Safety and efficacy of trifluridine/tipiracil +/− bevacizumab plus XB2001 (anti-IL-1α antibody): a single-center phase 1 trial by Marion Thibaudin, Nicolas Roussot, Chloé Burlot, Antonin Schmitt, Julie Vincent, Zoé Tharin, Leila Bengrine, Hélène Bellio, Aurélie Bertaut, Léa Hampe, Susy Daumoine, Emilie Rederstorff, Morgane Peroz, Titouan Huppe, Valentin Derangère, David Rageot, John Simard, Caroline Truntzer, Jean David Fumet, Francois Ghiringhelli

“…Abstract In the tumour microenvironment, IL-1α promotes neoangiogenesis, matrix remodelling, tumour proliferation, chemoresistance, and metastases. …”
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Corrigendum to “EOLA1 Inhibits Lipopolysaccharide-Induced Vascular Cell Adhesion Molecule-1 Expression by Association with MT2A in ECV304 Cells” by Weiling Leng, Xiaotian Lei, Hao Meng, Xinshou Ouyang, Ziwen Liang

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Theoretical Studies on the Design of Benzo[1,2-c:4,5-c’]bis[1,2,5]selenadiazole Acceptor-Based Organic Dyes by Taylor Dorlus, Jing Wang, Jerzy Leszczynski

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EXAMINATION OF ADAPTIVE AND AGRONOMIC CHARACTERS IN LINES OF COMMON WHEAT OMSKAYA 37 BEARING TRANSLOCATIONS 1RS.1BL AND 7DL-7Ai by I. A. Belan, L. P. Rosseeva, V. M. Rosseev, E. D. Badaeva, Y. I. Zelenskiy, N. P. Blokhina, S. S. Shepelev, L. A. Pershina

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FoxA1 knockdown promotes BMSC osteogenesis in part by activating the ERK1/2 signaling pathway and preventing ovariectomy-induced bone loss by Lijun Li, Renjin Lin, Yang Xu, Lingdi Li, Zhijun Pan, Jian Huang

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Information-theoretic bounds for accuracy of letter encoding and pattern recognition via ensembles of datasets M.M. Lange 1, A.M. Lange 1 by M.M. Lange, A.M. Lange

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Синтез и антиноцицептивная активность 2,2’-(1,4-фенилен)бис[3-арил-2-азаспиро[3.5]нонан-1-онов] by Р. Р. Махмудов, Е. А. Никифорова, Д. П. Зверев, Л. А. Балюкина, А. П. Скачков

Rapamycin-resistant polyclonal Th1/Tc1 cell therapy (RAPA-201) safely induces disease remissions in relapsed, refractory multiple myeloma by Lawrence G Lum, Parameswaran Hari, Aniko Szabo, Michele Donato, Jee Hyun Park, Daniel H Fowler, Binod Dhakal, Saurabh Chhabra, Deborah D Glass, David S Siegel, Tania C Felizardo

“…RAPA-201 drug products (DPs) were: polyclonal; enriched for TCM cells; reduced for immune checkpoint expression, including PD1, CD73, and LAIR1; and preferentially secreted Th1 cytokines. …”
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Crystal structure of ethyl 1-(4-fluorophenyl)-4-phenyl-1H-pyrrole-3-carboxylate, C19H16FNO2 by Song Hong-Yu, Liu Shan, Zhang Bo-Nan, Zhong Qi-Di, Qi Ya-Juan

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circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression by Yue Ma, Yanyi Ren, Huitao Wen, Chengcheng Cui

“…In the study, we explored the expression and function of circCOL1A1 (hsa_circ_0044556) in gastric cancer. We performed RT-PCR with divergent primers, mRNA stability assay, and RNase R digestion assay to characterize circCOL1A1 in gastric cancer cell lines. qRT-PCR was applied to detect the level of circCOL1A1 in both gastric cancer cell lines and tissues. …”
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Synthesis and preliminary ex vivo evaluation of the spasmolytic activity of 1,3-thiazolium- and 1,3,4-thiadiazolium-5-methylthio- and 5-thioacetate derivatives by Luis José A. S., Aquino Thiago M. De, Lira Bruno F., Filho Petrônio F. A., Scotti Marcus T., Scotti Luciana, Moura Ricardo O. De, Junior Francisco J. B. Mendonça

Subjects: “…1,3-thiazolium…”
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Optimum Operating Conditions of (PbxX1−x)(ZryTizY1−y−z) Piezoelectric Transducer for Vibrational Energy Harvesting Applications by Funda Demir, Mustafa Anutgan

“…The electrical energy production capability of bimorph (PbxX1-x)(ZryTizY1-y-z) fiber composite piezoelectric transducer has been investigated for energy harvesting applications. …”
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Luteolin Attenuates IL-1β-Induced THP-1 Adhesion to ARPE-19 Cells via Suppression of NF-κB and MAPK Pathways by Wen-Chung Huang, Chian-Jiun Liou, Szu-Chuan Shen, Sindy Hu, Chien-Yu Hsiao, Shu-Ju Wu

“…We found that luteolin decreased the levels of interleukin- (IL-) 6, IL-8, soluble intercellular adhesion molecule-1 (sICAM-1), and monocyte chemoattractant protein-1 (MCP-1) and attenuated adherence of the human monocytic leukemia cell line THP-1 to IL-1β-stimulated ARPE-19 cells. …”
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Administration of a Next-Generation Probiotic Escherichia coli Nissle 1917-GLP-1 Alleviates Diabetes in Mice With Type 1 and Type 2 Diabetes by Jie Luo, Yilin Fang, Zhanghua Qi, Fengyang Cui, Hong Hu, Shengjie Li, Tingtao Chen, Hongyan Zhang

“…In the case of T1DM mice, the results revealed that EcN-GLP-1 resulted in a notable decrease in blood glucose levels. …”
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The crystal structure of (E)-3-(2-chlorophenyl)-1-ferrocenylprop-2-en-1-one, C19H15ClFeO by Zhang Lilei, Xie Mengru

“…C19H15ClFeO, triclinic, P1‾ $P\overline{1}$ (no. 2), a = 10.2693(5) Å, b = 11.2568(6) Å, c = 20.8930(10) Å, α = 80.350(2)°, β = 76.9640(10)°, γ = 86.921(2)°, V = 2319.4(2) Å3, Z = 6, R gt(F) = 0.0534, wR ref(F 2) = 0.0968, T = 170 K.…”
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The Effect of the Thioether-Bridged, Stabilized Angiotensin-(1–7) Analogue Cyclic Ang-(1–7) on Cardiac Remodeling and Endothelial Function in Rats with Myocardial Infarction by Matej Durik, Richard van Veghel, Anneke Kuipers, Rick Rink, Marijke Haas Jimoh Akanbi, Gert Moll, A. H. Jan Danser, Anton J. M. Roks

“…Modulation of renin-angiotensin system (RAS) by angiotensin-(1–7) (Ang-(1–7)) is an attractive approach to combat the detrimental consequences of myocardial infarction (MI). …”
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High Glucose Level Disturbs the Resveratrol-Evoked Curtailment of CX3CL1/CX3CR1 Signaling in Human Placental Circulation by Dariusz Szukiewicz, Michal Pyzlak, Grzegorz Szewczyk, Aleksandra Stangret, Seweryn Trojanowski, Michal Bachanek, Wojciech Braksator, Jaroslaw Wejman

“…Hyperglycemia-induced hyperactivity of chemokine CX3CL1 (fractalkine) occurs in the human placenta. Anti-inflammatory/antioxidant activities of resveratrol (3,5,4′-trihydroxy-trans-stilbene) are related to the modulation of chemokine CX3CL1 and its receptor, CX3CR1, signaling pathways. …”
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The crystal structure of tetrakis(1-isopropyl-1H-imidazolium) octamolybdate, C24H44Mo8N8O26 by Yang Bingchuan, Lv Xueyan, Liu Rutao

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Kidney Injury Molecule 1 (KIM-1) as an Early Predictor for Acute Kidney Injury in Post-Cardiopulmonary Bypass (CPB) in Open Heart Surgery Patients by Nora A. Khreba, Mostafa Abdelsalam, A. M. Wahab, Mohammed Sanad, Rania Elhelaly, Mohammed Adel, Ghada El-Kannishy

“…Urinary kidney injury molecule 1 may play an important role as an early predictor of acute kidney injury post-cardiopulmonary in open heart surgery. …”
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Applications of MR Finger printing derived T1 and T2 values in Adult brain: A Systematic review [version 1; peer review: 2 approved] by Rajagopal Kadavigere, Obhuli Chandran M, Kaushik Nayak, Abhijith S, Saikiran Pendem, Varsha Raghu, Shailesh Nayak S, Riyan Mohamed Sajer, Tancia Pires, Priyanka -

“…In traumatic brain injury, longitudinal T1 changes strongly correlated with clinical recovery, surpassing T2 values. …”
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