Dyssynchronous heart failure models in canines: New insights into electrocardiographic, echocardiographic and histological features by Han Jin, Shengwen Yang, Hao Huang, Sijing Cheng, Pengkang He, Sixian Weng, Min Gu, Hongxia Niu, Wei Hua, Yiran Hu, Hui Li

“…The RAP+LBBB group exhibited a prolonged overall ventricular activation time, delayed left ventricular activation, and lesser impact on the right ventricle. The RVAP approach led to a reduction in overall right ventricular compliance and right ventricular enlargement. …”
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Compound weather and climate extremes in the Asian region: science-informed recommendations for policy by R. Krishnan, Chirag Dhara, Takeshi Horinouchi, C. Kendra Gotangco Gonzales, C. Kendra Gotangco Gonzales, A. P. Dimri, A. P. Dimri, M. Singh Shrestha, P. Swapna, M. K. Roxy, Seok-Woo Son, Seok-Woo Son, D. C. Ayantika, Faye Abigail T. Cruz, Fangli Qiao

“…Anthropogenic climate change has led to rapid and widespread changes in the atmosphere, land, ocean, cryosphere, and biosphere, leading to more pronounced weather and climate extremes globally. …”
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Comparative response mechanisms of two cultivars of Musa paradisiaca L. to Fusarium oxysporum f.sp. cubense infection by Yajie Duan, Yajie Duan, Zhiwei Jia, Zhiwei Lu, Huigang Hu, Rulin Zhan

“…The crude extract treatment led to a significant increase in malondialdehyde (MDA) levels, lignin content, and phenylalanine ammonia lyase (PAL) activity. …”
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Anti-invasion activities of heat-killed lactic acid bacteria isolates against Salmonella enterica serovar Typhimurium by Anis Syahirah Saifor Adzuan, Sharifah Aminah Syed Mohamad, Rashidah Iberahim, Noor Nadia Syahira Mohd Kamal, Nurliana Abd Mutalib, Nur Intan Hasbullah, Muneer Alsaydi, Nor'aishah Hasan, Low Kheng Oon, Olaide Olawunmi Ajibola, Rozila Alias, Maimunah Mustakim, Azlin Sham Rambely, Emida Mohamed, Mohammad Reza Pourmand

“…In the anti-invasion assay, the two HK-LAB isolates that had the strongest adherence to Caco-2 cells, Tairu-isolate inhibited at 78.1 ± 3.06% and R-isolate inhibited at 64.76 ± 9.02% compared to the positive control (63.81 ± 1.15%), which led to increased suppression of S. Typhimurium accordingly. …”
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Evaluation of the recombinant protein Sh-TSP-2 for the serological diagnosis of imported urogenital schistosomiasis and comparison with commercially available tests by María Pilar Luzón-García, Laura Navarro, Esther Rodríguez, Manuel Jesús Soriano-Pérez, José Vázquez-Villegas, María Isabel Cabeza-Barrera, Alex Loukas, Nerea Castillo-Fernández, María Jesús Perteguer, Javier Sotillo, Joaquín Salas-Coronas

“…CRS modelling showed that the ICT IgG–IgM, NovaLisa® and Sh-TSP-2 serum tests led in sensitivity at 97.1, 88.6 and 71.4%, respectively, with all tests except that the ICT IgG–IgM test having a specificity >90%. …”
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Impact of a pharmaceutical care service for patients with rheumatoid arthritis using a customised mobile device (the PROUD trial): study protocol for a randomised controlled trial by Jung-Yoon Choe, Hwajeong Lee, Yun-Kyoung Song, Seong-Kyu Kim, Ji-Won Kim, Ji-Eun Park, Ju-Eun Lee, Bo-Kyung Moon, Sung-Hoon Park

“…Introduction Rheumatoid arthritis (RA) generally requires lifelong treatment; however, its medication complexity might affect non-adherence. Pharmacist-led telehealth services were as effective as face-to-face services and reduced potential side effects in outpatients with chronic diseases. …”
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Unveiling the psychosocial and academic implications of living with sickle cell disease among undergraduates in a private university in Nigeria by Olumide T. Adeleke, Olufemi Folaranmi, Yetunde Olasinde, Larry Ayuba, Oludamola V. Adeleke, Modupe M. Ojo-Rufai, Efeturi Agelebe, Oyelola E. Adeoye, Aderemi T. Olabode, Dolapo E. Ajala, Titilola S. Akingbola

“…This negatively affected their academic performance, and sometimes led to feelings of frustration. Furthermore, the recurrent battles with pain due to vascular occlusion took a toll on their emotional and psychological health. …”
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EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma by Di Li, Meng Li, Zhenjian Zhuo, Huiqin Guo, Weixin Zhang, Yile Xu, Hai-Yun Wang, Jiabin Liu, Huimin Xia, Huiran Lin, Jue Tang, Jing He, Lei Miao

“…It was verified that high EDF1 expression in NB cells led to Lactosylceramide (LacCer) accumulation, as well as downstream ganglioside-GD3, which subsequently increased the expression of CD52 and immune checkpoint genes, chemotaxis, and apoptosis-related events in activated CD8+T cells. …”
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Impact of Polystyrene Microplastics on Soil Properties, Microbial Diversity and <i>Solanum lycopersicum</i> L. Growth in Meadow Soils by Shuming Liu, Yan Suo, Jinghuizi Wang, Binglin Chen, Kaili Wang, Xiaoyu Yang, Yaokun Zhu, Jiaxing Zhang, Mengchu Lu, Yunqing Liu

“…The PS1005 treatment notably increased microbial diversity and displayed the most complex ecological network, while PS1010 led to reduced network complexity and more negative interactions. …”
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Comparing propofol anaesthesia guided by Bispectral Index monitoring and frontal EEG wave analysis with standard monitoring in laparoscopic surgery: protocol for the ‘EEG in Genera... by Luzius A Steiner, Salome Dell-Kuster, Bettina U Gruber, Valerie Girsberger, Lukas Kusstatscher, Simon Funk, Anita Luethy, Lien Jakus, Julien Maillard, Christoph S Burkhart

“…Introduction The use of Bispectral Index (BIS) monitors for assessing depth of sedation has led to a reduction in both the incidence of awareness and anaesthetic consumption in total intravenous anaesthesia. …”
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Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations by Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen

“…In both experiments, brodifacoum doses of ≥ 75 µg/kg body weight caused prolonged or non-measurable blood coagulation times. Disturbed hemostasis led to hemorrhages and anemia with significantly decreased albumin levels. …”
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Sex differences in the neuroinflammatory signaling pathway: effect of miRNAs on fatty acid synthesis in microglia by Haolin Zheng, Akiko Mizokami, Sergio Romera-Giner, Jaime Llera-Oyola, Yosuke Yamawaki, Tomomi Sano, Eijiro Jimi, Francisco García-García, Takashi Kanematsu

“…Consequently, the suppression of FASN expression led to reduced expression and secretion of tumor necrosis factor-alpha following LPS stimulation in MG6 cells. …”
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A methotrexate labelled dual metal oxide nanocomposite for long-lasting anti-cancer theranostics by Joyce L.Y. Tang, Shehzahdi S. Moonshi, Yuao Wu, Gary Cowin, Karla X. Vazquez- Prada, Huong D.N. Tran, Andrew C. Bulmer, Hang Thu Ta

“…Intravenous infusion of Chit-IOCO-MTX-Cy5 (5 mg/kg MTX) led to significant tumor growth inhibition, indicating a synergistic enhancement of anti-cancer effects when combining MTX and nanoceria, compared to free MTX or nanoceria without MTX conjugation. …”
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Getah virus triggers ROS-mediated autophagy in mouse Leydig cells by Fengqin Li, Fengqin Li, Fengqin Li, Lishuang Deng, Tong Xu, Lei Xu, Zhiwen Xu, Zhiwen Xu, Siyuan Lai, Siyuan Lai, Yanru Ai, Yanru Ai, Yanqun Wang, Yanqun Wang, Guangwen Yan, Guangwen Yan, Ling Zhu, Ling Zhu

“…Interestingly, the use of rapamycin (Rapa) and 3-Methyladenine (3- MA) led to autophagy change in both infected and uninfected TM3 cells, with no signiffcant alterations in cellular ROS levels. …”
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Optimal radiation dose to induce an abscopal effect by combining carbon-ion radiotherapy and anti-CTLA4 antibody by Liqiu Ma, Yang Li, Yoshimitsu Sakamoto, Lin Xie, Saaya Suzuki, Yukari Yoshida, Li Sui, Gang Guo, Jialing Wen, Wangcai Ren, Kazuhiro Kakimi, Kensuke Osada, Akihisa Takahashi, Takashi Shimokawa

“…Background and purpose: Although carbon-ion radiotherapy (CIRT) has led to good outcomes, controlling metastasis is still crucial for improving overall survival. …”
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Small intestinal bacterial overgrowth syndrome and systemic inflammation in pathogenesis of hemodynamic changes at liver cirrhosis by R. V. Maslennikov, A. A. Driga, K. V. Ivashkin, M. S. Zharkova, M. V. Mayevskaya, Ch. S. Pavlov, M. G. Arslanyan, N. B. Musina, Ye. N. Berezina, V. T. Ivashkin

“…LC patients with SIBO as compared to LC patients without SIBO had lower mean blood pressure (82.7±9.0 mm Hg vs 92.0±14.0 mm Hg) and TPVR (16.4±4.4 mm Hg × min/l vs 21.3±5.3 mm Hg • min/l), higher CO (5.38±1.41 l/min vs 4.52±1.03 l/ min) and serum C-rp (SIBO - 1.2÷10.5÷16.5 mg/l vs 0.6÷2.8÷9.1 mg/l). The presence of SIBO led to similar changes only at decompensated LC. …”
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Auxin signaling related to H+-ATPase synthesis and antioxidant enzyme activities regulates fluoranthene uptake by ryegrass roots by Yuanzhou Xu, Yunyun Li, Xinyue Zhang, Zhuoliang Xiao, Jiaguo Jiao, Huijuan Zhang, Huixin Li, Feng Hu, Li Xu

“…The genes involved in IAA synthesis (TAA1, ALDH, and AAO1/2) were upregulated, which led to an increase in IAA content. Elevated IAA levels, in turn, promoted the expression of genes encoding H+-ATPase (ATP5A1, ATP5B, ATP5H, and ATP6E) and the ABC transporter protein (ABCB1), resulting in enhanced H+-ATPase activity, and facilitated the active transport of Flu. …”
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Research trends in glioma chemoradiotherapy resistance: a bibliometric analysis (2003–2023) by Shishi Yu, Jinya Wu, Yuan Jing, Ping Lin, Lang Lang, Yifan Xiong, Wangzhong Chen, Wenhua Liu, Changpeng Sun, Yuntao Lu

“…The United States, Switzerland, and Germany showed the highest citation impact, while China led in publication volume but demonstrated relatively lower citation influence. …”
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Computational and experimental exploration of morpholine pendent 2-hydrazineyl thiazole: Insights from DFT, ADME profiling, antifungal efficacy and molecular docking analyses by Vishnu A. Adole, I.Antony Danish, J.Jebasingh Kores, J.Winfred Jebaraj, S. Janani, Suresh K. Ghotekar, Rakesh D. Amrutkar

“…Significant hydrogen and hydrophobic contacts were observed in this interaction, which led to a docking score of −5.28 and a binding free energy of −65.65 kcal/mol.…”
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Impact of wave–current coupling on the bottom boundary layer in Bohai Bay by Siyu Liu, Siyu Liu, Guangxue Li, Xue Liu, Lulu Qiao, Nan Wang, Shidong Liu, Xiangdong Wang, Di Yu, Lei Zhang

“…Following the storm (β &lt; 10), the sediment gradually accumulated, and this led to the formation of the FML. Prolonged periods in which the value of β surpassed 10 for over 10 h while that of the Rouse number remained below 0.01 for more than 30 h resulted in considerable sediment resuspension and the destruction of the FML. …”
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