Mucosal leishmaniasis is associated with the Leishmania RNA virus and inappropriate cutaneous leishmaniasis treatment. by Fredy A Pazmiño, Marcela Parra-Muñoz, Carlos H Saavedra, Sandra Muvdi-Arenas, Clemencia Ovalle-Bracho, María C Echeverry

“…<h4>Background</h4>Mucosal leishmaniasis (ML) is a severe clinical form of leishmaniasis that is characterized by the destruction of the nasal and/or the oral mucosae and appears as a late complication in 5% to 10% of cutaneous leishmaniasis (CL) cases produced by species belonging to Leishmania (Viannia) subgenus. Some strains of Leishmania spp. carry an RNA virus known as Leishmania RNA virus (LRV) that may contribute to the appearance of ML.…”
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Pharmacological inhibition of key metabolic pathways attenuates Leishmania spp infection in macrophages. by Elaine Carvalho de Oliveira, Rafael Tibúrcio, Gabriela Duarte, Amanda Lago, Léon de Melo, Sara Nunes, Gustavo Gastão Davanzo, Ana Júlia Martins, Bruno Vinagre Ribeiro, Deborah Mothé, Juliana B P Menezes, Patrícia Veras, Natalia Tavares, Pedro M Moraes-Vieira, Cláudia Ida Brodskyn

“…We also analyzed the effects of both Leishmania spp. strain infection on mitochondria function, further revealing that infected cells display heightened mitochondrial mass and membrane potential. …”
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Peroxisome Proliferator-Activated Receptor-γ-Mediated Polarization of Macrophages in Leishmania Infection by Marion M. Chan, Nagasuresh Adapala, Cui Chen

“…Leishmanial activation of PPARγ promotes survival, whereas blockade of PPARγ facilitates removal of the parasite. Thus, Leishmania parasites harness PPARγ to increase infectivity.…”
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Effect of Environmental Disturbance on the Population of Sandflies and Leishmania Transmission in an Endemic Area of Venezuela by Elsa Nieves, Luzmary Oraá, Yorfer Rondón, Mireya Sánchez, Yetsenia Sánchez, Masyelly Rojas, Maritza Rondón, Maria Rujano, Nestor González, Dalmiro Cazorla

“…The results show the anthropogenic disturbance effect on the sandflies population and Leishmania transmission in endemic areas of Venezuela. …”
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Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease by Daniel Feijó, Rafael Tibúrcio, Mariana Ampuero, Cláudia Brodskyn, Natalia Tavares

“…In this review, we discuss (1) the interactions between DCs and parasites from different species of Leishmania and (2) the crosstalk of DCs and other cells during CL infection. …”
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Screening of six medicinal plant species for antileishmanial activity by Ferreira Fabiana Borges Padilha, Cabral Márcia Regina Pereira, Sarragiotto Maria Helena, Fernandez Carla Maria Mariano, Gazim Zilda Cristiani, Junior Ranulfo Piau, Demarchi Izabel Galhardo, Silveira Thaís Gomes Verzignassi, Lonardoni Maria Valdrinez Campana

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Ultrastructural Analysis of Leishmania infantum chagasi Promastigotes Forms Treated In Vitro with Usnic Acid by João S. B. da Luz, Erwelly B. de Oliveira, Monica C. B. Martins, Nicácio H. da Silva, Luiz C. Alves, Fábio A. B. dos Santos, Luiz L. S. da Silva, Eliete C. Silva, Paloma L. de Medeiros

“…The aim of this study was to evaluate the antileishmanial activity of usnic acid on Leishmania infantum chagasi promastigotes and the occurrence of drug-induced ultrastructural damage in the parasite. …”
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Subversion of Immunity by Leishmania amazonensis Parasites: Possible Role of Phosphatidylserine as a Main Regulator by Joao Luiz Mendes Wanderley, Jaqueline França Costa, Valéria Matos Borges, Marcello Barcinski

“…Leishmania amazonensis parasites cause progressive disease in most inbred mouse strains and are associated with the development of diffuse cutaneous leishmaniasis in humans. …”
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Natural Product Identification and Molecular Docking Studies of Leishmania Major Pteridine Reductase Inhibitors by Moses N. Arthur, George Hanson, Emmanuel Broni, Patrick O. Sakyi, Henrietta Mensah-Brown, Whelton A. Miller, Samuel K. Kwofie

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Mixed Cutaneous Infection Caused by Leishmania and Dermatophytes: A Rare Coincidence or Immunological Fact by Amresh Kumar Singh, Ankur Kumar, Jayesh Pandey, Vivek Gaur, Pratima Tripathi, Indra Prasad Adhikari

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Corrigendum to “Dendritic Cells and Leishmania Infection: Adding Layers of Complexity to a Complex Disease” by Daniel Feijó, Rafael Tibúrcio, Mariana Ampuero, Cláudia Brodskyn, Natalia Tavares

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Management of Canine Leishmaniasis and the Treatment Trends of Veterinarians in Aegean Region of Türkiye: A Questionnaire-based Survey by Metin Pekağırbaş, Mehmet Karakuş, Elif Dönmez, Hüseyin Gökhan Özdemir, Yusuf Özbel, Seray Töz

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Canine Cutaneous Leishmaniasis: Dissemination and Tissue Tropism of Genetically Distinct Leishmania (Viannia) braziliensis Populations by Guilherme Marx de Oliveira, Maria de Fátima Madeira, Fernanda Santos Oliveira, Marize Quinhones Pires, Raquel da Silva Pacheco

“…Little is known regarding the internal dissemination of initial cutaneous lesions and tissue tropism of Leishmania (Viannia) braziliensis populations in naturally infected dogs. …”
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YAT2150 is irresistible in Plasmodium falciparum and active against Plasmodium vivax and Leishmania clinical isolates by Inés Bouzón-Arnáiz, Mukul Rawat, Rachael Coyle, Lionel Brice Feufack-Donfack, Malen Ea, Agnes Orban, Jean Popovici, Lucía Román-Álamo, Antonino Nicolò Fallica, Bárbara Domínguez-Asenjo, Javier Moreno, Elsa M. Arce, Ana Mallo-Abreu, Diego Muñoz-Torrero, Marcus C. S. Lee, Xavier Fernàndez-Busquets

“…Tests performed in clinical isolates indicated that YAT2150 had also strong activity against Plasmodium vivax (IC50 between 4 and 36 nM) and Leishmania infantum (1.27 and 1.11 µM), placing it as a unique compound with perspectives of becoming the first drug to be used against both malaria and leishmaniasis.…”
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Prevalidation of an ELISA for Detection of a New Clinical Entity: Leishmania donovani-Induced Cutaneous Leishmaniasis by Bhagya Deepachandi, Sudath Weerasinghe, Himali Gunathilake, Thisira P. Andrahennadi, Mahendra N. Wickramanayake, Shantha Siri, Vishvanath Chandrasekharan, Preethi Soysa, Yamuna Siriwardana

“…This procedure described an optimization procedure of an ELISA technique for detection of anti-Leishmania antibodies in patients with L. donovani caused CL.…”
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Genome Assembly and Genome Annotation of Leishmania martiniquensis Isolated from a Leishmaniasis Patient in Thailand by Songtham Anuntakarun, Atchara Phumee, Vorthon Sawaswong, Kesmanee Praianantathavorn, Witthaya Poomipak, Rungrat Jitvaropas, Padet Siriyasatien, Sunchai Payungporn

“…Leishmaniasis is a parasitic disease caused by Leishmania spp. with worldwide distribution. Autochthonous leishmaniasis has been reported to result from the infection by Leishmania martiniquensis in Thailand. …”
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The histone methyltransferase DOT1B is dispensable for stage differentiation and macrophage infection of Leishmania mexicana by Nicole Eisenhuth, Elisa Theres Rauh, Melina Mitnacht, Andrea Debus, Ulrike Schleicher, Falk Butter, Katerina Pruzinova, Petr Volf, Christian J. Janzen

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R-loops acted on by RNase H1 influence DNA replication timing and genome stability in Leishmania by Jeziel D. Damasceno, Emma M. Briggs, Marija Krasilnikova, Catarina A. Marques, Craig Lapsley, Richard McCulloch

“…Here we show that both R-loops and RNase H1, a ribonuclease that resolves RNA-DNA hybrids, accumulate in Leishmania major chromosomes in a pattern that reflects their replication timing. …”
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Prevalence of asymptomatic Leishmania donovani infection and associated factors in Ethiopia: a systematic review and meta-analysis by Habtamu Belay, Adugna Abera, Esayas Aklilu, Tesfahun Bishaw, Ayinalem Alemu, Geremew Tasew, Berhanu Erko

“…Abstract Background Visceral leishmaniasis is endemic in Ethiopia and caused by Leishmania donovani. Although the disease manifests with significant clinical variability, a substantial number of individuals are asymptomatic. …”
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Leishmania major Infection in Synanthropic Rodents: Evidence for the Urbanization of Zoonotic Cutaneous Leishmaniasis (ZCL) in Southern Iran by Saeed Shahabi, Kourosh Azizi, Qasem Asgari, Bahador Sarkari

“…This study aimed to investigate the infection of rodents with Leishmania major in an urban area of Fars Province, located in southern Iran. …”
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