Performance of plasma biomarkers for diagnosis and prediction of dementia in a Brazilian cohort by Luis E. Santos, Paulo Mattos, Thais L. Pinheiro, Ananssa Silva, Claudia Drummond, Felipe Kenji Sudo, Fernanda Barros-Aragão, Bart Vanderborght, Carlos Otávio Brandão, Sergio T. Ferreira, IDOR Memory Clinic Initiative, Fernanda Tovar-Moll, Fernanda G. De Felice

“…Participants were clinically categorized as cognitively unimpaired (n = 49), amnestic mild cognitive impairment (n = 29), AD (n = 38), Lewy body dementia (n = 22), or vascular dementia (n = 7). …”
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Genetic evidence suggests a causal relationship linking thyroid function to prospective memory and dementia and Parkinson’s disease by Yang Wang, Yanying Liu, Huimin Yang, Zhuang Mo, Haiyan Liu, Qi Yu

“…Utilizing data from genome-wide association studies, the exposures included thyroid cancer (TC), thyroid-stimulating hormone (TSH), hypothyroidism, hyperthyroidism (HT), and radiation (RAD), while the outcome variables consisted of PM, Parkinson’s disease (PD) and four dementia subtypes: Alzheimer’s disease (AD), Lewy body dementia (DLB), frontotemporal dementia (FTD), and vascular dementia (VD). …”
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Alpha-Synuclein Dysregulation in Systemic Pathophysiology of Synucleinopathies by Hallie H. Dolin, Bowen Zhou, Robert W. Maitta

“…Alpha-synuclein (α-syn) has long been identified as the etiologic agent of multiple neurodegenerative diseases, the most common and well-known of which are Parkinson’s disease (PD) and Lewy body dementia (LBD). While it is known that the pathophysiology of these synucleinopathies involves aggregation of improperly-folded α-syn, the mechanisms leading to its accumulation have not been fully identified. …”
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Engineered sequestrins inhibit aggregation of pathogenic alpha-synuclein mutants by Linnea Charlotta Hjelm, Wojciech Paslawski, Christofer Lendel, Siri Flemming Svedmark, Per Svenningsson, Stefan Ståhl, Hanna Lindberg, John Löfblom

“…In an in vitro aggregation study, the sequestrins demonstrated complete inhibition of aSyn aggregation at equimolar concentrations, including the three familial mutants A30P, E46K, and A53T that are associated with Parkinson’s disease and Lewy body dementia.…”
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Decoding the genetic blueprints of neurological disorders: disease mechanisms and breakthrough gene therapies by Umar Saeed, Umar Saeed, Zahra Zahid Piracha, Zahra Zahid Piracha, Zahra Zahid Piracha, Muhammad Nouman Tariq, Shayan Syed, Maria Rauf, Laiba Razaq, Muhammad Kaleem Iftikhar, Amna Maqsood, Syed Muhammad Ahsan

“…Through an in-depth analysis of existing literature, the study examines the genetic landscape, disease mechanisms, and gene-based intervention possibilities across a range of neurological disorders, including Cerebellar Ataxias, Autosomal Recessive Ataxia, Mitochondrial Cerebellar Ataxia, Multiple System Atrophy (MSA), Idiopathic Late-Onset Cerebellar Ataxia, Hereditary Spastic Paraplegias, Alzheimer’s Disease, Vascular Dementia, Lewy Body Dementia, Frontotemporal Dementias, Inherited Prion Diseases, and Huntington’s Disease. …”
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Comprehensive short and long read sequencing analysis for the Gaucher and Parkinson’s disease-associated GBA gene by Marco Toffoli, Xiao Chen, Fritz J. Sedlazeck, Chiao-Yin Lee, Stephen Mullin, Abigail Higgins, Sofia Koletsi, Monica Emili Garcia-Segura, Esther Sammler, Sonja W. Scholz, Anthony H. V. Schapira, Michael A. Eberle, Christos Proukakis

“…Abstract GBA variants carriers are at increased risk of Parkinson’s disease (PD) and Lewy body dementia (LBD). The presence of pseudogene GBAP1 predisposes to structural variants, complicating genetic analysis. …”
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Pathological α-synuclein elicits granulovacuolar degeneration independent of tau by Dylan J. Dues, Madalynn L. Erb, Alysa Kasen, Naman Vatsa, Erin T. Williams, An Phu Tran Nguyen, Michael X. Henderson, Darren J. Moore

“…Abstract Background Pathologic heterogeneity is a hallmark of Lewy body dementia (LBD), yet the impact of Lewy pathology on co-pathologies is poorly understood. …”
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Concordance and test-retest consistency of sleep biomarker-based neurodegenerative disorder profiling by Daniel J. Levendowski, Debby Tsuang, Lana M. Chahine, Christine M. Walsh, Chris Berka, Joyce K. Lee-Iannotti, David Salat, Corrine Fischer, Gandis Mazeika, Bradley F. Boeve, Luigi Ferini Strambi, Simon J. G. Lewis, Thomas C. Neylan, Erik K. St. Louis

“…A four-class machine-learning algorithm was trained using age and nine sleep biomarkers from patients with clinically-diagnosed manifest and prodromal NDDs, including Alzheimer’s disease dementia (AD = 27), Lewy body dementia (LBD = 18), and isolated REM sleep behavior disorder (iRBD = 15), as well as a control group (CG = 58). …”
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Exploring the impact of coffee consumption and caffeine intake on cognitive performance in older adults: a comprehensive analysis using NHANES data and gene correlation analysis by Jinrui Li, Kai Yu, Fan Bu, Peng Li, Lei Hao

“…Mendelian Randomization (MR) studies suggested that increased coffee intake is associated with cognitive impairment progression, while coffee consumption may protect against Lewy body dementia (OR = 0.2365, 95% CI: 0.0582–0.9610). …”
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Unravelling the myriad physiologic roles of transthyretin: critical considerations for treating transthyretin amyloidosis by Morie A. Gertz, Mandar A. Aras, Nicole Bart, Thomas H. Brannagan, Jan M. Griffin, Amy R. Kontorovich, Andrew M. Rosen

“…In several disease states, including diabetes, Alzheimer’s disease, Lewy body dementia, cerebrovascular disease, and osteoporosis, higher TTR levels may be protective. …”
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α-synuclein and tau: interactions, cross-seeding, and the redefinition of synucleinopathies as complex proteinopathies by Francisco J. Padilla-Godínez, Francisco J. Padilla-Godínez, Eunice Ruth Vázquez-García, María Isabel Trujillo-Villagrán, Luis O. Soto-Rojas, Marcela Palomero-Rivero, Omar Hernández-González, Francisco Pérez-Eugenio, Omar Collazo-Navarrete, Oscar Arias-Carrión, Magdalena Guerra-Crespo

“…Parkinson’s disease and related synucleinopathies, including Lewy body dementia and multiple system atrophy, highlight the interplay between α-synuclein and tau, two key proteins implicated in these disorders. …”
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Lipidic folding pathway of α-Synuclein via a toxic oligomer by Vrinda Sant, Dirk Matthes, Hisham Mazal, Leif Antonschmidt, Franz Wieser, Kumar T. Movellan, Kai Xue, Evgeny Nimerovsky, Marianna Stampolaki, Magdeline Nathan, Dietmar Riedel, Stefan Becker, Vahid Sandoghdar, Bert L. de Groot, Christian Griesinger, Loren B. Andreas

“…This structural reconfiguration occurs in a conserved structural kernel shared by a vast number of αS-fibril polymorphs including extracted fibrils from Parkinson’s and Lewy Body Dementia patients. Consistent with reports of anti-parallel β-strands being a defining feature of toxic αS pre-fibrillar intermediates, I1 impacts viability of neuroblasts and disrupts cell membranes, resulting in an increased calcium influx. …”
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Models of Integrated Acute Care for Older Adult Inpatients That Incorporate Integrative Health: An Integrative Review by Bonvin E, Perruchoud E, Tacchini-Jacquier N, Perrenoud J, Melly P, Celik S, Jean M, Verloo H

“…Three integrated acute psychogeriatric-care models were identified: the Admiral Nursing model, the Lewy body dementia Admiral nursing service model, and the Care for Acute Mentally Infirm Elders model. …”
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Lower water-soluble vitamins and higher homocysteine are associated with neurodegenerative diseases by Cuiping Zhang, Yao Hu, Xinyi Cao, Yuhang Deng, Yuting Wang, Ming Guan, Xiaoyan Wu, Haoqin Jiang

“…The other dementia group comprised 25 patients with frontotemporal dementia, 38 with Lewy body dementia, 34 with vascular dementia, and 18 with semantic dementia. …”
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Basal forebrain activation improves working memory in senescent monkeys by Kendyl R. Pennington, Luca Debs, Sophia Chung, Janki Bava, Clément M. Garin, Fernando L. Vale, Sarah K. Bick, Dario J. Englot, Alvin V. Terry, Jr., Christos Constantinidis, David T. Blake

“…Degeneration of the basal forebrain cholinergic system parallels these changes in aging, Alzheimer's dementia, Parkinson's dementia, and Lewy body dementia, and thus is a common element linked to executive function across the lifespan and in disease states. …”
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Population-scale cross-disorder atlas of the human prefrontal cortex at single-cell resolution by John F. Fullard, Prashant NM, Donghoon Lee, Deepika Mathur, Karen Therrien, Aram Hong, Clara Casey, Zhiping Shao, Marcela Alvia, Stathis Argyriou, Tereza Clarence, David Burstein, Sanan Venkatesh, Pavan K. Auluck, Lisa L. Barnes, David A. Bennett, Stefano Marenco, PsychAD Consortium, Kiran Girdhar, Vahram Haroutunian, Gabriel E. Hoffman, Georgios Voloudakis, Jaroslav Bendl, Panos Roussos

“…Encompassing over 6.3 million nuclei from 1,494 donors, our dataset represents a diverse range of neurodegenerative and serious mental illnesses, including Alzheimer’s and Parkinson’s diseases, schizophrenia, bipolar disorder and diffuse Lewy body dementia, as well as neurotypical controls. Our dataset offers a unique opportunity to study disease interactions, as 21% of donors had comorbid diagnoses of two or more major brain disorders. …”
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Biological Implications of the Intrinsic Deformability of Human Acetylcholinesterase Induced by Diverse Compounds: A Computational Study by Ysaías J. Alvarado, Lenin González-Paz, José L. Paz, Marcos A. Loroño-González, Julio Santiago Contreras, Carla Lossada, Alejandro Vivas, Yovani Marrero-Ponce, Felix Martinez-Rios, Patricia Rodriguez-Lugo, Yanpiero Balladores, Joan Vera-Villalobos

“…The inhibition of AChE has emerged as a promising therapeutic approach for the management of neurological disorders such as Lewy body dementia and Alzheimer’s disease. The potential of various compounds as AChE inhibitors was investigated. …”
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The pharmacodynamics-based prophylactic benefits of GLP-1 receptor agonists and SGLT2 inhibitors on neurodegenerative diseases: evidence from a network meta-analysis by Ping-Tao Tseng, Bing-Yan Zeng, Chih-Wei Hsu, Chao-Ming Hung, Andre F. Carvalho, Brendon Stubbs, Yen-Wen Chen, Tien-Yu Chen, Wei-Te Lei, Jiann-Jy Chen, Kuan-Pin Su, Yow-Ling Shiue, Chih-Sung Liang

“…Our primary outcome was the incidence of seven major neurodegenerative diseases: Parkinson’s disease, Alzheimer’s disease, Lewy body dementia, multiple sclerosis, amyotrophic lateral sclerosis, frontotemporal dementia, and Huntington’s disease. …”
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Biomarkers for cognitive impairment in alpha-synucleinopathies: an overview of systematic reviews and meta-analyses by Elisa Mantovani, Alice Martini, Alessandro Dinoto, Chiara Zucchella, Sergio Ferrari, Sara Mariotto, Michele Tinazzi, Stefano Tamburin

“…., Parkinson’s disease, Lewy bodies dementia, and multiple system atrophy. We summarize data from systematic reviews/meta-analyses on neuroimaging, neurophysiology, biofluid and genetic diagnostic/prognostic biomarkers of CI in α-synucleinopathies. …”
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