Exclusive Cutaneous and Subcutaneous Sarcoidal Granulomatous Inflammation due to Immune Checkpoint Inhibitors: Report of Two Cases with Unusual Manifestations and Review of the Literature by Narciss Mobini, Rummit Dhillon, Jason Dickey, Jordan Spoon, Kaviyon Sadrolashrafi

“…We report 2 cases with unusual features. One patient is a female who was treated for metastatic renal cell carcinoma with combination of ipilimumab (anti-CTLA-4) and nivolumab (anti-PD-1). …”
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Unilateral Giant Varicocele Mimicking Inguinal Hernia Resulting from Portosystemic Shunt without Evidence of Portal Hypertension: An Unusual Case Report by Muhammed Zahir, Hassan R. Al Muttairi, Surjya Prasad Upadhyay, Piyush N. Mallick

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Aggressive Disease Course of Multiple Myeloma with Concomitant ALK-Negative Anaplastic Large Cell Lymphoma: A Case Report with an Unusual Presentation by Michela Staderini, Lara Mannelli, Elisabetta Antonioli, Benedetta Puccini, Valentina Berti, Francesco Mungai, Federica Vergoni, Valentina Carrai, Luigi Rigacci, Alberto Bosi

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Unusual open-system behaviour revealed by LA-MC-ICP-MS U–Th dating of coral and coralline algae bio-carbonates by Condomines, Michel, Bruguier, Olivier, Hajji, Inès, Zaara-Ben Mosbah, Chedia

“…An example is provided by the very unusual open-system behaviour found in the outer Mg-calcite border of a coral branch, formed by a coralline red alga. …”
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Unusual symptoms reveal a rare splenic lymphoma: a case report of PS-DLBCL with neck and shoulder pain as the initial presentation by Shifu Hu, Yuanyuan Hao, Xiangyu Liu, Hanbo Liu

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Intermittent Fever, Progressive Weight Gain, and Personality Changes in a Five-Year-Old Girl: Unusual Paraneoplastic Syndrome due to Presacral Ganglioneuroma by Chao Yang, Chang-chun Li, Jun Zhang, Xiang-ru Kong, Zhenzhen Zhao, Xiao-bin Deng, Liang Peng, Shan Wang

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Microwave Thermal Ablation in an Unusual Case of Malignant and Locally Advanced Rare Tumor of Pancreas in ASA IV Old Male Patient and Literature Review by Francesco D’Amico, Michele Finotti, Chiara Di Renzo, Alessio Pasquale, Alessandra Bertacco, Giorgio Caturegli, Gabriel E. Gondolesi, Umberto Cillo

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Acquired Vitamin K Deficiency as Unusual Cause of Bleeding Tendency in Adults: A Case Report of a Nonhospitalized Student Presenting with Severe Menorrhagia by Omid Reza Zekavat, Gholamreza Fathpour, Sezaneh Haghpanah, Seyed Javad Dehghani, Maryam Zekavat, Nader Shakibazad

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A Delayed and Rather Unusual Presentation of a Bladder Injury after Pelvic Trauma: 5 Years after a Road Traffic Accident by Nikolaos Davarinos, John Thornhill, JP McElwain, David Moore

“…To our knowledge, this is the first report of its kind in the literature showing such a particularly delayed (5 years) and rather unusual presentation of a bladder injury after pelvic trauma.…”
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Embolization for haemomediastinum due to spontaneous rupture of oesophageal branch arising from an unusual origin (inferior thyroidal artery) after vomiting: a case report by Jin Suk Lee, Eic Ju Lim, Min Jai Cho, Yook Kim

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An Unusually Short Latent Period of Therapy-Related Myeloid Neoplasm Harboring a Rare MLL-EP300 Rearrangement: Case Report and Literature Review by Reina Takeda, Kazuaki Yokoyama, Seiichiro Kobayashi, Toyotaka Kawamata, Sousuke Nakamura, Tomofusa Fukuyama, Mika Ito, Nozomi Yusa, Eigo Shimizu, Nobuhiro Ohno, Rui Yamaguchi, Seiya Imoto, Satoru Miyano, Kaoru Uchimaru, Arinobu Tojo

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Massive Sequencing of V3-V4 Hypervariable Region in Pyogenic Liver Abscesses Reveals the Presence of Unusual Bacteria Not Detected by Classical Culture Methods by Verónica Fernández-Sánchez, Estibeyesbo Said Plascencia-Nieto, Mónica Alethia Cureño-Díaz, Emilio Mariano Durán-Manuel, Aida Verónica Rodríguez-Tovar, Claudia Camelia Calzada-Mendoza, Clemente Cruz-Cruz, Miguel Ángel Loyola-Cruz, María Elizbeth Álvarez-Sánchez, Juan Carlos Bravata-Alcántara, Enzo Vásquez-Jiménez, Víctor Hugo Gutiérrez-Muñoz, Dulce Milagros Razo Blanco-Hernández, Liliana Nicolás-Sayago, Araceli Rojas-Bernabé, Omar García-Hernández, Erika Gómez-Zamora, Mireya Ruíz-Valdés, Graciela Castro-Escarpulli, Juan Manuel Bello-López

“…The massive sequencing revealed the presence of unusual pathogens that traditional culture failed to detect. …”
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A Novel Approach for Treatment of an Unusual Presentation of Radicular Cysts Using Autologous Periosteum and Platelet-Rich Fibrin in Combination with Demineralized Freeze-Dried Bone Allograft by Veena A. Patil, Manthan H. Desai, Veerendra S. Patil, Hanisha Reddy Kaveti, Kiran Kumar Ganji, Prasanna M. Danappanavar

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Initial-Stage Primary Intraosseous Squamous Cell Carcinoma Derived from Odontogenic Keratocyst with Unusual Keratoameloblastomatous Change of the Maxilla: A Case Report and Literature Discussion by Kentaro Kikuchi, Fumio Ide, Shota Takizawa, Seiji Suzuki, Hideaki Sakashita, Tie-Jun Li, Kaoru Kusama

“…Here, we report an extremely rare case of initial-stage PIOSCC derived from the OKC with unusual keratoameloblastomatous change of the maxilla.…”
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Competitive strategies of differentiation and cost minimization by O. Mikhailov

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Unusual hypertrophic cardiomyopathy: case report of an early onset wild-type ATTR amyloidosis accompanied by a chromosomal duplication involving the MYH6 and MYH7 gene by Jassin Hamidi, Yvonne Hanel, Sven Dittmann, Wanda Maria Gerding, Huu Phuc Nguyen, Karin Klingel, Eric Schulze-Bahr

“…While early onset wtATTR is an uncommon clinical finding, another significant clinical condition was identified in this patient, marked by an unusual copy number variation (CNV) in the genes MYH6 and MYH7.…”
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An Unusual Benign Cause of an Alarming Finding on Chest-X ray: A Case Report of Widened Mediastinum due to Rare Congenital Abnormality (Azygos Vein Continuation of Inferior Vena Cava) by Michael Hanna, Ghada Elshimy, Medhat Ismail, Mourad Ismail

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Cutaneous Squamous Cell Carcinoma with Signet-Ring Cell Component and CDX2 Expression in a Patient Treated with PD-1 Inhibitor: A Case Report of a Common Tumor with Unusual Differentiation by Sherehan Zada, Jeremiah Tao, Maria Del Valle Estopinal

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Mixed Germ Cell Tumor with Extensive Yolk Sac Tumor Elements in the Frontal Lobe of an Adult by Toshihide Takahashi, Eiichi Ishikawa, Yosuke Masuda, Tetsuya Yamamoto, Taiki Sato, Makoto Shibuya, Akira Matsumura

“…Intracranial nongerminomatous germ cell tumors (NGGCTs) in unusual locations are extremely rare. Here, we report a case of a yolk sac tumor in the frontal lobe in a middle-aged patient. …”
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Cryptococcemia Resulting in an Incomplete Abortion in an HIV-Positive Patient by Kurosh Rahimi, Runjan Chetty, Blaise Clarke

“…Exotic infections and unusual presentations are the norm in immunocompromised patients. …”
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