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Solid Self-Microemulsifying Drug Delivery System for Improved Oral Bioavailability of Relugolix: Preparation and Evaluation
Published 2025-01-01“…Zi-Lin Li,1,* Guo-Xing Deng,1,* Chuan-Zhou Fang,1,* Yue-Qi Zhao,1 Jing Yuan,2 Liang Chen,3 Hai-Jun Zhong,1 Feng Guo1 1School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China; 2College of Basic Medicine and Forensic Medicine, Henan University of Science and Technology, Luoyang, 471000, People’s Republic of China; 3Jiangxi Prozin Pharmaceutical Co., LTD, Jian, 343100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Feng Guo; Hai-JunZhong, School of Pharmacy, Jiangxi Medical College, Nanchang University, Nanchang, 330006, People’s Republic of China, Tel +86 0791 86361839, Email fengguo@ncu.edu.cn; zhonghj@ncu.edu.cnPurpose: To improve the oral absorption of relugolix (RLGL), which has low oral bioavailability due to its low solubility and being a substrate of P-glycoprotein (P-gp). …”
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3643
Identification of Potential Diagnostic Biomarkers of Carotid Atherosclerosis in Obese Populations
Published 2025-02-01“…Xize Wu,1,* Jiaxiang Pan,2,* Xue Pan,1,3,* Jian Kang,1 Jiaqi Ren,1 Yuxi Huang,1 Lihong Gong,2,4 Yue Li2,4 1Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110847, People’s Republic of China; 2Department of Cardiology, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning, 110032, People’s Republic of China; 3College of Traditional Chinese Medicine, Dazhou Vocational College of Chinese Medicine, Dazhou, Sichuan, 635000, People’s Republic of China; 4Liaoning Provincial Key Laboratory of TCM Geriatric Cardio-Cerebrovascular Diseases, Shenyang, Liaoning, 110032, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lihong Gong; Yue Li, Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 33, Beiling Street, Huanggu District, Shenyang, Liaoning, 110032, People’s Republic of China, Tel +86 024-82961105, Email Linda1795@sina.com; med_liyue@163.comObjective: This study aimed to investigate the potential mechanisms and biomarkers between Obesity (OB) and carotid atherosclerosis (CAS).Methods: The GSE12828, GSE125771, GSE43292, and GSE100927 datasets were combined and normalized to obtain CAS-related differentially expressed genes (DEGs), and OB-related DEGs were obtained from the GSE151839 dataset and the GeneCards database. …”
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The Role of Thickening Agent Proportions in Optimizing Nanoemulsion Gel for Dermatophytosis Treatment
Published 2025-01-01“…Xiao Zhang,1,* Chen-Chen Wu,1 Hua Jiang,2 Jia-Fu Zhao,1,3 Zhong-Jian Pan,1 Yin Zheng1,3,* 1College of Animal Science, Guizhou University, Guiyang, Guizhou, People’s Republic of China; 2College of Veterinary Medicine, Gansu Agriculture University, Lanzhou, Gansu, People’s Republic of China; 3Key Laboratory of Animal Genetics, Breeding and Reproduction in The Plateau Mountainous Region, Ministry of Education, Guizhou University, Guiyang, Guizhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yin Zheng, College of Animal Science, Guizhou University, Mingyi Building (Teaching and Research Center), Room 428, West Campus of Guizhou University, Huaxi District, Guiyang City, Guizhou Province, 550025, People’s Republic of China, Email yzheng@gzu.edu.cnBackground: Adjusting thickening agent proportions in nanoemulsion gel (NG) balances its transdermal and topical delivery properties, making it more effective for dermatophytosis treatment.Methods: Carbomer 940 and α-pinene were used as model thickening agent and antifungal, respectively. …”
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Comprehensive Analysis of Programmed Cell Death-Related Genes in Diagnosis and Synovitis During Osteoarthritis Development: Based on Bulk and Single-Cell RNA Sequencing Data
Published 2025-01-01“…JiangFei Zhou,1,* SongSong Jiao,1,* Jian Huang,2,* TianMing Dai,3,* YangYang Xu,1,* Dong Xia,4,* ZhenCheng Feng,1 JunJie Chen,1 ZhiWu Li,5 LiQiong Hu,4 QingQi Meng1,3 1Department of Orthopedics, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 2Qingdao Medical College, Qingdao University, Qingdao, 266071, People’s Republic of China; 3Guangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 4Critical Care Medicine Department, Guangzhou Red Cross Hospital of Jinan University, Guangzhou, 510220, People’s Republic of China; 5Department of Orthopedics, the 2nd People’s Hospital of Bijie, Guizhou, 551700, People’s Republic of China*These authors contributed equally to this workCorrespondence: LiQiong Hu; QingQi Meng, Email 13929526981@163.com; mengqingqi@jnu.edu.cnBackground: Synovitis is one of the key pathological feature driving osteoarthritis (OA) development. …”
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3648
6G-ADM: knowledge based 6G network management and control architecture
Published 2022-06-01“…Starting from the network design idea of "Da Dao Zhi Jian", starting with efficient network management and control, the network architecture can be simplified, complex protocols can be simplified, manual operation and maintenance can be reduced, and the full scene network on-demand services can berealized through the rapid and efficient organization and allocation of multi-level resources in the whole network. …”
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3649
“Restoration of the Past Scenery-Realm”: A Research on the Scenery-Realm Restoration of Jiang’s Fu Garden During Qing Dynasty in the Historical Revolution of the Humble Administrat...
Published 2025-02-01“…In terms of realm experience, the research analyzes the generation of typical comprehensive experience and emotional activities in the garden from the perspectives of “Dong You Jian Jing Can” (roaming in motion and meditation in stillness) and “Ya Ji Yu Yuan Ju” (elegant gathering and garden dwelling), pointing out that the former, in short-term composite perceptions, is more likely to form differentiated results due to changes in mood, season, and combinations of dynamic and static appreciation, while the latter, through long-term interactive attachment and more nuanced examinations over time, can make the emotional sustenance of guests in the garden more genuine and varied. 2) In response to the question of what qualified the garden as a restoration of the past scenery-realm, the focus is on the “Yuanxiang Hall” area as a clue to explore the value orientation of the Fu Garden’s restoration. …”
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Simulation Analysis of Large Diameter Shield Cutting through Diaphragm Wall Impact on Metro Station Deformation
Published 2025-01-01“…[Method] Based on the actual project of the super-large diameter shield tunnel of Nanjing Jianning West Road river-crossing passage that cuts through the diaphragm wall of the existing metro station, a three-dimensional numerical model of tunnel-station-stratum is established, to study the ground settlement and the deformation of the station structure when the tunnel cuts through the diaphragm wall and pile foundation of the station. …”
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Quantitative Analysis and Comparison of Flavonoids in Lotus Plumules of Four Representative Lotus Cultivars
Published 2017-01-01“…Xianglian from Xiangtan (1173.07 mg/100 g), and cv. Jianlian from Jianning (930.08 mg/100 g). However, similar percentages of flavonoid C-glycosides in the total flavonoids were found for four cultivars, which were 80.83% for cv. …”
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Research Progress of SGLT2 Inhibitors in Cancer Treatment
Published 2025-01-01“…Xiaoyong Miao,1,* Jianing Zhang,2,* Weiyan Huang,2,* Yifei Wang,1 Aixia Jin,1 Jianping Cao,1 Zhenzhen Zhao3 1Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, People’s Republic of China; 2Student Brigade, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 3Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhenzhen Zhao, Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, 200433, People’s Republic of China, Email zpluto@163.com Jianping Cao, Department of Anesthesiology, Naval Medical Center, Naval Medical University, Shanghai, 200050, People’s Republic of China, Email cjpcl221019@sina.comAbstract: Sodium glucose co-transporter 2 (SGLT2) inhibitors represent a novel class of hypoglycemic drugs that have emerged in recent years. …”
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FAULT CHARACTERISTICS ANALYSIS OF 2BFQ-6 PRECISION SEEDER FOR RAPESEED
Published 2017-01-01“…A brand new seeder was conducted to work in rice stubble field lasting longer than 30 hectare in Jianli County,Hubei Province,in 2013. Trouble-free working time and area,phenomenon of the fault,repair time and the cause of the fault of the seeder in the course of the work were recorded and used for fault characteristics analysis. …”
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Keratosis Follicularis Squamosa in Unilateral Buttock: A Case Report and Review of Literature in China
Published 2024-01-01Get full text
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Three Solutions for Fourth-Order Impulsive Differential Inclusions via Nonsmooth Critical Point Theory
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Peripheral Blood NMLR Can Predict 5-Year All-Cause Mortality in Patients with Chronic Obstructive Pulmonary Disease
Published 2025-01-01“…Yuer Li,1 Shaobo Ge,1 Jin Liu,1 Rui Li,1 Rui Zhang,1 Juan Wang,2 Jianli Pan,3 Qiuhong Zhang,1 Jie Zhang,1 Ming Zhang1 1Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Ultrasound, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China; 3Department of Special Need, Xi’an Children’s Hospital, Xi’an, Shaanxi, People’s Republic of ChinaCorrespondence: Ming Zhang, Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 West Fifth Road, Xi’an, Shaanxi, 710004, People’s Republic of China, Email zhangmingdr@163.comBackground: Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. …”
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3660
Research of the Isogeometric Analysis of Gear Frictionless Contact
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