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    Framework for Exploration of Statistical Heterogeneity in Multi-Database Studies: A Case Study Using EXACOS-CV Studies by Rhodes KM, Garbe E, Müllerová H, Ekwaru P, Kossack N, Baak BN, Lobier M, Hawkins NM, Nordon C

    Published 2025-06-01
    “…Kirsty Marie Rhodes,1 Edeltraut Garbe,2 Hana Müllerová,3 Paul Ekwaru,4 Nils Kossack,5 Brenda N Baak,6 Muriel Lobier,7 Nathaniel M Hawkins,8 Clementine Nordon3 1Real-World Science and Analytics, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK; 2Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany; 3Respiratory Evidence Strategy, BioPharmaceuticals Medical, AstraZeneca, Cambridge, UK; 4Medlior Health Outcomes Research Ltd., Calgary, AB, Canada; 5WIG2 Institute, Leipzig, Germany; 6PHARMO Institute for Drug Outcomes Research, Utrecht, Netherlands; 7Biostatistics, Real World Solutions, IQVIA, Espoo, Finland; 8Division of Cardiology, Centre for Cardiovascular Innovation, University of British Columbia, Vancouver, BC, CanadaCorrespondence: Kirsty Marie Rhodes, AstraZeneca, Academy House, Hills Road, Cambridge, CB2 8PA, United Kingdom, Email kirsty.rhodes@astrazeneca.comPurpose: Multi-database studies may provide heterogeneous results despite using common protocols, leading to challenges in interpretation, but also providing an opportunity to gain insights on populations or healthcare systems. …”
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