Antistaphylococcal Triazole-Based Molecular Hybrids: Design, Synthesis and Activity by Kostiantyn Shabelnyk, Alina Fominichenko, Oleksii Antypenko, Olexandr Gaponov, Svitlana Koptieva, Svitlana Shyshkina, Oleksii Voskoboinik, Sergiy Okovytyy, Serhii Kovalenko, Valentyn Oksenych, Oleksandr Kamyshnyi

“…At the same time, the introduction of a methyl group into the aniline moiety led to an enhancement of activity. The introduction of halogen into the aniline fragment has an ambiguous effect on the level of antistaphylococcal activity and depends on the nature of the substituent in the third position. …”
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Exosomal mir-126-3p derived from endothelial cells induces ion channel dysfunction by targeting RGS3 signaling in cardiomyocytes: a novel mechanism in Takotsubo cardiomyopathy by Xuehui Fan, Guoqiang Yang, Yinuo Wang, Haojie Shi, Katja Nitschke, Katherine Sattler, Mohammad Abumayyaleh, Lukas Cyganek, Philipp Nuhn, Thomas Worst, Bin Liao, Gergana Dobreva, Daniel Duerschmied, Xiaobo Zhou, Ibrahim El-Battrawy, Ibrahim Akin

“…Exo derived from HCMECs treated with Epi (Epi-exo) mimicked or enhanced the effects of Epi. Epi exposure led to elevated levels of miR-126-3p in both HCMECs and their exosomes. …”
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Epithelial NSD2 maintains FMO‐mediated taurine biosynthesis to prevent intestinal barrier disruption by Yue Xu, Xiuying Xiao, Chunxiao Ma, Ziyi Wang, Wenxin Feng, Hanyu Rao, Wei Zhang, Ningyuan Liu, Rebiguli Aji, Xiangjun Meng, Wei‐Qiang Gao, Li Li

“…Mechanistically, NSD2 loss led to downregulation of H3K36me2 and flavin‐containing monooxygenase (FMO) (taurine‐synthesis enzyme) mRNA, resulting in decreased taurine biosynthesis in IECs. …”
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Placental trophoblast aging in advanced maternal age is related to increased oxidative damage and decreased YAP by Song Guo, Song Guo, Qihao Pan, Qihao Pan, Baokang Chen, Baokang Chen, Yijuan Huang, Yijuan Huang, Si Li, Si Li, Chenyu Gou, Chenyu Gou, Yu Gao, Yu Gao

“…Furthermore, employing molecular modification to silence YAP expression in these cells led to an induction of aging. Conversely, overexpressing YAP ameliorated both trophoblast cell aging and the associated DNA oxidative damage that arised from H2O2.ConclusionThe decline of YAP in AMA pregnancy should be responsible for the increased oxidative injury and premature placenta aging, indicating that YAP plays a significant role in combating oxidative damage and delaying aging, thereby providing a new guidance for prenatal care in AMA pregnancies. …”
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Steatohepatitis-induced vascular niche alterations promote melanoma metastasis by Johannes Hoffmann, Julia Schüler, Bianca Dietsch, Sina Wietje Kürschner-Zacharias, Carsten Sticht, Felix A. Trogisch, Maren Schreitmüller, Tinja Baljkas, Kai Schledzewski, Manuel Reinhart, Sebastian A. Wohlfeil, Manuel Winkler, Christian David Schmid, Joerg Heineke, Cyrill Géraud, Sergij Goerdt, Philipp-Sebastian Reiners-Koch, Victor Olsavszky

“…Results Feeding a CDAA diet, in contrast to a HFD, led to increased metastasis before the development of liver fibrosis. …”
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Characteristics and multi-omics analysis of spontaneous spondyloarthritis in non-human primates: Case report by Lei Cai, Qing Lv, Ronghua Ma, Wei Liu, Yalun Guan, Zhongqiang Huang, Qingyu Liu, Yunfeng Li, Shuhua Liu, Ge Li, Yu Zhang

“…Its intricate pathological mechanisms have led to a scarcity of animal models capable of replicating the disease progression in humans, making it a prominent area of research interest in the field. …”
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Development and usability testing of a multifaceted intervention to reduce low-value injury care by Mélanie Bérubé, Alexandra Lapierre, Michael Sykes, Jeremy Grimshaw, Alexis F. Turgeon, François Lauzier, Monica Taljaard, Henry Thomas Stelfox, Holly Witteman, Simon Berthelot, Éric Mercier, Catherine Gonthier, Jérôme Paquet, Robert Fowler, Natalie Yanchar, Barbara Haas, Paule Lessard-Bonaventure, Patrick Archambault, Belinda Gabbe, Jason R. Guertin, Yougdong Ouyang, Lynne Moore, the Canadian Traumatic Brain Injury Research Consortium

“…A total of 61 issues were identified during the usability testing, of which eight were critical, 33 were moderately important, and 18 were minor. These issues led to numerous improvements, including the addition of information on the drivers and benefits of reducing low-value practices, changes in the definition of these practices, the addition of proposed strategies to facilitate de-implementation, and the tailoring of educational/facilitation visits. …”
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Effects of Temperature and Light Intensity on the Growth and Physiological and Biochemical Characteristics of Young Sporophyte of a Novel Saccharina japonica "Huangguan No.2" by Guiyang SONG, Zhourui LIANG, Xiaoping LU, Yanmin YUAN, Wenjun WANG

“…This indicates that the light energy conversion efficiency and light energy utilization efficiency significantly increased in the low light environment, which led to an increase in the absorption of light energy. …”
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Optimasi Data Tidak Seimbang pada Interaksi Drug Target dengan Sampling dan Ensemble Support Vector Machine by Nabila Sekar Ramadhanti, Wisnu Ananta Kusuma, Annisa Annisa

“…This unknown interaction led drug target interaction to become imbalanced data. …”
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CHARACTERISTICS OF CYTOPROTECTIVE EFFECT ON THE GASTRIC MUCOSA OF CRYOPRESERVED PLACENTA EXTRACT UNDER WATER-IMMOBILIZATION STRESS by Illia Koshurba, Fedir Hladkykh, Mykola Chyzh

“…The use of CEP, as well as esomeprazole, led to a weakening of GM ulcers. This was indicated by a statistically significant (p<0.05) decrease in ulcer index (UI) relative to the indicators of control rats by 9.8 and 3.3 times, respectively. …”
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Efficacy of total transanal laparoscopic pull‑through and pure transanal endorectal pull‑through in the treatment of common‑type Hirschsprung disease by Guizhen Huang, Wenqian Huang, Chi Sun, Meng Li, Chaosheng He, Yi Su, Weili Xu, Suolin Li

“…Improvements in laparoscopic skills among pediatric surgeons, along with technological advancements, have led to the widespread use of the natural orifice transluminal endoscopic surgery (NOTES) technique; however, reports on long-term outcomes and high-quality follow-up data on anorectal manometry in patients treated with this approach are scarce. …”
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Translation and assessment of encultured meaning of the Multi-Dimensional Scale of Perceived Social Support in Din&eacute; bizaad (Navajo) using community-based participatory actio... by Tapati Dutta, Jon Agley, Camille Keith, Gregory Zimet

“…Methods: This study was led by a faculty member at a Native American-Serving Nontribal Institution (NASNTI) in south-western Colorado, US. …”
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The Rise of Accounting Administration and Its Impact on the Profitability of Microeconomic Management by R. Acosta Velarde, M. Campaña Lara, E. Melendres Medina, J. Flores Dávila

“…A greater growth of SMEs that use RISE as part of their administration, especially grocery stores, has been identified in the commercial sector in the city of Macas, Morona canton, Morona Santiago province, Ecuador. This has led to a lack of knowledge about their profitability because the nature of the tax can lead to reduced use of accounting tools. …”
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Socio-economic assessment of drought impacts in Lesotho: implications for early action by Relebohile Agnes Mojaki, Makoala Vitalis Marake, Evan Easton-Calabria, Joalane Rethabile Marunye, Erin Coughlan de Perez

“…Given that the research team has worked with humanitarian organisations in the study area after which development interventions were implemented, this might have led to interviewees exaggerating the negative impacts of drought hoping the team to bring assistance into the community. …”
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Measuring the uptake of clinic-based HIV treatment and prevention services following HIV testing and referral at private pharmacies in Kenya by Victor Omollo, Stephanie D. Roche, Shengruo Zhang, Magdalene Asewe, Bernard K. Rono, Benn Kwach, Greshon Rota, Patricia Ong’wen, Kendall Harkey, Josephine Odoyo, Daniel Were, Kenneth Ngure, Elizabeth A. Bukusi, Katrina F. Ortblad

“…Conclusions Although offering free HIV testing at private pharmacies led to the identification and referral of clients who could benefit from HIV services, additional interventions (e.g., incentives, patient navigators) may be needed to support PrEP referral follow-through. …”
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Designing an Innovative Human Resources Model Based on Perceived Organizational Support Case Study of Qazvin's Government organizations by Hossein Rasouli, Morteza Mousakhani, Mahdi Alvani, parham azimi

“…This thorough investigation led to the emergence of innovative themes that were distinctly extracted from the disparities between the theoretical literature, past research background, and enriched insights obtained from expert interviews. …”
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Response to Aflibercept Therapy in Three Types of Choroidal Neovascular Membrane in Neovascular Age-Related Macular Degeneration: Real-Life Evidence in the Czech Republic by Jan Nemcansky, Alexandr Stepanov, Michal Koubek, Miroslav Veith, Yun Min Klimesova, Jan Studnicka

“…The primary outcome of our study is that the treatment with aflibercept in nAMD patients led to statistically significant improvement in BCVA and to a decrease in CRT throughout the follow-up period in both occult and classic types of CNV. …”
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Mechanism of the effect of chitosan combined with EICP on the erosion resistance of slopes in open-pit mine dump by Zhile WANG, Yu TIAN, Wei ZHOU, Yi WANG, Rui LI, Yihan GUO, Ya TIAN, Ao LU

“…The results showed that: the optimal reaction parameters for EICPcorrosion resistance of the slope in the drainage field were urea and calcium chloride concentration of 1 mol/L, chitosan doping of 5 g/L, and temperature not higher than 60 ℃; after rainfall erosion, the control group had uneven distribution of surface craters, while there was no obvious change in the modified group, and the final erosion amount of the soil in the EICP and chitosan combined EICP groups was reduced by 85.4% and 91.6%, respectively. and the surface strength was increased by 9.8% and 14.2%, respectively. EICP treatment led to the decrease of soil pH, while the addition of chitosan could stabilize urease activity and ensure urea hydrolysis; chitosan adsorbed urease and Ca2+ to provide nucleation sites for EICP through electrostatic and acid-base interactions, respectively, to promote the production and dispersal of the steady-state mineralization products (calcite) in the EICP and the distribution of the soil. …”
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Evaluation of primary HPV-based cervical screening among older women: Long-term follow-up of a randomized healthcare policy trial in Sweden. by Qingyun Yao, Jiangrong Wang, K Miriam Elfström, Björn Strander, Joakim Dillner, Karin Sundström

“…We were limited by a partial imbalance of invitations during the follow-up between the 2 arms which may have led to an underestimation of the effectiveness of primary HPV-based screening.…”
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The role of Nazi organizations in German repatriation from the Baltic states (1939-1941) by Ingrida Jakubavičienė

“…The German Nazi movement (Bewegung) was especially active in Latvia, led by Erhard Kroeger. The Nazi organization in Estonia was directed by Oskar Lutz and Baron Wrangel, the president of the German community. …”
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