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5181
New Players for Advanced Prostate Cancer and the Rationalisation of Insulin-Sensitising Medication
Published 2013-01-01“…Hyperinsulinaemia, dyslipidaemia, hypoxia, ER stress, and inflammation associated with expanded adipose tissue are thought to be among the main culprits driving malignant growth and cancer advancement. This observation has led to the proposal of the potential utility of “old players” for the treatment of type 2 diabetes and metabolic syndrome as new cancer adjuvant therapeutics. …”
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5182
The Association of TNF-Alpha Inhibitors and Development of IgA Nephropathy in Patients with Rheumatoid Arthritis and Diabetes
Published 2020-01-01“…Discontinuation of anti-TNF-alpha therapy and initiation of immunosuppressive therapy led to improvement in serologic abnormalities and renal function in two patients, while the third patient’s 24-hour proteinuria was only partially reduced, which supports previous reports on TNF-alpha inhibitor induced autoimmunity. …”
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5183
Goat-derived cell line (<i>Capra hircus</i>) TCh generated by karyological and morphological transformation of YаDK-04 CCL during subcultivation with lanthanide-treated bovine seru...
Published 2023-12-01“…Use of the bovine serum purified and supplemented with lanthanides during the cultivation of the continuous cell line YаDK-04 led to significant chromosomal rearrangements and contributed to the formation of a stable and productive new TCh cell line, which differed in cytomorphological and karyological characteristics and had unlimited potential for passaging without changing the cell karyotype and morphology. …”
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5184
Subtoxic Concentrations of Hepatotoxic Drugs Lead to Kupffer Cell Activation in a Human In Vitro Liver Model: An Approach to Study DILI
Published 2015-01-01“…Additional activation of KC using supernatants of hepatocytes treated with hepatotoxic drugs increased KC activity and led to donor-dependent changes in the formation of ROI compared to KC incubated with supernatants from untreated hepatocytes. …”
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5185
The Properties of Damaged Starch Granules: The Relationship Between Granule Structure and Water–Starch Polymer Interactions
Published 2024-12-01“…Therefore, it was suggested that the changes in granule structure led to a weaker water–starch polymer chain interactions due to the increase in DS. …”
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5186
Non-carcinogenic health risks of fluoride exposure in minors based on national surveillance in China, 2014 and 2018
Published 2024-12-01“…The implementation of improvement initiatives led to a reduction in the non-carcinogenic risk of fluoride exposure for minors, with odds ratios (95% CI) for infants, children, and teens were 0.369 (0.268, 0.509), 0.556 (0.452, 0.683), and 0.823 (0.740, 0.914), respectively. …”
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5187
Differentiation between 3,4- and 4,15-Epoxyeudesmanolides by Electrospray Ionization Tandem Mass Spectrometry
Published 2017-01-01“…The elimination of the different ester substituent at C(1) directly from protonated 1 and 2 (A) led to the formation of two regioisomer product ions B (A − RCO2H). …”
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5188
The paradoxical simile, A stylistic feature in the poems of Seyyed Hasan Hosseini and Qeysar Aminpoor
Published 2021-09-01“…The researchers’ too much emphasis on the resistance poetry during this period has led to the marginalization of literary creativity and innovation in these poems. …”
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5189
Features of the electrolyte distribution in various tissues in miniature pigs
Published 2017-12-01“…However, despite the widespread interest in this breed of animals, the distribution of water and electrolytes in the tissues of miniature pigs remains poorly understood, which led us to conduct this study. The distribution of sodium, potassium cations and water in skeletal muscles, myocardium, smooth muscle elements of the vascular system, liver and skin of mini-pigs differing in gender and behavioral response to humans has been studied. …”
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5190
Fetal Safety in MRI During Pregnancy: A Comprehensive Review
Published 2025-01-01“…As medical imaging continues to expand, concerns about the potential risks of ionizing radiation to the developing fetus have led to a preference for non-radiation-based alternatives such as ultrasonography and fetal MRI. …”
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5191
Structure of ADI Cast Iron as a Cast “in situ” Composite Reinforced with TiC Ceramic Particles
Published 2024-12-01“…As a result of the initiated Self-propagating High-temperature Synethesis reaction in Bath (liquid metal) of the type “solid Ti” – “solid C” type, led to the formation of ceramic phases in the form of titanium carbides. …”
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5192
Assessment of the Water Quality of WWTPs’ Effluents through the Use of Wastewater Quality Index
Published 2024-09-01“…The monitoring of many water quality parameters related to the compliance of treated wastewater with environmental standards has led to the development of a unitless metric, the Wastewater Quality Index (WWQI), which serves as a practical tool for regulatory authorities. …”
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5193
Flexural and Shear Strengthening of High-Strength Concrete Beams Using near Surface Basalt Fiber Bars
Published 2024-12-01“…However, the use of BFRP bars also led to a shift in failure modes from flexural to shear, particularly in specimens with increased flexural reinforcement. …”
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5194
Resin-Dentin Bonding Interface: Mechanisms of Degradation and Strategies for Stabilization of the Hybrid Layer
Published 2019-01-01“…The enzymatic degradation of collagen matrix, together with resin leaching, has led to seeking strategies that inhibit the endogenous proteases, cross-linking the denudated collagen fibrils and improving the adhesive penetration removing water from the interface. …”
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5195
Perioperative emergency laparotomy pathway for patients undergoing emergency laparotomy: A propensity score matched study
Published 2024-12-01“…Results: The utilisation of the EMLA perioperative care bundle led to a significant reduction in surgical complications (34.8% to 20.6%, <P=0.01), a decrease in LOS by 3.3 days (15.4 to 12.1 days, P=0.03) and lower hospitalisation costs (SGD 40,160 to 30,948, P=0.04). …”
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5196
Boost pressure influence on combustion, emission characteristics, and performance of diesel engines with various fuel types
Published 2025-03-01“…However, higher boost pressure also led to increased Brake Specific Fuel Consumption (BSFC), particularly for biodiesel fuels; for B100, BSFC increased from 297.1 g/kWh to 304.95 g/kWh at 50 % engine load. …”
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5197
The U.S.-Turkey ‘Model Partnership’: Testing the Limits (2009–2010)
Published 2020-11-01“…The author demonstrates that various methods of persuasion and coercion practiced by the Obama administration were not necessarily effective and their use led to a deterioration of situation on several occasions. …”
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5198
E-Commerce Fraud Detection Based on Machine Learning Techniques: Systematic Literature Review
Published 2024-06-01“…The e-commerce industry’s rapid growth, accelerated by the COVID-19 pandemic, has led to an alarming increase in digital fraud and associated losses. …”
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5199
Transport and Mitigation of Exhaled Electronic Cigarette Aerosols in a Multizone Indoor Environment
Published 2020-05-01“…Closing the connecting door between the two rooms produced the largest reduction (42%) of PNC in the non-vaping room; however, it also led to a 26% increase of PNC in the vaping room. …”
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5200
Processes of Secession and Irredentism in Bosnia and Herzegovina: History, Status, Prospects
Published 2024-12-01“…The fierce military conflicts generated by this disintegration led to secessionist-irredentist projects on the part of the Serbian and, partly, Croatian population and Bosniak attempts to reincarnate the previous (Yugoslav) concept based on the primacy of citizenship over other forms of identity. …”
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