Progression patterns in patients with advanced hepatocellular carcinoma treated with local therapy, targeted drugs, and PD-1/PD-L1 inhibitors by Yanan Zhao, Di Wu, Quanjun Yao, Hang Yuan, Hongtao Hu, Hailiang Li

Subjects: Get full text

Serum Concentrations of Transforming Growth Factor-Beta 1 in Predicting the Occurrence of Diabetic Retinopathy in Juvenile Patients with Type 1 Diabetes Mellitus by Katarzyna Zorena, Ewa Malinowska, Dorota Raczyńska, Małgorzata Myśliwiec, Krystyna Raczyńska

“…In the present study, we have decided to evaluate if serum transforming growth factor-beta 1 (TGF-β1) concentrations may have diagnostic value in predicting the occurrence of diabetic retinopathy (DR) in juvenile patients with type 1 diabetes mellitus (T1DM). …”
Get full text

TNF-alpha but not IL-1alpha are Correlated with PGE1-Dependent Protection Against Acute D-Galactosamine-Induced Liver Injury by J Muntané, JL Montero, JM Lozano, A Miranda-Vizuete, M de la Mata, G Miño

“…BACKGROUND: Prostaglandin E1 (PGE1) treatment of humans and rodents during acute hepatic failure ameliorates different parameters of hepatic dysfunction.…”
Get full text

Tribbles 3 Regulates the Fibrosis Cytokine TGF-β1 through ERK1/2-MAPK Signaling Pathway in Diabetic Nephropathy by Luwei Zhang, Jinhang Zhang, Xinnong Liu, Shengli Liu, Jun Tian

“…To reveal the expression and possible role of tribbles homolog 3 (TRB3) in the incidence of type 2 diabetic nephropathy, we used immunohistochemistry, real-time quantitative PCR, western blot analysis, and enzyme-linked immunosorbent assay (ELISA) to study the expression of TRB3, extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase (ERK1/2 MAPK), transforming growth factor β1 (TGF-β1), and collagen type IV in kidneys of db/db diabetic mice and in murine renal mesangial cells stimulated with high glucose. …”
Get full text

Kupffer Cells Promote the Differentiation of Adult Liver Hematopoietic Stem and Progenitor Cells into Lymphocytes via ICAM-1 and LFA-1 Interaction by Deping Meng, Yuhong Qin, Nan Lu, Keke Fang, Yuan Hu, Zhigang Tian, Cai Zhang

“…A blockade of intercellular cell adhesion molecule-1 (ICAM-1) in a liver HSPC and kupffer cell coculture system impaired the adhesion, expansion, and differentiation of HSPCs. …”
Get full text

Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1 by Huizhen Fan, Chunyan Jiang, Baoyuan Zhong, Jianwen Sheng, Ting Chen, Qingqing Chen, Jingtao Li, Hongchuan Zhao

“…Five targets, including interleukin 6 (IL-6), the 26S proteasome, tumor necrosis factor alpha (TNF-α), transforming growth factor beta 1 (TGF-β1) and p53, and corresponding high-mobility group box 1 (HMGB1) signaling and T helper cell differentiation were thought to be associated with matrine’s mechanism. …”
Get full text

Crystal structure of N-(diaminomethylene)-1-(dimethylamino)-1-iminiomethanaminium dichloride, C4H13Cl2N5 by Xia Yu-Pei

Get full text

Changes in performance and thermal stability of Ni0.8Co0.1Al0.1/graphite batteries with excessive water by Xi Liu, Jingbo Mao, Hongtao Yan, Chunjing Lin, Chuang Qi, Tao Yan, Li Lao, Yazhou Sun

Get full text

Activation of CD147 with Cyclophilin A Induces the Expression of IFITM1 through ERK and PI3K in THP-1 Cells by Ju-Young Kim, Ho Kim, Kyoungho Suk, Won-Ha Lee

“…Interferon-induced transmembrane 1 (IFITM1) was detected to be induced and it was confirmed by RT-PCR and Western blot analysis. …”
Get full text

PD-1-expressing macrophages and CD8 T cells are independent predictors of clinical benefit from PD-1 inhibition in advanced mesothelioma by Solange Peters, Urania Dafni, Panagiota Zygoura, Sanjay Popat, Mary O'Brien, Rolf A Stahel, Alessandra Curioni-Fontecedro, Georges Coukos, Amy Roy, Riyaz Shah, Krisztian Homicsko, James Spicer, Stephen P Finn, David Gilligan, Maxim Norkin, Stephanie Tissot, Nicholas Shakarishvili, Anthony Pope, Patricia Fisher, Sylvie Rusakiewicz, Ekaterina Fortis, Nesa Marti, Roswitha Kammler

“…Background Few tissue biomarkers exist to date that could enrich patient with cancer populations to benefit from immune checkpoint blockade by programmed cell death protein 1/ligand-1 (PD-/L-1) inhibitors. PD-L1 expression has value in this context in some tumor types but is an imperfect predictor of clinical benefit. …”
Get full text

Activation of FGD5-AS1 Promotes Progression of Cervical Cancer through Regulating BST2 to Inhibit Macrophage M1 Polarization by Guokun Liu, Xuan Du, Li Xiao, Qing Zeng, QianLing Liu

“…Accumulating evidence has elucidated the biological function of lncRNAs in various tumors. FGD5 antisense RNA 1 (FGD5-AS1) is identified as a significant tumor regulator in malignancies. …”
Get full text

Some New Inequalities of Hermite-Hadamard Type for (α1,m1)-(α2,m2)-Convex Functions on Coordinates by Ling Chun

“…The author introduces a new concept “(α1,m1)-(α2,m2)-convex functions on coordinates” and establishes some new inequalities of Hermite-Hadamard type for (α1,m1)-(α2,m2)-convex functions of two variables on co-ordinates.…”
Get full text

Synthesis and Characterization of Some Ni(II) and Cu(II) Complexes with 2-[(4-Aminophenyl)imino]-1, 2-diphenyl-1-ethanone by K. M. Khalifa, A. M. Hamil, A. Gasem, A. Abdulsalam

“…The present work deals with synthesis and characterization of the ligand 2-[(4-aminophnyl)imino]-1,2-diphenyl-1-ethanone and their complexes with Ni(II) and Cu(II) ions. …”
Get full text

Effect of Reduction in Thickness and Rolling Conditions on Mechanical Properties and Microstructure of Rolled Mg-8Al-1Zn-1Ca Alloy by Yuta Fukuda, Masafumi Noda, Tomomi Ito, Kazutaka Suzuki, Naobumi Saito, Yasumasa Chino

“…A cast Mg-8Al-1Zn-1Ca magnesium alloy was multipass hot rolled at different sample and roll temperatures. …”
Get full text

Nutrient Induced Type 2 and Chemical Induced Type 1 Experimental Diabetes Differently Modulate Gastric GLP-1 Receptor Expression by Olga Bloch, Efrat Broide, Gilad Ben-Yehudah, Dror Cantrell, Haim Shirin, Micha J. Rapoport

“…T2DM patients demonstrate reduced GLP-1 receptor (GLP-1R) expression in their gastric glands. …”
Get full text

New Investigation of Millimeter-Wave Rotational Spectrum of CCl3CN in Ground, v7 = 1 and v8 = 1 States by Masoud Motamedi, Tahere Zohrevand

“…The millimeter-wave rotational spectra of the ground and excited vibrational states v7 =1 and v8 =1 of the symmetric top molecule, CCl3CN, have been analyzed again. …”
Get full text

Electroacupuncture Mitigates Hippocampal Cognitive Impairments by Reducing BACE1 Deposition and Activating PKA in APP/PS1 Double Transgenic Mice by Yinshan Tang, Shujun Shao, Yu Guo, You Zhou, Jin Cao, Anping Xu, Jihong Wu, Zhigang Li, Dulian Xiang

“…Increased amyloid-β (Aβ) plaque deposition is thought to be the main cause of Alzheimer’s disease (AD). β-Site amyloid precursor protein cleaving enzyme 1 (BACE1) is the key protein involved in Aβ peptide generation. …”
Get full text

Chromatin Structure and U2AF1-RS1 Gene Expression in Embryonic Stem Cells following RA-Induced Apoptosis by N. Andollo, M.D. Boyano, M. Garcia-Sanz, A. Asumendi, M.M. Zalduendo, J. Arechaga

Get full text

The Arizona Molecular ISM Survey with the SMT: Variations in the CO(2–1)/CO(1–0) Line Ratio across the Galaxy Population by Ryan P. Keenan, Daniel P. Marrone, Garrett K. Keating

“…The J  = 1 → 0 spectral line of carbon monoxide (CO(1–0)) is the canonical tracer of molecular gas. …”
Get full text

Artificial 64-Residue HIV-1 Enhancer-Binding Peptide Is a Potent Inhibitor of Viral Replication in HIV-1-Infected Cells by Mouhssin Oufir, Leslie R. Bisset, Stefan R. K. Hoffmann, Gongda Xue, Stephan Klauser, Bianca Bergamaschi, Alain Gervaix, Jürg Böni, Jörg Schüpbach, Bernd Gutte

“…Moreover, HIV-1 replication is inhibited by this peptide in HIV-1-infected CEM-GFP cells as revealed by HIV-1 p24 ELISA and real-time RT-PCR of HIV-1 RNA. …”
Get full text