The accumulation of harmful genes within the ROH hotspot regions of the Tibetan sheep genome does not lead to genetic load by Lixia Sun, Chao Yuan, Tingting Guo, Yaqin Bai, Zengkui Lu, Jianbin Liu

“…Abstract Background Prolonged natural selection and artificial breeding have contributed to increased uniformity within the Tibetan sheep population, resulting in a reduction in genetic diversity and the establishment of selective signatures in the genome. This process has led to a loss of heterozygosity in specific genomic regions and the formation of Runs of Homozygosity (ROH). …”
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Understanding the cost-utility of implementing HIV self-testing with digital-based supports by Brianna Empringham, Brianna Empringham, Angela Karellis, Marta Fernandez-Suarez, Sergio Carmona, Nitika Pant Pai, Alice Zwerling

“…Digital-based supports were associated with an increased cost compared to facility-based testing, but they also had increased utility, which led to favorable cost-utility estimates.DiscussionHIVST with digital supports has the potential to be a highly cost-effective approach, with the potential to make HIV testing more available and accessible, thereby increasing overall uptake and coverage of HIV testing. …”
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The adaptation process of a safety planning intervention to promote connectedness and reduce distress in Diné adolescents and adults during the COVID-19 pandemic by Joshuaa Dominic Allison-Burbank, Vanessa Begaye, Kyann Dedman-Cisco, Lisa Jim, Shannon Archuleta, Renae Begay, Lacey Howe, Emily E. Haroz

“…When Safety Planning and Caring Contacts messaging was selected, the study team, which consisted primarily of Navajo research personnel led by a Navajo community-based principal investigator (PI) and allied PIs with extensive experience in implementation science, infectious disease prevention, and CBPR, were adapted and presented to CAB members. …”
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The proneural transcription factor Atoh1 promotes odontogenic differentiation in human dental pulp stem cells (DPSCs) by Camila Sabatini, Huey-Jiun Lin, Galib Ovik, Richard Hall, Techung Lee

“…The increased BMP/Wnt signaling led to up to 8-fold increased expression of the master osteogenic transcription factor Osterix (P < 0.005) while exhibiting no significant effect on Runx2 or Dlx5, which are abundantly expressed in DPSCs. …”
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Turbulent heat flux dynamics along the Dotson and Getz ice-shelf fronts (Amundsen Sea, Antarctica) by B. Jacob, B. Y. Queste, M. D. du Plessis

“…Using a 1D model, we show that the mean co-located ERA5 heat loss underestimation of 28 W m<span class="inline-formula">⁻²</span> led to an overestimation of the summer evolution of sea surface temperature (heat content) by <span class="inline-formula">+</span>0.76 °C (<span class="inline-formula">+</span>8.2<span class="inline-formula">×</span>10<span class="inline-formula">⁷</span> J) over 35 d. …”
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Towards an Automated Design Evaluation Method for Wire Arc Additive Manufacturing by Johannes Pusicha, Henrik Stromberg, Markus Quanz, Armin Lohrengel

“…Freedom of design and the cost-effective production of structural parts have led to much research interest in <i>Wire Arc Additive Manufacturing</i> (WAAM). …”
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Y2O3NPs induce selective cytotoxicity, genomic instability, oxidative stress and ROS mediated mitochondrial apoptosis in human epidermoid skin A-431 Cancer cells by Hanan RH Mohamed, Shrouk H.A Hemdan, Ahmed A. El-Sherif

“…When A-431 cancer cells were treated with the half-maximal inhibitory concentration (IC50) of Y2O3NPs for 72 h, a significant increase in ROS generation was noted. This led to oxidative stress, along with severe damage to genomic DNA and mitochondrial membrane potential, triggering substantial apoptosis. …”
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De organografía, organología y etnolaudería como propuesta para el estudio de los instrumentos musicales tradicionales by Víctor Hernández Vaca

“…Abstract In a review of the classical literature on traditional Mexican musical instruments, several results come to light: scholars, including myself, have spoken indistinctively of organography and organology as the conceptual and methodological frameworks for the study of the traditional musical instrument. This has led to a certain epistemological ambiguity when using these terms, which have been understood as disciplines, methods, arts, sciences, and, mainly, as a system of taxonomies. …”
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Understanding the dynamics of compliance to smoke-free policy regulations: Exploring the perspectives of venue owners and staff in Türkiye by Ezgi Baltacı, Aslı Çarkoğlu, Sejal Saraf, Toker Ergüder, Gül Ergör, Mutlu Hayran, Connie Hoe

“…The effects of the COVID-19 pandemic were reported as an initial increase in compliance and awareness among customers and staff, but some respondents noted negative changes due to the emotional and financial effects of prolonged restrictions. These challenges have led to decreased attention on the smoke-free policy among venue owners, staff and customers. …”
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Integrating Indigenous healing practices within collaborative care models in primary healthcare in Canada: a rapid scoping review by Ginny Brunton, Pierre Côté, Silvano Mior, Hainan Yu, Anne Taylor-Vaisey, Melissa Corso, Astrid DeSouza, Carolina Cancelliere, Kathy MacLeod-Beaver

“…Twenty-four studies (77%) involved Indigenous leadership or collaboration at each phase of the study and, seven (23%) included consultation only or the level of engagement was unclear.Conclusions We found that collaborative and Indigenous-led strategies were more likely to facilitate and implement the integration of Indigenous healing practices. …”
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Recent trends in research on the role of cholesterol in leukemia: a bibliometric and visualization study by Huijuan Lv, Ke Lu, Ximing Wang, Yanfang Zhang, Mengqi Zhuang, Jing Li, Keli Su, Wen Gao

“…Publication output demonstrated a significant rise from 1980 to 2024, peaking in 2022. The United States led in total publications (381) and citations (40,462), followed by China (137 articles) and Japan (102). …”
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The Eagle Eyes: an Intervention Utilizing Visual Thinking Strategies to Enhance the Observation Skills of Medical Students by Najmeh Ghorbani, Maryam Alizadeh, Azadeh Sayarifard, Abdoljavad Khajavi, Philip Yenawine

“…While both interventions were equally effective in the delayed follow-up and real-world settings regarding the total number of observations and words used, the VTS and VTA approach led to a notable increase in the time spent on observation descriptions. …”
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Design and Evaluation of a Management Dashboard for a Children\'s Subspecialty Hospital: An Action Research Approach by Malihe Ghanaatjoo, Nader Jahanmehr, Hamed Dehnavi, Aida Samadi

“…Background and Aim: The increase in the amount of information and the need for their daily monitoring have led to the development of tools called management dashboards that have the ability to analyze graphical data. …”
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Evaluating the Safety and Usability of an Over-the-Counter Medical Device for Adults With Mild to Moderate Hearing Loss: Formative and Summative Usability Testing by Megan Elizabeth Salwei, Shilo Anders, Carrie Reale, Jason M Slagle, Todd Ricketts, Matthew B Weinger

“…There were minimal safety-related issues with the device. Round 1 testing led to several design modifications which then increased task success in round 2 testing. …”
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“You’re telling us to go first?!” COVID-19 pandemic and vaccination experiences among Aboriginal adults in Western Australia by Samantha J. Carlson, Carla Puca, Paige Wood-Kenney, Justin Kickett, Valerie Swift, Katie Attwell, Christopher C. Blyth

“…Very few participants trusted government and any government information due to both historical and contemporary factors. This led participants to be wary of the fact they were among the first to be prioritised for COVID-19 vaccination in Australia. …”
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Safety of tenecteplase vs. alteplase in telestroke: a large multistate experience (STAT) by Morgan Figurelle, Sandro Corti, Oleg Collins, Lan Gao, Amanda Avila, Kristie Delfino, Laurie Mayer, Theresa Sevilis

“…TNK is not FDA-approved for treatment, which has led to hesitation in its use and increased attention on its complication profile, including the risk of intracranial hemorrhage (ICH).MethodsData from AIS consults conducted in the emergency departments of 220 facilities across 26 states, between 1 January 2022 and 31 May 2023, were extracted from the TeleCare by TeleSpecialists™ database. …”
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Household dietary diversity and associated factors in rural and peri-urban areas of Mbale District, Eastern Uganda by Sunday Mark Oyet, Robert Mbabazi Kaahwa, Christopher Muggaga, Duncan Ongeng, Ipolto Okello-Uma

“…However, increasing urbanization has led to shifts in dietary preferences, food consumption patterns, and a greater reliance on less nutritious processed foods. …”
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Treadmill training improves lung function and inhibits alveolar cell apoptosis in spinal cord injured rats by Xianbin Wang, Yingxue Fu, Xianglian Yang, Yan Chen, Ni Zeng, Shouxing Hu, Shuai Ouyang, Xiao Pan, Shuang Wu

“…The upregulation of miR145-5p in spinal cord injury (SCI) rats led to a reduction in MAP3K3 protein expression within lung tissues, thereby inhibiting the MAPK/Erk signaling pathway and decreasing apoptosis. …”
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Cultural adaptation of ENABLE (Educate, Nurture, Advise, Before Life Ends) an early palliative care model for Iranian patients with heart failure and their caregivers: a qualitativ... by Arvin Mirshahi, Ali Khanipour-Kencha, Marie Bakitas, J. Nicholas Odom, Rachel Wells, Arpi Manookian

“…Abstract Background ENABLE (Educate, Nurture, Advise, Before Life Ends) is a model of nurse-led, early palliative care that was originally developed for U.S. patients with advanced cancer and their family caregivers and then adapted for patients with heart failure. …”
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Comparative analysis of techno-economic and techno-environmental approach to optimal sizing and dispatch of hybrid solar–battery systems by Luka Smajila, Silvia Trevisan, Farzin Golzar, Ketan Vaidya, Rafael Guedez

“…In Sweden, the economic approach led to higher system utilisation due to greater price volatility, while the environmental approach prioritised lower emissions. …”
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