Optineurin overexpression ameliorates neurodegeneration through regulating neuroinflammation and mitochondrial quality in a murine model of amyotrophic lateral sclerosis by Shumin Zhao, Shumin Zhao, Ranran Chen, Ranran Chen, Yi An, Yali Zhang, Yali Zhang, Cheng Ma, Ying Gao, Ying Gao, Yanchao Lu, Yanchao Lu, Fei Yang, Fei Yang, Xue Bai, Xue Bai, Jingjing Zhang, Jingjing Zhang, Jingjing Zhang

“…In addition, the influences on cellular apoptosis, mitochondrial dynamics, mitophagy, and neuroinflammation were further investigated.ResultsOptn expression was increased in the spinal cord of SOD1G93A mice at the pre-symptomatic phase, but decreased after disease onset. Optn overexpression led to a 9.7% delay in the onset of disease and improved motor performance in SOD1G93A mice. …”
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Investigating the response mechanisms of the intertidal seagrass Zostera japonica to increased UVB radiation through physiological, transcriptomic, and metabolomic analyses by Jiayi Xin, Song Xue, Hongzhen Wang, Xinqi Li, Yu Zang, Lei Liu, Xuexi Tang, Jun Chen

“…Global climate change has led to increased ultraviolet-B (UVB) radiation, which is now a major global environmental issue that poses significant threats to ecosystems. …”
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Platycodin D inhibits tumor proliferation by modulating macrophage polarization through promoting JAK2 ubiquitination by Wei Wu, Jie Zhang, Zijiao Wang, Chuan Cheng, Dongdong Yuan, Li Peng, Le Li

“…Based on this, we hypothesized that PD could have anti-melanoma potential and set out to investigate its molecular mechanisms in relation to TAMs. Treatment with PD led to a significant reduction in melanoma tumor weight, inhibition of the mTOR pathway, and suppression of M2-polarized macrophages. …”
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Evaluation of chicken liver meal as fish meal alternative in large yellow croaker Larimichthys crocea diet: Effects of growth performance, antioxidant capacity, intestinal health a... by Jianchun Shao, Yujie Wang, Liwen Wu, Qingyin Zheng, Wenbo Zhu, Zhengbang Chen, Dianguang Zhang

“…The CLM75 and CLM100 diets led to a significant decrease in the activity of amylase (AMS), lipase (LPS), catalase (CAT) as well as total antioxidant capacity (T-AOC) for liver of Larimichthys crocea, while remarkably increasing malondialdehyde (MDA) content. 16S rRNA sequencing revealed that CLM75 and CLM100 diets resulted in increased relative abundances of Proteobacteria phylum and decreased relative abundances of Firmicutes phylum. …”
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Mortality of elder financial and psychological abuse victims in rural Malaysia: a prospective cohort study by Raudah Mohd Yunus, Farizah Hairi, Noran N Hairi, Wan Yuen Choo, Sajaratulnisah Othman, Rajini Sooryanarayana, Norliana Ismail, Sharifah Nor Ahmad, Inayah Abdul Razak, Devi Peramalah, Awang Bulgiba Awang Mahmud, Halima B Awang, Siti Zaharah Jamaludin, Jamali Samsuddin, Mohammad Mafrukhin Mokhtar, Syed Mohd Fauzi, Zainudin Mohd Ali

“…Among all the variables studied, only cognitive impairment led to higher mortality risk (HR 1.32, 95% CI 1.03 to 1.69).Conclusion Our findings contradict prior empirical studies that supported the link between elder abuse and neglect (EAN) and mortality, even though we focused on two abuse subtypes. …”
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Predicting dupilumab effectiveness with Type-2 biomarkers: A real-world study of severe asthma by Kenji Mizumura, Yasuhiro Gon, Norihiro Harada, Shiho Yamada, Asami Fukuda, Ryosuke Ozoe, Shuichiro Maruoka, Sumiko Abe, Kazuhisa Takahashi, Akihiko Tanaka, Hironori Sagara, Taisuke Akamatsu, Toshihiro Shirai, Katsunori Masaki, Koichi Fukunaga, Konomi Kobayashi, Hiroyuki Nagase, Nobuaki Miyahara, Arihiko Kanehiro, Noboru Kitamura, Naruhiko Sugihara, Fumio Kumasawa, Junko Terada-Hirashima, Masayuki Hojo, Kazuyuki Chibana, Etsuko Tagaya

“…Results: Treatment with dupilumab led to a reduction in exacerbations and enhancement in asthma control, FEV1, and CASA-Q scores. …”
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Dose-dependent effects of hydroquinone on liver injury and lipid dysregulation based on SCD1/AMPK signaling pathway in C57BL/6 mice by Lijun Zou, Fen Lin, Jinying Wen, Jinyu Huang, Yue Tan, Hui Huang, Gonghua Hu

“…Our findings indicated that lower doses of HQ (12.5 and 25.0 mg/kg) led to lipid accumulation in the liver, accompanied by increased liver TG and serum TC. …”
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Effect of Selected Nanospheres on the Mechanical Strength of Lime-Stabilized High-Plasticity Clay Soils by Ali Ghorbani, Hadi Hasanzadehshooiili, Mostafa Mohammadi, Fariborz Sianati, Mahdi Salimi, Lukasz Sadowski, Jacek Szymanowski

“…Finally, the results obtained from scanning electron microscopy (SEM) analysis revealed that the nanospheres caused a dense and compact matrix to form in the soil, which led to the enhancement of the mechanical strength of the treated samples.…”
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Identification and Prediction of Allo-Source Overpressure Caused by Vertical Transfer: Example from an HTHP Gas Reservoir in the Ledong Slope in the Yinggehai Basin by Caiwei Fan, Changgui Xu, Chao Li, Aiqun Liu, Hu Li, Jingxian Hou, Xiaoying Zhang, Bin Lu, Jun Li

“…The high-magnitude overpressure fluid generated by the high mature ultradeep buried N1s source rock migrated to the shallower reservoirs via hidden faults/microfractures, which led to the vertical transfer of overpressure. Vertically transferred overpressure was generated at 1.5 ~0.2 Ma, which is beneficial for the preservation of overpressure in lenticular sandbodies. …”
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Graphene-metal sulfide composite based gas sensors for environmental sustainability: A review by Deepak Balram, Kuang-Yow Lian, Neethu Sebastian, Vineet Kumar, Virendra Kumar Yadav, Ashish Patel, Kulvinder Singh

“…This review reflects the fact that advancements in material synthesis has led to improvement in gas sensing performances as evidenced from the comparatively better performance metrics reported in recently published articles which utilized hybrid nanocomposites as sensing material.…”
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Barriers and facilitators for healthcare access among immigrants in Japan: a mixed methods systematic review and meta-synthesisResearch in context by Yu Par Khin, Floret Maame Owusu, Nobutoshi Nawa, Pamela J. Surkan, Takeo Fujiwara

“…Limited healthcare information led immigrants to seek alternative information sources and affected immigrants' perceived healthcare needs. …”
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Multichannel Enhanced Millimeter-Wave SAR Imaging via Low-Rank Tensor-Train Decomposition by Bangjie Zhang, Gang Xu, Xiang-Gen Xia, Jianlai Chen, Rui Zhou, Shuai Shao, Wei Hong

“…However, the high propagation loss of mmWave bands and the limitation of transmitting power have led to limited imaging performance for mmWave SAR. …”
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Bisphenol A induces apoptosis and disrupts testosterone synthesis in TM3 cells via reactive oxygen species-mediated mitochondrial pathway and autophagic flux inhibition by Wenzhe Yang, Feilong Pan, Tong Zhao, Fangfang Chen, Wenqi Shao, Jinhao Wang, Shirui Wang, Zichen Zhao, Kexiang Liu, Shuchen Zhao, Lijia Zhao

“…BPA treatment increased ROS production, which led to a marked decrease in antioxidant enzyme activity and the expression levels of antioxidant-related genes and proteins in TM3 cells. …”
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Rapid diagnostic testing combined with an immediate infectious disease consultation increases the rate of septic intensive care unit patients on targeted antibiotic therapy by Evelyn Kramme, Nadja Käding, Nadja Käding, Tobias Graf, Karolin Schmoll, Heidi Linnen, Katharina Nagel, Esther Grote-Levi, Susanne Hauswaldt, Dennis Nurjadi, Dennis Nurjadi, Jan Rupp, Jan Rupp, Jan Rupp

“…Overall adherence to the local antibiotic therapy guideline for sepsis was significantly lower in the control than in the intervention group (27.8% versus 89.3%, p<0.001).ConclusionIntegration of an RDT system in the microbiological workflow for septic patients in ICU combined with a standardized ID intervention led to a significantly higher percentage of adequate antimicrobial treatment and greater adherence to local antibiotic therapy recommendations, even in a setting where 24/7 service is not available.…”
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Defining national research priorities for prostate cancer in Zambia: using the Delphi process for comprehensive cancer policy setting in sub-Saharan Africa by Ajay Aggarwal, Janet Seeley, Virginia Bond, Kennedy Lishimpi, John Kachimba, Musonda Simwinga, Andrew Sentoogo Ssemata, Susan Msadabwe, Dorothy Chilambe Lombe, Monde Mwamba, Richard Muhumuza, Victor Mapulanga

“…Objectives Locally led research on cancer is needed in sub-Saharan Africa to set feasible research priorities that inform national policy. …”
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Chalcogenide perovskites: enticing prospects across a wide range of compositions and optoelectronic properties for stable photodetector devices by Shilpa Mariam Samuel, Sadasivan Shaji, David Avellaneda Avellaneda, Bindu Krishnan

“…Inspired by the perovskite structure, intense investigation in search of highly stable, non-toxic and earth abundant materials with superior optoelectronic features has led to the discovery of chalcogenide perovskites (CPs). …”
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Human inborn errors of immunity underlying Talaromyces marneffei infections: a multicenter, retrospective cohort study by Huifeng Fan, Zhiyong Yang, Yuhui Wu, Xiulan Lu, Tian Li, Xuyang Lu, Gen Lu, Liming He, Guoping Lu, Li Huang

“…Gain-of-function (GOF) mutations in STAT1 led to STAT1 GOF in four cases. One patient was diagnosed with caspase-recruitment domain (CARD9) deficiency due to a compound mutation in the CARD9 gene, while another patient was confirmed with adenosine deaminase (ADA) deficiency.ConclusionT. marneffei infections in children with IEIs induced severe systemic complications. …”
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Interferon gamma‐mediated prevention of tumor progression in a mouse model of multiple myeloma by Zoltán Kellermayer, Sabrin Tahri, Madelon M. E. deJong, Natalie Papazian, Cathelijne Fokkema, Elodie C. G. Stoetman, Remco Hoogenboezem, Gregory vanBeek, Mathijs A. Sanders, Louis Boon, Chelsea Den Hollander, Annemiek Broijl, Pieter Sonneveld, Tom Cupedo

“…Transfer of 5TGM1 cells in C57Bl/6 mice led to stable disease with low tumor burden in a subset of animals. …”
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Integrated farming system-A means of improving farmers’ well-being in the wetland ecosystem of Bangladesh by Saifun Akter, Jasim Uddin Ahmed, Ismat Ara Begum, Md Abdur Rouf Sarkar, Kanij Fatema, Asif Mahmud, Shijun Ding, Mohammad Jahangir Alam

“…Moreover, the adoption of IFSs led to a statistically significant increase in farming income (p ​< ​0.10), contributing to a notable rise in total income. …”
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Pressure-relief and anti-impact technology of near-fault blasting by high-level roadway in deep pressure bumps mine by REN Wentao, WANG Hao, YU Bingbing, ZUO Jinjing, GU Peng, ZHANG Yuantong, ZHENG Xingbo, WANG Bo, ZHANG Bin, WAN Xiao

“…Under the horizontal principal stress, the deformation of the roadway was larger than that of the roof and floor, and the stress of the overlying strata was transferred to the solid coal side, which led to the deformation of the solid side larger than that of the goaf side. …”
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