Transcriptomics analysis reveals potential mechanisms underlying mitochondrial dysfunction and T cell exhaustion in astronauts’ blood cells in space by Maria Moreno-Villanueva, Maria Moreno-Villanueva, Luis E. Jimenez-Chavez, Luis E. Jimenez-Chavez, Stephanie Krieger, Liang-Hao Ding, Ye Zhang, Adriana Babiak-Vazquez, Mark Berres, Sandra Splinter, Kristen E. Pauken, Brian C. Schaefer, Brian E. Crucian, Honglu Wu

“…The dysregulated genes and pathways were mostly involved in energy and oxygen metabolism, immune responses, cell adhesion/migration and cell death/survival.DiscussionBased on the DEG and the associated pathways and functions, we propose that mitochondria dysfunction was caused by constant modulation of mechano-sensing receptors in microgravity, which triggered a signaling cascade that led to calcium overloading in mitochondria. The response of PBMC in space shares T-cell exhaustion features, likely initiated by microgravity than by infection. …”
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PARP‐1 Inhibition Increases Oxidative Stress in Ets‐1‐Expressing MDA‐MB‐231 Breast Cancer Cells by Magalie Hervieu, Arnaud J. Legrand, Emilie Floquet, Thierry Idziorek, Corentin Spriet, Didier Monté, Vincent Villeret, Marc Aumercier, Souhaila Choul‐li

“…Next, we evaluated PARP‐1 inhibition effect on oxidative DNA damage in Ets‐1‐overexpressing and Ets‐1‐non‐expressing breast cancer cells and we showed that PARPi led only Ets‐1‐overexpressing cells to accumulate it, which triggers the DNA damage response as revealed by the increase in the level of a panel of DNA damage‐related proteins. …”
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The grapevine ABC transporter B family member 15 is a trans-resveratrol transporter out of grapevine cells by Ascensión Martínez-Márquez, Ascensión Martínez-Márquez, Viviana Martins, Susana Sellés-Marchart, Susana Sellés-Marchart, Hernâni Gerós, Purificación Corchete, Roque Bru-Martínez, Roque Bru-Martínez, Roque Bru-Martínez

“…Its stable expression in both yeast and Silybum marianum cells’ heterologous systems led to increased trans-resveratrol transport in these hosts. …”
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Agroforestry systems favor bat conservation but only when old and grazed by Manon Edo, Martin H. Entling, Felix Herzog, Kira Noe, João HN Palma, Ayla Seithe, Will Simonson, Jo Smith, Anja Weiler, Verena Rösch

“…The resulting habitat loss has led to the decline in the diversity and abundance of many taxa including bats, which are highly dependent on woody plants for foraging, roosting and reproduction. …”
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Operational research as a mechanism to improve treatment outcomes for drug-resistant TB in the WHO European Region by G.B. Migliori, O. Korotych, J. Achar, A. Ciobanu, G. Dravniece, M. Germanovych, E. Gurbanova, A. Hovhannesyan, N. Khachatryan, L. Kuksa, N. Lomtadze, M.L. Rich, A. Skrahina, A. Yedilbayev

“…Most occurred in 18 high-priority countries of eastern Europe and central Asia, many of which joined an initiative led by the WHO Regional Office for Europe. The aim was to introduce three, fully oral, 9-month modified shorter treatment regimens (mSTR) to treat RR/MDR-TB under operational research conditions. …”
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Climate change impacts on shoreline migration and community livelihood resilience: evidence from coastal Bangladesh by Md. Tariqul Islam, Md. Tariqul Islam, Md. Monabbir Hossain, Nur Mohammad Ha-Mim, Md. Zakir Hossain, Sujit Kumar Sikder

“…The in-depth interviews reveal several adaptive practices to effectively deal with the situation, including community knowledge, stakeholder engagement, local-led adaptation, and most importantly, temporal migration. …”
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A Qualitative Study Exploring Facilitators for Improved Health Behaviors and Health Behavior Programs: Mental Health Service Users’ Perspectives by Candida Graham, Crystal Rollings, Sarah de Leeuw, Lesley Anderson, Brenda Griffiths, Nansi Long

“…Mental health service users experience high rates of cardiometabolic disorders and have a 20–25% shorter life expectancy than the general population from such disorders. Clinician-led health behavior programs have shown moderate improvements, for mental health service users, in managing aspects of cardiometabolic disorders. …”
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Ochratoxin A induces immunotoxicity by targeting Annexin A1 mediated neutrophil apoptosis in zebrafish by Yihong Zheng, Yinuo Liu, Jin Tian, Shuhong Liu, Gaowei Ma, Yupeng Xie, Chenhua Zheng, Zekai Wu

“…Additionally, OTA exposure led to a significant reduction in the number of neutrophils and macrophages, indicating compromised formation of innate immune cells. …”
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A genomic strategy for precision medicine in rare diseases: integrating customized algorithms into clinical practice by Cristina Méndez-Vidal, Nereida Bravo-Gil, Javier Pérez-Florido, Irene Marcos-Luque, Raquel M. Fernández, José Luis Fernández-Rueda, María González-del Pozo, Marta Martín-Sánchez, Elena Fernández-Suárez, Marcela Mena, Rosario Carmona, Joaquín Dopazo, Salud Borrego, Guillermo Antiñolo

“…Also, 131 autosomal-recessive cases could be partially genetically diagnosed. These results led to over 5000 additional studies including carrier, prenatal and preimplantational tests or pharmacological and gene therapy treatments. …”
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Self-Assembly Strategy for Synthesis of WO₃@TCN Heterojunction: Efficient for Photocatalytic Degradation and Hydrogen Production via Water Splitting by Li Zhou, Wenjie Zhang, Zezhao Huang, Feng Hu, Peng Li, Xiaoquan Yao

“…The synergistic effect between WO₃ and TCN, along with the porous structure of TCN, facilitated the formation of a heterojunction that promoted the absorption of visible light, accelerated the interfacial charge transfer, and inhibited the recombination of photogenerated electron–hole pairs. This led to excellent photocatalytic performance of 3%WO₃@TCN in degrading TC and catalyzing H₂ evolution from water splitting under visible-light irradiation. …”
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X-Linked Lymphoproliferative Syndrome and Common Variable Immunodeficiency May Not Be Differentiated by SH2D1A and XIAP/BIRC4 Genes Sequence Analysis by Nesrin Gulez, Guzide Aksu, Afig Berdeli, Neslihan Karaca, Sema Tanrıverdi, Necil Kutukculer, Elif Azarsiz

“…The clinical and laboratory resemblance, no gene mutations, and normal XIAP protein expression led us to think that there may be another responsible gene for XLP. …”
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Explaining the Basics and Principles of maintenance and upgrading urban streets with the approach of Islamic teachings and Iranian culture (Imam Reza Zaman Street of Mashhad) by mahdi moharreri, mohammad naghizade, fereshte ahmadi, shirin toghyani

“…The results of this study indicate neglecting the indigenous material, art, culture, religion, needs and interests of citizens which has led to the construction of unqualified urban spaces in the metropolitan areas of today's Iranian cities. …”
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Gellan Gum Enhances the Quality of Egg-Based Yoghurt by Changing the Water Phase Distribution and Improving the Gel Texture by Yuanyuan Zhang, Jianwei Zang, Shutong Liu, Bingxu Yan, Daobang Tang, Jiguang Chen, Dongwen Li, Dayong Peng, Zebo Liu, Zhongping Yin

“…Confocal laser scanning microscopy revealed that EBY with 0.045% gellan gum had a better texture, whereas too much or too little gellan gum led to a coarser structure. In summary, gellan gum altered the water phase state and enhanced the water holding capacity through increased hydrogen bonding interactions, which consequently improved the yoghurt’s texture and sensory qualities. …”
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Status Epilepticus due to Intraperitoneal Injection of Vehicle Containing Propylene Glycol in Sprague Dawley Rats by Evon S. Ereifej, Seth M. Meade, Cara S. Smith, Keying Chen, Nanette Kleinman, Jeffrey R. Capadona

“…Blood tests from the seizing rat support a diagnosis of hemolysis and lactic acidosis which may have led to the seizures, all of which appeared to be a consequence of the propylene glycol administration. …”
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A Novel Audio Copy Move Forgery Detection Method With Classification of Graph-Based Representations by Beste Ustubioglu, Gul Tahaoglu, Arda Ustubioglu, Guzin Ulutas, Muhammed Kilic

“…The rapid advancement of digital environments has led to an increase in multimedia forgery, particularly in the realm of audio, which leads to significant threats to the reliability of digital evidence. …”
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Single‐Nucleus RNA Sequencing Reveals That Gabra6+ Neurons in Prefrontal Cortex Promote the Progression of PTSD After Shockwave‐Induced TBI by Xiaowei Fei, Zehan Zhang, Ya‐nan Dou, Weihao Lv, Hongqing Chen, Li Wang, Xin He, Wangshu Chao, Peng Luo, Zhou Fei

“…Mechanistically, the Smad3/4 complex activation led to the upregulation of Gabra6 expression in cortical neurons. …”
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High-integrity diffusion bonding of laser powder bed fused, forged, and rolled Ti–6Al–4V alloys by Seoyeon Jeon, Hyunjong Ha, Dong Jun Lee, Hyeonil Park, Yong Nam Kwon, Hyunjoo Choi, Hyokyung Sung

“…Extended bonding durations led to β phase coarsening and thickened, elongated α′ laths in LPBFed materials, negatively impacting their mechanical properties. …”
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Targeted gut microbiome therapy: Applications and prospects of probiotics, fecal microbiota transplantation and natural products in the management of type 2 diabetes by Luqi Qin, Bei Fan, Yixia Zhou, Jiahuan Zheng, Rao Diao, Fengzhong Wang, Jiameng Liu

“…Although existing studies have suggested that these interventions may delay or even halt the progression of T2DM, most research remained limited to animal models and observational clinical studies, with a lack of high-quality clinical data. This has led to an imbalance between theoretical research and clinical application. …”
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Functional state of the nigrostriatal system of Krushinsky – Molodkina rats during audiogenic seizure expression by N. A. Dorofeeva, L. S. Nikitina, D. V. Zosen, M. V. Glazova, E. V. Chernigovskaya

“…The observed exocytosis activation led to secretion of glutamate in the striatum and, as a result, to stimulation of seizures. …”
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Hydrodynamic cavitation induced fabrication of soy protein isolate–polyphenol complexes: Structural and functional properties by Fengyan Wei, Xianʹe Ren, Yongchun Huang, Ning Hua, Yuting Wu, Feng Yang

“…The results showed that HC treatment led to SPI structure stretching, which increased the binding level of polyphenols, especially that of TA (increased from 35.08 ± 0.73% to 66.42 ± 1.35%). …”
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