The Association Between Mitral Regurgitation and Long-Term Outcomes in Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention: A Retrospective Large Sample Cohor... by Yan N, Wu P, Zhu B, Ma A, Wang X, Hai X, Ma X, Jiang H, Yang S

“…The cumulative 3-year incidence of MACCEs was 19.21% overall, with rates of 15.26%, 20.37%, and 37.37% in the no MR, mild MR, and moderate/severe MR groups, respectively (log-rank p < 0.001). Kaplan–Meier survival curves of MR with all-cause death and RHF were also plotted (log-rank p < 0.001). …”
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Comparative efficacy of repurposed drugs lopinavir-ritonavir and darunavir-ritonavir in hospitalised COVID-19 patients: insights from a tertiary centre cohort by Dóra Paróczai, Dóra Paróczai, András Bikov, András Bikov, Andreea Blidaru, Emanuel Bobu, Ana Lascu, Ana Lascu, Cristian Ion Mot, Cristian Ion Mot, Stefan Mihaicuta, Stefan Mihaicuta, Stefan Frent, Stefan Frent

“…Patients were assigned to the LPV/r, DRV/r, or control (standard-of-care) group based on clinical decisions made by the attending infectious disease specialists, aligned with national treatment protocols. Kaplan-Meier and Cox proportional hazards regression analyses were conducted to compare in-hospital mortality and to identify factors associated with clinical improvement or fatal outcomes.ResultsBy day 10, more patients showed improvement with LPV/r and DRV/r (p=0.03 and 0.01, respectively), but only LPV/r was associated with improved survival compared to the control group (p=0.05). …”
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Impact of Clinical Characteristics and Treatment on Cholangiocarcinoma Prognosis in Southern Thailand by Chirawadee Sathitruangsak, Tanawat Pattarapuntakul, Apichat Kaewdech, Tortrakoon Thongkan, Apinya Prisutkul, Phatcharaporn Thongwatchara, Hutcha Sriplung, Chanon Kongkamol, Kanyanatt Kanokwiroon, Sumalee Obchoei, Pimsiri Sripongpun

“…Overall survivals (OS) were determined by Kaplan–Meier method and multivariable Cox regressions. …”
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Serum advanced glycation end products as a putative biomarker in Type2 DKD patients’ prognosis by Ze-Hou Wang, Ze-Hou Wang, Zong-Jin Zhang, Yue-Fen Wang, Jin Xie, Jin Xie, Yi-Min Li, Cun Shen, Yuan Meng, Wen-Jing Zhao, Lu-Ying Sun, Wei Jing Liu

“…Receiver operating characteristic (ROC) curve was utilized to evaluate the predictive performance of corrected lgAGEs alone and in combination with the urinary albumin-to-creatinine ratio (UACR).ResultsHigh level of corrected lgAGEs was independently associated with adverse renal outcomes [hazard ratio (HR), 3.252; 95% confidence interval (CI), 1.461–7.243; p = 0.003]. Kaplan-Meier analysis demonstrated that patients in the high-level group (12 months) exhibited significantly shorter median survival times compared with those in the low-level group (50 months). …”
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Lung transplant outcomes for recipients with alpha-1 antitrypsin deficiency, by use of alpha-1 antitrypsin augmentation therapy by Atharv V. Oak, MEng, Jessica M. Ruck, MD, PhD, Alfred J. Casillan, MD, PhD, Armaan F. Akbar, BS, Ramon A. Riojas, MD, PhD, Pali D. Shah, MD, Jinny S. Ha, MD, MHS, Sara Strout, PharmD, Allan B. Massie, PhD, Dorry L. Segev, MD, PhD, Christian A. Merlo, MD, MPH, Errol L. Bush, MD

“…We categorized recipients by use of AAT augmentation therapy post-LT and compared their baseline characteristics using Fisher’s exact test and Wilcoxon rank-sum tests. We used Kaplan-Meier analyses and estimated the average treatment effect (ATE) of post-LT AAT augmentation therapy on mortality and all-cause graft failure (ACGF). …”
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Effect of antiretroviral therapy on the mortality of HIV-1 infection long-term non-progressors: a cohort study by Jinming Su, Jie Liu, Fengxiang Qin, Rongfeng Chen, Tongxue Qin, Xing Tao, Xiu Chen, Wen Hong, Bingyu Liang, Ping Cui, Li Ye, Junjun Jiang, Hao Liang

“…Multivariate logistic, Cox regression, and Kaplan-Meier method were employed to scrutinize associated factors and mortality risk of LTNP. …”
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Identification and validation of BATF as a prognostic biomarker and regulator of immune cell infiltration in acute myeloid leukemia by Zhe Zhao, Dongmei Wang, Dongmei Wang, Xue Sheng, Shuying Li, Tingting Liu, Mengyuan Chang, Lei Feng, Di Zhang, Chunyan Ji, Chunyan Ji, Fei Lu, Jingjing Ye

“…In the meantime, the prognostic value of BATF was evaluated using univariate and multivariate analyses, receiver operating characteristic (ROC) curve (AUC) analysis, and Kaplan-Meier (KM) survival analysis. EdU, colony formation, and CCK-8 assays were employed to evaluate the proliferation of cells. …”
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SLC1A5 is a key regulator of glutamine metabolism and a prognostic marker for aggressive luminal breast cancer by Lutfi H. Alfarsi, Rokaya El Ansari, Busra Erkan, Ali Fakroun, Madeleine L. Craze, Mohammed A. Aleskandarany, Kiu Wai Cheng, Ian O. Ellis, Emad A. Rakha, Andrew R. Green

“…Statistical analysis was performed using chi-squared tests, ANOVA, Spearman’s correlation, Kaplan–Meier analysis, and Cox regression. SLC1A5 mRNA and SLC1A5 protein expression were strongly correlated in luminal B, HER2 + and triple-negative BC (TNBC). …”
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Polo-like Kinase 1 Expression as a Biomarker in Colorectal Cancer: A Retrospective Two-Center Study by Lana Jajac Brucic, Vesna Bisof, Majana Soce, Marko Skelin, Ivan Krecak, Andjela Nadinic, Branka Vrbicic, Zivana Puljiz, Suzana Hancic, Slavko Gasparov

“…Multiple logistic regression confirmed that age is a significant predictor of PLK-1 expression, independent of the covariates (<i>p</i> = 0.036). The Kaplan–Meier analysis revealed no significant association between PLK-1 expression and PFS (<i>p</i> = 0.397) or OS (<i>p</i> = 0.448). …”
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Specimen oriented intraoperative margin assessment in oral cavity and oropharyngeal squamous cell carcinoma by P. Horwich, C. MacKay, M. Bullock, S. M. Taylor, R. Hart, J. Trites, L. Geldenhuys, B. Williams, M. H. Rigby

“…Study design Retrospective case series and subsequent prospective cohort study Setting Tertiary care academic teaching hospital Subjects and methods Retrospective case series of all institutional T1-T2 OCSCC or OPSCC treated with primary surgery between January 1st 2009 – December 31st 2014. Kaplan-Meier survival estimates with log rank tests were used to compare patients based on final margin status. …”
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Granulocyte-Macrophage Colony-Stimulating Factor-Activated Neutrophils Express B7-H4 That Correlates with Gastric Cancer Progression and Poor Patient Survival by Zhi-guo Shan, Zong-bao Yan, Liu-sheng Peng, Ping Cheng, Yong-sheng Teng, Fang-yuan Mao, Kun Fan, Yuan Zhuang, Yong-liang Zhao

“…Finally, we performed Kaplan-Meier plots for overall survival by using the log-rank test to evaluate the clinical relevance of neutrophils and their subsets. …”
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Prognostic Impact of Adjuvant Immunotherapy in Patients With Resectable NSCLC After Neoadjuvant Chemoimmunotherapy: A Brief Report by Yichen Dong, MD, Long Xu, MD, Jialiang Wen, MD, Haojie Si, MD, Juemin Yu, MD, Tao Chen, MD, Huikang Xie, MD, Xinjian Li, MD, Minglei Yang, MD, Junqiang Fan, MD, Junqi Wu, MD, Yunlang She, MD, Deping Zhao, MD, Chang Chen, MD, PhD

“…Recurrence-free survival (RFS) and overall survival (OS) were estimated using Kaplan-Meier methods and tested by log-rank test. …”
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Increased Interleukin-11 Levels Are Correlated with Cardiac Events in Patients with Chronic Heart Failure by Jing Ye, Zhen Wang, Di Ye, Yuan Wang, Menglong Wang, Qingwei Ji, Ying Huang, Ling Liu, Ying Shi, Lei Shi, Tao Zeng, Yao Xu, Jianfang Liu, Huimin Jiang, Yingzhong Lin, Jun Wan

“…Furthermore, the CHF patients were divided into two groups based on the median plasma IL-11 concentrations. The Kaplan-Meier analysis revealed that the patients with high IL-11 concentrations had a higher risk of cardiac events compared with those with low IL-11 concentrations. …”
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Outcomes of patients after successful left ventricular assist device explantation: a EUROMACS study by Christiaan F.J. Antonides, Felix Schoenrath, Theo M.M.H. deBy, Rahatullah Muslem, Kevin Veen, Yunus C. Yalcin, Ivan Netuka, Jan Gummert, Evgenij V. Potapov, Bart Meyns, Mustafa Özbaran, David Schibilsky, Kadir Caliskan, the EUROMACS investigators

“…The follow‐up data after explantation were collected via a questionnaire. A Kaplan–Meier analysis for freedom of the composite endpoint of death, heart transplantation, LVAD reimplantion, or heart failure (HF) relapse was conducted. …”
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Mortality in patients with giant cell arteritis in Spain: results from the ARTESER registry by Juan Molina-Collada, Marta Domínguez-Álvaro, Rafael B. Melero-González, Eugenio de Miguel, Maite Silva-Díaz, Jesús Alejandro Valero Jaimes, Ismael González, Julio Sánchez Martín, Javier Narváez, Joan Calvet, Ivette Casafont-Solé, Jose A Román Ivorra, Selene Labrada Arrabal, Margarida Vasques Rocha, Carlota L Iñiguez, María Sagrario Bustabad Reyes, Cristina Campos Fernández, María Alcalde Villar, Antonio Juan Mas, Ricardo Blanco, on behalf of the ARTESER Project Collaborative Group

“…The mortality rates were expressed as the number of deaths per 1000 person-years, with 95% confidence interval (CI) by sex and age group. Kaplan-Meier method was performed for survival analysis. …”
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Survival analysis of a 16-year cohort of follicular lymphoma patients receiving systemic treatment in Brazil by Pamela Santos Azevedo, Isabella Zuppo Laper, Deborah Marta do Santos Oliveira, Adriano de Paula Sabino, Marina Morgado Garcia, Isabela Cristina Menezes de Freitas, Isabela Cristina Menezes de Freitas, Wallace Mateus Prata, Wallace Mateus Prata, Mariângela Leal Cherchiglia, Juliana Álvares-Teodoro, Juliana Álvares-Teodoro, Francisco de Assis Acurcio, Francisco de Assis Acurcio, Augusto Afonso Guerra Júnior, Augusto Afonso Guerra Júnior

“…There are few studies on FL in Brazil, so this study aims to evaluate the patient’s profile, morbidity and mortality treated by the Brazilian national health service (SUS) and evaluate risk factors associated with treatment failure.MethodsThis is a nationwide 16 years cohort with patients that underwent chemotherapy in the SUS (2000–2015). The Kaplan-Meier method was used to estimate survival until treatment failure, and the Cox proportional hazards model was used to evaluate risk factors.ResultsThe cohort included 10,009 patients and survival rates were 73.3%, 45.3%, and 30.7% for the first, fifth and 10th year respectively. …”
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具核梭杆菌诱导内质网应激相关蛋白GRP78及XBP1高表达在食管鳞癌中的临床意义 by 陈斯默, 张哲源, 张家豪, 何珂瑶, 刘怡文, 周福有

“…利用卡方检验分析各因素与患者临床病理特征之间的相关性。采用Kaplan-Meier生存分析比较各因素对患者生存期的影响。结果与Fn未感染的KYSE150及KYSE140组细胞相比，Fn感染组（12 h、24 h及48 h）细胞中ROS与MDA含量逐渐增加，SOD活性逐渐降低，且GRP78及XBP1表达量逐渐增高（均<italic>P </italic>&lt; 0.05）。…”
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The Effect of Coronary Artery Disease on the Prognosis of Hypertrophic Cardiomyopathy: A Multi-Center Cohort Study by Guoqing Hou, Qian Liao, Huihui Ma, Yan Shu, Shengzhi Zeng, Yongmei Zhou, Liangjun Luo, Gang Zhao, Tao He, Mingjiang Liu, Jianhong Tao, Wei Hua, Xiaoping Li

“…Using logistic regression, nine indicators were selected for 1:1 propensity score matching (PSM). Additionally, Kaplan–Meier survival curves and Cox proportional hazards regression analyses were used to assess the impact of CAD on the prognosis of patients with HCM. …”
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早中期结直肠癌手术前后外周血循环肿瘤细胞的监测及预后分析 by 曹霞

“…利用受试者工作曲线（ROC）及约登指数判定CTC诊断结直肠癌的临界值，采用Kaplan-Meier和Log-rank方法进行生存分析，多因素COX回归分析进行多因素校正，综合评估CTC诊断早中期结直肠癌的价值，然后结合临床病理特征以及术后随访资料，分析外周血循环肿瘤细胞与临床病理特征及预后的关系。…”
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Post-extrasystolic variation of ST segment and T wave as a mortality risk predictor after myocardial infarction by Ralf J. Dirschinger, Ralf J. Dirschinger, Alexander Müller, Petra Barthel, Alexander Steger, Michael Dommasch, Axel Bauer, Karl-Ludwig Laugwitz, Georg Schmidt, Daniel Sinnecker, Daniel Sinnecker

“…A strong association was found with ϕ1/ϕ2 encompassing 40–230 ms after the J point, which was used to calculate PEST in the analysis. Kaplan-Meier curves and univariable/multivariable Cox proportional hazards models were used to study mortality prediction by PEST. …”
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