The Expression of T Cell FOXP3 and T-Bet Is Upregulated in Severe but Not Euthyroid Hashimoto’s Thyroiditis by Stana Tokić, Mario Štefanić, Ljubica Glavaš-Obrovac, Sonja Jaman, Eva Novosadová, Jana Petrkova, Zdenka Navratilova, Mirjana Suver Stević, Martin Petrek

“…Th1 and Treg subset of CD4+ cells have been implicated in the pathogenesis; however, less is known about their respective roles across the spectrum of HT clinical presentations. To shed more light on CD4+ subsets role in HT, we investigated the mRNA expression levels of several Th1/Treg-associated transcription factors (T-bet/ETS1, HIF1α/BLIMP1/FOXP3) in peripheral blood T cells of 10 hypothyroid, untreated HT patients, 10 hypothyroid patients undergoing hormone replacement therapy, 12 euthyroid HT subjects, and 11 healthy controls by the qRT-PCR. …”
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Unveiling the effects of post-monsoon agricultural biomass burning on aerosols, clouds, and radiation in Northwest India by Pradeep Khatri, Tadahiro Hayasaka, Prabir K. Patra, Husi Letu, Hiren Jethva, Sachiko Hayashida

“…These agricultural biomass burning activities substantially elevate total and light-absorbing aerosols, thereby affecting cloud properties and altering the radiation budget. …”
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Green synthesis and enhanced photocatalytic performance of Co-Doped CuO nanoparticles for efficient degradation of synthetic dyes and water splitting by Daniel Masekela, Lovedonia K. Kganyakgo, Kwena D. Modibane, Tunde L. Yusuf, Sheriff A. Balogun, Wilson M. Seleka, Edwin Makhado

“…The evaluation of photocatalytic activity revealed that the fabricated Co-doped CuO nanoparticles (NPs) demonstrated excellent photocatalytic activity compared to pure CuO NPs. Under UV–vis light irradiation, Co-doped CuO NPs achieved photocatalytic degradation efficiency of about 88 % within 100 min, whereas for pristine CuO NPs it was 75 % under the same irradiation time. …”
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Interaction of human neutrophils with Trichomonas vaginalis protozoan highlights lactoferrin secretion by Wei-Hung Cheng, Ruei-Min Chen, Seow-Chin Ong, Yuan-Ming Yeh, Po-Jung Huang, Chi-Ching Lee

“…Conclusions: This study represents the first to identify the origin of lactoferrin during T. vaginalis infection, shedding light on the potential reason for T. vaginalis's ability to attract neutrophils to the infection site: the acquisition of the iron source, lactoferrin.…”
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Investigation of the post-cryogenic regeneration ability of potato varieties under different cultivation conditions by E. S. Bespalova, Yu. V. Ukhatova, N. N. Volkova, E. V. Oves, N. A. Gaitova, T. A. Gavrilenko

“…The factor “prolonged dark incubation of explants” did not have a significant effect on the frequency of post-cryogenic regeneration of the studied varieties except for one variety (Krepysh), for which a significant increase in the regeneration rate was observed for the shoot tips cultivated in the darkness compared to the cultivation under the photoperiod 16/8 hours (light/darkness). The frequency of post-cryogenic regeneration of shoot tips was higher than that of the axillary buds for all varieties; however, these differences were significant (p < 0.05) only in two cases: for the variety Udacha (a photoperiod of 16/8 hours) and for the variety Krepysh (the dark incubation). …”
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Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1 by Zhiming Wu, Peng Zhang, Wenyan Huang, Yifen Zhou, Zhengliu Cao, Chunhong Wu

“…Conclusion: Our findings indicate that Qufeng epimedium decoction suppresses FLSs pyroptosis and RA progression via CYLD-mediated Sirt1 deubiquitination and deactivation of the NF-kB /GSDMD signaling pathway. This study sheds light on the underlying mechanism of Qufeng epimedium decoction's effectiveness in RA treatment.…”
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Two Cysteines in Raf Kinase Inhibitor Protein Make Differential Contributions to Structural Dynamics In Vitro by Hyun Sang Cho, Mohammad Faysal Al Mazid, Eun-Young Lee, Md Abu Rayhan, Hyoun Sook Kim, Byung Il Lee, Hye Jin You

“…Mutation of alanine or serine instead of cysteine in RKIP proteins did not affect the biochemical characteristics, while dynamic light scattering and liquid chromatography (LC) quadrupole time-of-flight (Q-TOF) mass spectrometry (MS) suggested distinct peaks in solution, which were identified via LC–MS/MS analyses, and further clarified the role of cysteine in RKIP dimerization. rhRKIP dimer formation was abrogated by a 32-aa peptide mimicking the region between two RKIP proteins for dimerization. …”
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Coupling ICESat-2 and Sentinel-2 data for inversion of mangrove tidal flat to predict future distribution pattern of mangroves by Xiaoyong Ming, Yichao Tian, Qiang Zhang, Yali Zhang, Jin Tao, Junliang Lin

“…Therefore, we aim to rely entirely on Earth observation satellite platforms, combining satellite-based Light Detection and Ranging (LiDAR) and optical remote sensing to monitor extensive mangrove tidal flat topography. …”
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Exploring the paradigm shift towards sustainability: A systematic literature review on circular economy and eco-innovation by Ruchira R N Ghormare, Sana Fatima, Priya Grover, Nidhi Phutela, Vinay Kandpal, Ernesto D. R. Santibanez Gonzalez

“…The results emphasized that the incorporation of eco-innovations can help in mitigating the environmental consequences of production and consumption activities. It also sheds light on notable instances of eco-innovations that have been developed for deployment in the circular economy. …”
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Addressing unmet mental health needs of older adults in Turbo, Colombia: a multi-component psychosocial intervention feasibility study by Clarissa Giebel, Erika Montoya, Gabriel Saldarriaga, Thais Caprioli, Mark Gabbay, Danicza Martinez, Jessica Rua, Maria Isabel Zuluaga

“…Normally, this group would not be able to access services to address their social and psychological isolation and distress. In light of limited mental health support across LMICs, this intervention could provide mental health for older adults in other communities in Colombia and elsewhere developed through co-production, cultural adaptation, subject to further evaluation.…”
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A look at the global educational crisis through the lens of experience of the history of science. Part II. The structure of general education content by V. L. Gapontsev, V. A. Fedorov, Ye. M. Dorozhkin

“…The perspectives of further development of formulated ideas about the scientific knowledge structure and the general education content structure in light of trends in STEM are also discussed.Practical significance. …”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…In this study, we demonstrate that GPN3 interacts with clathrin light chain A (CLTA), a vesicle coat protein, as well as clathrin-mediated endocytosis associated modulators AP2B1 and AP2S1. …”
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Transformer-Based Person Detection in Paired RGB-T Aerial Images With VTSaR Dataset by Xiangqing Zhang, Yan Feng, Nan Wang, Guohua Lu, Shaohui Mei

“…However, existing person detection models designed for aerial images heavily rely on numerous labeled instances and exhibit limited tolerance towards complex lighting conditions commonly encountered in search and rescue (SaR) scenarios. …”
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Prevalence and Intensity of Soil-Transmitted Helminths and Associated Factors among Adolescents and Adults in Bibugn Woreda, Northwest Ethiopia: A Community-Based Cross-Sectional S... by Abrham Goshu, Getaneh Alemu, Animen Ayehu

“…Fecal egg counts revealed that 96.5% (112/116) of the infections were with light parasite intensity, while 3.5% (4/116) were with moderate parasite intensity. …”
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Unlocking the Potential of RNA Sequencing in COVID-19: Toward Accurate Diagnosis and Personalized Medicine by Heba M. Saad Eldien, Abdulrahman H. Almaeen, Ahmed Abo El Fath, Ahmed E. Taha, Rehab Ahmed, Hassabelrasoul Elfadil, Helal F. Hetta

“…It allows for the differentiation between asymptomatic and symptomatic individuals and sheds light on the immune response mechanisms that contribute to disease progression. …”
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Genetic methods in honey bee breeding by M. D. Kaskinova, A. M. Salikhova, L. R. Gaifullina, E. S. Saltykova

“…In addition, the annual assessment of the allelic diversity of the csd gene will shed light on the frequency of formation of new allelic variants and other issues related to the evolution of this gene.…”
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A combined recombinase polymerase amplification CRISPR/Cas12a assay for detection of Fusarium oxysporum f. sp. cubense tropical race 4 by Megan Ceris Matthews, Jos van der Linden, Isabelle Robène, Samuel Rozsasi, Beatrix Coetzee, Manuela Campa, Johan Burger, Uzoma Nobel Akwuruoha, Ndubuisi Johnkennedy Madufor, Willem Perold, Umezuruike Linus Opara, Altus Viljoen, Diane Mostert

“…The RPA-Cas12a assay detected Foc TR4 from naturally infected banana samples collected in the field and visualization was possible with the naked eye under LED blue light transillumination. The method can be integrated with inexpensive fluorescent or electronic detection devices to accelerate Foc TR4 in-field detection and, thereby, fast-track disease containment strategies.…”
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Implementasi QR Code Berbasis Android pada Sistem Presensi by Afif Priyambodo, Ledya Novamizanti, Koredianto Usman

“…The system was tested with black-box testing, detection distance testing, light-based detection testing, and stained and damaged student card testing. …”
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Adolescent mice exposed to TBI developed PD-like pathology in middle age by Rong Sha, Mingzhe Wu, Pengfei Wang, Ziyuan Chen, Wei Lei, Shimiao Wang, Shun Gong, Guobiao Liang, Rui Zhao, Yingqun Tao

“…Our results revealed that chronic inflammation associated with the damage of TH+ neurons and the development of progressive PD-like pathology after chronic TBI in mice. Our study shed new light on the TBI-triggered molecular events on PD-like pathology. …”
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Nanoscale ultrafast dynamics in Bi2Te3 thin film by terahertz scanning near-field nanoscopy by Ziyu Huang, Jing Li, Peiyan Li, Lin Du, Mingcong Dai, Jiahua Cai, Zejun Ren, Tianxiao Nie, Xiaojun Wu

“…Summary: Ultrafast laser interactions with topological insulators (TIs) have garnered tremendous interest for understanding light-matter interactions and developing optoelectronic devices across visible to terahertz (THz) regions owning to their high carrier mobility and sensitivity to electric fields. …”
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