Reduction of chickens use to perform in vitro pre-screening of novel anticoccidials by miniaturisation and increased throughput of the current Eimeria tenella compound-screening mo... by Virginia Marugan-Hernandez, Javier Regidor-Cerrillo, Luis Ortega-Mora, Sara Arias-Maroto, Kelsilandia Aguiar-Martins

“…The use of our in vitro model for the pre-screening of essential oils led to a reduction of 67% of the chickens used in the in vivo trials for validation. …”
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Evaluation of the current status and risks of aquatic ecology in the Jialing River Basin based on the characteristics and succession trends of phytoplankton communities by Maojin Huang, Fei Xu, Jia Xia, Xue Yang, Fubin Zhang, Siyao Liu, Tuo Zhang

“…River ecosystems are vital for maintaining ecosystem balance but rapid development in China’s Yangtze River Basin has led to severe ecological degradation. Therefore, this study aimed to evaluate the aquatic ecosystem health of the Jialing River Basin, investigate the influencing factors of the aquatic ecology, and predict the succession trend of the phytoplankton community. …”
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In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney by Toshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito, Yukiko Kamiya, Hiroyuki Asanuma, Shoichi Maruyama

“…The subcutaneous administration of SGLT2-SNA-ASO led to a dose-dependent reduction in renal SGLT2 expression and subsequent glucosuria. …”
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Emission Characteristics of Volatile Organic Compounds from Typical Coal Utilization Sources: A Case Study in Shanxi of Northern China by Yang Xu, Hualong Yu, Yulong Yan, Lin Peng, Rumei Li, Cheng Wang, Zhiyong Li

“…As a major source of volatile organic compounds (VOCs), coal utilization also led to high national emissions of these pollutants. …”
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Cytotoxic Activity of Bisphosphonic Derivatives Obtained by the Michaelis–Arbuzov or the Pudovik Reaction by Zsuzsanna Szalai, Janka Bednárik, Boldizsár Szigfrid Tóth, Angéla Takács, Szilárd Tekula, László Kőhidai, Konstantin Karaghiosoff, László Drahos, György Keglevich

“…<b>Results:</b> After converting α-hydroxy-benzylphosphonates and -phosphine oxides to the α-halogeno- and α-sulfonyloxy derivatives, they were utilized in the Michaelis–Arbuzov reaction with trialkyl phosphites and ethyl diphenylphosphinite to afford the corresponding bisphosphonate, bis(phosphine oxide) and phosphonate–phosphine oxide derivatives. The Pudovik approach led to α-hydroxy-methylenebisphosphonic species and to their rearranged products. …”
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Abnormal Expression of DICER1 Leads to Dysregulation of Inflammatory Effectors in Human Synoviocytes by Congshan Jiang, Jing Xu, Wenhua Zhu, Yongsong Cai, Si Wang, Yuanxu Guo, Ke Xu, Manman Geng, Nazim Hussain, Yan Han, Fujun Zhang, Qilan Ning, Liesu Meng, Shemin Lu

“…Firstly, RNAi of DICER1 led to increased COX2, MMP3, and MMP13 protein production, while DICER1 overexpression could reduce MMP13 expression. …”
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Vibroacoustic Study of a Miniature Jet Engine Under Blade-Casing Rubbing Condition by Bartłomiej Cywka, Wojciech Prokopowicz, Bartosz Ciupek, Grzegorz M. Szymański, Daniel Mokrzan, Andrzej Frąckowiak

“…The cause of the undesirable technical condition of the engine was a significantly higher temperature of gases (exhaust gases) affecting the working elements of the engine (turbine shaft, rotor, and blades), which consequently led to engine damage. This phenomenon and the results obtained from the unexpected technical condition constitute a valuable premise for considering the issue of proper operation of the turbojet engine during fuel changes, especially following current trends related to the decarbonization of the aviation sector. …”
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Ceftriaxone-associated dysbiosis decreases voriconazole bioavailability by upregulating intestinal P-glycoprotein expression through activation of the Nrf2-mediated signalling path... by Xiaokang Wang, Xiaokang Wang, Chunxiao Ye, Xixiao Yang, Maoxun Yang, Maoxun Yang, Maoxun Yang

“…Finally, in vitro findings in Caco-2 cells treated with OMVs from the ceftriaxone-associated dysbiotic group suggested that Nrf2 translocation into the nucleus induced high expression of P-gp.ConclusionOMVs from intestinal bacterial in the ceftriaxone-associated dysbiotic group induced high P-gp expression by regulating the Nrf2 signalling pathway, which led to an in vivo reduction in the bioavailability of voriconazole due to ceftriaxone-associated dysbiosis.…”
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Promoting ER stress in a plasmacytoid dendritic cell line drives fibroblast activation by Beatriz H. Ferreira, Inês S. Silva, Andreia Mendes, Fátima Leite-Pinheiro, Adrienne W. Paton, James C. Paton, Iola F. Duarte, Philippe Pierre, Catarina R. Almeida

“…Results Direct contact of CAL-1 and IMR-90 cells under ER stress conditions led to increased expression of fibronectin and alpha-smooth muscle actin (α-SMA). …”
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Reflecting on partnerships established and sustained over four cycles of a federally funded cancer prevention and control research program: lessons learned for community-academic n... by Swann Arp Adams, Swann Arp Adams, Lauren Workman, Lauren Workman, Mayank Sakhuja, Brooks Yelton, Karen E. Wickersham, Ciaran Fairman, Jan Eberth, Sue Heiney, James R. Hebert, James R. Hebert, Jaron H. King, Freda Allyson Hucek, Lauren Schaurer, Daniela B. Friedman

“…While future analysis is planned to utilize this same approach with our community partners, this work marks an important step in reflecting upon the approaches which have led to our success and how they can be applied in future collaborations to maximize impact and sustained health improvements.…”
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A new potential of sodium anthraquinone-2-sulfonate as a corrosion inhibitor for carbon steel in 0.5 M H2SO4 by Nikolay Akatyev, Roza Kenzhegalieva, Meruyet Khapiyeva, Gauhar Uzakbay, Aruzhan Talapova, Ruben Vardanyan

“…The spontaneous physisorption (ΔG0ads ˃ -20 kJ mol-1) of the inhibitor molecules led to high efficiency. Analysis of dynamic polarization curves showed that AQ2SNa acts as an inhibitor of a mixed nature. …”
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A Multimodal Workshop to Improve Medical Student Self-Assessment of Knowledge and Comfort Managing Patients With Suicidality by Paige C. Chardavoyne, Amanda Liewen, Paige McKenzie, Jill Sorby, Ana Navarro, Julie R. Owen

“…Methods This was a 2.5-hour multimodal workshop developed for formal third-year medical student suicide education that included: flipped learning with a preworkshop presentation; experiential learning, scaffolding, reflection, and feedback with two standardized patient encounters; think-pair-share with small- and large-group discussion; and a facilitator-led large-group didactic. Results Of the 105 third-year medical students who completed the workshop in the first half of the 2023–2024 academic year, 84% (88/105) completed the presurvey and 70% (73/105) completed the postsurvey. …”
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Phage vB_KlebPS_265 Active Against Resistant/MDR and Hypermucoid K2 Strains of <i>Klebsiella pneumoniae</i> by Vyacheslav I. Yakubovskij, Vera V. Morozova, Yuliya N. Kozlova, Artem Yu. Tikunov, Valeria A. Fedorets, Elena V. Zhirakovskaya, Igor V. Babkin, Alevtina V. Bardasheva, Nina V. Tikunova

“…Horizontal transfer even involved conservative genes and led to clear genomic mosaicism, indicating multiple recombination events in the ancestral phages during evolution.…”
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Unveiling unique effector function-related bulk antibody profiles in long-term hemodialysis patients following COVID-19 mRNA booster vaccination by Chia-Yi Chou, Chung-Yi Cheng, Chih-Hsin Lee, Makoto Kuro-O, Tso-Hsiao Chen, San-Yuan Wang, Yung-Kun Chuang, Yun-Jung Yang, Yun-Hsuan Lin, I-Lin Tsai

“…In contrast, infection led to an additional decrease in the fucosylation of IgG2 and IgA, demonstrating a more intense proinflammatory biosignature than vaccination. …”
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Low-input redoxomics facilitates global identification of metabolic regulators of oxidative stress in the gut by Xina Xiao, Meng Hu, Li Gao, Huan Yuan, Baochen Chong, Yu Liu, Rou Zhang, Yanqiu Gong, Dan Du, Yong Zhang, Hao Yang, Xiaohui Liu, Yan Zhang, Huiyuan Zhang, Heng Xu, Yi Zhao, Wenbo Meng, Dan Xie, Peng Lei, Shiqian Qi, Yong Peng, Tao Tan, Yang Yu, Hongbo Hu, Biao Dong, Lunzhi Dai

“…Two-month CR intervention led to the recovery of many antioxidative metabolites and reshaped the Cys redoxome. …”
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Examining reliability of WHOBARS: a tool to measure the quality of administration of WHO surgical safety checklist using generalisability theory with surgical teams from three New... by Jennifer M Weller, Carmen Skilton, Derryn A Gargiulo, Oleg N Medvedev, Simon J Mitchell, Alan F Merry

“…Removing any items from the WHOBARS led to a decrease in the overall reliability of the instrument.Conclusions Assessing checklist administration quality is important for promoting improvement in its use, and WHOBARS offers a reliable approach for doing this.…”
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A dataset on bathymetry and hydrology of an emerging periglacial lagoon in Svalbard, ArcticMendeley Data by Andrius Šiaulys, Aleksej Šaškov, Greta Kilmonaitė, Dzmitry Lukashanets, Tobia Politi, Aurelija Samuilovienė, Anastasija Zaiko, Sergej Olenin

“…In recent decades, the melting of glaciers has led to a consistent increase in the number of periglacial coastal lagoons that form in the place of receding glaciers in Svalbard, European Arctic. …”
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Lysine deacetylase inhibitors have low selectivity in cells and exhibit predominantly off‐target effects by Kiara E. Bornes, Marcus A. Moody, Thomas M. Huckaba, Megan C. Benz, Emily C. McConnell, Maryam Foroozesh, Van H. Barnes, Bridgette M. Collins‐Burow, Matthew E. Burow, Terry J. Watt, Tasha B. Toro

“…Furthermore, Tubastatin A treatment led to increased histone acetylation, while inactivation of KDAC6 or KDAC8 did not. …”
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Simultaneously Enhanced Permeability and Selectivity of Pebax-1074-Based Mixed-Matrix Membrane for CO₂ Separation by Rujing Hou, Junwei Xie, Yawei Gu, Lei Wang, Yichang Pan

“…Both the strengthened CO₂ solubility coefficients coming from the additional CO₂ adsorption sites of amino groups in BPEI and the reinforced CO₂ diffusivity coefficients originating from the fast transport channels created by KAUST-8 led to the promising CO₂ separation performance for KAUST-8@BPEI/Pebax-1074 MMM. …”
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The disinfectant effects of portable ultraviolet light devices and their application to dentures by Kae Harada, Reiya Horinouchi, Mamoru Murakami, Masakazu Isii, Yuji Kamashita, Naohiro Shimotahira, Fumio Suehiro, Yasuhiro Nishi, Hiroshi Murata, Masahiro Nishimura

“…Among these, devices A, B, and C used bulb light sources, while devices D, E, F, and G utilized LED (light-emitting diode) light sources. All devices were assessed in agar plate assay, and Candida albicans and Staphylococcus aureus spread on agar plates and irradiated under two conditions: inoculated surface facing upward and downward. …”
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