The Leukemic Stem Cell Niche: Adaptation to “Hypoxia” versus Oncogene Addiction by Giulia Cheloni, Martina Poteti, Silvia Bono, Erico Masala, Nathalie M. Mazure, Elisabetta Rovida, Matteo Lulli, Persio Dello Sbarba

“…The data reported here indicated that driver oncogenic proteins of several leukemias are suppressed following cell incubation at oxygen concentration compatible with SCN physiology. …”
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Oncolytic Virotherapy for Hematological Malignancies by Swarna Bais, Eric Bartee, Masmudur M. Rahman, Grant McFadden, Christopher R. Cogle

“…Hematological malignancies such as leukemias, lymphomas, multiple myeloma (MM), and the myelodysplastic syndromes (MDSs) primarily affect adults and are difficult to treat. …”
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Synthesis and biological evaluation of new tri-heterocyclic derivatives as anti-colorectal cancer agents by Benjamin Victoir, Océane Pertegaz, Elfi Ducrocq, Marion Polomski, Maxime Guéguinou, William Raoul, Cécile Croix, Gildas Prié

“…This work was guided by the previous identification of a potent STAT5 inhibitor in the fight against myeloid leukemias. Pharmacomodulations were strategically performed, and the in vitro activities of all tri-heterocyclic derivatives were assessed on HT29 and Lovo colorectal cancer cell lines, as well as on the non-tumoral NCM356 colonic epithelial cell line derived from normal mucosa. …”
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Lymphoma of the Urinary Bladder by Anthony Kodzo-Grey Venyo

“…Secondary LUB occurs in 10% to 25% of leukemias/lymphomas and in advanced-stage systemic lymphoma. …”
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A Novel Approach for the Enumeration of Peripheral Blood Stem Cells Suitable for Transplantation by Winston Costa Pereira, Omar Alsuhaibani, Ghaleb Elyamany, Abdulaziz Al Abdulaaly

“…These well-characterized stem cells are clinically relevant in the treatment of diseases such as breast cancer, leukemias, and congenital immunodeficiencies. Peripheral blood stem transplantation is a standard procedure after its first successful transplantation more than 35 years ago. …”
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Orchard: Building large cancer phylogenies using stochastic combinatorial search. by Ethan Kulman, Rui Kuang, Quaid Morris

“…Our evaluations demonstrate that Orchard outperforms state-of-the-art cancer phylogeny reconstruction methods in reconstructing more plausible phylogenies across 90 simulated cancers and 14 B-progenitor acute lymphoblastic leukemias (B-ALLs). Remarkably, Orchard accurately reconstructs cancer phylogenies using up to 1,000 mutations. …”
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Isocitrate Dehydrogenase 1 and 2 Mutations in Pediatric Neuroblastoma Patients by Emre LEVENTOGLU, Gurses SAHIN, Sule YESIL, Ceyhun BOZKURT, Nazmiye YUKSEK, Ali FETTAH, Sule TOPRAK, Burcak KURUCU BILGIN, Emre CAPKINOGLU, Nilgun EROGLU, Sibel AKPINAR TEKGUNDUZ, Ayse Ulya ERTEM

“…IDH1 and IDH2 mutations have been found in many types of cancer, such as malignant gliomas, acute myeloid leukemias, chondrosarcoma, and thyroid carcinoma. This study aimed to investigate the presence of IDH1 or IDH2 mutations in patients with neuroblastoma and to determine whether these mutations were different in terms of age, clinical findings, and response to treatment. …”
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