PDE4 and Epac1 Synergistically Promote Rectal Carcinoma via the cAMP Pathway by Xiangyu Kong, Ganghao Ai, Dai Wang, Renzhen Chen, Dongbei Guo, Youliang Yao, Kai Wang, Guiye Liang, Fengjie Qi, Wenzhi Liu, Yongxing Zhang

“…To assess the expression levels of exchange protein 1 directly activated by cAMP (Epac1) and phosphodiesterase 4 (PDE4) in rectal carcinoma, and their associations with clinicopathological indexes. …”
Get full text

Efficacy of Rg1-Oil Adjuvant on Inducing Immune Responses against Bordetella bronchiseptica in Rabbits by Xiao Chenwen, Ji Quanan, Huang Yee, Liu Yan, Wang Jiaoyu, Wei Qiang, Qiao Litao, Nan Li, Bao Guolian

“…This study is aimed at examining the immune effects of Rg1, Rg1 plus oil, and other common adjuvants on inactivated B. bronchiseptica vaccine in rabbits. …”
Get full text

Paradoxical dominant negative activity of an immunodeficiency-associated activating PIK3R1 variant by Patsy R Tomlinson, Rachel G Knox, Olga Perisic, Helen Su, Gemma V Brierley, Roger L Williams, Robert K Semple

Subjects: “…PIK3R1…”
Get full text

Associations of Serum Urate and Cardiovascular Events in a Clinical Trial of Interleukin-1β Blockade by Nicholas H. Adamstein, MD, Jean G. MacFadyen, BA, Brittany N. Weber, MD, PhD, Peter Libby, MD, Daniel H. Solomon, MD, MPH, Paul M Ridker, MD, MPH

“…Objectives: The purpose of this study was to assess whether SU predicts CV risk in a trial of interleukin (IL)-1β inhibition with canakinumab, and whether IL-1β blockade, kidney function, or gout alter these associations. …”
Get full text

Development and Characterization of Poly(1-vinylpyrrolidone-co-vinyl acetate) Copolymer Based Polymer Electrolytes by Nurul Nadiah Sa’adun, Ramesh Subramaniam, Ramesh Kasi

“…Gel polymer electrolytes (GPEs) are developed using poly(1-vinylpyrrolidone-co-vinyl acetate) [P(VP-co-VAc)] as the host polymer, lithium bis(trifluoromethane) sulfonimide [LiTFSI] as the lithium salt and ionic liquid, and 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl) imide [EMImTFSI] by using solution casting technique. …”
Get full text

A Research Synthesis of Therapeutic Interventions for Whiplash-Associated Disorder: Part 1 – Overview and Summary by Robert W Teasell, J Andrew McClure, David Walton, Jason Pretty, Katherine Salter, Matthew Meyer, Keith Sequeira, Barry Death

Get full text

Investigation of the effıciency of pomegranate (punica granatum l.) peel extract on herpes simplex virus-1 by Irmak Dik, Hatice Pelin Aslım

Subjects: “…hsv-1…”
Get full text

FGF21 and APOA1 mRNA-based therapies for the treatment of experimental acute pancreatitis by Amaya Lopez-Pascual, Eva Santamaria, Nuria Ardaiz, Iker Uriarte, Tiffany Palmer, Anne-Renee Graham, Celia Gomar, Roberto C. Barbero, M. Ujue Latasa, Maria Arechederra, Jesus M. Urman, Carmen Berasain, Antonio Fontanellas, Carlos L. del Rio, Maite G. Fernandez-Barrena, Paolo G.V. Martini, Joshua R. Schultz, Pedro Berraondo, Matias A. Avila

Subjects: Get full text

Current State of Type 1 Diabetes Immunotherapy: Incremental Advances, Huge Leaps, or More of the Same? by Brett Phillips, Massimo Trucco, Nick Giannoukakis

“…Thus far, none of the preclinically successful and promising immunomodulatory agents for type 1 diabetes mellitus (T1DM) has conferred stable, long-term insulin independence to diabetic patients. …”
Get full text

High-resolution Observations of an X-1.0 White-light Flare with Moving Flare Ribbons by Xu Yang, Meiqi Wang, Andrew Cao, Kaifan Ji, Vasyl Yurchyshyn, Jiong Qiu, Sijie Yu, Jinhua Shen, Wenda Cao

“…We analyze high-resolution observations of an X-1.0 white-light flare, triggered by a filament eruption, on 2022 October 2. …”
Get full text

Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma by Gorkem Odabas, Metin Cetin, Serdar Turhal, Huseyin Baloglu, A. Emre Sayan, Tamer Yagci

“…Our observations in cancer databases that PLXNC1 is upregulated in HCC led us to investigate the expression profile of Plexin C1 mRNA and protein in HCC cell lines and tissues. …”
Get full text

Internalizing and externalizing symptoms in individuals with neurofibromatosis type 1: a systematic review and meta-analysis by Dan Liu, Liyan Yu, Xian Wu, Julia Moreira, Benjamin Felipe Mujica, Elora Shelly Mukhopadhyay, Angelena Novotney, André B. Rietman, Yang Hou

“…Abstract Background Individuals with neurofibromatosis type 1 (NF1) frequently report psychosocial problems, among which internalizing and externalizing symptoms are the most poorly understood due to limited research and inconsistent evidence. …”
Get full text

Naturally occurring anti-P1 with high thermal amplitude complicating ABO blood grouping by Shirin Ferdowsi, Saeed Mohammadi, Moharram Ahmadnezhad, Fahimeh Herfat, Azita Rezvani, Peyman Eshghi, Arezoo Oodi

“…Anti-P1 is immunoglobulin M type and occurs naturally; it is often detected as a weak- and cold-reactive antibody. …”
Get full text

Bifurcation analysis of HIV-1 infection model with cell-to-cell transmission and immune response delay by Jinhu Xu, Yicang Zhou

Get full text

Associations of Dietary Antioxidants with Glycated Hemoglobin and Insulin Sensitivity in Adults with and without Type 1 Diabetes by Arpita Basu, Amy C. Alman, Janet K. Snell-Bergeon

“…Type 1 diabetes (T1D) has been associated with increased risks of atherosclerotic cardiovascular disease, and poor glycemic control and oxidative stress play a major role in its pathology. …”
Get full text

Membranes of Polymer of Intrinsic Microporosity PIM-1 for Gas Separation: Modification Strategies and Meta-Analysis by Boya Qiu, Yong Gao, Patricia Gorgojo, Xiaolei Fan

Subjects: Get full text

Predictors of Cardiovascular Autonomic Neuropathy Onset and Progression in a Cohort of Type 1 Diabetic Patients by M. Matta, A. Pavy-Le Traon, S. Perez-Lloret, C. Laporte, I. Berdugo, N. Nasr, H. Hanaire, J. M. Senard

“…Hereby, we assessed the rate and the major risk factors for CAN initiation and progression in a cohort of type 1 diabetic patients followed over a three-year period. …”
Get full text

„Duch Pana JHWH nade mną”. Tożsamość proroka w Iz 61,1-3 by Jolanta Judyta Pudełko

“…There is disappointment and at the same time anticipation of the realization of earlier prophecies of restoration. In Isa 61: 1-3 there is a confession of a mysterious figure sent by God. …”
Get full text

DNA Methylation May be Involved in the Analgesic Effect of Hyperbaric Oxygen via Regulating FUNDC1 by Kun Liu, Hao Wu, Rui Gao, Guang Han

“…We investigated the role of hyperbaric oxygen (HBO) in expression of FUN14 domain-containing 1 (FUNDC1), which is associated with DNA methylation. …”
Get full text

Comentarios a la Observación General n° 1 del Comité de Trabajadores Migrantes by María Teresa Palacios Sanabria

“…A su vez, se plantea la importancia de la Observación General n° 1 de este Comité, con el propósito de examinar si dicho pronunciamiento contribuye o no al desarrollo progresivo de los derechos de los trabajadores migratorios y sus familias. …”
Get full text