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7541
Management of a COVID-19 outbreak using a multidisciplinary approach and infection prevention control practices at a community living center in Veterans Administration Hospital, No...
Published 2025-01-01“… Abstract Background: The increase in severe acute respiratory coronavirus virus 2 (SARS-CoV-2) cases due to the omicron strain led to reduced acute care hospital beds at the Veterans Administration (VA) Hospital, North Texas; veterans with non-severe coronavirus disease 2019 (COVID-19) disease were managed at a community living center (CLC), a VA nursing home. …”
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7542
Variations in Water Stress and Its Driving Factors in the Yellow River Basin
Published 2024-12-01“…However, rising domestic water withdrawals have led to an overall increase in total water withdrawal, with agricultural water use accounting for the largest proportion of total water consumption. …”
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7543
Neoantigen-specific stimulation of tumor-infiltrating lymphocytes enables effective TCR isolation and expansion while preserving stem-like memory phenotypes
Published 2024-05-01“…Furthermore, neoantigenic stimulation improved the in vivo antitumor efficacy of TILs relative to the conventional OKT3-induced rapid TIL expansion in p53-mutated or KRAS-mutated xenograft mouse models.Conclusions Taken together, neoantigenic stimulation of TILs selectively expands neoantigen-reactive TILs by frequencies and by their clonal repertoire. NeoExpand led to improved phenotypes and functions of neoantigen-reactive TILs. …”
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7544
Deletion of sphingosine 1-phosphate receptor 1 in myeloid cells reduces hepatic inflammatory macrophages and attenuates MASH
Published 2025-02-01“…MASH was established by feeding mice a high-fat, -fructose, and -cholesterol (FFC) diet for 24 weeks, which led to the development of steatohepatitis and MASH-defining cardiometabolic risk factors. …”
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7545
Genetic investigations of autosomal recessive inherited ichthyosis impressed by fetal ultrasound: Exome sequencing and haplotype linkage analysis
Published 2025-01-01“…Both cases were diagnosed by high coverage WES and led to successful subsequent pregnancies by preimplantation genetic diagnosis and genetic amniocentesis. …”
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7546
Nature and Origin of Mineralizing Fluids in Hyperextensional Systems: The Case of Cretaceous Mg Metasomatism in the Pyrenees
Published 2019-01-01“…During the Albian, the hyperextension of the Pyrenean passive margin led to a hyperthinning of the continental crust and the subsequent subcontinental mantle exhumation. …”
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7547
Frequency of remission achievement in the pre-treat-to-target decade in juvenile idiopathic arthritis
Published 2025-01-01“…Abstract Background Over the past two decades there has been a remarkable advance in the management of juvenile idiopathic arthritis (JIA), which has led to considerable improvement in prognosis. In 2018, the introduction of the treat-to-target (T2T) strategy in JIA has been advocated to further ameliorate disease outcome. …”
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7548
IRG1/itaconate enhances efferocytosis by activating Nrf2-TIM4 signaling pathway to alleviate con A induced autoimmune liver injury
Published 2025-02-01“…Exogenous 4-octyl itaconate (OI) supplementation promoted the expression of Nrf2 and TIM4 and restored IRG1-/- bone marrow-derived macrophage (BMDM) efferocytosis, whereas inhibition of Nrf2 mediated by ML385 led to impaired efferocytosis of BMDMs, decreased expression of TIM4, and aggravated liver inflammation injury. …”
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7549
Heart–brain microvascular MRI study: protocol for a multicentre, observational, cohort study in the UK assessing associations between small vessel disease of the heart and brain
Published 2024-12-01“…It has also been demonstrated that coronary microvascular dysfunction and CSVD share common vascular risk factors and pathophysiological mechanisms of disease. This has led to a link between the conditions being hypothesised, however, there is an evidence gap clearly demonstrating this relationship. …”
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7550
Humoral and cellular immune durability of different COVID-19 vaccine platforms following homologous/heterologous boosters: one-year post vaccination
Published 2025-01-01“…We also evaluated the long-lasting specific humoral IgG levels and T-cell immunity of the Memory CD8 cells.ResultsWe found that heterologous prime boosters led to significantly higher IgG antibody levels)9.09(than homologous boosters)5.236) one year after vaccination. …”
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7551
Newly identified c-di-GMP pathway putative EAL domain gene STM0343 regulates stress resistance and virulence in Salmonella enterica serovar Typhimurium
Published 2025-01-01“…Our findings revealed that the deletion of this gene (269ΔSTM0343) led to a 29.85% increase in c-di-GMP. In terms of stress resistance, the strain 269ΔSTM0343 showed significant improvements compared to the wild strain WT269. …”
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7552
Effects of different-valent vaccines against human papillomavirus (HPV) to prevent persistent HPV16/18 infections and CIN2+ in women: a systematic review and network meta-analysis
Published 2025-02-01“…In addition to 4- and 9-valent vaccines, 2-valent vaccines could also provide satisfactory protection against persistent HPV16/18-related infections and CIN2+, especially over the long term, and may constitute an alternative for government-led vaccination programs in developing countries.…”
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7553
A Physics-Based Hyper Parameter Optimized Federated Multi-Layered Deep Learning Model for Intrusion Detection in IoT Networks
Published 2025-01-01“…The sudden uptick in the ubiquitous nature of IoT devices ranging from fitness watches to aircraft has led to a surge of cyber-attacks. Artificial Intelligence powered Intrusion Detection Systems (IDS) are being used recently to combat this increasing surge of attacks in the IoT environment. …”
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7554
Humanizing processes after harm part 1: patient safety incident investigations, litigation and the experiences of those affected
Published 2025-01-01“…Systemic fear of litigation not only failed to meet the needs of those affected, but also inadvertently led to some pursuing litigation. Staff had parallel experiences of exclusion, lacking support and feeling left with an incomplete narrative. …”
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7555
Impact of a phone call with a medical student/general practitioner team on morbidity of chronic patients during the first French COVID-19 lockdown (COVIQuest): a cluster randomised...
Published 2022-07-01“…Objectives The first COVID-19 lockdown led to a significantly reduced access to healthcare, which may have increased decompensations in frail patients with chronic diseases, especially older patients living with a chronic cardiovascular disease (CVD) or a mental health disorder (MHD). …”
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7556
Evaluation of a transdiagnostic mental health intervention in German primary care: study protocol for a parallel-group, two-arm, cluster randomised controlled pilot study
Published 2025-01-01“…Discussion The pilot study will address the research gap concerning general practitioner-led psychological interventions in primary care and will give insights into whether the adoption of a transdiagnostic approach is of benefit to general practitioners and patients. …”
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7557
Temperature-dependent toxicity and mechanisms of florfenicol on the embryonic development of marine medaka (Oryzias melastigma)
Published 2025-01-01“…For inflammatory response-related genes (nf-κb, nlrx1, pycard, caspase 1, and il-1β), an increase of florfenicol dose led to gene upregulation at 25 °C. Conversely, gene upregulation was also observed for all treatments at 30 °C, while predominantly downregulation was observed for all treatments at 20 °C. …”
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7558
Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model
Published 2018-01-01“…The blockade of the LPS-LBP interaction decreased neutrophil infiltration, led to increased white blood cell count, and decreased hepatic neutrophil infiltration, irrespective of dose. …”
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7559
Proteogenomic annotation of T6SS components identified in Bacteroides fragilis secretome
Published 2025-02-01“…Intensive study of the T6SS structure has led to an understanding of certain issues related to its functional activity, but the exact regulatory mechanisms of E-I protein pair activity remain unclear. …”
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7560
Unraveling the impact of SARS-CoV-2 mutations on immunity: insights from innate immune recognition to antibody and T cell responses
Published 2024-12-01“…This immune escape has led to waves of breakthrough infections, raising questions about the efficacy and durability of immune protection. …”
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