Antihuman Immunodeficiency Virus Type 1 (HIV-1) Activity of Rare Earth Metal Complexes of 4-Hydroxycoumarins in Cell Culture

“…<p>The cerium Ce(III), lanthanum La(III), and neodymium Nd(III) complexes with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one (warfarin) (<bold>W</bold>) and 3,<mml:math alttext="$3'$"> <mml:msup> <mml:mn>3</mml:mn> <mml:mo>&#x2032;</mml:mo> </mml:msup> </mml:math>-benzylidenebis[4-hydroxycoumarin] (<bold>1</bold>) were synthesized and studied for the first time for cytotoxicity (on MT-2 cells) and as anti-HIV agents under acute and chronic infection. …”
Get full text

Thyroid Hormone Increases TGF-β1 in Cardiomyocytes Cultures Independently of Angiotensin II Type 1 and Type 2 Receptors by Gabriela Placoná Diniz, Marcela Sorelli Carneiro-Ramos, Maria Luiza Morais Barreto-Chaves

“…TH-induced cardiac hypertrophy in vivo is accompanied by increased cardiac Transforming Growth Factor-β1 (TGF-β1) levels, which is mediated by Angiotensin II type 1 receptors (AT1R) and type 2 receptors (AT2R). …”
Get full text

Type 1 Diabetes (T1D) and Latent Autoimmune Diabetes in Adults (LADA): The Difference Between a Honeymoon and a Holiday by Livia M. R. Marcon, Carmine G. Fanelli, Riccardo Calafiore

“…Type 1 diabetes mellitus (T1D) is a chronic autoimmune disease in which destruction of the insulin-producing β-cells in the pancreatic islets requires regular lifelong insulin replacement therapy, the only lifesaving treatment available at this time. …”
Get full text

Epac1 Blocks NLRP3 Inflammasome to Reduce IL-1β in Retinal Endothelial Cells and Mouse Retinal Vasculature by Youde Jiang, Li Liu, Elizabeth Curtiss, Jena J. Steinle

“…Thus, we hypothesized that Epac1, a downstream mediator of β-adrenergic receptors, would block TLR4/HMGB1-mediated stimulation of the NLRP3 inflammasome, leading to reduced cleavage of caspase-1 and interleukin-1 beta (IL-1β). …”
Get full text

Atractylenolide III Improves Mitochondrial Function and Protects Against Ulcerative Colitis by Activating AMPK/SIRT1/PGC-1α by Jieru Han, Wenhao Li, Guangyu Shi, Yunlei Huang, Xutao Sun, Na Sun, Deyou Jiang

“…The protein levels of p-AMPK, SIRT1, and PGC-1α along with acetylated PGC-1α were also upregulated by AT III in vivo and in vitro. …”
Get full text

Molecular and Serological Investigation of Equine Herpesvirus Type 1 (EHV-1) and Type 4 (EHV-4) in Horses In Ibagué, Tolima by Julieth Michel Petano-Duque, Edwin Urueña-Martinez, Laura Liliana Cabezas-Callejas, Jorge Perilla-Amaya, Valentina Rueda-García, Iang Schroniltgen Rondón-Barragán, Ricaurte Lopera-Vásquez

“…EHV-1 is one of the most prevalent viral pathogens in horses; however, its prevalence is not well defined by cross-reactions of serological tests. …”
Get full text

PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury by Hui Liu PhD, MD, Hongjun Jin PhD, Xuyi Yue PhD, Junbin Han PhD, Pamela Baum SRS, Dana R. Abendschein PhD, Zhude Tu PhD

“…Sphingosine-1-phosphate receptor (S1PR) activation plays a key role in vascular inflammatory response. …”
Get full text

N′-[(1E)-(4–Fluorophenyl)methylidene]adamantane-1-carbohydrazide, C18H21FN2O by Al-Wahaibi Lamya H., Abdelbaky Mohammed S. M., Garcia-Granda Santiago, Reiss Guido J., Tiekink Edward R. T., El-Emam Ali A.

“…C18H21FN2O, triclinic, P1‾$P\overline{1}$ (no. 2), a = 10.6377(5) Å, b = 14.4869(7) Å, c = 21.0557(13) Å, α = 98.583(5)°, β = 91.979(4)°, γ = 90.101(4)°, V = 3206.5(3) Å3, Z = 8, Rgt(F) = 0.0815, wRref(F2) = 0.1930, T = 172 K.…”
Get full text

Discovery of Novel Nav1.7-Selective Inhibitors with the 1H-Indole-3-Propionamide Scaffold for Effective Pain Relief by Gaoang Wang, Hang Wu, Yingying Wang, Xiangying Liu, Shuijiao Peng, Wenxing Wang, Meijing Wu, Yifei Liu, Ercheng Wang, Zhe Wang, Lei Xu, Xiaojian Wang, Wei Yang, Haiyi Chen, Xi Zhou, Tingjun Hou

“…Nav1.7 is considered a promising target for developing next-generation analgesic drugs, given its critical role in human pain pathologies. …”
Get full text

Critical Clinical forms of influenza AH1N1: What we have learned from assisting the ill in Cienfuegos. by Grupo Operativo Provincial de Atención Médica a los enfermos adultos hospitalizados

“…We currently possess a growing information level on the effects of the influenza AH1N1epidemics in a range of countries in the world. …”
Get full text

Dual targeting PD-L1 and 4-1BB to overcome dendritic cell-mediated lenalidomide resistance in follicular lymphoma by Zhong Zheng, Jian-Biao Wang, Rui Sun, Nan Wang, Xiang-Qin Weng, Tian-Yuan Xu, Di Fu, Yan Feng, Peng-Peng Xu, Shu Cheng, Li Wang, Yan Zhao, Bin Qu, Chuan-Xin Huang, Wei-Li Zhao

“…We found that inferior progression-free survival of the patients was significantly associated with elevated serum β2m and lymph node >6 cm, linking to decreased lymphoma cell autophagy and dendritic cell infiltration within the tumor microenvironment. PU.1 transcriptionally downregulated PD-L1 (Programmed death ligand 1) expression and upregulated 4-1BBL (4-1BB ligand) expression, increased lymphoma cell autophagy and dendritic cell maturation via PD-1/PD-L1 and 4-1BB/4-1BBL interaction. …”
Get full text

Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Apical Membrane Antigen 1 (AMA1) by Umashankar Vetrivel, Shalini Muralikumar, B Mahalakshmi, K Lily Therese, HN Madhavan, Mohamed Alameen, Indhuja Thirumudi

Subjects: “…apical membrane antigen 1…”
Get full text

Synthesis and crystal structure analysis of 1-ethyl-1,3-dihydro-2H-benzo[d]imidazole-2-thione by Atash V. Gurbanov, Firudin I. Guseinov, Aida I. Samigullina, Tuncer Hökelek, Khudayar I. Hasanov, Tahir A. Javadzade, Alebel N. Belay

Get full text

Aspects of Screening and Confinement in a Topologically Massive U1W×U(1)Y Chern-Simons-Higgs Theory by Patricio Gaete, José A. Helayël-Neto

“…By using the gauge-invariant but path-dependent variables formalism, we consider a recently proposed topologically massive U1W×U(1)Y Chern-Simons-Higgs theory in 2+1 dimensions. …”
Get full text

Influenza A H1N1 Community-Acquired Pneumonia: Characteristics and Risk Factors—A Case-Control Study by Romina Abelleira, Alberto Ruano-Ravina, Adriana Lama, Gema Barbeito, María E. Toubes, Cristina Domínguez-Antelo, Francisco J. González-Barcala, Nuria Rodríguez-Núñez, Pedro J. Marcos, María L. Pérez del Molino, Luis Valdés

“…Introduction. Influenza A H1N1 community-acquired pneumonia (CAP) is a quite frequent respiratory disease. …”
Get full text

Inhibition of KLF5 promotes ferroptosis via the ZEB1/HMOX1 axis to enhance sensitivity to oxaliplatin in cancer cells by Zheng Zhang, Huaxiang Xu, Junyi He, Qiangsheng Hu, Yuxin Liu, Zijin Xu, Wenhui Lou, Wenchuan Wu, Lei Zhang, Ning Pu, Chenye Shi, Yaolin Xu, Wenquan Wang, Liang Liu

“…Mechanistically, we found that KLF5 inhibited the expression of heme oxygenase 1 (HMOX1) via repressing zinc finger E-box-binding homeobox 1 (ZEB1). …”
Get full text

4d N $$ \mathcal{N} $$ = 1 from 6d D-type N $$ \mathcal{N} $$ = (1, 0) by Jin Chen, Babak Haghighat, Shuwei Liu, Marcus Sperling

“…Abstract Compactifications of 6d N $$ \mathcal{N} $$ = (1, 0) SCFTs give rise to new 4d N $$ \mathcal{N} $$ = 1 SCFTs and shed light on interesting dualities between such theories. …”
Get full text

Synthesis and Antimicrobial Activity of 1-[2-(10-p-Chlorobenzyl) phenothiazinyl]-3-(substituted aryl)-2-propen-1-ones by R. K. Upadhyay, Megha S. Upadhyay, S. Jain

Get full text

Ellagic Acid Alleviates Rheumatoid Arthritis in Rats through Inhibiting MTA1/HDAC1-Mediated Nur77 Deacetylation by Huanjin Song, Hao Wu, Jun Dong, Sihua Huang, Jintao Ye, Ruoxi Liu

“…It was found that the level of metastasis-associated gene 1 (MTA1)/histone deacetylase 1 (HDAC1) protein complex was downregulated by polyphenols in several human disorders. …”
Get full text

Monocyte Chemotactic Protein 1-Induced Protein 1 Is Highly Expressed in Inflammatory Bowel Disease and Negatively Regulates Neutrophil Activities by Jian Lin, Gengfeng Li, Chunjin Xu, Huiying Lu, Cui Zhang, Zhi Pang, Zhanju Liu

“…Monocyte chemotactic protein 1-induced protein 1 (MCPIP-1) is highly expressed in activated immune cells and plays an important role in negatively regulating immune responses. …”
Get full text