Inhibidores de la tirosina quinasa en el adenocarcinoma pulmonar con mutación del receptor del factor de crecimiento epidérmico by Yoanna Ivette Flores Vega, Diana Laura Páramo González, Alejandro Manuel Perez Fonteboa, Sofia de Alsina Sarmiento, Janet Lamadrid García, Ángel René Elejalde Larinaga, Claudia Elejalde Tamayo, Danay Corrales Otero, Iniris Greca Santana Alvarez, Iris Beatriz Inguanzo Valdés, Alexander Oretega Carballosa, Maydelin Frontela Noda, Ramón Ropero Toirac, Elizabeth Bárbara Cuétara Lugo, Miguel Emilio García Rodríguez

“…Se utilizaron medidas de resumen de estadística descriptiva y estimaciones de supervivencia por método de Kaplan-Meier y el test de log-rank en la comparación de las curvas. …”
Get full text

The analysis of gene co-expression network and immune infiltration revealed biomarkers between triple-negative and non-triple negative breast cancer by Yao Yi, Yao Yi, Yu Zhong, Yu Zhong, Lianhua Xie, Lianhua Xie, Shuxian Lu, Shuxian Lu, Yifeng Zhang, Yifeng Zhang

“…Furthermore, to gain insights into the prognostic implications of these key genes, we performed relapse-free survival (RFS) analysis using the Kaplan-Meier plotter online tool. CIBERSORT analysis was used to characterize the composition of immune cells within complex tissues based on gene expression data, typically derived from bulk RNA sequencing or microarray datasets. …”
Get full text

NLR, A Convenient Early-Warning Biomarker of Fatal Outcome in Patients With Severe Fever With Thrombocytopenia Syndrome by Yuanyuan Wei, Yuanyuan Wei, Zilong Wang, Luyang Kang, Lingling He, Lingling He, Nan Sheng, Nan Sheng, Jiangfeng Qin, Jiangfeng Qin, Shuangshuang Ma, Honghai Xu, Lifen Hu, Guizhou Zou, Yufeng Gao, Yufeng Gao, Jiabin Li, Jiabin Li

“…The efficacy of SFTVS viral load and NLR in predicting fatal outcomes was significantly higher than AST/ALT, AST, and BUN. The Kaplan–Meier survival curves show that the case fatality rate was significantly increased in patients whose SFTSV viral load was higher than 500,000 or NLR higher than 2.0. …”
Get full text

Real‐world effectiveness and safety of oral azvudine versus nirmatrelvir‒ritonavir (Paxlovid) in hospitalized patients with COVID-19: a multicenter, retrospective, cohort study by Haiyu Wang, Guangying Cui, Ming Cheng, Tuerganaili Aji, Guotao Li, Xinjun Hu, Guangming Li, Shixi Zhang, Yanyang Zhang, Linqi Diao, Pan Li, Ling Wang, Yiqiang Yuan, Guowu Qian, Ruiqing Zhang, Xiaoli Jin, Juan Wang, Hong Luo, Donghua Zhang, Mingming Wang, Silin Li, Zhan Song, Mengzhao Yang, Guanyue Su, Ranran Sun, Junbiao Chang, Zujiang Yu, Zhigang Ren

“…Clinical outcomes were compared between the two drugs via Kaplan–Meier analysis and Cox regression models. Additionally, in vitro and in vivo experiments were used to evaluate the antitumor effects and safety of both drugs. …”
Get full text

Prognostic Value of Skull Base Foramen Invasion Subclassification in T Category Modification and Induction Chemotherapy Management for Nasopharyngeal Carcinoma: Post‐Hoc Analysis o... by Siyu Zhu, Shuqi Li, Di Cao, Chao Luo, Zhiying Liang, Shaobo Liang, Guoyi Zhang, Qin Zhao, Guangying Ruan, Lizhi Liu, Gui Fu, Haojiang Li

“…Univariate and multivariate analyses with Kaplan–Meier method are performed to compare survival outcomes. …”
Get full text

Characterizing executive functioning and associated behaviors in individuals with dual-specificity tyrosine phosphorylation-regulated kinase 1A (DYRK1A) syndrome by Hannah M. Rea, Sara Jane Webb, Sara Jane Webb, Evangeline C. Kurtz-Nelson, Caitlin M. Hudac, Caitlin M. Hudac, Raphael A. Bernier, Conor Miles, Rachel Earl, Alana Whiting, Curtis Eayrs, Margaret Johansson, Tianyun Wang, Tianyun Wang, Tianyun Wang, Evan E. Eichler, Evan E. Eichler, Emily Neuhaus, Emily Neuhaus

“…Specifically, executive functioning, or cognitive processes that are necessary for goal-directed behavior, has not yet been characterized in this population.MethodsIndividuals with DYRK1A variants (n = 29; ages 4 to 21 years) were assessed with a standardized protocol with multiple measures of executive functioning: Delis-Kaplan Executive Function Schedule, and chronologically age-appropriate caregiver-report forms of the Behavior Rating Inventory of Executive Function (BRIEF) and Achenbach System of Empirically Based Assessment (ASEBA). …”
Get full text

Previous treatment decreases efficacy of pralsetinib in RET fusion-positive non-small-cell lung cancer by Lei Wang, Yafei You, Wenzhuo He, Yu Hou, Lan Li, Li Wang, Chang Jiang, Jiahong Yi, Yaoxiong Xia, Liangping Xia

“…Progression-free survival (PFS) and overall survival (OS) were evaluated by a Kaplan-Meier analysis and log-rank test. A Cox regression model was performed to identify independent prognostic factors.ResultsA total of 28 patients were enrolled, and the median follow-up time was 18.1 months. …”
Get full text

Long term outcomes associated with the use of perioperative systemic chemotherapy on low grade appendiceal mucinous neoplasms with pseudomyxoma peritonei treated with cytoreductive... by Samantha M. Ruff, Gyulnara Kasumova, Manoj Palavalli, Oliver S. Eng, Laura Lambert, Callisia Clarke, Sameer Patel, Jula Veerapong, Keith Fournier, Daniel Abbott, Charles Staley, Travis Grotz, Fabian Johnston, Mustafa Raoof, Sean Dineen, Jordan M. Cloyd, Alex C. Kim

“…Survival and variables associated with survival were evaluated with the Kaplan-Meier analysis and cox regression, respectively.ResultsAmong the 529 included patients with LAMN, 63 (11.9%) received systemic chemotherapy and CRS+HIPEC, while 466 (88.1%) were treated with only CRS+HIPEC. …”
Get full text

Prognostic value of intraductal carcinoma subtypes and postoperative radiotherapy for localized prostate cancer by Fang Cao, Qing Li, Tianyu Xiong, Yingjie Zheng, Tian Zhang, Mulan Jin, Liming Song, Nianzeng Xing, Yinong Niu

“…Screening cases with pathological results of intraductal carcinoma, subtyping was completed by a pathologist, grouped by intraductal carcinoma (+/-; pattern 1/ 2) and treatment regimen (RP + PORT / RP only), Kaplan-Meier curves were plotted based on the time to biochemical recurrence-free and overall survival of the patients, and Cox regression analyses were performed. …”
Get full text

Associations of HLA-G 3’UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis by Ines Zemni, Daria Bortolotti, Sabrine Dhouioui, Sana Baroudi, Malek Ferjani, Inès Nasri, Yosr Zenzri, Md Ataur Rahman, Abdel Halim Harrath, Roberta Rizzo, Nadia Boujelbene, Inès Zidi

“…Assessment of patients' survival by Kaplan-Meier analysis indicated that the Del allele was significantly associated with reduced overall survival (OS) in GC patients at advanced stages III + IV (p = 0.043). …”
Get full text

Pharmacogenetic and pharmacokinetic factors for dexmedetomidine-associated hemodynamic instability in pediatric patients by Yanping Guan, Bilian Li, Yiyu Zhang, Hao Luo, Xueding Wang, Xue Bai, Zhuoling Zheng, Yaying Huang, Wei Wei, Min Huang, Xingrong Song, Guoping Zhong

“…LASSO regression was used to identify significant factors, and a Cox’s proportional hazards model-derived nomogram for hemodynamic instability was developed.ResultsHemodynamic instability was observed in 52 out of 270 patients (209 events), resulting in a cumulative incidence of 16.30% at 90 min, as estimated by Kaplan–Meier estimation, and it was associated with a median time to event of 35 min. …”
Get full text

Clinical implication of NT-proBNP to predict mortality in patients with acute type A aortic dissection: a retrospective cohort study by Rui Zhang, Hao Wang, Chenxi Song, Rui Fu, Kefei Dou, Shuai Liu, Qianqian Liu, Xiaohui Bian, Weida Liu, Chengang Zhu, Jingjing Gao, Sheng Yuan, Xinming Cui, Sijia Qin, Yumeng Li

“…Compared with patients with low NT-proBNP, the Kaplan-Meier estimates for primary 1-year mortality were higher in intermediate (32.5% vs 18.1%; HR 1.91, 95% CI 1.35 to 2.69) and high (42.0% vs 18.1%; HR 2.56, 95% CI 1.84 to 3.57) NT-proBNP groups, respectively. …”
Get full text

Correlation between immune signature and high‐density lipoprotein cholesterol level in stage II/III colorectal cancer by Yun Wang, Xiao‐qiang Sun, Hao‐cheng Lin, De‐shen Wang, Zhi‐qiang Wang, Qiong Shao, Feng‐hua Wang, Shu‐mei Yan, Jie‐ying Liang, Zhao‐lei Zeng, Huai‐qiang Ju, Rui‐hua Xu, Yu‐hong Li

“…A total of 667 CRC patients were enrolled and divided into two groups based on the lower limit of normal HDL‐C values (0.78 mmol/L). We used Kaplan‐Meier curves and the Cox regression model to analyze the prognostic role of HDL in both disease‐free survival (DFS) and overall survival (OS). …”
Get full text

An exploratory study of INPP4B, a biomarker of gemcitabine chemoresistance in pancreatic cancer by REN Jiaqiang, WU Shuai, SU Tong, LI Jie, HAN Liang, WU Zheng

“…Immunohistochemical analysis revealed that INPP4B expression was significantly higher in drug resistant pancreatic cancer tissues compared to non-drug resistant tissues, and lower in normal tissues than in both cancerous tissue types. Kaplan-Meier curves demonstrated that patients with low INPP4B expression had significantly better progression-free survival (PFS) than those with high expression (HR=2.874, 95% CI: 1.262-6.544, P=0.013). …”
Get full text

Prediction of pathological complete response after neoadjuvant chemotherapy for HER2-negative breast cancer patients with routine immunohistochemical markers by Lothar Häberle, Ramona Erber, Paul Gass, Alexander Hein, Melitta Niklos, Bernhard Volz, Carolin C. Hack, Rüdiger Schulz-Wendtland, Hanna Huebner, Chloë Goossens, Matthias Christgen, Thilo Dörk, Tjoung-Won Park-Simon, Andreas Schneeweiss, Michael Untch, Valentina Nekljudova, Sibylle Loibl, Arndt Hartmann, Matthias W. Beckmann, Peter A. Fasching

“…Associations among pCR-prob, prognostic IHC3 distant recurrence and disease-free survival were studied using Cox regression and Kaplan–Meier analyses. The model’s utility was further evaluated in independent external validation cohorts. …”
Get full text

Bulk and single-cell transcriptome revealed the metabolic heterogeneity in human glioma by Yong Xiao, Mengjie Zhao, Ran Wang, Liang Liu, Chong Xiang, Taiping Li, Chunfa Qian, Hong Xiao, Hongyi Liu, Yuanjie Zou, Xianglong Tang, Kun Yang

“…The glioma energy metabolic subtypes were constructed using the R package ConsensusClusterPlus. Kaplan–Meier analysis was conducted to compare clinical outcomes between different metabolic groups. …”
Get full text

Real-World Evidence of Clinical Outcomes of the Use of the Adalimumab Biosimilar SB5 in Rheumatic and Gastrointestinal Immune-Mediated Inflammatory Diseases: 12-Month Data from the... by Bruno Fautrel, Yoram Bouhnik, Carine Salliot, Franck Carbonnel, Mathurin Fumery, Christophe Bernardeau, Yves Maugars, Mathurin Flamant, Fabienne Coury, Ben Braithwaite, Salima Hateb, Janet Addison, the PERFUSE investigators

“…Analyses of clinical data were descriptive, while persistence was assessed using a Kaplan–Meier survival analysis. Results Overall, 911 patients were included: 507 from rheumatology centres [116 with rheumatoid arthritis (RA), 78 psoriatic arthritis (PsA), and 313 ankylosing spondylitis (AS)] and 404 from gastroenterology centres [316 with Crohn’s disease (CD) and 88 ulcerative colitis (UC)]. …”
Get full text

An anoikis-related signature predicts prognosis and immunotherapy response in gastrointestinal cancers by Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Ruyi Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Yuchen Liu, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Weicheng Huang, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Pengxiang Chen, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng, Yufeng Cheng

“…The model was validated and evaluated using Kaplan–Meier analysis, receiver operating characteristic curves, univariate Cox regression analysis, multivariate Cox regression analysis, column charts, and calibration curves. …”
Get full text

The expression of CCL17 and potential prognostic value on tumor immunity in thyroid carcinoma based on bioinformatics analysis by Xue Gu, Bingfeng Chen, Shengcan Zhang, Xinyu Zhai, Ying Hu, Hui Ye

“…Next, the association of CCL17 with survival in the thyroid carcinoma patients was examined by using the Kaplan–Meier plotter database. Then, weighted gene co-expression network (WGCNA) was employed to analyze the 1424 DEGs to classify 9 modules. …”
Get full text

Association between prognosis and the use of angiotensin‐converting enzyme inhibitors and/or angiotensin II receptor blockers in frail patients with heart failure with preserved ej... by Akihiro Sunaga, Shungo Hikoso, Shunsuke Tamaki, Masahiro Seo, Masamichi Yano, Takaharu Hayashi, Akito Nakagawa, Yusuke Nakagawa, Hiroyuki Kurakami, Tomomi Yamada, Tetsuhisa Kitamura, Taiki Sato, Bolrathanak Oeun, Hirota Kida, Yohei Sotomi, Tomoharu Dohi, Katsuki Okada, Hiroya Mizuno, Daisaku Nakatani, Takahisa Yamada, Yoshio Yasumura, Yasushi Sakata, OCVC‐Heart Failure Investigators

“…Of 1059 patients, median age was 83 years and 45% were male. Kaplan–Meier analysis showed that the risk of composite endpoint (log‐rank P = 0.001) and all‐cause death (log‐rank P = 0.005) in patients with ACE‐I/ARB was lower in those with CFS ≥ 5, but similar between patients with and without ACE‐I/ARB in patients with CFS ≤ 4 (composite endpoint: log‐rank P = 0.830; all‐cause death: log‐rank P = 0.192). …”
Get full text