Fhl1, a new spatially specific protein, regulates vein graft neointimal hyperplasia by Chaoqun Wang, Jiantao Chen, Zicong Feng, Bohao Jian, Suiqing Huang, Kangni Feng, Haoliang Liu, Zhuoming Zhou, Ziyin Ye, Jing Lu, Mengya Liang, Zhongkai Wu

“…Immunohistochemical analysis identified neointima‐specific markers, while NIH progression was assessed in SD rats with four and a half LIM domains protein 1 (Fhl1) knockout and in human saphenous veins (HSV) with adenovirus‐mediated Fhl1 overexpression. …”
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ATP1B3 may promote glioma proliferation and migration through MAPK/NF-KB signaling pathway by Qikang Yan, Quan Sun, Yan Feng, Qingyun Hu, Jinling Zhu

“…The mRNA and protein expression levels of ATP1B3 were significantly decreased after knockout, and the proliferation, migration and invasion ability of cells in knockout group were significantly lower than those in control group, with statistical difference. …”
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Tendon Stem/Progenitor Cells and Their Interactions with Extracellular Matrix and Mechanical Loading by Chuanxin Zhang, Jun Zhu, Yiqin Zhou, Bhavani P. Thampatty, James H-C. Wang

“…Finally, future research efforts are suggested, which include using specific gene knockout models and single-cell transcription profiling to enable a broad and deep understanding of the physiology and pathophysiology of tendons.…”
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LOX-1, OxLDL, and Atherosclerosis by Angela Pirillo, Giuseppe Danilo Norata, Alberico Luigi Catapano

“…The key contribution of LOX-1 to the atherogenic process has been confirmed in animal models; LOX-1 knockout mice exhibit reduced intima thickness and inflammation and increased expression of protective factors; on the contrary, LOX-1 overexpressing mice present an accelerated atherosclerotic lesion formation which is associated with increased inflammation. …”
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Tubulin tyrosination/detyrosination regulate the affinity and sorting of intraflagellar transport trains on axonemal microtubule doublets by Aditya Chhatre, Ludek Stepanek, Adrian Pascal Nievergelt, Gonzalo Alvarez Viar, Stefan Diez, Gaia Pigino

“…Here, we test whether tubulin detyrosination (enriched on B-tubules) and tyrosination (enriched on A-tubules) have a role in IFT logistics. We report that knockout of tubulin detyrosinase VashL in Chlamydomonas reinhardtii causes frequent IFT train stoppages and impaired ciliary growth. …”
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Peroxisome Proliferator-Activated Receptor α Plays an Important Role in the Expression of Monocyte Chemoattractant Protein-1 and Neointimal Hyperplasia after Vascular Injury by Yu Peng, Qiang Li, Lu Zhang, Ming Bai, Zheng Zhang

“…Carotid artery injury was performed in the PPARα knockout and wild type (WT) mice, treated and untreated with Wy14643, a PPARα activator. …”
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Cell-specific functions of androgen receptor in skeletal muscles by Hiroshi Sakai, Yuuki Imai

“…Drawing from insights gained using conditional knockout mouse models facilitated by Cre/loxP technology, we review the cell-specific functions of AR in skeletal muscles. …”
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The role of oxidative stress, glucocorticoid receptor and ARMC5 in lipid metabolism by Yosuke Okuno, Atsunori Fukuhara, Iichiro Shimomura

“…Using adipocyte-specific glucocorticoid receptor knockout mice, we found that glucocorticoids also inhibited healthy adipose expansion and decreased insulin sensitivity. …”
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RNA helicase MOV10 suppresses fear memory and dendritic arborization and regulates microtubule dynamics in hippocampal neurons by Temirlan Shilikbay, Aatiqa Nawaz, Megan Doon, Stephanie Ceman

“…Results We generated a brain-specific knockout mouse (Mov10 Deletion) with greatly reduced MOV10 expression in cortex and hippocampus. …”
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RLS-associated MEIS transcription factors control distinct processes in human neural stem cells by Volker Kittke, Chen Zhao, Daniel D. Lam, Philip Harrer, Wojciech Krezel, Barbara Schormair, Konrad Oexle, Juliane Winkelmann

“…They can execute redundant functions when co-expressed in the same cell types, but their roles during early stages of neural differentiation have not been systematically compared. By separate knockout and overexpression of MEIS1 and MEIS2 in human neural stem cells, we find they control specific sets of target genes, associated with distinct biological processes. …”
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Bach2: A Key Regulator in Th2-Related Immune Cells and Th2 Immune Response by Guo Liu, Feng Liu

“…Furthermore, studies in various animal models show that Bach2 knockout animals spontaneously develop Th2 inflammation in the airway and gastrointestinal tract. …”
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Muscular TOR knockdown and endurance exercise ameliorate high salt and age-related skeletal muscle degradation by activating the MTOR-mediated pathway. by Shi-Jie Wang, Deng-Tai Wen, Ying-Hui Gao, Jing-Feng Wang, Xing-Feng Ma

“…TOR overexpression yielded similar results to the high salt diet(HSD) alone, with the opposite effect of TOR knockout found in regard to endurance exercise and HSD-induced age-related skeletal muscle degradation. …”
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Lactoferrin alleviates the adverse effects of early-life inflammation on depression in adults by regulating the activation of microglia by Wenli Wang, Qin An, Yunxia Zou, Yunping Dai, Qingyong Meng, Yali Zhang

“…Lactation LF-deficient mice were established by nursing wild-type mice using LF systemic knockout mother mice. Additionally, 14-day-old mice were injected with lipopolysaccharide (LPS) and subjected to chronic unpredictable mild stress when they reached 6 weeks of age. …”
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The autophagy component LC3 regulates lymphocyte adhesion via LFA1 transport in response to outside-in signaling by Naoyuki Kondo, Yuko Mimori-Kiyosue, Keizo Tokuhiro, Giuseppe Pezzotti, Tatsuo Kinashi

“…LFA1 clusters co-trafficked with LC3, facilitating LFA1 accumulation at the contact surface. LC3b knockout decreased lymphocyte adhesiveness. LFA1 activation did not induce autophagy, whereas it increased mTOR and AMPK activity. …”
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Loss of Kat2b impairs intraflagellar transport and the Hedgehog signaling pathway in primary cilia by Jae Hee Jun, Hwayeon Cha, Je Yeong Ko, Ho-Shik Kim, Kyung Hyun Yoo, Jong Hoon Park

“…Kat2b regulates the rate of cilia assembly, particularly in the early stages, and loss of Kat2b reduces the recruitment of intraflagellar transport (IFT) components to the ciliary axoneme and impairs Hedgehog (Hh) signaling activation. In addition, Kat2b-knockout mice showed mild abnormalities and ciliary IFT defects in the kidneys. …”
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The Role of −786T/C Polymorphism in the Endothelial Nitric Oxide Synthase Gene in Males with Clinical and Biochemical Features of the Metabolic Syndrome by Blazej Misiak, Marta Krolik, Anna Kukowka, Anna Lewera, Przemyslaw Leszczynski, Joanna Stankiewicz-Olczyk, Ryszard Slezak

“…Extensive evidence, arising from models of endothelial nitric oxide synthase gene (NOS3)-knockout mice supports the role of endothelial malfunction in the pathogenesis of the metabolic syndrome (MS). …”
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Selectivity of Inhibition of N-Succinyl-l,l-Diaminopimelic Acid Desuccinylase in Bacteria: The product of dapE-gene Is Not the Target of l-Captopril Antimicrobial Activity by Narasimha Rao Uda, Marc Creus

“…Here, we tested the selectivity of l-captopril against DapE in bacteria. Since DapE knockout strains of gram-negative bacteria are viable upon chemical supplementation with mDAP, we reasoned that the antimicrobial activity of compounds targeting DapE should be abolished in mDAP-containing media. …”
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The Expanding Role for Retinoid Signaling in Heart Development by Loretta L. Hoover, Elizabeth G. Burton, Bonnie A. Brooks, Steven W. Kubalak

“…Germline and conditional knockout mice have revealed which molecular players in the vitamin A signaling cascade are potentially responsible for regulating specific developmental events, and many of these molecules have been temporally and spatially characterized. …”
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Early Social Enrichment Improves Social Motivation and Skills in a Monogenic Mouse Model of Autism, the Oprm1−/− Mouse by Luciana Garbugino, Eleonora Centofante, Francesca R. D’Amato

“…The results show that double mothering normalized the abnormal response to maternal separation in Oprm1−/− pups and increased social motivation in juveniles and adult knockout mice. Additionally, we observed that Oprm1−/− mice act as less attractive social partners than wild types, which suggests that social motivation can be modulated by the stimulus employed. …”
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Nuclear Factor Erythroid 2-Related Factor 2 Intervenes the Release of Neutrophil Extracellular Traps during Lipopolysaccharide-Induced Acute Lung Injury in Mice by Junying Lu, Guilan Xiong, Hongxiang Li, Dong Zhang, Xiaohao Zhang

“…Results showed that the levels of Cit-H3 measured by western blot in Nrf2-knockout (KO) mice were higher compared with the WT mice after LPS stimulation. …”
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