Medical student experiences of Case-Based Learning (CBL) at a multicultural medical school by Catherine Bruen, Jan Illing, Ronan Daly, Frances Meagher, Caroline Delany, Gozie Offiah, Sally Doherty, Ellen Stuart, Martina Crehan, Helen Kelly

“…It has long been acknowledged that adapting to more active ways of learning form part of the challenge for new university students as the pedagogical distance between the didactical approach largely followed by secondary school systems the world over differs quite significantly from the often more student-led, critical approach taken by universities. University students encounter various learning challenges, particularly during the transition from secondary school to university. …”
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Addressing inhaler technique challenges in cognitively impaired chronic obstructive pulmonary disease patients: the impact of customized training programs by Vaishnavi V Gaonkar, Vinay V Shanbhag, Shreya S Kajave, Mahek R Mattikop, Mandati Santhosh Reddy

“…At follow-up, CAT score (25±5.61 vs. 18.48±5.24 p=0.001), SGRQ score (53.82±20.59 vs. 37.61±22.17 p=0.001), mMRC score (3.21±0.76 vs. 3.20±0.75 p=0.001), and forced expiratory volume in 1 second/forced vital capacity score (66.86±9.35 vs. 70.08±9.07 p=0.001) had significantly improved in patients demonstrating the correct technique. Pharmacist-led interventions demonstrated improvements in health-associated quality of life and therapeutic outcomes for individuals with COPD and CI. …”
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Increased expression of plasma mir-9-3p and let-7b-3p in methamphetamine use disorder and its clinical significance by Wei Wang, Chen Li, Guangsheng Sun, Cunxi Qiu, Junyi Fan, Yuhan Jin, Kunpeng Liu, Peng Sun

“…Furthermore, qRT-PCR and Western blot analyses demonstrated that transfection with miR-9-3p mimic led to overexpression of miR-9-3p, while transfection with let-7-3p mimic promoted overexpression of let-7-3p, concurrently inhibiting the protein levels of BDNF and GSK3B in cells (P < 0.05); ROC curve analysis indicated that the AUC for miR-9-3p was 0.782 (95% CI 0.716–0.848) and for let-7b-3p was 0.720 (95% CI 0.650–0.789). …”
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Impact of zero-markup consumable policy and national procurement of coronary stents on hospitalization expenses: an interrupted time series analysis by Shao-long Wu, Shao-long Wu, Kun Wang, Xin Yang, Ning Liu, Ning Liu, Wen-xin Zou, Xiao-wei Li, Dan-hua Huang, Tian-hao Yu

“…However, the implementation of the national procurement policy for coronary stents led to a significant reduction in medical consumables expenses. …”
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Resveratrol contributes to NK cell-mediated breast cancer cytotoxicity by upregulating ULBP2 through miR-17-5p downmodulation and activation of MINK1/JNK/c-Jun signaling by Bisha Ding, Jie Li, Jia-Lin Yan, Chun-Yan Jiang, Ling-Bo Qian, Jie Pan

“…The JNK inhibitor sp600125 was utilized to elucidate the specific role of JNK in modulating ULBP2 expression.ResultsRES increased ULBP2 expression on BC cells, thereby augmenting their vulnerability to NK cell-mediated cytotoxicity both in vitro and in vivo. RES administration led to a reduction in cellular miR-17-5p level. …”
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The aptamer BC 007 for treatment of dilated cardiomyopathy: evaluation in Doberman  Pinschers of efficacy and outcomes by Sabine Werner, Gerd Wallukat, Niels‐Peter Becker, Katrin Wenzel, Johannes Müller, Ingolf Schimke, Gerhard Wess

“…Forty‐eight hours after treatment, the DP's blood was free of β1‐AAB, which led to a reduction or stabilization of left ventricular end‐systolic volume (ESVI) during β1‐AAB free time in 10 of the treated DP. …”
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Severe soft tissue injuries in multiple trauma patients—a challenge we can meet? A matched-pair analysis from the TraumaRegister DGU® by Nora Kirsten, Georg Maximilian Franke, Rolf Lefering, Tim Klüter, Matthias Weuster, Michael Müller, Sebastian Lippross, Andreas Seekamp, TraumaRegister DGU®, Stefanie Fitschen-Oestern

“…In this study, we were able to show that although concomitant severe soft tissue injuries required more ICU interventions and led to a longer length of stay, 24-h and all-cause mortality were not significantly increased.…”
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Effectiveness of Virtual Reality Training in Improving Outcomes for Dialysis Patients: Systematic Review and Meta-Analysis by Xin Kang, Yiping Zhang, Chaonan Sun, Jiaxin Zhang, Zhe Che, Jinhui Zang, Rongzhi Zhang

“…The meta-analysis demonstrated that VR training led to significant improvements across multiple domains. …”
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THE EFFECT OF NUTRITIONAL THERAPY ON QUALITY OF LIFE INDICATORS FOR PATIENTS WITH GASTRIC CANCER AT THE STAGE OF SURGICAL TREATMENT by A. D. Sergienko, V. E. Khoronenko, E. V. Gameeva, A. B. Ryabov, V. M. Khomyakov

“…Improving appetite in patients of the main group led to an improvement in the functioning of the gastrointestinal tract as a whole. …”
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Randomized, observer-blind, controlled Phase 1 study of the safety and immunogenicity of the Na-GST-1/Alhydrogel hookworm vaccine with or without a CpG ODN adjuvant in hookworm-naï... by David J Diemert, Maria Zumer, Mark Bova, Christina Gibbs-Tewary, Elissa M Malkin, Doreen Campbell, Lara Hoeweler, Guangzhao Li, Maria Elena Bottazzi, Peter J Hotez, Jeffrey M Bethony

“…These promising results have led to inclusion of the CpG 10104 formulation of Na-GST-1/Alhydrogel in a Phase 2 proof-of-concept controlled human infection trial.…”
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Synergistic impact of Salmonella typhimurium and Eimeria spp. coinfection on turkey poults: Growth performance, salmonella colonization, and ceca microbiota insights by Hamid Reza Rafieian-Naeini, Hanseo Ko, Doyun Goo, Venkata Sesha Reddy Choppa, Seshidhar Reddy Gudidoddi, Hemanth Reddy Katha, Woo Kyun Kim

“…Coinfection with Salmonella and Eimeria spp. led to changes in gut microbiota and increased liver Salmonella colonization and fat deposition in turkey poults.…”
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A KSHV RNA-binding protein promotes FOS to inhibit nuclease AEN and transactivate RGS2 for AKT phosphorylation by Vladimir Majerciak, Beatriz Alvarado-Hernandez, Yanping Ma, Shivalee Duduskar, Alexei Lobanov, Maggie Cam, Zhi-Ming Zheng

“…Knockout of the ORF57 gene from the KSHV genome led BAC16-iSLK cells incapable of FOS expression in KSHV lytic infection. …”
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Curcumin administration alleviates seminal vesicle damage in type 1 diabetic rats by promoting AQP8 expression through AR activation by Dawei Ni, Kun Liu, Ning Wu, Bin You, Baibing Yang, Wei Wu, Yutian Dai

“…Western blot and PCR results demonstrated that the expression levels of androgen receptor (AR) and aquaporin (AQP)8 in the seminal vesicle tissues of diabetic rats were decreased, whereas curcumin treatment led to increases in the expression levels of AR and AQP8. …”
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Design and Validation of Policy Making Model with Open Government Approach by Zahra Mohammadi, Abdolmajid Imani, Farahnaz Ahang

“…This comprehensive exploration led to the creation of a research model, which was subsequently validated using a questionnaire designed on a Likert scale. …”
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Influence of substrate bias on the properties of CrAlN wear-resistant coating prepared by arc/magnetron composite technology by Xiaoyan NIU, Mingze LIU, Guoqiang DONG, Yujiang WANG, Haoliang TIAN

“…At this bias −60 V, the coating demonstrated a low wear rate, while a higher substrate bias led to severe abrasive wear. Tuning the substrate bias voltage, allowed for effectively optimizing the microstructure, mechanical properties, frictional behavior, and wear resistance of CrAlN coatings. …”
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Pornography-Watching Disorder and Its Risk Factors Among Young Adults: Cross-Sectional Survey by Csaba Erdős, Oguz Kelemen, Dávid Pócs, Edit Paulik, András Papp, Edina Horváth, Arbel Golan, Krisztián Széll

“… BackgroundThe widespread availability of internet-based pornography has led to growing concerns about its impact on mental health, particularly among young adults. …”
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Sentiments of Individuals with Interstitial Cystitis/Bladder Pain Syndrome Toward Pentosan Polysulfate Sodium: Infodemiology Study by Yulin Hswen, Qiuyuan Qin, Pressley Smith, Alison Swierczynski, Stuart Bauer, Erika Ladson, Amanda Leigh Garrett, Catherine A Brownstein

“…As remains a complex syndrome, this study highlights the value of patient-led discussions in informing treatment decisions. …”
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3D plants: the impact of integrating science, design, and technology on high school student learning and interests in STEAM subjects and careers by Sandra Arango-Caro, Tiffany Langewisch, Kaitlyn Ying, Michelle Arellano Haberberger, Nate Ly, Christopher Branton, Kristine Callis-Duehl

“…Our findings indicate that our STEAM module effectively integrated science, art, design, and technology, enhancing student literacy in these fields, and providing students with essential 21st century skills. The module led to interdisciplinary learning and development of interest in STEAM subjects and careers. …”
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Effect of visceral fat area on prognosis of patients undergoing radical gastrectomy and construction of nomogram by Zhicheng Huang, Baohua Zheng, Zhiwei Wang, Xiaobin Chen, Yu Wang

“…Multivariate Cox regression analysis led to the construction of a nomogram prediction model for the total survival of gastric cancer patients. …”
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Performance evaluation of inset feed microstrip patch antenna parameters with different substrate materials for 5G wireless applications by Kebbekoppalu Shrinivasa Praveena, M Patil Chandrashekar

“…Polystyrene and Rogers 6002 also exhibited commendable performance, especially in the thicker substrates (3.2 mm and 4.8 mm), with Polystyrene achieving the highest directivity at 4.8 mm thickness. Rogers 5880 again led the performance in terms of efficiency, with efficiency values consistently above 70 % across all thicknesses, peaking at 86.38 % at 1.6 mm and 86.39 % at 3.2 mm. …”
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