Intra-articular injections with Carboxymethyl-Chitosan in patients affected by knee osteoarthritis non-responders to hyaluronic acid: a pilot study by Nicola Manocchio, Concetta Ljoka, Nicolò Piacentini, Roberto Sorge, Giulia Vita, Calogero Foti

“…This retrospective study aims to evaluate the efficacy of a single injection of Carboxymethyl-Chitosan for advanced (Kellgren-Lawrence ≥3) and symptomatic knee OA in non-responders to hyaluronic acid. …”
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Pain Sensitization and Neuropathic Pain-like Symptoms Associated with Effectiveness of Exercise Therapy in Patients with Hip and Knee Osteoarthritis by Takafumi Hattori, Kazuhiro Shimo, Yuto Niwa, Yuichi Katsura, Yuji Tokiwa, Satoshi Ohga, Takako Matsubara

“…Before treatment, the Kellgren–Lawrence (K-L) grade; minimum joint space width (mJSW); pressure pain threshold (PPT) and temporal summation of pain (TSP) at the affected joint, tibia, and forearm; Central Sensitization Inventory-9; and painDETECT questionnaire (PDQ) were assessed. …”
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Mid-latitude clouds contribute to Arctic amplification via interactions with other climate feedbacks by David B Bonan, Jennifer E Kay, Nicole Feldl, Mark D Zelinka

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STRUCTURAL AND FUNCTIONAL CONDITION OF THE KNEE JOINT IN PATIENTS WITH MONOGONARTHROSIS IN THE STAGE OF EXACERBATION by Taras Khanyk

“…The structural and functional state of the knee joints in patients with monogonarthrosis of the 1st-2nd grade according to the Kellgren-Lawrence classification is characterized by degenerative changes in almost all elements of the knee joint with moderate pain syndrome and functional disorders.…”
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Innovative CDR grafting and computational methods for PD-1 specific nanobody design by Jagadeeswara Reddy Devasani, Girijasankar Guntuku, Nalini Panatula, Murali Krishna Kumar Muthyala, Mary Sulakshana Palla, Teruna J. Siahaan

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Multi-functional role of apolipoprotein E in neurodegenerative diseases by Sadequl Islam, Arshad Noorani, Yang Sun, Makoto Michikawa, Kun Zou

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GD-1 Stellar Stream and Cocoon in the DESI Early Data Release by M. Valluri, P. Fagrelius, S. E. Koposov, T. S. Li, Oleg Y. Gnedin, E. F. Bell, R. G. Carlberg, A. P. Cooper, J. Aguilar, S. Ahlen, C. Allende Prieto, V. Belokurov, L. Beraldo e Silva, D. Brooks, A. Byström, T. Claybaugh, K. Dawson, A. Dey, P. Doel, J. E. Forero-Romero, E. Gaztañaga, S. Gontcho A Gontcho, J. Han, K. Honscheid, T. Kisner, A. Kremin, A. Lambert, M. Landriau, L. Le Guillou, M. E. Levi, A. de la Macorra, M. Manera, P. Martini, G. E. Medina, A. Meisner, R. Miquel, J. Moustakas, A. D. Myers, J. Najita, C. Poppett, F. Prada, M. Rezaie, G. Rossi, A. H. Riley, E. Sanchez, D. Schlegel, M. Schubnell, D. Sprayberry, G. Tarlé, G. Thomas, B. A. Weaver, R. H. Wechsler, R. Zhou, H. Zou

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Hopping backward to move forward: Single-leg backward hopping can better detect decreased quadriceps strength induced by a fatigue protocol compared to forward and vertical hopping by Yu Song, Lauren Salsgiver, Kaden Van Valkenburg, Natalie Christofferson, Yessica Lo, Zhichen Feng, Brenna McGuinness, Boyi Dai

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Beamline and Flight Comparisons of the ARMAS Flight Module With the Tissue Equivalent Proportional Counter for Improving Atmospheric Radiation Monitoring Accuracy by Brad “Buddy” Gersey, W. Kent Tobiska, William Atwell, Dave Bouwer, Leonid Didkovsky, Kevin Judge, Seth Wieman, Richard Wilkins

“…In addition, both detectors were exposed neutrons at the Los Alamos Neutron Science Center, protons at Loma Linda University Medical Center, 56Fe particles at the NASA Space Radiation Laboratory, and also a gamma radiation source at Lawrence Livermore National Laboratory. The response of each of these instruments as well as derived dosimetric quantities are compared for each radiation exposure and the ratio for converting ARMAS absorbed dose in silicon to an estimated absorbed dose in tissue is obtained. …”
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How the Suboxone Education Programme presented as a solution to risks in the Canadian opioid crisis: a critical discourse analysis by Quinn Grundy, Fiona Webster, Daniel Z Buchman, Sheryl Spithoff, Ross E G Upshur, Abhimanyu Sud, Matthew Strang

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Event-Type Identification in Power Grids Using a Spectral Correlation Function-Aided Convolutional Neural Network by Ozgur Alaca, Ali Riza Ekti, Jhi-Young Joo, Nils Stenvig

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Out‐Diffusion and Uphill‐Diffusion of Mg in Czochralski‐Grown (100) β‐Ga2O3 Under High‐Temperature Annealing and Its Influence on Lateral MOSFET Devices by Ta‐Shun Chou, Thi Thuy Vi Tran, Hartwin Peelaers, Kornelius Tetzner, Oliver Hilt, Jana Rehm, Saud Bin Anooz, Andreas Fiedler, Zbigniew Galazka, Martin Albrecht, Andreas Popp

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Future increase in compound soil drought-heat extremes exacerbated by vegetation greening by Jun Li, Yao Zhang, Emanuele Bevacqua, Jakob Zscheischler, Trevor F. Keenan, Xu Lian, Sha Zhou, Hongying Zhang, Mingzhu He, Shilong Piao

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The role of sex, age, and BMI in treatment decisions for knee osteoarthritis: conservative management versus total knee replacement by Fabiola Ojeda, Laura Tío, Francisco Castro-Domínguez, Simone Tassani, Jerome Noailly, Jordi Monfort

“…Methods This case–control study compared patients assigned to TKR versus conservative management, examining subjects aged 60–75 years with radiographically confirmed KOA (Kellgren–Lawrence grades 2–3), with all participants evaluated by blinded clinicians using validated assessment tools including Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), Hospital Anxiety and Depression Scale (HADs), Pain Catastrophizing Scale (PCS) and Daily physical activity (DPA) questionnaires. …”
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Immunohistological Localization of BMP-2, BMP-7, and Their Receptors in Knee Joints with Focal Cartilage Lesions by Hagen Schmal, Alexander T. Mehlhorn, Ingo H. Pilz, David Dovi-Akue, Christina Kirchhoff, Norbert P. Südkamp, Ulrike Gerlach, Christian Lohrmann, Philipp Niemeyer

“…Defect size, KOSS, Henderson or Kellgren-Lawrence score did not statistically significant correlate with the expression of the analyzed proteins or Mankin and Pritzker scores. …”
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Microfragmented Adipose Tissue Injection (MFAT) May Be a Solution to the Rationing of Total Knee Replacement: A Prospective, Gender-Bias Mitigated, Reproducible Analysis at Two Yea... by Nima Heidari, Tiffanie-Marie Borg, Stefano Olgiati, Mark Slevin, Alessandro Danovi, Brady Fish, Adrian Wilson, Ali Noorani

“…We identified all patients with KOA Kellgren-Lawrence grade 3 and 4 in our dataset of patients treated with a single injection of MFAT and applied published OKS thresholds for referral for TKR to separate them into 3 cohorts according to their functional impairment. 220 patients (95 females, 125 males) with KOA were given one MFAT injection. …”
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Quantile-Dependent Expressivity of Serum Uric Acid Concentrations by Paul T. Williams

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Spatio-Temporal Dynamics of Sediment Transport Pathways: Sand Apron Bars and Islands of Tokelau and Kiribati, Central Pacific by Eugene C. Rankey, Tion Uriam, Mika Perez

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Peptide Design for Enhanced Anti-Melanogenesis: Optimizing Molecular Weight, Polarity, and Cyclization by Putri SA, Maharani R, Maksum IP, Siahaan TJ

“…Selvi Apriliana Putri,1 Rani Maharani,1 Iman Permana Maksum,1 Teruna J Siahaan2 1Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Bandung, 40173, Indonesia; 2Department of Pharmaceutical Chemistry, School of Pharmacy, The University of Kansas, Lawrence, KS, 66047, USACorrespondence: Iman Permana Maksum, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Padjadjaran University, Bandung, 40173, Indonesia, Email iman.permana@unpad.ac.idAbstract: Melanogenesis is a biochemical process that regulates skin pigmentation, which is crucial role in protecting against ultraviolet radiation. …”
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Thermal Stability of Schottky Contacts and Rearrangement of Defects in β‐Ga2O3 Crystals by Palvan Seyidov, Joel B. Varley, Ymir Kalmann Frodason, Detlef Klimm, Lasse Vines, Zbigniew Galazka, Ta‐Shun Chou, Andreas Popp, Klaus Irmscher, Andreas Fiedler

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