PAK5 Induces EMT and Promotes Cell Migration and Invasion by Activating the PI3K/AKT Pathway in Ovarian Cancer by Diyou Li, Yinglin Pan, Yating Huang, Ping Zhang, Xuhong Fang

“…Knockdown of PAK5 in SKOV3 cells caused epithelial cell phenotypes, whereas overexpression of PAK5 led to remarkable mesenchymal cell phenotypes in A2780 cells. …”
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The effect of a community-based health behaviour intervention on healthcare services use among people with type 2 diabetes in Nepal by Grish Paudel, Corneel Vandelanotte, M Mamun Huda, Padam Kanta Dahal, Lal Rawal

“…The participants in the intervention group received a community health worker and peer supporter-led health behavioural intervention for 6 months. …”
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Validation of an MPS-based intestinal cell culture model for the evaluation of drug-induced toxicity by Stefanie Hoffmann, Philip Hewitt, Isabel Koscielski, Dorota Kurek, Wouter Strijker, Kinga Kosim

“…Overall, from the 23 tested compounds, 15 showed the expected outcome, i.e., the compound led to a decrease of the TEER for the positive control compounds, or the TEER value remained stable after treatment with non-GI-toxic compounds.ConclusionIn summary, this MPS model allowed the recapitulation of the human intestinal GI barrier and will enable a faster and more robust assessment of drug-induced damage in the GI tract.…”
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"They gave us the right to choose." A qualitative study of preferences for differentiated service delivery location among recipients of antiretroviral therapy at Lighthouse Trust i... by Lisa Orii, Kate S Wilson, Jacqueline Huwa, Christine Kiruthu-Kamamia, Odala Sande, Agness Thawani, Astrid Berner-Rodoreda, Evelyn Viola, Hannock Tweya, Petros Tembo, Wapu Masambuka, Richard Anderson, Caryl Feldacker

“…In this qualitative study, we explore reasons why RoC enrolled in LT clinics and eligible for DSD chose clinic-based ART services or a Nurse-led Community-based ART Program (NCAP) that reaches clients in established community peer support groups. …”
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From paternalism to self-determination: examining evolving tribal-federal relationships and co-management arrangements through three case studies by Clarita Lefthand-Begay, Lauren Redmore, Christopher Armatas, Jesse Brisbois, Kunsang Choden, Dara Craig, Angelo Baca, Jaime Martin, Michael Ross, Regina Lopez-Whiteskunk, Alfred Lomahquahu, Monte Mills

“…Nonetheless, failure to recognize and account for the weight of broken treaties, discriminatory laws and policies, and the historical trauma caused by these injustices emphasizes the importance of understanding the dynamics surrounding Tribal land management. As government-led land management paradigms around the world shift to consider self-determination of Indigenous nations and communities as a critical piece of improved stewardship, decision makers have many historically-informed dynamics to consider when shaping future co-management practices. …”
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Optimized reinforcement of granite residual soil using a cement and alkaline solution: A coupling effect by Bingxiang Yuan, Jingkang Liang, Baifa Zhang, Weijie Chen, Xianlun Huang, Qingyu Huang, Yun Li, Peng Yuan

“…The results indicated that the addition of 2% cement and an alkaline solution with an SiO2/Na2O ratio of 0.5 led to the densest matrix, lowest porosity, and highest static compressive strength, which was 4994 kPa with a dynamic impact resistance of 75.4 kN after adding glass fiber. …”
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Influence of organism stimulation with bacterial lipopolysaccharide on the metabolism of the extracellular matrix of the heart of rats under conditions of experimental metabolic sy... by O.Ye. Akimov, A.O. Mykytenko, V.O. Kostenko

“…The combined effect of stimulation of the organism with bacterial lipopolysaccharide and metabolic syndrome modeling led to an increase in the total concentration of glycosaminoglycans in the heart of rats by 73.46% compared to the control group. …”
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ROS-mediated M1 polarization-necroptosis crosstalk involved in Di-(2-ethylhexyl) phthalate-induced chicken liver injury by Guangxing Li, Menglin Wu, Kaiting Chen, Yue Xu, Xiandan Zhang, Yang Chen, Hong Zhang, Ruili Zhang, Xiaodan Huang

“…Further studies revealed the increase of reactive oxygen species (ROS) level and malonaldehyde (MDA) content, and the decrease of total antioxidant capacity (T-AOC) level, total superoxide dismutase (T-SOD) and glutathione peroxidase (GSH-Px) activities, which led to excessive oxidative stress in the liver. …”
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House Dust Mite and Cat Dander Extract Induce Asthma-Like Histopathology with an Increase of Mucosal Mast Cells in a Guinea Pig Model by Patricia Ramos-Ramírez, Jielu Liu, Sofia Mogren, Joshua Gregory, Malin Noreby, Anne Petrén, Ying Lei, Henric Olsson, Marianne van Hage, Jukka Kervinen, Lars Hellman, Cecilia Andersson, Gunnar Nilsson, Mikael Adner

“…Repetitive administration of HDM or CDE led to the accumulation of inflammatory cells into the proximal and distal airways as well as increased airway smooth muscle mass. …”
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Enhancement of Cytomegalovirus-Specific Cytokine Production after Modulation of the Costimulation in Kidney Transplant Patients by Theresa Dornieden, Benjamin Wilde, Johannes Korth, Kai Werner, Peter A. Horn, Oliver Witzke, Monika Lindemann

“…BTLA antibodies, however, led only to a marginal increase of CMV-specific IFN-γ and of IL-21 production. …”
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Tuberculosis healthcare service disruptions during the COVID-19 pandemic in Brazil, India and South Africa: A model-based analysis of country-level data. by Abigail K de Villiers, Muhammad Osman, Claudio J Struchiner, Anete Trajman, Dheeraj Tumu, Vaibhav V Shah, Guilherme L Werneck, Layana C Alves, Megha Choudhary, Sunita Verma, Sanjay K Mattoo, Sue-Ann Meehan, Urvashi B Singh, Anneke C Hesseling, Florian M Marx

“…In recent years, stringent measures to contain the spread of SARS-CoV-2 have led to considerable disruptions of healthcare services for TB in many countries. …”
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Lipidomic and Instrumental Evaluation of a Melatonin-Based In & Out Strategy Versus Topical Treatment in Skin Aging: A Randomized Prospective Trial by Francesca Colombo, Stefano Alfano, Massimo Milani

“…The addition of oral melatonin supplementation to the topical regimen led to improvements in the skin’s lipid profile and moisturization levels. …”
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Political Crisis in France: «Gilets Jaunes» and the End of the «First Period» of the Emmanuel Macron’s Governance by E. O. Obichkina

“…The government’s response – revocation of the law that triggered the movement and the launch of «big national debates» – led to a relative decline in the activity of «gilets jaunes», but the main reason for the downturn is preparation for the upcoming European elections, which could be used as an opportunity to voice their discontent with the president and to return the civil protest in the electoral channel. …”
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Modelo para la gestión de la innovación tecnológica en el sector inmobiliario Management model for technological innovation in real estate by Daniel Barrio, Salvador García, Juan Pablo Solís

“…<br>There has not been implemented, in Mexico, a model for the management of technological innovation, which refers to the creation or modification of a product or process in a practical way that is useful to generate economic benefits by introducing the innovation to the market. This has led to isolated and irregular efforts in this area; however, the real state sector has recognized the need to implement such management of technological innovation in order to achieve differentiation. …”
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The influence of the forest corridors to the north of the Andes on the diversification of the bright‐rumped Attila, Attila spadiceus (Passeriformes, Tyrannidae), during the climati... by Patrícia Mendonça, Lincoln Silva Carneiro, Victor Leandro‐Silva, Alexandre Aleixo, Juliana Araripe, Péricles S. Rêgo

“…The phylogeographic profile of A. spadiceus diverges from the patterns observed in other Neotropical birds, which emphasizes the need for further research on the role of the forest corridors of the northern Andes as drivers of diversification, to provide comprehensive insights into the processes that led to the formation of the region's present‐day avian diversity.…”
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Sistem Pakar : Deteksi Dini Stres pada Masa Pandemi Covid-19 Menggunakan Metode Forward Chaining by Angga Wijaya Narwa Putra, Nadea Cipta Laksmita

“…Abstract Starting with the spread of the Covid-19 virus from China to various countries until finally entering Indonesia in March 2020, it led to social and economic instability. This virus has a tendency to be transmitted and spread quickly through droplets. …”
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Valorization of pinecone as a pyrolysis feedstock: identification of bio-oil and synthesis of activated biochar for Cr(VI) elimination from wastewater by Alfares, Amenah Adnan, Younis, Afyaa Muayed, Rasheed, Lana Abdalhameed, Fadhil, Abdelrahman Basil

“…The thermal pyrolysis of pinecone (PC) to produce pyrolytic oil (PO) and solid biochar (BC) in a batch-scale fixed-bed reactor at numerous temperatures (400–600 °C) for diverse time intervals (30–120 min) using different particle sizes (0.26–0.841 mm) and various rates of heating (10–50 °C/min), as established in this work, led to the production of a high yield of the PO (42.12%) at 500 °C for 1 h with a 0.40 mm particle size and a heating rate of 30 °C/min. …”
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Effects of Different Carbohydrate Levels in Diets on Growth Performance and Muscle Nutritive Value of Ying Carp and Scattered-Scaled Mirror Carp (Cyprinus carpio) by Pengfei Xiao, Yunya Wu, Hang Sha, Xiangzhong Luo, Guiwei Zou, Hongwei Liang

“…However, excessive carbohydrate intake (40%) led to pronounced liver fat deposition in both varieties, with scattered-scaled mirror carp showing less severe deposition than Ying carp. …”
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AozC, a zn(II)2Cys6 transcription factor, negatively regulates salt tolerance in Aspergillus oryzae by controlling fatty acid biosynthesis by Wenbin Yu, Zeying Zhao, Yufei Zhang, Yayi Tu, Bin He

“…Moreover, the overexpression of AozC led to a downregulation of the FAD2 gene, a pivotal enzyme in the biosynthesis of unsaturated fatty acids (UFAs), which are essential for preserving cell membrane fluidity and integrity under saline conditions. …”
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Morphological, Physiological, and Transcriptional Changes in <i>Crocus sativus</i> L. Under In Vitro Polyethylene Glycol-Induced Water Stress by Suman Gusain, Rohit Joshi

“…Significant chlorophyll and carotenoid level changes were observed in shoots exposed to higher PEG concentrations. PEG-induced drought led to decreased plant growth and biomass and lowered relative water content of leaves. …”
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