-resolved model by Z. Zhang, Z. Zhang, J. Wang, J. Wang, J. Wang, J. Wang, N. Riemer, C. Liu, C. Liu, Y. Jin, Y. Jin, Z. Tian, Z. Tian, J. Cai, J. Cai, Y. Cheng, Y. Cheng, G. Chen, G. Chen, B. Wang, B. Wang, S. Wang, A. Ding, A. Ding

“…<p>Black carbon (BC) exerts a notable warming effect due to its strong light absorption, largely influenced by its “mixing state”. …”
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Hameaux et villages paysans de la période romaine en plaine d’Alsace by Antonin Nüsslein, Pascal Flotté, Mathias Higelin, Muriel Roth-Zehner

“…Analysis of the geographical context close to the settlements of the lower Bruche valley shows that they develop almost systematically near a river (less than 250 m) but almost invariably on terraces or light slopes that protect them from flooding and wetland-related problems. …”
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Heterologous vaccination with subunit protein vaccine induces a superior neutralizing capacity against BA.4/5‐included SARS‐CoV‐2 variants than homologous vaccination of mRNA vacci... by Dandan Peng, Tingmei Zhao, Weiqi Hong, Minyang Fu, Cai He, Li Chen, Wenyan Ren, Hong Lei, Jingyun Yang, Aqu Alu, Yanghong Ni, Jian Liu, Jiong Li, Wei Wang, Guobo Shen, Zhiwei Zhao, Li Yang, Jinliang Yang, Zhenling Wang, Yoshimasa Tanaka, Guangwen Lu, Xiangrong Song, Xiawei Wei

“…Abstract BA.4 and BA.5 (BA.4/5), the subvariants of Omicron, are more transmissible than BA.1 with more robust immune evasion capability because of its unique spike protein mutations. In light of such situation, the vaccination against severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is in desperate need of the third booster. …”
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A phenomenological study of knowledge concealment in country water and sewage engineering company by Gholamreza Moghadasi, Hamidreza Rezaei Kelidbari, Mohammad Doostar

“…Chen et al, (2020) investigated the integration of light and dark aspects of communication transparency for knowledge management and creativity: the moderating role of regulatory focus. …”
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Blood biomarkers to identify patients with different intracranial lesion combinations after traumatic brain injury by Pia Koivikko, Ari J. Katila, Riikka SK. Takala, Iftakher Hossain, Teemu M. Luoto, Rahul Raj, Mari Koivisto, Olli Tenovuo, Kaj Blennow, Peter Hutchinson, Henna-Riikka Maanpää, Mehrbod Mohammadian, Virginia F. Newcombe, Jean-Charles Sanchez, Jussi Tallus, Mark van Gils, Henrik Zetterberg, Jussi P. Posti

“…S100 calcium-binding protein B (S100B), glial fibrillary acidic protein (GFAP), heart fatty-acid binding protein (H-FABP), neurofilament light (NF-L), interleukin-10 (IL-10), total-tau (t-tau), and β-amyloids 1–40 (Aβ40) and 1–42 (Aβ42) were analysed from plasma samples. …”
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INTERNATIONAL FORUM OF AMERICAN SOCIETY FOR ENGINEERING EDUCATION by Vasily Ivanov, Yulia Ziyatdinova

“…Larrondo Petrie gave an overview of engineering education in Latin America in the light of Vision 2025 approved in these countries. …”
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À propos des foyers protohistoriques à pierres chauffantes en Provence-Alpes-Côte d’Azur by Denis Dubesset

“…In the light of recent archaeological discoveries since the early 2000s, this paper reviews the question of protohistoric heating stone hearths in Provence-Alpes-Côte d’Azur. …”
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Blood and Iron: The Rise and Fall of the German Empire 1871 – 1918 by Arzu Melek Ozgumus

“… It is always very interesting to read the German history, which sheds light on a nation which has been built in less than two centuries and hit almost the top of Human Development Index. …”
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New Information and Communication Technologies for climate services: Evidence from farmers in Ada East District, Ghana by Rebecca Sarku, Famous Addi, Emmanuel M.N.A.N. Attoh

“…The findings of the study have implications for CIS developers and providers to incorporate design principles such as revision of text structure, font style and size, symbols, wording pattern and word counts. It shed light on the evolving landscape of CIS delivery in farming communities, where traditional methods coexist with emerging digital platforms and provided knowledge on the need to raise awareness on the use of new ICTs with CIS among farmers. …”
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Discourse Structure Analysis of Hasanak-e-Vazir’s Hanging Tale: A Study based on Van Dijk’s (2007) Socio-Cognitive Approach by Nader Abyar, Mousa Ghonchepour, Zahra Iranmanesh

“…Additionally, examining this socio-political and cultural event sheds light on the feelings, thoughts, and beliefs of the participants of that time.      …”
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