Effect of practicing water-saving irrigation on greenhouse gas emissions and crop productivity: A global meta-analysis by Mingdong Tan, Ningbo Cui, Shouzheng Jiang, Liwen Xing, Shenglin Wen, Quanshan Liu, Weikang Li, Siwei Yan, Yaosheng Wang, Haochen Jin, Zhihui Wang

“…Furthermore, water use efficiency (WUE) significantly improved by 0.265 (95 %CI: 0.203–0327). However, WSI also led to an increase in nitrous oxide (N2O) emissions by 0.126 (95 %CI: 0.057–0.196) while a slight decrease of crop yield by −0.048 (95 %CI: −0.071 to −0.026). …”
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Impact of co-infections and immune responses on clinical severity of human adenovirus 3 and 7 infections in hospitalized children with lower respiratory tract infections: a compara... by Xiaolin Ma, Yuting Wu, Ri De, Hailan Yao, Feng He, Yi Wang, Wei Wang, Chao Yan, Qinwei Song, Chunjie Guo, Li Wen, Linqing Zhao, Ling Cao, Chunmei Zhu

“…Immune cell analysis indicated that HAdV-7 infections led to a more pronounced decrease in CD3+ T cells (1596.8 vs 2444.8 cells/𝛍l, p=0.042), CD8+ cytotoxic T cells (668.6 vs 774.0 cells/µl, p=0.045), and increased NK cell percentages (11.5% vs 9.0%, p=0.044) compared to HAdV-3 infections.ConclusionsHospitalized children with HAdV-7-associated LRTIs exhibit greater severity, multiple infections, and significant potential for greater cellular immune dysregulation compared to those with HAdV-3 infection, indicating a more severe clinical course and distinct pathogenic profiles.…”
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Placental growth factor modulates endothelial NO production and exacerbates experimental hepatopulmonary syndrome by Fabien Robert, Feriel Benchenouf, My Ngoc Ha, Alessandra Cuomo, Mina Ottaviani, Maxime Surbier, Raphaël Thuillet, Corinne Normand, Florent Dumont, Céline Verstuyft, Frederic Fiore, Frederic Guinut, Marc Humbert, Audrey Coilly, Emmanuel Gonzales, Olivier Sitbon, Ly Tu, Christophe Guignabert, Laurent Savale

“…In vitro, PlGF stimulation enhanced eNOS activity in human pulmonary microvascular endothelial cells, whereas PlGF knockdown led to a decrease. Conclusions: These findings indicate that PlGF aggravates cirrhosis-induced HPS through modulation of pulmonary eNOS activity, and is not involved in HPS from extrahepatic portal hypertension. …”
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A Neural Circuit From Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens Mediates Inflammatory Pain in Mice by Xi Liu, Xi Zhang, Dongxu Wang, Ya Cao, Ling Zhang, Zhonghua Li, Qin Zhang, Yu Shen, Xian Lu, Keyu Fan, Mingxia Liu, Jingqiu Wei, Siping Hu, He Liu

“…In addition, compared to the control group, CFA‐induced inflammatory pain led to increased c‐Fos protein expression in PVT, which means that some of the neurons in this area of the brain region have been activated. …”
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TP53 germline testing and hereditary cancer: how somatic events and clinical criteria affect variant detection rate by Paula Rofes, Carmen Castillo-Manzano, Mireia Menéndez, Álex Teulé, Sílvia Iglesias, Elisabet Munté, Mireia Ramos-Muntada, Carolina Gómez, Eva Tornero, Esther Darder, Eva Montes, Laura Valle, Gabriel Capellá, Marta Pineda, Joan Brunet, Lidia Feliubadaló, Jesús del Valle, Conxi Lázaro

“…The implementation of multi-gene panel germline testing in different clinical settings has led to the identification of TP53 PV carriers outside the classic LFS-associated cancer phenotypes, leading to a broader cancer phenotypic redefinition and to the renaming of the condition as “heritable TP53-related cancer syndrome” (hTP53rc). …”
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Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression by Alena Laschtowitz, Eric L. Lindberg, Anna-Maria Liebhoff, Laura Anne Liebig, Christian Casar, Silja Steinmann, Adrien Guillot, Jun Xu, Dorothee Schwinge, Michael Trauner, Ansgar Wilhelm Lohse, Stefan Bonn, Norbert Hübner, Christoph Schramm

“…Validation against an external data set of 73 liver biopsies from patients with PSC with different fibrosis stages led to a condensed set of 150 (out of 367) differentially expressed genes. …”
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A staged integrated model informing the promotion of healthy dietary behaviors in adolescents: a prospective study by Qijiao Liu, Huanyu Xu, Zihao Yuan, Lan Yu, Ruizhe Shang, Wanjie Tang, Yuchen Li, Shiying Li, Qiaolan Liu

“…Interventions within the staged integrated model, led to increased adoption of healthy dietary behaviors in intervention group compared to control group (33.40% vs. 25.70%, P < .05), indicating certain effectiveness, particularly in targeting action self-efficacy (stronger direct effects on behavioral intentions and maintenance self-efficacy, β = 0.489 to 0.704, P < .001). …”
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Long-term outcomes of robot-assisted versus minimally invasive esophagectomy in patients with thoracic esophageal cancer: a propensity score-matched study by Toru Sakurai, Akihiro Hoshino, Kenta Miyoshi, Erika Yamada, Masaya Enomoto, Junichi Mazaki, Hiroshi Kuwabara, Kenichi Iwasaki, Yoshihiro Ota, Shingo Tachibana, Yutaka Hayashi, Tetsuo Ishizaki, Yuichi Nagakawa

“…Conclusions Compared with MIE, RAMIE led to no differences in long-term results, suggesting that RAMIE is a comparable technique.…”
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Clinical integration of germline findings from a tumor testing precision medicine program by Maria Carolina Sanabria-Salas, Nina C. Anggala, Brittany Gillies, Kirsten M. Farncombe, Renee Hofstedter, Larissa Peck, Helia Purnaghshband, Laura Redondo, Emily Thain, Wei Xu, Peter Sabatini, Philippe L. Bedard, Raymond H. Kim

“…Methods Between August 2022 and August 2023, a clinical pathway led by a germline Molecular Tumor Board (gMTB) was established to review tumor genetic variants (TGVs) flagged as potential germline findings in patients with advanced cancer via a multigene panel. …”
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Associations between local COVID-19 policies and anxiety in the USA: a longitudinal digital cohort study by Jeffrey E Olgin, Gregory M Marcus, Rita Hamad, John Kornak, Carmen R Isasi, Ana Sanchez-Birkhead, Mark Pletcher, Soo Park, Natasha Williams, Thomas Carton, Aaron E Cozen, Madelaine Faulkner Modrow, Amy Chiang, Matthew Brandner, Jaime H Orozco, Kristen Azar, Sylvia E K Sudat, Pelin Ozluk, Heather Kitzman, Sara J Knight

“…Introduction A lack of coordinated federal guidance led to substantial heterogeneity in local COVID-19 policies across US states and counties. …”
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Exploring the alleviating effects of Bifidobacterium metabolite lactic acid on non-alcoholic steatohepatitis through the gut-liver axis by Hongmei Zhao, Hongmei Zhao, Juan Zhou, Lingzhi Yuan, Zhiyi Sun, Yi Liu, Xinyu Zhao, Feng Ye

“…Further addition of G-3P led to more pronounced improvement in NAFLD symptoms, while overexpression of NLRP3 weakened the protective effects of Bifidobacterium. …”
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Discontinuation of immune checkpoint inhibitors for reasons other than disease progression and the impact on relapse and survival of advanced melanoma patients. A systematic review... by Konstantinos Lallas, Eftychia Chatziioannou, Derya Durak, Georg Frey, Lina Maria Serna-Higuita, Marie-Lena Rasch, Athanassios Kyrgidis, Eleni Timotheadou, Zoe Apalla, Ulrike Leiter, Lukas Flatz, Lukas Flatz, Aimilios Lallas, Teresa Amaral, Teresa Amaral

“…Treatment duration before cessation was not associated with risk and time to relapse, while mucosal melanomas and non-CR as BOR during treatment led to increased risk for relapse and shorter time to PD compared to other histologic subtypes or CR. …”
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The carbon cost of impaired welfare on sheep farms by L. Lanzoni, M.C. Reeves, K. Waxenberg, R. Ramsey, A.S. Atzori, J. Bell, R.M. Rees, G. Vignola, C.M. Dwyer

“…Most impaired welfare scenarios led to a slight decrease in total farm emissions (0.03–3%), with a few exceptions. …”
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Low-activity [18F]-somatostatin receptor (SSTR) imaging using [18F]SiTATE on a long axial field-of-view PET/CT scanner by Nils F. Trautwein, Eduardo Calderón, Pia M. Linder, Gerald Reischl, Philippe Driessen, Wenhong Lan, Andreas S. Brendlin, Thorben Groß, Helmut Dittmann, Martina Hinterleitner, Christian la Fougère, Fabian P. Schmidt, Lena S. Kiefer

“…However, reduced activities led to an increase in SUVSD, which in turn caused a decrease in SNR (at 1 MBq/kg: 7.3 in HS and 9.0 in UHS mode and an increase in deviation of the MTV. …”
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Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis... by Wenji Pu, Wenji Pu, Wenji Pu, Wenqi Chen, Haiman Jing, Jishi Li, Yong Jiang, Shasha Li, Weijie Wen, Zhiyuan Xu, Jing Jin

“…Compared with the standard LCCRT, TNT treatment on the basis of SCRT/CCT increased the pCR rate significantly [RR = 1.67, 95% CI (1.36, 2.04), P &lt; 0.00001], especially in ≥ 4 cycles of the CCT arm [RR = 1.77, 95% CI: (1.41–2.23), p &lt; 0.00001], and led to a similar tumor downstaging rate [RR = 0.99, 95% CI (0.85, 1.15), P = 0.92]. …”
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IL-6/GATA2/SERPINE1 pathway is implicated in regulating cellular senescence after acute kidney injury by Hongshuang Su, Xiaoxi Lin, Ayinuer Paredong, Ayinuer Paredong, Congcong Yao, Yan Zhang, Mengke Geng, Yuqian Guan, Lichao Gong, Feng Jiang, Qi Lv, Songtao Shou, Heng Jin

“…Inhibition of the IL-6 receptor by tocilizumab in these cells led to a reduction in cellular senescence, accompanied by decreased of the cell cycle regulatory proteins P53 and P21 in mRNA and protein levels, while alleviating cell cycle arrest. …”
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Anti-PD-1 amplifies costimulation in melanoma-infiltrating Th1-like Foxp3+ regulatory T cells to alleviate local immunosuppression by Fernando Alvarez, Fan Huang, Sonia V Del Rincon, Mikhaël Attias, Tho-Alfakar Al-Aubodah, Roman Istomine, Paige McCallum, Abrahim Sleiman, Tamiko Nishimura, Yasser Riazalhosseini, Ciriaco A Piccirillo

“…Further characterization revealed that melanoma-infiltrating Treg cells progressively acquire T-bet and interferon gamma expression, exclusively in HRs, and induction of this T helper cell 1 (Th1)-like phenotype in vitro led to CD8+ T cell evasion from Treg cell-mediated suppression. …”
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The Role of Bronchoalveolar Lavage in Therapeutic Antimicrobial Choices for Hematologic Patients with Pulmonary Infiltrates by Filippo Patrucco, Mattia Bellan, Davide Martinotti, Giuseppe Ielo, Paola Rebecca Iovine, Martina Mascheroni, Francesco Todisco, Martina Ubaldi, Nadia Castaldo, Francesco Gavelli, Alberto Fantin

“…The patients with higher immunosuppression and the febrile ones underwent BAL earlier than the patients with mild immunosuppression (<i>p</i> = 0.01) and those with other presenting symptoms (<i>p</i> = 0.0001). BAL positivity led to a change in empirical antimicrobial therapy in 79 out of 104 cases (77% vs. 36.3%; <i>p</i> < 0.001); these data were also confirmed among the hospitalized patients (81% vs. 44%; <i>p</i> < 0.001). …”
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«Green-Ligand» in Metallodrugs Design—Cu(II) Complex with Phytic Acid: Synthetic Approach, EPR-Spectroscopy, and Antimycobacterial Activity by Kseniya A. Koshenskova, Natalia V. Makarenko, Fedor M. Dolgushin, Dmitriy S. Yambulatov, Olga B. Bekker, Matvey V. Fedin, Sergei A. Dementev, Olesya A. Krumkacheva, Igor L. Eremenko, Irina A. Lutsenko

“…The interaction of sodium phytate hydrate C₆H₁₈O₂₄P₆·xNa·yH₂O (phytNa) with Cu(OAc)₂·H₂O and 1,10-phenanthroline (phen) led to the anionic tetranuclear complex [Cu₄(H₂O)₄(phen)₄(phyt)]·2Na⁺·2NH₄⁺·32H₂O (<b>1</b>), the structure of the latter was determined by X-ray diffraction analysis. …”
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Toxic effects and mechanisms of nanoplastics and sulfonamide antibiotics on Scenedesmus obliquus by Jianyuan Yang, Zhen Yang, Jing Wang, Yanpeng Liang, Honghu Zeng, Litang Qin, Xiaohong Song, Lingyun Mo

“…The exposure of two NPs and four SAs and their binary mixtures differently promoted or inhibited superoxide dismutase and catalase activities in algal cells to different degrees and resulted in elevated levels of malondialdehyde content, suggesting that oxidative stress led to significant inhibition of chlorophyll content, total protein content, and growth of algal cells. …”
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