Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…The fusion protein has an IL-2 connected to the light chain complementarity-determining region (CDR) domain of a humanized antibody that binds to IL-2 at the same epitope as IL-2 Rα. …”
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Synthesis and Characterization of Paclitaxel-Loaded Silver Nanoparticles: Evaluation of Cytotoxic Effects and Antimicrobial Activity by Tutku Tunç, Ceylan Hepokur, Afşin Kari̇per

“…The synthesized AgNPs and AgNPs-PTX were characterized by dynamic light scattering (DLS), scanning transmission electron microscopy, UV-visible spectroscopy, Fourier transform infrared spectroscopy, and X-ray spectroscopy. …”
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Supporting older adults with mobility disabilities through voice-activated digital assistants and smart home technologies by Jaewon Kang, Emma Lachs, Kathryn Huang, Laura A. Rice, Wendy A. Rogers

“…Method: We provided twenty-four community-dwelling older adults with mobility disabilities with an Amazon Echo Show, a smart plug, and a smart light, along with instructional manuals tailored to their needs. …”
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Proton motive force generated by microbial rhodopsin promotes extracellular electron transfer by Wenqi Ding, Tong Lin, Yun Yang, Wen-Wei Li, Shaoan Cheng, Hao Song

“…Our further transcriptomics analyses of the energy and materials metabolism of strain cR-1 showed that the underlying mechanism of enhanced EET efficiency was resulted from heterologous expression of the light-driven proton pump. The results suggested that strain cR-1 effectively expels protons to generate additional PMF and provide extra ATP supply to the cells, which facilitated lactate uptake and utilization, thus enhancing electrons generation in cells. …”
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Geomatics and metaverse for lost heritage sites documentation and dissemination: the case study of Palmyra Roman Theatre (Syria) by Anna Forte, Yara Jamil Alkhatib, Gabriele Bitelli, Eva Savina Malinverni, Roberto Pierdicca

“…This study also includes experiments to assess user response, providing insights into methodology effectiveness in conveying Palmyra’s Theatre historical relevance and shedding light on the users’ perceptions of virtual tools usage for lost heritage dissemination. …”
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Predicting the exposure of mycophenolic acid in children with autoimmune diseases using a limited sampling strategy: A retrospective study by Ping Zheng, Ting Pan, Ya Gao, Juan Chen, Liren Li, Yan Chen, Dandan Fang, Xuechun Li, Fei Gao, Yilei Li

“…Ten algorithms, including Random Forest, XGBoost, LightGBM, Gradient Boosting Decision Tree, CatBoost, Artificial Neural Network, Grandient Boosting Machine, Transformer, Wide&Deep, and TabNet, were employed for modeling based on two, three, or four concentrations of MPA. …”
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Multicentre, prospective, randomised controlled trial to evaluate hexaminolevulinate photodynamic therapy (Cevira) as a novel treatment in patients with high-grade squamous intraep... by Fei Chen, Jinghe Lang, Peter Hillemanns, Youzhong Zhang, Zoltán Novák, Long Sui, Ling Han, Christian Dannecker, Ctirad Mokráš, Zhixue You

“…APRICITY is a multicentre, prospective, double-blind, randomised controlled phase 3 study further evaluating the efficacy and safety of Cevira, an integrated drug-delivery and light-delivery device for hexaminolevulinate photodynamic therapy, which shows promise as a novel, non-invasive outpatient therapy for women with HSIL.Methods and analysis Patients with biopsy-confirmed HSIL histology are invited to participate in the study planned to be conducted at 47 sites in China and 25 sites in Ukraine, Russia and the European Union. …”
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Remediation technologies for oil contaminated soil by M. Mambwe, K. Kalebaila, T. Johnson

“…Clay will be incorporated with metal ions and with hydrophobic groups to enhance light absorption and oil-clay interaction, respectively. …”
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Meta-Analysis of Randomized Trials: Efficacy and Safety of Colchicine for Secondary Prevention of Cardiovascular Disease by Elie Akl, Nazanin Sahami, Christopher Labos, Jacques Genest, Ali Zgheib, Nicolo Piazza, Sanjit Jolly

“…Further trials are underway that will shed light on non-CV mortality and colchicine NCT03048825, and NCT02898610.…”
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Emulsifying Properties of Dietary Fiber from Different Sources by Yao WANG, Xue ZHAO, Hao WU, Xinglian XU

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Challenges of community participation in health emergency and disaster risk management in an Iranian context: a qualitative study by Mohammad Azim Mahmodi, Mehrdad Farrokhi, Seyyed Mohammad Reza Hosseini, Mehdi Najafi, Mohammad Esmaeel Motlagh, Hamid Reza Khankeh

“…These themes addressed issues of insufficient risk perception, community traumatization, and poor social capital.ConclusionThis study sheds light on the multifaceted challenges that hinder effective community participation in health emergency and disaster risk management in Iran. …”
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Deep learning model based prediction of vehicle CO2 emissions with eXplainable AI integration for sustainable environment by Gazi Mohammad Imdadul Alam, Sharia Arfin Tanim, Sumit Kanti Sarker, Yutaka Watanobe, Rashedul Islam, M. F. Mridha, Kamruddin Nur

“…This study used deep learning techniques to construct a CO2 emission prediction model, specifically a light multilayer perceptron (MLP) architecture called CarbonMLP. …”
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Autoantibodies in systemic sclerosis: From disease bystanders to pathogenic players by Aurélien Chepy, Aurore Collet, David Launay, Sylvain Dubucquoi, Vincent Sobanski

“…Newly discovered antibodies shed light on SSc cases where Aab had previously gone unidentified. …”
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Insights into depolymerization of chitosan using acid hydrolysis, direct photolysis, and photocatalysis: A review by Nurul Amanina A. Suhaimi, Nur Batrisyia Amirul, Alessandra Anne Hasman, Nurulizzatul Ningsheh M. Shahri, Nur Nabaahah Roslan, Harry Lik Hock Lau, Cristina Pei Ying Kong, Eny Kusrini, Anwar Usman

“…The conventional methods to convert HMWCs to LMWCs include acid depolymerization and direct photolysis upon UV light irradiation. The use of highly concentrated acids unexpectedly modifies the functional groups of chitosan and has raised the environmental concerns. …”
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Zmienność runa leśnego w grądzie wysokim rezerwatu Las Bielański pod wpływem ruchu turystycznego by Anita Grutkowska

“…The number of sprouts of this species is the highest in spring, and it decreases gradually, due to heavy mortality of seedlings and juvenile specimens, with the progressive light shortage. It means the tourist traffic is not the only factor affecting plant abundance.…”
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Prevalence and Associated Factors of Intestinal Parasitic Infections among Food Handlers in Mettu Town, Southwest Ethiopia by Solomon Yeshanew, Melaku Tadege, Abdulhakim Abamecha

“…Stool specimens collected from each food handlers participated in the study were then examined using light microscopy of the wet mount followed by formol-ether concentration methods to see infection status. …”
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Bioinspired materials for batteries: Structural design, challenges and future perspective by Wasif ur Rehman, Yanan Ma, Zahoor khan, Fatima Zahra Ait Laaskri, Jiawei Xu, Youlong Xu, Hamid Rehman, Umar Farooq, Ali Altalbe, Jian Li

“…This study also explored modifications to the surface and interface of smart functionalities, such as self-healing and light-responsiveness, which are essential for integrated energy storage systems. …”
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Cell-Based Therapies for the Treatment of Shoulder and Elbow Tendinopathies: A Scoping Review by Berardo Di Matteo, Riccardo Ranieri, Angelo Manca, Simone Cappato, Maurilio Marcacci, Elizaveta Kon, Alessandro Castagna

“…The aim of this paper is to perform a scoping review of the available clinical evidence on the application of cell-based therapies for the management of elbow and rotator cuff tendinopathies, in order to summarize the current application methods and to shed light on the therapeutic potential and current limitations of these biologic approaches. …”
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The comprehensive assessment of epigenetics changes during skin development by Li Lei, Ling Jiang, Yibo Hu, Menglu Chen, Jinhua Huang, Jing Chen, Qinghai Zeng

“…The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R (version 4.0.3) software. …”
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Management of rare and undiagnosed diseases: insights from researchers and healthcare professionals in Türkiye by Sinem Durmus, Emrah Yucesan, Sinem Aktug, Begum Utz, Ahmet Okay Caglayan, Ahmet Okay Caglayan, Pinar Gencpinar, Cagatay Günay, Yavuz Oktay, Ravza Nur Yildirim, Ayca Yigit, Ugur Ozbek

“…This study provides a detailed survey analysis that sheds light on the challenges that researchers and healthcare professionals face in diagnosing, treating, managing and conducting research on RD.MethodsWe developed a national online survey with three RD stakeholder groups (Researchers, Healthcare professionals and researcher-healthcare professionals) to identify the main challenges and needs in Türkiye for the diagnosis, treatment and follow-up processes of rare and undiagnosed diseases.ResultsThe survey was completed by 363 participants, revealing that participants face key challenges such as the need to refer patients to specialized centers, financial burdens, limited access to necessary tests, inadequate support for rare disease research and a lack of interdisciplinary collaboration. …”
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